A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

(2014) Diogo Fonseca-Pereira et al.   NATURE

Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer

(2014) W Nakajima et al.   Cell Death & Disease

Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells

(2013) Albana Gattelli et al.   EMBO Molecular Medicine

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

(2013) Zamal Ahmed et al.   JOURNAL OF CELL BIOLOGY

The Relationship between Over-expression of Glial Cell-derived Neurotrophic Factor and Its RET Receptor with Progression and Prognosis of Human Pancreatic Cancer

(2013) Q Zeng et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

(2012) Luke R. G. Pike et al.   BIOCHEMICAL JOURNAL

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response

(2012) Emmanuel Ampofo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation

(2012) P Ballerini et al.   LEUKEMIA

Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene

(2012) M Díaz-Beyá et al.   LEUKEMIA

Alternative splicing results in RET isoforms with distinct trafficking properties

(2012) Douglas S. Richardson et al.   MOLECULAR BIOLOGY OF THE CELL

KIF5B-RET fusions in lung adenocarcinoma

(2012) Takashi Kohno et al.   NATURE MEDICINE

RET, ROS1 and ALK fusions in lung cancer

(2012) Kengo Takeuchi et al.   NATURE MEDICINE

cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of thePeriod2Gene

(2011) Satoru Koyanagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

(2010) L Zhang et al.   CELL DEATH AND DIFFERENTIATION

The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells

(2010) D. Vitagliano et al.   ENDOCRINE-RELATED CANCER

Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis

(2010) Christopher L. Frank et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs

(2010) C Sheridan et al.   ONCOGENE

c-RET Molecule in Malignant Melanoma from Oncogenic RET-Carrying Transgenic Mice and Human Cell Lines

(2010) Yuichiro Ohshima et al.   PLoS One

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

(2010) Qiuyan Wang et al.   PLoS One

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

(2009) Zamal Ahmed et al.   CELLULAR SIGNALLING

Targeting the RET Pathway in Thyroid Cancer

(2009) S. A. Wells et al.   CLINICAL CANCER RESEARCH

Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells

(2009) Jane L. Armstrong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medullary Thyroid Carcinoma Cell Lines Contain a Self-Renewing CD133+Population that Is Dependent on Ret Proto-Oncogene Activity

(2009) Wen Zhu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

(2008) Y. Nikolsky et al.   CANCER RESEARCH

Sp1 and p73 activate PUMA following serum starvation

(2008) L. Ming et al.   CARCINOGENESIS

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE