Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

(2011) HongMin Zhang et al.   FASEB JOURNAL

Constraining Enzyme Conformational Change by an Antibody Leads to Hyperbolic Inhibition

(2011) David Oyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Metallo-β-lactamases: a last frontier for β-lactams?

(2011) Giuseppe Cornaglia et al.   LANCET INFECTIOUS DISEASES

Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

(2011) Dustin King et al.   PROTEIN SCIENCE

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

Biochemical and Structural Characterization of the Subclass B1 Metallo-β-Lactamase VIM-4

(2010) Patricia Lassaux et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro antiviral activity of single domain antibody fragments against poliovirus

(2010) Bert Thys et al.   ANTIVIRAL RESEARCH

Evidence of Adaptability in Metal Coordination Geometry and Active-Site Loop Conformation among B1 Metallo-β-lactamases,

(2010) Javier M. González et al.   BIOCHEMISTRY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Current Challenges in Antimicrobial Chemotherapy

(2010) Carine Bebrone et al.   DRUGS

Substrate-dependent modulation of enzyme activity by allosteric effector antibodies

(2009) John N. Barlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

β-Lactamase Inhibitors: The Story so Far

(2009) Francisco Perez-Llarena et al.   CURRENT MEDICINAL CHEMISTRY

Motion of the Zinc Ions in Catalysis by a Dizinc Metallo-β-Lactamase

(2009) Robert M. Breece et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular dynamic simulations of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor

(2008) Freddie R. Salsbury et al.   JOURNAL OF MOLECULAR MODELING

Metal Content and Localization during Turnover inB. cereusMetallo-β-lactamase

(2008) Leticia I. Llarrull et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping and Characterization of a Reaction Intermediate in Carbapenem Hydrolysis byB. cereusMetallo-β-lactamase

(2008) Mariana F. Tioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility

(2008) P. E. Tomatis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY