Mutational study of the “catalytic tetrad” of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance

Title
Mutational study of the “catalytic tetrad” of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance
Authors
Keywords
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Journal
BIOCHEMICAL PHARMACOLOGY
Volume 76, Issue 5, Pages 608-619
Publisher
Elsevier BV
Online
2008-07-08
DOI
10.1016/j.bcp.2008.06.019

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