Journal
BIOCHEMICAL GENETICS
Volume 48, Issue 9-10, Pages 779-788Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10528-010-9359-7
Keywords
Growth traits; Goat; PC1; PCR-SSCP; SNP
Funding
- Natural Science Foundation of Jiangsu Province [BK2008120]
- 13115 Sci-Tech innovation program of Shaanxi province [2008ZDKG-11]
- Research Fund for the Doctor Program of Higher Education of China [20080712001]
- Talents Foundation of Northwest AF University [01140411]
- National 863 Program of the People's Republic of China [2008AA10Z138]
- Natural science fund for colleges and universities in Jiangsu Province [09KJD180002]
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Proprotein convertase 1 (PC1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway in endocrine cells. Mutations in the PC1 gene are thought to cause obesity, and multiple alternatively spliced transcript variants have been described for this gene. In this study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PC1 gene were detected in 447 individuals from three breeds. Only the P-1, P-2, P-3, P-9, and P-10 loci showed polymorphisms, and 12 SNPs in the PC1 gene were identified. Additionally, an association analysis between mutations in the 5'-UTR and four growth traits indicated that the polymorphisms were significantly associated with caprine body height (P < 0.05) and chest circumference (P < 0.01).
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