Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolismin vivo

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

(2011) Stephen Jamieson et al.   BIOCHEMICAL JOURNAL

Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells

(2010) Kyota Aoyagi et al.   BIOCHEMICAL JOURNAL

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

(2010) P. Workman et al.   CANCER RESEARCH

Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation

(2010) Victoria Rotter Sopasakis et al.   Cell Metabolism

A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

(2010) A. A. Butler et al.   DIABETES

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

Both p110α and p110β Isoforms of Phosphatidylinositol 3-OH-Kinase are Required for Insulin Signalling in the Hypothalamus

(2010) A. Tups et al.   JOURNAL OF NEUROENDOCRINOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over-Expressing Soluble Leptin Receptor

(2010) Phing-How Lou et al.   PLoS One

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation

(2008) Ji Eun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat

(2008) G. C. Smith et al.   DIABETOLOGIA

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling