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Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

(2016) Marie-Thérèse Château et al.   Aging-US

Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation

(2011) Yun Liu et al.   FEBS LETTERS

Trehalose extends longevity in the nematode Caenorhabditis elegans

(2010) Yoko Honda et al.   AGING CELL

Antioxidant activity of Astragalus polysaccharides and antitumour activity of the polysaccharides and siRNA

(2010) Rui Li et al.   CARBOHYDRATE POLYMERS

Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides

(2010) Hui Yan et al.   CARBOHYDRATE POLYMERS

Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune

(2010) Haifeng Li et al.   CARBOHYDRATE POLYMERS

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

(2010) B. R. Underwood et al.   HUMAN MOLECULAR GENETICS

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Modeling anhydrobiosis: activation of the mitogen-activated protein kinase ERK by dehydration in both human cells and nematodes

(2010) Zebo Huang et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Ageing and protein aggregation-mediated disorders: from invertebrates to mammals

(2010) A. Dillin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance

(2010) S. Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

The lifespan-promoting effect of acetic acid and Reishi polysaccharide

(2009) Ming-Hong Chuang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes

(2009) Nian Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism

(2009) Xian-qing Mao et al.   PHYTOMEDICINE

Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-α and interleukin-8

(2009) Yuan Yuan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Oxidative stress in neurodegeneration and available means of protection

(2008) Amos Akintayo Fatokun   Frontiers in Bioscience-Landmark

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Moving towards a vaccine

(2008) David M. Holtzman   NATURE

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE