Preparation andin vivocharacterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine

Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage

(2012) Yang Gao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice

(2012) Stephen Brimijoin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity

(2012) Katherine E. Larrimore et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

(2012) Xavier Brazzolotto et al.   FEBS Journal

Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose?

(2012) Fang Zheng et al.   Future Medicinal Chemistry

Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

(2012) Marilyn E. Carroll et al.   PLoS One

Modeling of Pharmacokinetics of Cocaine in Human Reveals the Feasibility for Development of Enzyme Therapies for Drugs of Abuse

(2012) Fang Zheng et al.   PLoS Computational Biology

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High Yield of Human Monoclonal Antibody Produced by Stably Transfected Drosophila Schneider 2 Cells in Perfusion Culture Using Wave Bioreactor

(2011) Lulan Wang et al.   MOLECULAR BIOTECHNOLOGY

Regulation of the dopamine transporter

(2010) Kyle C. Schmitt et al.   Annals of the New York Academy of Sciences

Characterization of a high-activity mutant of human butyrylcholinesterase against (−)-cocaine

(2010) Wenchao Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Enzyme-therapy approaches for the treatment of drug overdose and addiction

(2010) Fang Zheng et al.   Future Medicinal Chemistry

Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system

(2010) Hong Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine

(2010) L. Xue et al.   MOLECULAR PHARMACOLOGY

Free-Energy Perturbation Simulation on Transition States and Redesign of Butyrylcholinesterase

(2009) Wenchao Yang et al.   BIOPHYSICAL JOURNAL

Recent progress in protein drug design and discovery with a focus on novel approaches to the development of anticocaine medications

(2009) Fang Zheng et al.   Future Medicinal Chemistry

Modeling the Catalysis of Anti-Cocaine Catalytic Antibody: Competing Reaction Pathways and Free Energy Barriers

(2008) Yongmei Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Most Efficient Cocaine Hydrolase Designed by Virtual Screening of Transition States

(2008) Fang Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cocaine Hydrolase Engineered from Human Butyrylcholinesterase Selectively Blocks Cocaine Toxicity and Reinstatement of Drug Seeking in Rats

(2008) Stephen Brimijoin et al.   NEUROPSYCHOPHARMACOLOGY

Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction

(2007) Fang Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY