The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

(2011) Stephen Jamieson et al.   BIOCHEMICAL JOURNAL

PI3K p110β: More Tightly Controlled or Constitutively Active?

(2011) Peter K. Vogt   MOLECULAR CELL

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

(2011) Xuxiao Zhang et al.   MOLECULAR CELL

PI3K kinase and scaffold functions in heart

(2010) Federico Damilano et al.   Annals of the New York Academy of Sciences

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases

(2010) Alessandra Ghigo et al.   BIOESSAYS

Key Role of Phosphoinositide 3-Kinase Class IB in Pancreatic Cancer

(2010) C. E. Edling et al.   CLINICAL CANCER RESEARCH

The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation

(2010) Sandra Beer-Hammer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

(2010) Alex Berndt et al.   Nature Chemical Biology

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A biochemical mechanism for the oncogenic potential of the p110  catalytic subunit of phosphoinositide 3-kinase

(2010) H. A. Dbouk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-derived mutations in the regulatory subunit p85  of phosphoinositide 3-kinase function through the catalytic subunit p110 

(2010) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Form and flexibility in phosphoinositide 3-kinases

(2009) Roger Williams et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110  and are disrupted in oncogenic p85 mutants

(2009) H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110 

(2009) B. Kurig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gβγ-Copurified Lipid Kinase Impurity from Sf9 Cells

(2009) Aliaksei Shymanets et al.   PROTEIN AND PEPTIDE LETTERS

PI3K  Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells

(2009) T. Bohnacker et al.   Science Signaling

Signal Amplification Between Gβγ Release and PI3Kγ-Mediated PI(3,4,5)P3Formation Monitored by a Fluorescent Gβγ Biosensor Protein and Repetitive Two Component Total Internal Reflection/Fluorescence Redistribution after Photobleaching Analysis†

(2008) Astrid Tannert et al.   BIOCHEMISTRY

Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins

(2008) Inga Preuß et al.   CELLULAR SIGNALLING

G Protein β γ Subunits as Targets for Small Molecule Therapeutic Development

(2008) Alan Smrcka et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING