Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

(2011) J. Xu et al.   BLOOD

Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

(2011) Joseph R. Burgoyne et al.   FASEB JOURNAL

Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern

(2011) S. Eisenberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Palmitoylation of oncogenic NRAS is essential for leukemogenesis

(2010) B. Cuiffo et al.   BLOOD

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

(2010) Matthias Drosten et al.   EMBO JOURNAL

TCR-Induced Activation of Ras Proceeds at the Plasma Membrane and Requires Palmitoylation of N-Ras

(2010) I. Rubio et al.   JOURNAL OF IMMUNOLOGY

Compartmentalized Ras Proteins Transform NIH 3T3 Cells with Different Efficiencies

(2010) C.-M. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Ras Localization by Acylation Enables a Mode of Intracellular Signal Propagation

(2010) A. Lorentzen et al.   Science Signaling

Using cells devoid of RAS proteins as tools for drug discovery

(2009) Jelena Urosevic et al.   MOLECULAR CARCINOGENESIS

A novel switch region regulates H-ras membrane orientation and signal output

(2008) Daniel Abankwa et al.   EMBO JOURNAL

Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs

(2008) Kerry Inder et al.   MOLECULAR BIOLOGY OF THE CELL

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine

(2008) C. D. Harvey et al.   SCIENCE