Article
Biochemical Research Methods
Naima Ahmed Fahmi, Khandakar Tanvir Ahmed, Jae-Woong Chang, Heba Nassereddeen, Deliang Fan, Jeongsik Yong, Wei Zhang
Summary: Research has shown that alternative polyadenylation (APA) can regulate gene expression; current bioinformatics pipelines have limitations in analyzing 3'-UTR APA events; APA-Scan is a powerful program that can detect 3'-UTR APA events and provide high-resolution results.
BMC BIOINFORMATICS
(2022)
Review
Biochemistry & Molecular Biology
Nitika Kandhari, Calvin A. Kraupner-Taylor, Paul F. Harrison, David R. Powell, Traude H. Beilharz
Summary: Alternative transcript cleavage and polyadenylation are associated with cancer cell transformation, proliferation, and outcome. Researchers have developed methods to detect and analyze alternative polyadenylation as potential cancer biomarkers, which, if integrated into standard prognostic measures, may advance cancer prognostic testing and guide therapy. This review focuses on existing methodologies, both experimental and computational, to support the use of alternative polyadenylation as cancer biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Zhonghui Xu, John Platig, Sool Lee, Adel Boueiz, Rob Chase, Dhawal Jain, Andrew Gregory, Rahul Suryadevara, Seth Berman, Russell Bowler, Craig P. Hersh, Alain Laederach, Peter J. Castaldi
Summary: Cigarette smoking induces significant transcriptomic and systemic inflammatory responses, affecting gene expression, alternative isoform regulation, and exon usage. Lengthening of 3' UTRs associated with smoking suggests potential biomarkers and therapeutic targets for smoking-related diseases, emphasizing the importance of further research in this area.
Review
Biochemistry & Molecular Biology
Siyao Guo, Shuibin Lin
Summary: mRNA polyadenylation plays a crucial role in regulating mRNA metabolism. Mis-regulation of mRNA polyadenylation is often associated with abnormal gene expression and disease progression. This review summarizes the classical process of mRNA 3'-terminal formation, discusses the mechanisms of poly(A) length control in the nucleus and cytoplasm, reviews the progress in alternative polyadenylation regulation and APA site selection mechanism, and finally summarizes the functional roles of APA in gene expression regulation and diseases including cancers.
Article
Multidisciplinary Sciences
Ziqing Wang, Mustafa Ozcam, Behnam Abasht
Summary: In this study, gene expression profiles in abdominal fat of broiler chickens with different feed efficiency levels were analyzed. The results indicated that efficient muscle growth and fat deposition may be associated with gene expression regulation, extracellular matrix remodeling, and peroxisome and lipid metabolism.
Article
Biochemical Research Methods
Xiaohui Wu, Tao Liu, Congting Ye, Wenbin Ye, Guoli Ji
Summary: APA plays a crucial role in transcriptome diversity and gene expression regulation. The newly developed tool scAPAtrap can accurately identify poly(A) sites at the whole genome level in individual cells, even for sites with low read coverage, without relying on priori genome annotation. Compared to existing methods, scAPAtrap shows higher accuracy and sensitivity in identifying poly(A) sites, making it a valuable tool for exploring APA dynamics and heterogeneous APA isoform expression at the single-cell level.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Cell Biology
Prakash Dharmalingam, Rajasekaran Mahalingam, Hari Krishna Yalamanchili, Tingting Weng, Harry Karmouty-Quintana, Ashrith Guha, Rajarajan A. Thandavarayan
Summary: Research has shown that alternative cleavage and polyadenylation (APA) play a crucial role in the pathogenesis of various human diseases, leading to dysfunctional gene regulation and abnormal cell proliferation. While the functions of the core APA machinery and its role in disease conditions remain largely unknown, the mechanism of APA has become a hot topic in disease research.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Buki Kwon, Mervin M. Fansler, Neil D. Patel, Jihye Lee, Weirui Ma, Christine Mayr
Summary: Multi-UTR genes express their alternative 3' UTR isoforms in a cell type-specific manner. Transcriptional enhancers, along with transcription factors, regulate the expression of these isoforms by influencing the cleavage activity of polyadenylation sites.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Fuwen Yuan, William Hankey, Eric J. Wagner, Wei Li, Qianben Wang
Summary: Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3' end of RNA polymerase II transcripts from over 60% of human genes, mainly occurring within the untranslated region (3'UTR), leading to significant impact on the regulatory potential of mRNA.
Article
Biochemistry & Molecular Biology
Yuanlin He, Qiuzhen Chen, Jing Zhang, Jing Yu, Meng Xia, Xi Wang
Summary: Oocyte maturation is crucial for the development of healthy individuals in mammals. Transcriptomic analysis at different stages of oocyte development revealed the importance of isoform expression in distinguishing oocyte stages. Furthermore, alternative usage of 3'-UTR isoforms played a significant role in the molecular mechanisms underlying mammalian early development.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Larry C. Cheng, Dinghai Zheng, Qiang Zhang, Aysegul Guvenek, Hong Cheng, Bin Tian
Summary: Transcripts encoding membrane and secreted proteins can associate with the ER through translation-dependent or translation-independent mechanisms. Certain functional groups of genes, such as those involved in cell signaling, tend to have higher TiERA potentials, indicating the importance of ER association for their mRNA metabolism. Changes in transcript features, such as alternative polyadenylation isoforms and 3' UTR lengthening during cell differentiation, can affect the TiERA potential of transcripts. Competing with translation-dependent ER association, TiERA suggests a limited space on the ER for mRNA association.
Article
Genetics & Heredity
Zhongxiao Li, Yisheng Li, Bin Zhang, Yu Li, Yongkang Long, Juexiao Zhou, Xudong Zou, Min Zhang, Yuhui Hu, Wei Chen, Xin Gao
Summary: In this study, we propose a deep learning architecture, DeeReCT-APA, to quantitatively predict the usage of all alternative polyadenylation sites (PASs) of a given gene. Compared to existing methods, DeeReCT-APA outperforms in multiple tasks and can be used to predict the effect of genetic variations on APA patterns.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Oncology
Ai Lin, Ping Ji, Xiangjie Niu, Xuan Zhao, Yamei Chen, Weiling Liu, Yachen Liu, Wenyi Fan, Yanxia Sun, Chuanwang Miao, Shaosen Zhang, Wen Tan, Dongxin Lin, Eric J. Wagner, Chen Wu
Summary: High-throughput analysis revealed that the recurrent shortening of the BID 3'UTR is a driver of disease progression in esophageal squamous cell carcinoma.
Article
Plant Sciences
Taotao Wang, Wenbin Ye, Jiaxiang Zhang, Han Li, Weike Zeng, Sheng Zhu, Guoli Ji, Xiaohui Wu, Liuyin Ma
Summary: High-salt stress induces global alternative polyadenylation (APA) dynamics in Spartina alterniflora, leading to 3'UTR lengthening of transcripts and increased protein synthesis. These alternative 3'UTRs are mainly enriched in salt stress-related ion transporters, such as SaHKT1. Regulatory AU-rich elements in alternative 3'UTRs enhance the protein level of SaHKT1, and the biogenesis of 3'UTR lengthening in SaHKT1 is controlled by SaCPSF30. Over-expression of SaHKT1 with an alternative 3'UTR in rice protoplasts promotes the mRNA accumulation of salt-tolerance genes.
Article
Biology
Yang Yang, Anirban Paul, Thao Nguyen Bach, Z. Josh Huang, Michael Q. Zhang
Summary: This study introduced a novel computational framework, SAPAS, to identify APA and its association with cell types using single-cell RNA-seq data. The research revealed cell type-specific APA events that play important roles in synaptic architecture and communication. Additionally, the study found a strong enrichment of heritability for psychiatric disorders and brain traits in altered 3' UTRs and coding sequences of cell type-specific APA events.
Article
Biochemistry & Molecular Biology
Ting-Fu Chen, Yu-Chuan Chang, Yi Hsiao, Ko-Han Lee, Yu-Chun Hsiao, Yu-Hsiang Lin, Yi-Chin Ethan Tu, Hsuan-Cheng Huang, Chien-Yu Chen, Hsueh-Fen Juan
Summary: The current global health crisis due to COVID-19 has prompted researchers to develop DockCoV2, a drug database that focuses on predicting the binding affinity of drugs with key proteins of SARS-CoV-2 in order to expedite the discovery of potential treatments.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemical Research Methods
Kuei-Yueh Ko, Cho-Yi Chen, Hsueh-Fen Juan, Hsuan-Cheng Huang
Summary: The hourglass model posits that developmental constraints in the middle of a developmental process are higher, and phenotypes are evolutionarily more conserved. Research found that network stochasticity follows an anti-hourglass trajectory, supporting Raff's hypothesis. Different species activate similar biological process groups during development, with higher interspecies correlations at mid-developmental stages.
Article
Pharmacology & Pharmacy
Pei-Chen Yu, Chen-Hao Huang, Chih-Jung Kuo, Po-Huang Liang, Lily Hui-Ching Wang, Max Yu-Chen Pan, Sui-Yuan Chang, Tai-Ling Chao, Si-Man Ieong, Jun-Tung Fang, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: This study utilized bioinformatics to screen compounds with therapeutic potential for COVID-19 and evaluated their inhibitory effect and binding capability. The results revealed that tamoxifen possesses anti-SARS-CoV-2 property, which may accelerate drug screening for COVID-19 and other diseases.
Article
Multidisciplinary Sciences
Cherng-Shyang Chang, Wen-Hsua Yu, Chang-Chao Su, Jhen-Wei Ruan, Chiao-Mei Lin, Chih-Ting Huang, Yi-Ting Tsai, I-Jung Lin, Chao-Yang Lai, Tsung-Hsien Chuang, Wen-Jye Lin, Tse-Hua Tan, Hsuan-Cheng Huang, Hsueh-Fen Juan, Cheng-Yuan Kao
Summary: In this study, scRNA-seq was used to analyze the individual compositional and transcriptional alterations of intestinal leukocytes in D6KO mice. The results showed that D6KO-derived intestinal leukocytes are in an inactivated or immature status, with decreased sensitivity to microbes. Additionally, D6KO leukocytes may be associated with both immune-related and previously non-immune-related diseases.
Article
Chemistry, Medicinal
Chiao-Hui Hsieh, Hsiang-Ning Yeh, Chen-Tsung Huang, Wei-Hsuan Wang, Wen-Ming Hsu, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: This study discovers the correlation between high levels of MCM2 and MCM10 and poor survival rate in neuroblastoma patients. The drug BI-2536 can inhibit the expression of MCM2 and MCM10, promoting mitochondrial fusion, G2/M arrest, and apoptosis, providing a new strategy for neuroblastoma therapy.
Article
Biochemistry & Molecular Biology
Richard Kuan-Lin Lee, Tian-Neng Li, Sui-Yuan Chang, Tai-Ling Chao, Chun-Hsien Kuo, Max Yu-Chen Pan, Yu-Ting Chiou, Kuan-Ju Liao, Yi Yang, Yi-Hsuan Wu, Chen-Hao Huang, Hsueh-Fen Juan, Hsing-Pang Hsieh, Lily Hui-Ching Wang
Summary: This study developed a new method to detect the molecular interaction between the receptor-binding domain (RBD) of SARS-CoV-2 and the ACE2 receptor, and identified two drugs, Etravirine and Dolutegravir, as effective entry inhibitors against SARS-CoV-2. These drugs showed similar neutralizing activities against different variants of the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Yi-Wen Chang, Chia-Chi Wang, Chieh-Fan Yin, Chang-Hsun Wu, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: The tumor microenvironment plays a crucial role in cancer development. This study reveals that mesenchymal stem cells (MSCs), a key regulator of the microenvironment, promote lung cancer progression through the ERK/phospho-c-Fos-S374 pathway, as demonstrated by quantitative phosphoproteomics analysis. Additionally, the study also highlights the role of extracellular ATP, secreted by ATP synthase on the surface of MSCs, in activating the ERK/phospho-c-Fos-S374 pathway in lung cancer cells. These findings contribute to a better understanding of the complex interactions within the tumor microenvironment and provide potential targets for therapeutic interventions.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Peng-Hsuan Li, Ting-Fu Chen, Jheng-Ying Yu, Shang-Hung Shih, Chan-Hung Su, Yin-Hung Lin, Huai-Kuang Tsai, Hsueh-Fen Juan, Chien-Yu Chen, Jia-Hsin Huang
Summary: pubmedKB is a web server designed to extract and visualize semantic relationships between biomedical entities. It utilizes natural language processing techniques to extract semantic relations from a large number of PubMed abstracts, enabling users to rapidly and intelligently search for and gain useful knowledge and insights.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Albert Li, Jhih-Yu Chen, Chia-Lang Hsu, Yen-Jen Oyang, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: This study investigates the transcriptome of COVID-19 patients and applies biological network analysis to identify gene signatures associated with PCPF. The identified signature shows potential as a diagnostic and assessment biomarker for pulmonary fibrosis. Moreover, a network-based drug repurposing method is utilized to explore novel treatments for PCPF.
Article
Biochemistry & Molecular Biology
Kai-Pu Chen, Chia-Lang Hsu, Yen-Jen Oyang, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: Microbial communities are abundant in the human body and dysbiosis is associated with various diseases. This study used miRNA sequencing data from the TCGA database to evaluate bacterial abundance in 32 types of cancer and developed the BIC database to provide information on cancer-associated bacteria.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Chia-Lang Hsu, Chieh-Fan Yin, Yi-Wen Chang, Ya-Chih Fan, Shih-Han Lin, Yu-Ching Wu, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: SNHG1 is an oncogenic long non-coding RNA that is aberrantly expressed in different tumor types. It plays a crucial role in maintaining the identity of neuroblastoma (NB) through chromatin regulation and interacts with core regulatory circuitry transcription factors.
CELL DEATH & DISEASE
(2022)
Article
Biochemical Research Methods
Yueh-Hua Tu, Hsueh-Fen Juan, Hsuan-Cheng Huang
Summary: Gene regulatory networks play a crucial role in various biological phenomena. Single-cell techniques provide higher resolution for studying gene expression, but constructing comprehensive gene regulatory networks across different cell types remains a challenge.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Hsueh-Fen Juan, Hsuan-Cheng Huang
Summary: The study of multiple omes is widely used in biomedical research to gain a comprehensive perspective on biological systems. The generation of high-dimensional multiomics data through high-throughput techniques is enabled, but the quantitative analysis and integration of different types of omics data pose challenges. This article provides an up-to-date review on the methods used for quantification and integration of omics data, focusing on transcriptomics, proteomics, and batch effects reduction. The potential of network analysis in understanding biological systems and the current trends in extending quantitative omics data analysis to biological networks are also discussed.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2023)
Article
Biology
Yi-Chun Kao, Yi-Wen Chang, Charles P. Lai, Nai-Wen Chang, Chen-Hao Huang, Chien-Sheng Chen, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: This study reveals that cancer cells express higher levels of eATP synthase under starvation stress, leading to increased production of EVs. The eATP synthase generates extracellular ATP to stimulate EV secretion by enhancing P2X(7) receptor-triggered Ca2+ influx. Surprisingly, eATP synthase is also found on the surface of tumor-secreted EVs. The eATP synthase-coated EVs increase uptake by immune cells and inhibit their proliferation and cytokine release.
COMMUNICATIONS BIOLOGY
(2023)
Article
Genetics & Heredity
Wen-Hsuan Yu, Chia-Lang Hsu, Chen-Ching Lin, Yen-Jen Oyang, Hsueh-Fen Juan, Hsuan-Cheng Huang
Summary: This study proposes an analysis framework to investigate the relationship between lncRNAs and different subtypes of breast cancer through gene expression data analysis. The results reveal potential regulatory mechanisms and therapeutic directions for breast cancer treatment.
BMC MEDICAL GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)