Article
Pharmacology & Pharmacy
Changwei Zou, Ying Chen, Hongyu Li, Wenyu Li, Jin Wei, Ziyan Li, Xinliang Wang, Tingtao Chen, Hong Huang
Summary: Cadmium exposure is a global problem with limited treatment options. A genetically modified strain of Escherichia coli that expresses metallothionein was found to effectively bind cadmium and reduce cadmium levels in the liver. The strain also improved liver function and restored the disrupted microbial ecology.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Monazza Shahab, Samson Jamesdaniel
Summary: The article discusses the induction and therapeutic value of targeting nitrate stress in auditory tissue.
Article
Biochemistry & Molecular Biology
Anna Marchelak, Joanna Kolodziejczyk-Czepas, Paulina Wasielewska, Pawel Nowak, Monika A. Olszewska
Summary: The study showed that phytochemically standardized Prunus spinosa flower extracts, their primary native polyphenols, and potential phenolic metabolites can protect fibrinogen from structural changes under oxidative stress conditions induced by peroxynitrite, particularly reducing oxidation and nitration of amino acid residues and formation of high molecular weight aggregates. Low molecular weight polyphenols were found crucial for this protective activity.
Article
Pharmacology & Pharmacy
Wen Su, Mingji Feng, Yuan Liu, Rong Cao, Yiao Liu, Junyao Tang, Ke Pan, Rongfeng Lan, Zhuo Mao
Summary: Deficiency of ZnT8 in mice alleviates APAP-induced liver injury by inhibiting oxidative stress and promoting hepatocyte proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Hematology
Lauren G. Poole, Anna K. Kopec, Dafna J. Groeneveld, Asmita Pant, Kevin S. Baker, Holly M. Cline-Fedewa, Matthew J. Flick, James P. Luyendyk
Summary: This study investigated the mechanisms of fibrin polymerization and cross-linking in acute liver injury induced by acetaminophen overdose. It was found that deficiency in FXIII dramatically reduced fibrin(ogen) cross-linking, while the impact on fibrin(ogen) deposition and cross-linking was less significant in Fib(AEK) mice. The presence of oxidative mediators in the injured liver was proposed as a factor affecting fibrin polymerization without affecting FXIII-mediated cross-linking.
Article
Biochemistry & Molecular Biology
P. Aravind, Sarojini R. Bulbule, N. Hemalatha, R. L. Babu, K. S. Devaraju
Summary: The study analyzed the gene expression of major calcium binding proteins under oxidative stress, revealing enhanced expression of certain proteins and down-regulation of others. Additionally, Akt protein expression was enhanced in most stress inducers except under hyperglycemic conditions.
Review
Pharmacology & Pharmacy
Veronica Souza-Arroyo, Jessica J. Fabian, Leticia Bucio-Ortiz, Roxana U. Miranda-Labra, Luis E. Gomez-Quiroz, Maria Concepcion Gutierrez-Ruiz
Summary: Cadmium is a toxic element that can accumulate in the human body, particularly in the liver, leading to liver damage and potentially hepatocellular carcinoma. The cellular response to cadmium involves oxidative stress, apoptosis, adipogenesis, and autophagy dysfunction, with the severity depending on the duration of cadmium exposure.
Article
Physiology
Tae-Hwan Park, Hye-Jin Lee, Jeong-Beom Lee
Summary: The study aimed to assess the impact of heat stimulation on circulating irisin levels in healthy females. Results showed that hot water immersion led to increased levels of irisin, as well as cortisol, CK, and LDH in the blood. Heat stimulation may increase circulating irisin levels in response to oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
F. Impellitteri, K. Yunko, V. Martyniuk, T. Matskiv, S. Lechachenko, V. Khoma, A. Mudra, G. Piccione, O. Stoliar, C. Faggio
Summary: This study aimed to investigate the impact of caffeine on marine mussels in combination with microplastics. The results showed that the combination of microplastics and caffeine had effects on the physiological indicators of mussels, while caffeine alone did not have a significant impact on oxidative stress indicators.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemical Research Methods
Maria-Pilar Martinez-Moral, Kurunthachalam Kannan
Summary: This study presents a novel methodology for determining 19 biomarkers of health effects associated with environmental factors. By analyzing these biomarkers in urine, it is possible to assess the direct effects of chemical exposure and their precursors to adverse health outcomes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
M. Majdeddin, U. Braun, A. Lemme, A. Golian, H. Kermanshahi, S. De Smet, J. Michiels
Summary: Dietary guanidinoacetic acid (GAA) affects creatine (Cr) metabolic pathways, leading to increased cellular Cr and improved broiler performance. However, its impact on oxidative status remains unclear. This study showed that GAA can enhance muscle energy metabolism and indirectly support tolerance against oxidative stress.
Article
Chemistry, Analytical
Xiao Wang, Xuechuan Wang, Qingxin Han
Summary: Mercury is a toxic heavy metal pollutant that poses serious threats to the environment and organism health. Oxidative stress caused by Hg2+ exposure results in the production of reactive oxygen and nitrogen species, damaging the health of organisms. Developing an efficient screening method to monitor the fluctuations in Hg2+ and ONOO- levels is crucial.
ANALYTICA CHIMICA ACTA
(2023)
Article
Pharmacology & Pharmacy
Yunxia Luo, Hansen Chen, Bun Tsoi, Qi Wang, Jiangang Shen
Summary: Ethanol extract of DSS is effective in reducing infarct sizes and improving neurological deficit scores in post-ischemic stroke rats; it attenuates apoptotic cell death by down-regulating cleaved-caspase 3 and Bax expression, up-regulating bcl-2, and decreasing oxidative/nitrosative stress. Additionally, DSS increases the expression of SIRT1 in the brain, leading to neuroprotective effects against cerebral ischemic-reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bruno da Silva Pierri, Alcir Luiz Dafre, Allan David Silva, Douglas Ismael Cadorin, Jaco Joaquim Mattos, Vera Lucia Azzolin Frescura Bascunan, James E. Pettigrew, Debora Machado Fracalossi
Summary: The study evaluated the effects of dietary supplementation with an organic micromineral complex on antioxidant defenses and mineral deposition in Nile tilapia juveniles. It was found that intermediate doses of the organic microminerals promoted metal metabolism homeostasis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Environmental Sciences
Kalpana Chhaya Lakra, Tarun Kumar Banerjee, Bechan Lal
Summary: A multi-biomarker approach was used to assess the toxicity of coal mine effluent on the catfish Clarias batrachus, revealing high metal bioaccumulation in the liver, kidney, and gills of exposed fish tissues. Significant alterations in enzyme activity and oxidative stress markers were also detected, with histopathological changes in various tissues justifying the high metal accumulation and biochemical alterations. Overall, the results indicate that the Rajrappa coal mine effluent is very toxic and may have adverse health effects on both fish and humans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Ophthalmology
Jinyu Li, Xiangjun Chen, Yongbin Yan, Ke Yao
EXPERIMENTAL EYE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Li-Dan Hu, Jing Wang, Xiang-Jun Chen, Yong-Bin Yan
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Cell Biology
Tian-Li Duan, Han Jiao, Guang-Jun He, Yong-Bin Yan
Article
Biochemistry & Molecular Biology
Feng Liu, Wen-Fei Xu, Hang Mu, Zhi-Rong Lv, Jie Peng, Chao Guo, Hai-Meng Zhou, Zhuo-Ming Ye, Xu-Hui Li
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2020)
Review
Cell Biology
Yong-Bin Yan
Summary: DDR is a coordinated network of cellular processes involving detection, signaling, and repair of DNA damage. Adjusting RNA fate through modulating polyadenylation and deadenylation plays a crucial role in reshaping gene expression profile to deal with DNA damage.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2021)
Article
Biochemistry & Molecular Biology
Kai-Jie Wang, Xiao-Yan Liao, Kunxia Lin, Yi-Bo Xi, Sha Wang, Xiu-Hua Wan, Yong-Bin Yan
Summary: A novel F30S mutation in gamma S-crystallin was identified in a Chinese family with ADCC, leading to nuclear cataract phenotype. The mutation destabilized the protein, altered its unfolding process, and disrupted cooperativity between domains during unfolding, providing new insights into the molecular mechanism underlying ADCC caused by mutations in beta/gamma-crystallins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Xiao-Hui Song, Xiao-Yan Liao, Xu-Ying Zheng, Jia-Qian Liu, Zhe-Wei Zhang, Li-Na Zhang, Yong-Bin Yan
Summary: Cancer cells reprogram gene expression profiles to support continuous growth, proliferation, and metastasis. Dysregulation of the human deadenylases Ccr4a/b and Caf1a/b is observed in various types of cancers, and depletion of these enzymes inhibits cell proliferation and tumorigenicity. Targeting global RNA metabolism may offer a potential novel strategy for cancer treatment.
Article
Cell & Tissue Engineering
Danni Lyu, Lifang Zhang, Zhenwei Qin, Shuang Ni, Jiayong Li, Bing Lu, Shengjie Hao, Qiaomei Tang, Houfa Yin, Zhijian Chen, Yong-Bin Yan, Junfeng Ji, Jiliang He, Andras Nagy, Qiuli Fu, Ke Yao
Summary: This study established a human congenital cataract in vitro model by differentiating patient-specific induced pluripotent stem cells (iPSCs) into regenerated lenses, which recapitulated the clinical manifestations and protein aggregation characteristics of patients' cataracts.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Ma, Caijing Lu, Yuting Chen, Shulin Li, Ningjia Ma, Xuan Tao, Ying Li, Jing Wang, Min Zhou, Yong-Bin Yan, Pilong Li, Kartoosh Heydari, Haiteng Deng, Min Zhang, Cong Yi, Liang Ge
Summary: In this study, the researchers identified CCT2 as an autophagy receptor that regulates the clearance of aggregation-prone proteins in cells and mouse brains. CCT2 selectively associates with aggregation-prone proteins and interacts with autophagosome marker ATG8s. Furthermore, CCT2 specifically promotes the autophagic degradation of solid protein aggregates, independent of other ubiquitin-binding receptors or chaperone-mediated autophagy.
Article
Chemistry, Analytical
Yingying Xue, Xinyi Luo, Wenfei Xu, Ke Wang, Mengqi Wu, Lei Chen, Gewei Yang, Kun Ma, Ming Yao, Qinghe Zhou, Qingshan Lv, Xuhui Li, Jianhua Zhou, Jiasi Wang
Summary: In this study, a polydisperse droplet digital CRISPR-Cas-based assay (PddCas) was developed for rapid and ultrasensitive detection of viral DNA/RNA. The method demonstrated high sensitivity, with a limit of detection of 100 aM for target DNA and 10 aM for target RNA. It also showed 100% sensitivity and specificity in detecting SARS-CoV-2 and HPV 18 in clinical samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xin-Hang Zhang, Xiang-Jun Chen, Yong-Bin Yan
Summary: This study uncovered the molecular mechanism of cytosolic CK recruitment by the mitotic apparatus, showing that Fam96b acts as a scaffold protein to coordinate ATP supply and Fe/S cluster homeostasis during mitosis. Depletion of Fam96b or CKB resulted in mitotic defects, impaired cell proliferation, increased cell death, and aberrant cell cycle progression.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Chemistry, Analytical
Wenfei Xu, Jie Peng, Chao Guo, Yingjie Chai, Haimeng Zhou, Jiasi Wang, Xuhui Li
Summary: Cervical cancer is a common tumor in women, and early diagnosis is crucial. However, there is a lack of specific biomarkers and efficient methods. In this study, methylated SEPT9 (mSEPT9) was identified as a specific biomarker, and a novel method called MeCRISPR was developed for rapid and ultrasensitive detection of mSEPT9. The results showed high sensitivity and specificity in detecting mSEPT9 in clinical cervical cancer patients. This method has the potential for cancer screening in low-resource settings.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Microbiology
Yuelin Guan, Yan Wang, Xudong Fu, Guannan Bai, Xue Li, Jianhua Mao, Yongbin Yan, Lidan Hu
Summary: Stress granules are RNA granules induced by stress and are evolutionarily conserved. They act as a self-protection mechanism during stress responses. Viral infections can trigger cellular stress responses, potentially interacting with stress granule formation. This review summarizes the role of stress granules in viral infection, particularly focusing on SARS-CoV-2. Additionally, it outlines drugs targeting stress granules and their potential effectiveness against SARS-CoV-2.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiao-Yan Liao, Yong-Bin Yan
Summary: In eukaryotic cells, deadenylation is achieved by deadenylases, which specifically degrade poly(A) or oligo(A) at the 3'-end of RNAs. Deadenylases play important roles in RNA metabolism, transcription regulation, translation efficiency, stress response, immune response, genome integrity, and stem cell differentiation. They are also involved in diverse cellular processes and associated with various diseases. The regulation of deadenylases involves a complex network of cis-acting elements, RNA-binding proteins, and post-translational modifications, which modulate RNA homeostasis and gene expression.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Chemistry, Applied
Xuhui Li, Chunxin Xia, Danni Kong, Ming Xu, Jin Zhu, Congfen He, Bingliang Wang, Junxiang Li
Summary: This study evaluated the therapeutic effects of Euglena gracilis-derived peptides on allergic inflammation and verified their efficacy through simulated experiments and clinical trials. The results showed that Euglena gracilis-derived peptides have antioxidant and anti-inflammatory activities, and can repair inflammation-induced damages. Therefore, Euglena gracilis-derived peptides can be considered as a novel cosmetic ingredient for preventing allergic responses.
JOURNAL OF COSMETIC SCIENCE
(2022)