Adaptive evolution of drug targets in producer and non-producer organisms

Versatile Enzyme Expression and Characterization System for Aspergillus nidulans, with the Penicillium brevicompactum Polyketide Synthase Gene from the Mycophenolic Acid Gene Cluster as a Test Case

(2011) Bjarne G. Hansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

(2011) Torsten Bak Regueira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi

(2011) Bjarne G Hansen et al.   BMC MICROBIOLOGY

Fungal Indole Alkaloid Biosynthesis: Genetic and Biochemical Investigation of the Tryptoquialanine Pathway inPenicillium aethiopicum

(2011) Xue Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

A mutant Pfu DNA polymerase designed for advanced uracil-excision DNA engineering

(2010) Morten HH Nørholm   BMC BIOTECHNOLOGY

Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

(2010) Yit-Heng Chooi et al.   CHEMISTRY & BIOLOGY

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

(2010) Iain S. MacPherson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Homologous recombination in the antibiotic producer Penicillium chrysogenum: strain ΔPcku70 shows up-regulation of genes from the HOG pathway

(2009) Birgit Hoff et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

(2009) Cara A Tracewell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

(2008) Marco A van den Berg et al.   NATURE BIOTECHNOLOGY