Journal
BIOCHEMICAL JOURNAL
Volume 443, Issue -, Pages 339-353Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20112017
Keywords
cancer; head and neck squamous cell carcinoma (HNSCC); human papillomavirus (HPV); oropharyngeal squamous cell carcinoma (OPSCC)
Categories
Funding
- National Institutes of Health/National Institute of Dental and Craniofacial Research [F31DE021926]
- National Institutes of Health/National Cancer Institute [R01CA085870]
Ask authors/readers for more resources
The current literature fully supports HPV (human papillomavirus)-associated OPSCC (oropharyngeal squamous cell carcinoma) as a unique clinical entity. It affects an unambiguous patient population with defined risk factors, has a genetic expression pattern more similar to cervical squamous cell carcinoma than non-HPV-associated HNSCC (head and neck squamous cell carcinoma), and may warrant divergent clinical management compared with HNSCC associated with traditional risk factors. However, a detailed understanding of the molecular mechanisms driving these differences and the ability to exploit this knowledge to improve clinical management of OPSCC has not yet come to fruition. The present review summarizes the aetiology of HPV-positive (HPV+) OPSCC and provides a detailed overview of HPV virology and molecular pathogenesis relevant to infection of oropharyngeal tissues. Methods of detection and differential gene expression analyses are also summarized. Future research into mechanisms that mediate tropism of HPV to oropharyngeal tissues, improved detection strategies and the pathophysiological significance of altered gene and microRNA expression profiles is warranted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available