Article
Plant Sciences
Yin-Ai Deng, Li Li, Qian Peng, Ling-Fang Feng, Jin-Fen Yang, Ruo-Ting Zhan, Dong-Ming Ma
Summary: In this study, a C2H2-type transcription factor AaZFP1 was found to bind to the AGT-N1-10-AGT box of AaIPPI1pro and activate the expression of AaIPPI1 involved in artemisinin biosynthesis. This provides insights into the transcriptional regulation of genes involved in artemisinin biosynthesis in Artemisia annua.
Review
Oncology
Janna A. Hol, Rosalyn Jewell, Tanzina Chowdhury, Catriona Duncan, Kayo Nakata, Takaharu Oue, Marion Gauthier-Villars, Annemieke S. Littooij, Yasuhiko Kaneko, Norbert Graf, Franck Bourdeaut, Marry M. van den Heuvel-Eibrink, Kathy Pritchard-Jones, Eamonn R. Maher, Christian P. Kratz, Marjolijn C. J. Jongmans
Summary: The updated Wilms tumour surveillance guidelines have been released for clinical geneticists, pediatricians, pediatric oncologists, and radiologists caring for children at risk of WT. These guidelines stress the importance of registering all patients with cancer predisposition syndromes in order to improve future tumor risk estimation and surveillance programs.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Ranjeet Maurya, Aparna Swaminathan, Uzma Shamim, Smriti Arora, Pallavi Mishra, Aakarshan Raina, Varsha Ravi, Bansidhar Tarai, Sandeep Budhiraja, Rajesh Pandey
Summary: The emergence of multiple SAR-CoV-2 variants during the COVID-19 pandemic has led to an increased understanding of the host-immune kinetics associated with these variants. A longitudinal investigation revealed a robust antiviral response in Omicron infection, which was largely absent in the Pre-VOC and Delta waves. The study also highlighted differential protein-protein interactions and gene expression patterns, particularly in relation to zinc finger proteins, that contribute to the immune response.
Article
Pediatrics
Maria Pia Falcone, Kathryn Pritchard-Jones, Jesper Brok, William Mifsud, Richard D. Williams, Kayo Nakata, Suzanne Tugnait, Reem Al-Saadi, Lucy Side, John Anderson, Catriona Duncan, Stephen D. Marks, Detlef Bockenhauer, Tanzina Chowdhury
Summary: The study found that nearly two-thirds of children with WT and constitutional WT1 pathogenic variant had sustained native kidney function, despite the high risk of kidney disease. This suggests that nephron-sparing surgery should be attempted when possible, and larger international studies are needed to accurately assess the correlation between WT1 genotype and kidney function phenotype.
PEDIATRIC NEPHROLOGY
(2022)
Article
Plant Sciences
Jinqiu Liu, Haoran Wang, Mengmeng Liu, Jinkui Liu, Sujun Liu, Qing Cheng, Huolin Shen
Summary: Multicellular trichomes in plants are controlled by a key gene called Hairiness, which plays an essential role in regulating the formation of non-glandular trichomes. Differential expression of Hairiness is mainly due to variations in promoter sequences. Transgenic experiments confirmed that low activity of Hairiness promoter leads to a hairless phenotype, indicating a potential pathway for regulating multicellular trichome formation in crops.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Microbiology
Alyssa C. Baugh, Cory Momany, Ellen L. Neidle
Summary: LysR-type transcriptional regulators (LTTRs) are a large family of bacterial regulators that contribute to various aspects of metabolism and physiology. They bind DNA in the presence or absence of a small-molecule ligand, undergo conformational changes in response to cellular signals, and can act as repressor-activators. This review updates on the molecular basis, regulatory complexity, and applications of LTTRs in biotechnology and medicine.
ANNUAL REVIEW OF MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianwen Zhao, Tinghui Shao, Yuwen Zhu, Gengjie Zong, Junjie Zhang, Shifan Tang, Yanshan Lin, Hongzhen Ma, Zhifan Jiang, Yong Xu, Xiaoyan Wu, Tao Zhang
Summary: This study found that myofibroblasts play an important role in renal fibrosis. By deleting myocardin-related transcription factor A (MRTF-A), the researchers discovered that MRTF-A promotes renal fibrosis by activating the transcription of Zeb1 and IRF9. These findings reveal a potential pathway for treating renal fibrosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Agronomy
Z. E. N. G. Xiaoqin, Z. H. U. A. N. G. Hui, Cheng Qinglan, T. A. N. G. Jun, Y. A. N. G. Fayu, H. U. A. N. G. Mingjiang, W. A. N. G. Ziyi, L. Zhongcheng, Z. H. U. Honghui, C. H. E. N. Rui, H. E. Guanghua, L. Yunfeng
Summary: The study identified five allelic mutants related to branch development in rice, where the SB1 gene was found to act as a transcriptional repressor of branch meristem activity by negatively regulating a series of genes. This repression leads to prolonged branch meristem fate and increased numbers of branches and spikelets per panicle.
Article
Plant Sciences
Xiaofei Liang, Bingxuan Li, Xuemei Zhao, Liqiang Yao, Yuanyuan Kong, Wenkui Liu, Rong Zhang, Guangyu Sun
Summary: In this study, the researchers identified and characterized two zinc finger transcription factors (TFs) that are involved in the regulation of 1,8-dihydroxynaphthalene (DHN) melanin biosynthesis in the phytopathogen Colletotrichum fructicola. They found that these TFs are not only important for melanin production, but also regulate perithecial development in the fungus. The study expands our understanding of DHN melanin regulation and reveals a new function for melanin in sex regulation.
Article
Multidisciplinary Sciences
Jianwen Song, Lele Shang, Changxing Li, Wenqian Wang, Xin Wang, Chunli Zhang, Guo Ai, Jie Ye, Changxian Yang, Hanxia Li, Zonglie Hong, Robert M. Larkin, Zhibiao Ye, Junhong Zhang
Summary: This study identified the molecular mechanism underlying fruit tip development in tomato and elucidated the role of the PT gene in this process, revealing the functional differences between the PTH and PTR alleles.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
Norbert Bollier, Nathalie Gonzalez, Christian Chevalier, Michel Hernould
Summary: The ZHD/MIF protein family is a plant-specific family of transcription factors that play important roles in plant growth and development, as well as in response to environmental stresses. Despite limited information on their functions, various studies have shown their diverse roles in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Jing Zhang, Miao Tian, Kai Chen, Guanxiong Yan, Jie Xiong, Wei Miao
Summary: Meiosis, an important process in eukaryotic sexual reproduction, is initiated by diverse mechanisms involving transcription factors in many species. This study reveals that a putative Cys2His2 zinc finger-containing transcription factor, encoded by the ZFP1 gene, is specifically expressed during sexual reproduction in Tetrahymena thermophila. Cells lacking ZFP1 fail to initiate meiosis, and transcriptome analysis indicates that Zfp1 is required for the expression of meiosis-specific genes. These findings suggest that Zfp1 may act as a transcriptional activator for meiosis initiation in T. thermophila.
Review
Oncology
Xinxin Li, Mengzhen Han, Hongwei Zhang, Furong Liu, Yonglong Pan, Jinghan Zhu, Zhibin Liao, Xiaoping Chen, Bixiang Zhang
Summary: Zinc finger proteins, characterized by their different DNA binding motifs, play a significant role in gene regulation. In hepatocellular carcinoma (HCC), zinc finger proteins exhibit diverse functions in tumorigenesis and progression, and they are also of great significance in HCC diagnosis and prognostic evaluation.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Shiyao Qiao, Wenmeng Wang, Cheng Yi, Qingqing Xu, Wenfei Wang, Jinming Shi, Daniel B. Stovall, Dangdang Li, Guangchao Sui
Summary: YY1 regulates various cancer-related genes and activates key oncoproteins. The oncoprotein binding (OPB) domain of YY1 is necessary and stimulatory to its oligomerization. Hydrophobic residues, especially F219, in the OPB are essential to YY1 intermolecular interaction. Mutations of the hydrophobic residues showed better ability than wild-type YY1 in promoting breast cancer cell proliferation and migration. Further study revealed improved binding affinity of YY1 proteins with mutated hydrophobic residues to EZH2. Our data support the model of a mutually exclusive process between YY1 oligomerization and its regulation of oncoproteins.
Review
Plant Sciences
Xiaoman Zou, Hongmei Sun
Summary: Plant biological processes are regulated by gene transcriptional regulation, in which transcription factors play a crucial role. DOF (DNA binding with One Finger) is a plant-specific transcription factor family characterized by its single zinc finger structure, and recent studies have shown their vital roles in various biological processes. This article reviews the origin, evolution, protein structure, and functions of DOF members reported in studies to provide directions for future research.
FRONTIERS IN PLANT SCIENCE
(2023)
Correction
Oncology
N. Vasan, E. Toska, M. Scaltriti
ANNALS OF ONCOLOGY
(2020)
Article
Genetics & Heredity
Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Yanyan Cai, Jordan E. Otto, Lorenzo Ferrando, Pier Selenica, Erik Ladewig, Carmen Chan, Arnaud Da Cruz Paula, Matthew Witkin, Yuanming Cheng, Jane Park, Cristian Serna-Tamayo, HuiYong Zhao, Fan Wu, Mirna Sallaku, Xuan Qu, Alison Zhao, Clayton K. Collings, Andrew R. D'Avino, Komal Jhaveri, Richard Koche, Ross L. Levine, Jorge S. Reis-Filho, Cigall Kadoch, Maurizio Scaltriti, Christina S. Leslie, Jose Baselga, Eneda Toska
Article
Endocrinology & Metabolism
Zachary C. Ahart, Laura E. Martin, Bailey R. Kemp, Debarghya Dutta Banik, Stefan G. E. Roberts, Ann-Marie Torregrossa, Kathryn F. Medler
Article
Oncology
Patrizia Mondello, Saber Tadros, Matt Teater, Lorena Fontan, Aaron Y. Chang, Neeraj Jain, Haopeng Yang, Shailbala Singh, Hsia-Yuan Ying, Chi-Shuen Chu, Man Chun John Ma, Eneda Toska, Stefan Alig, Matthew Durant, Elisa de Stanchina, Sreejoyee Ghosh, Anja Mottok, Loretta Nastoupil, Sattva S. Neelapu, Oliver Weigert, Giorgio Inghirami, Jose Baselga, Anas Younes, Cassian Yee, Ahmet Dogan, David A. Scheinberg, Robert G. Roeder, Ari M. Melnick, Michael R. Green
Article
Oncology
Amaia Arruabarrena-Aristorena, Jesper L. V. Maag, Srushti Kittane, Yanyan Cai, Wouter R. Karthaus, Erik Ladewig, Jane Park, Srinivasaraghavan Kannan, Lorenzo Ferrando, Emiliano Cocco, Sik Y. Ho, Daisylyn S. Tan, Mirna Sallaku, Fan Wu, Barbara Acevedo, Pier Selenica, Dara S. Ross, Matthew Witkin, Charles L. Sawyers, Jorge S. Reis-Filho, Chandra S. Verma, Ralf Jauch, Richard Koche, Jose Baselga, Pedram Razavi, Eneda Toska, Maurizio Scaltriti
Article
Biochemistry & Molecular Biology
Tareg Belali, Chigeru Wodi, Bethany Clark, Man-Kim Cheung, Tim J. Craig, Gabrielle Wheway, Nicole Wagner, Kay-Dietrich Wagner, Stefan Roberts, Sean Porazinski, Michael Ladomery
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2020)
Article
Multidisciplinary Sciences
Amy E. Loats, Samantha Carrera, Anna F. Fleming, Abigail R. E. Roberts, Alice Sherrard, Eneda Toska, Alexander J. Moorhouse, Kathryn F. Medler, Stefan G. E. Roberts
Summary: The study reveals that the lipidated protein BASP1 recruits cholesterol to the promoter region of target genes in the cell nucleus through a conserved interaction motif, and that BASP1's interaction with cholesterol is required for chromatin remodeling and the direction of transcription programs controlling cell differentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Andrew L. Wolfe, Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A. Ku, Richard P. Koche, Sourav Bandyopadhyay, Maurizio Scaltriti, Carlito B. Lebrilla, Frank McCormick, Sung Eun Kim
Summary: The enzyme UGP2, which synthesizes UDP-glucose, plays a crucial role in maintaining pancreatic ductal adenocarcinoma (PDAC) growth. Its transcription is directly regulated by the YAP-TEAD complex, and loss of UGP2 leads to decreased glycogen levels and defects in glycosylation of important targets for PDAC survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Hematology
Megan Wagstaff, Olga Tsaponina, Gilian Caalim, Hayley Greenfield, Leanne Milton-Harris, Erika J. Mancini, Allison Blair, Kate J. Heesom, Alex Tonks, Richard L. Darley, Stefan G. Roberts, Rhys G. Morgan
Article
Multidisciplinary Sciences
Alexander J. Moorhouse, Amy E. Loats, Kathryn F. Medler, Stefan G. E. Roberts
Summary: The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Removal of active histone modifications H3K9ac and H3K4me3 by BASP1 requires N-terminal myristoylation, while placement of the repressive histone modification H3K27me3 does not require lipidation. BASP1 regulates activity of multiple transcription factors and induces extensive changes in chromatin accessibility, with about 50% of BASP1 target genes showing lipidation-dependent chromatin compaction and transcriptional repression.
Editorial Material
Oncology
Ryan Blawski, Eneda Toska
Summary: In this study, the authors investigated the mechanisms of differential therapy response in invasive lobular carcinomas (ILC) compared to invasive ductal carcinomas (IDC). They found an alternative chromatin accessibility state in ILC driven by the pioneer factor FOXA1, which promotes the transcription of genes associated with tumor progression and tamoxifen resistance. Targeting the FOXA1 enhancer region blocks this transcriptional program and inhibits ILC proliferation.
Article
Oncology
Anuj Anuj, Nina Reuven, Stefan G. E. Roberts, Ari Elson
Summary: The cytokine RANKL is involved in the differentiation of monocytes/macrophages into bone-resorbing osteoclasts, and it down-regulates the expression of BASP1 which is a negative regulator of osteoclastogenesis. Knocking down or eliminating BASP1 enhances RANKL-induced osteoclastogenesis, promoting cell-cell fusion and increasing mineral degrading abilities of osteoclasts.
EXPERIMENTAL CELL RESEARCH
(2023)
Meeting Abstract
Oncology
Neil Vasan, Pedram Razavi, Jared Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Meeting Abstract
Oncology
Erik Ladewig, Lauren Fairchild, Maurizio Scaltriti, Christina Leslie, Eneda Toska, Jose Baselga
Article
Biology
Yankun Gao, Debarghya Dutta Banik, Mutia M. Muna, Stefan G. E. Roberts, Kathryn F. Medler
LIFE SCIENCE ALLIANCE
(2019)