Article
Biochemistry & Molecular Biology
Priyanka Priyanka, Madhur Sharma, Sanjeev Das, Sandeep Saxena
Summary: In this study, an upregulated lncRNA, HMS, was identified in lung adenocarcinoma patient database, which has a significant impact on cell proliferation and colony formation of cancer cells. It was found that HMS stabilizes HOXC10 mRNA to sustain the invasive phenotype of cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Eugene N. Kozlov, Roman V. Deev, Elena V. Tokmatcheva, Anna Tvorogova, Zaur M. Kachaev, Rudolf A. Gilmutdinov, Mariya Zhukova, Elena V. Savvateeva-Popova, Paul Schedl, Yulii V. Shidlovskii
Summary: Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of nerve impulses. Cytoplasmic polyadenylation element binding (CPEB) proteins play an essential role in long-term memory (LTM) formation by regulating local translation in synapses.
Article
Oncology
Xiaohui Liu, Xiuzhu Huang, Jie Ma, Lu Li, Huifan Hu, Junxia Feng, Xuejuan Gao, Yunfang Zhang, Langxia Liu
Summary: The study found that GSN 3'UTR exerts anticancer functions in NSCLC cells by suppressing the promotional effects of GSN protein and affecting actin-cytoskeleton remodeling and epithelial-mesenchymal transition processes. It was also shown to target co-expressed proteins to the plasma membrane and interact with Tra2 beta to regulate localized protein expression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Qiang Zhang, Bin Tian
Summary: The 3' untranslated region (3'UTR) of mRNA is crucial for post-transcriptional regulation of gene expression. Eukaryotic protein-coding genes express multiple 3'UTR isoforms due to alternative cleavage and polyadenylation (APA). Cell proliferation, differentiation, and stress conditions lead to changes in the 3'UTR isoform expression profile. This review focuses on the regulation of 3'UTR isoforms in cell metabolic reprogramming, specifically exploring cell growth and autophagy responses mediated by the mTOR pathway.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Article
Medicine, Research & Experimental
Wei Bai, Zhi Lin, Jin Ye, Linshuang Zhou, Jingqiao Xi, Wenpin Cai
Summary: Polymorphisms in the 3'UTR of the HLA-G gene are associated with the development of URSA and may serve as predictors of pregnancy outcome.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Microbiology
Maryam Hajikarimlou, Mohsen Hooshyar, Noor Sunba, Nazila Nazemof, Mohamed Taha Moutaoufik, Sadhena Phanse, Kamaledin B. B. Said, Mohan Babu, Martin Holcik, Bahram Samanfar, Myron Smith, Ashkan Golshani
Summary: Mitochondria possess their own DNA (mtDNA) and are capable of carrying out their transcription and translation. The presence of the 3'-UTR from OXA1 gene is correlated with mitochondrial translation in yeast.
Review
Biochemistry & Molecular Biology
Bruna Rodrigues Gontijo, Isabella Possatti, Caroline Ferreira Fratelli, Alexandre Sampaio Rodrigues Pereira, Larissa Sousa Silva Bonasser, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Silva
Summary: This systematic review aims to investigate the role of the SLC6A3 gene variant on the modulation of pharmacotherapy in Major Depressive Disorder (MDD). The presence of the SS (9R/9R) genotype and S (9R) allele has been associated with an increased risk of developing MDD and a decreased response to antidepressant therapy. However, conflicting findings among studies indicate the need for further research to understand the role of this polymorphism in the onset of MDD.
Article
Plant Sciences
Marta Budziszewska, Przemyslaw Wieczorek
Summary: Research described the genetic variability of necrosis-inducing ToTV-Wal'17 derived from ToTV-Wal'03 after long-term passages in plants, including single nucleotide substitutions, amino acid changes in viral polyproteins, and a shorter 3'UTR compared to Wal'03. Sequence analyses revealed that the 3'UTR of RNA1 of ToTV-Wal'17 is the most divergent among all previously described European isolates.
Article
Cell Biology
Catia Andreassi, Raphaelle Luisier, Hamish Crerar, Marousa Darsinou, Sasja Blokzijl-Franke, Tchern Lenn, Nicholas M. Luscombe, Giovanni Cuda, Marco Gaspari, Adolfo Saiardi, Antonella Riccio
Summary: The 3' untranslated regions (3' UTRs) of mRNA play essential roles in mRNA metabolism, with incorrect processing potentially leading to developmental defects and neurological disorders. Deep sequencing revealed cleavage of 3' UTRs in transcripts in sympathetic neuron axons, generating translatable isoforms crucial for axon integrity. This study provides insights into mRNA metabolism that regulates local protein synthesis and generates a new class of 3' UTR-derived RNAs.
Article
Biochemistry & Molecular Biology
Daisuke Kaida, Kenta Shida
Summary: Pre-mRNA splicing is a critical mechanism in gene expression in eukaryotes, and splicing inhibition can impact various cellular functions. This study reveals that the potent splicing inhibitor spliceostatin A (SSA) causes stabilization of the p27 protein by increasing the stability of CDKN1B mRNA. The 3' untranslated region of CDKN1B mRNA is involved in this stabilization process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Estanislao Navarro, Adrian Mallen, Miguel Hueso
Summary: This paper discusses the polymorphic nature of 3'UTR regions in mRNAs and the mechanisms that control their length and sequence, impacting the accessibility of functional effectors and ultimately gene expression regulation.
Article
Biochemical Research Methods
Stefan Gerber, Gerhard Schratt, Pierre-Luc Germain
Summary: The diffUTR Bioconductor package simplifies and improves differential exon usage analysis, enabling differential 3' UTR usage analysis as well. It is more flexible and accurate than current state-of-the-art alternatives, facilitating DEU and exploration of their results.
BMC BIOINFORMATICS
(2021)
Article
Veterinary Sciences
Jinchao Xing, Youyue Zhang, Ziying Lin, Lele Liu, Qiang Xu, Jiaqi Liang, Zhaoxia Yuan, Cuiqin Huang, Ming Liao, Wenbao Qi
Summary: Japanese encephalitis virus (JEV) is an important pathogen causing fatal neurological disease, and the study found that mutations in the 3' untranslated region (3' UTR) of different JEV strains can affect viral proliferation and pathogenicity. These findings highlight the crucial role of the 3'UTR in JEV life cycle and provide valuable insights for the development of candidate vaccines and virus production.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ankita Agarwal, Suresh Alagar, Shri Kant, Ranjit Prasad Bahadur
Summary: This study investigates the molecular mechanism of interaction between the N-terminal tandem RNA-recognition motifs (tRRMs) of HuR and mRNA using molecular dynamics simulation. The researchers also explore the effect of point mutations on the binding specificity of HuR-mRNA interactions. The findings reveal that certain mutations significantly affect the binding affinity due to unfavorable conformations and loss of critical interactions.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Medicine, Research & Experimental
Siwei Pan, Jiaming Zhu, Pengfei Liu, Qiaochu Wei, Siyu Zhang, Wen An, Yuxin Tong, Zhenguo Cheng, Funan Liu
Summary: The study suggests that FN1 3'-UTR has stronger prognostic implications than FN1 protein in gastric cancer patients and can be a better therapeutic target for constructing targeted drugs.