Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood–retinal barrier dysfunction

Protein Kinase C  Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor-Induced Permeability In Vivo

(2012) T. Murakami et al.   DIABETES

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C–ι

(2012) Mini P. Sajan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of proliferative diabetic retinopathy with anti-VEGF agents

(2011) Aysha Salam et al.   ACTA OPHTHALMOLOGICA

A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma

(2011) Prajit Pillai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Double Anti-angiogenic and Anti-inflammatory Protein Valpha Targeting VEGF-A and TNF-α in Retinopathy and Psoriasis

(2011) Keehoon Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

Expanded 2-Year Follow-up of Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema

(2011) Michael J. Elman et al.   OPHTHALMOLOGY

EFFECT OF RUBOXISTAURIN (RBX) ON VISUAL ACUITY DECLINE OVER A 6-YEAR PERIOD WITH CESSATION AND REINSTITUTION OF THERAPY

(2011) Matthew J Sheetz et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Role of GTPases in control of microvascular permeability

(2010) V. Spindler et al.   CARDIOVASCULAR RESEARCH

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

(2010) C. A. Aveleira et al.   DIABETES

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis

(2010) Brad A. Bryan et al.   FASEB JOURNAL

Protein Kinase C Activation Modulates Reversible Increase in Cortical Blood–Brain Barrier Permeability and Tight Junction Protein Expression during Hypoxia and Posthypoxic Reoxygenation

(2010) Colin L Willis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers

(2010) Richard D. Minshall et al.   MICROVASCULAR RESEARCH

Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema

(2010) Michael J. Elman et al.   OPHTHALMOLOGY

Diabetic macular oedema and visual loss: relationship to location, severity and duration

(2009) Thomas W. Gardner et al.   ACTA OPHTHALMOLOGICA

Metabolic functions of atypical protein kinase C: “good” and “bad” as defined by nutritional status

(2009) Robert V. Farese et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Screening of a PKC ζ-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis

(2009) Jing Wu et al.   INVESTIGATIONAL NEW DRUGS

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrosterol Sulfates from the Philippine SpongeLissodendoryx(Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

(2009) Emily L. Whitson et al.   JOURNAL OF ORGANIC CHEMISTRY

Identification and Analysis of Occludin Phosphosites: A Combined Mass Spectrometry and Bioinformatics Approach

(2009) Jeffrey M. Sundstrom et al.   JOURNAL OF PROTEOME RESEARCH

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

(2009) Langtian Yuan et al.   Molecular BioSystems

Clinical Review: Anti-TNFα Therapies in Uveitis: Perspective on 5 Years of Clinical Experience

(2009) Srilakshmi M. Sharma et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

(2009) C. M. L. Beckers et al.   THROMBOSIS AND HAEMOSTASIS

Etiology and Treatment of Macular Edema

(2008) Mark W. Johnson   AMERICAN JOURNAL OF OPHTHALMOLOGY

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor

(2008) John I. Trujillo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Vascular endothelial growth factor in eye disease

(2008) J.S. Penn et al.   PROGRESS IN RETINAL AND EYE RESEARCH