Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 505, Issue 2, Pages 485-491Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2018.09.094
Keywords
Solasodine; Stemness; Epithelial-mesenchymal transition; Migration; Colorectal cancer
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Funding
- National Natural Science Foundation of China [81202954]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD]
- Clinical Medical Research Center of Digestive Diseases on Chinese Medicine of Jiangsu Province [BL2014100]
- College Project of Jiangsu Province Hospital of TCM [Y2018CX73]
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Adverse side effects of conventional chemotherapy, acquired resistance and fatal tumor metastasis of human colorectal cancer (CRC) are propelling the exploration for novel selective anticarcinogens. Solasodine is a main active component isolated from Solanum incanum L that exhibited a potent sternness and invasion inhibitory effect on human colorectal cancer HCT116 cells. Colony Spheroid formation assay showed that solasodine dose-dependently prohibited HCT116 cell sternness. CD133, CD44, Nanog, Oct-4 and Sox-2 were inhibited by solasodine to reverse sternness and similar mechanism was stimulated in vivo. Transwell and scratch wound assays revealed that solasodine impeded HCT116 cell invasion and migration potential strengthened by TGF-beta 1. Moreover, solasodine attenuated TGF-beta 1-induced EMT and decreased MMPs while in vivo study showed the same trend. The results of this study implied that solasodine may be a novel therapeutic drug for CRC treatment. (C) 2018 Elsevier Inc. All rights reserved.
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