Article
Medical Laboratory Technology
Qing Li, Yueming Wang, Jingdong He
Summary: The study revealed that miR-133a-3p was significantly downregulated in gefitinib-resistant NSCLC cells, and overexpression of miR-133a-3p could increase the sensitivity of cells to gefitinib. SPAG5 was identified as an important target gene of miR-133a-3p, which could reverse the miR-133a-3p-mediated gefitinib sensitivity.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Gaoqing Wang, Yin Jiang, Caide Lu, Wei Jiang, Shugeng Wu, Yongfei Hua
Summary: The study unveiled that circFOXM1 promotes cell proliferation and metastasis in HCC through regulating the miR-1179/SPAG5 axis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jinjin Duan, Li Wang, Liqun Shang, Shumei Yang, Hua Wu, Yongcheng Huang, Yi Miao
Summary: The study found that TNS1 is upregulated in NSCLC cells and tissues, and is associated with the prognosis of NSCLC patients. Additionally, TNS1 promotes the growth and metastasis of NSCLC cells via the Akt/mTOR/RhoA pathway. miR-152 targets TNS1 to influence the progression of NSCLC.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Ming Li, Wulin Shan, Yan Hua, Fengmei Chao, Yayun Cui, Lei Lv, Xiaoyan Dou, Xing Bian, Jinglu Zou, Hong Li, Wenchu Lin
Summary: The study revealed that miR-92b-3p expression was increased in SCLC patients and correlated with chemoresistance. By affecting the PTEN/AKT regulatory network, miR-92b-3p mediated cell migration and chemoresistance in SCLC. Additionally, miR-92b-3p was identified as a potential dynamic biomarker for monitoring chemoresistance in SCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Qing Zhu, Yixuan Zhang, Mo Li, Ying Zhang, Huan Zhang, Jiayi Chen, Zhaoyang Liu, Peng Yuan, Zhaogang Yang, Xiaobing Wang
Summary: This study identifies the important role of miR-124-3p in metastasis of non-small cell lung cancer (NSCLC) and reveals that miR-124-3p suppresses metastasis through extracellular exosome transport and intracellular PI3K/AKT signaling in NSCLC. These findings provide new insights toward a better understanding of NSCLC metastasis and suggest miR-124-3p as a potential treatment biomarker for NSCLC.
BIOMARKER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xiaofeng Yu, Ying Li, Guodong Jiang, Jian Fang, Zhaolei You, Guangyuan Shao, Zheng Zhang, Aihong Jiao, Xiaonu Peng
Summary: This study revealed that FGF21 is upregulated in lung cancer and can promote cell growth and migration by activating the SIRT1/PI3K/AKT signaling pathway, indicating FGF21 as a potential therapeutic target for lung cancer treatment.
Article
Cell Biology
Hua-Si Zhao, Xiao-Min Tao, Qun Wang, Yuan-Yuan Fang, Hong-Yu Zhang, Hua-Qi Wang, Guo-Jun Zhang
Summary: The study revealed that miR-7160 inhibits NSCLC cell growth and progression by silencing SIX1.
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Jinghan Hua, Xiaolin Wang, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang, Wenchu Lin
Summary: circVAPA promotes the progression of small cell lung cancer through the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
Article
Oncology
Neda K. Dezfuli, Shamila D. Alipoor, Neda Dalil Roofchayee, Sharareh Seyfi, Babak Salimi, Ian M. Adcock, Esmaeil Mortaz
Summary: The study found that miR-146a expression was significantly downregulated in NSCLC patients, while IL-6 and TGF-beta levels were elevated. The frequencies of immune cells CD3+ CTLA-4+ and Treg cells were also higher in patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Xueru Guo, Mengmeng Chen, Limin Cao, Yiming Hu, Xueqin Li, Qicheng Zhang, Yinghui Ren, Xiang Wu, Zhaowei Meng, Ke Xu
Summary: The downregulation of miR-101-3p in tumor-associated CAFs promotes lung cancer metastasis by regulating VEGFA/AKT signaling pathway, indicating miR-101-3p as a potential candidate for metastasis therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xuan Lu, Ningning Kang, Xinxin Ling, Ming Pan, Wenjing Du, Shan Gao
Summary: The study investigated the biological activity of SLC7A11 in NSCLC cells through various methods, revealing that miR-27a-3p modulates ferroptosis by targeting SLC7A11 in NSCLC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Krishnaprasad Baby, Swastika Maity, Chetan Hasmukh Mehta, Usha Y. Nayak, Gautham G. Shenoy, Karkala Sreedhara Ranganath Pai, Kuzhuvelil B. Harikumar, Yogendra Nayak
Summary: Non-small cell lung carcinomas (NSCLC) are the leading cause of cancer-related deaths and Akt deregulation is frequently observed in NSCLC. This study aimed to identify allosteric Akt-1 inhibitors from FDA-approved drugs through computational analysis. Fourteen best hits were identified from a library of optimized compounds, with valganciclovir, dasatinib, indacaterol, and novobiocin showing high stability to the Akt-1 allosteric site. Computational tools were used to predict possible biological interactions. These findings suggest a new class of allosteric Akt-1 inhibitors for the treatment of NSCLC.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Xinju Zhang, Xianyi Wang, Binshu Chai, Zong Wu, Xiaomin Liu, Heng Zou, Ziyi Hua, Zhongliang Ma, Weiwei Wang
Summary: The miR-17-92 cluster is upregulated in non-small cell lung cancer (NSCLC), promoting tumor growth and progression. MiR-92a facilitates tumor growth by inhibiting SPRY4 expression and mediating Epithelial-Mesenchymal Transition (EMT). AntagomiR-18a treatment significantly inhibits tumor growth in xenografted mice.
Article
Oncology
Hanxiao Cui, Luyao Dai, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Hao Wu, Xiaobin Ma, Huafeng Kang
Summary: This study aimed to evaluate the impact of primary tumor surgery on survival in female patients with de novo stage IV breast cancer and develop competing risk nomograms to predict clinical outcomes. The results showed that surgery was associated with better survival. Subgroup analyses revealed that in bone-only metastases pattern, mastectomy was associated with worse prognosis, while in visceral metastases pattern, breast-conserving surgery and reconstruction recipients had similar survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaobin Ma, Wenyu Yan, Peng Xu, Li Ma, Ying Zan, Lanxuan Huang, Guanying Wang, Lili Liu, Wentao Hui
Summary: The tumor suppressor gene lncRNA-p21 was found to be associated with advanced disease stage and poor survival in gastric cancer. Through regulating the expression of miR-514-3p and ARHGEF9, lncRNA-p21 influenced the proliferation and apoptosis of gastric cancer cells. This study reveals a novel lncRNA-p21/miR-514b-3p/ARHGEF9 pathway that can be targeted for gastric cancer therapy.
BIOLOGICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Xiaobin Ma, Tianyi Yan, Song Miao, Like Mao, Donghong Liu
Summary: In this study, nanoemulsions loaded with beta-carotene were prepared using ultrasound-prepared electrostatic complexes and covalent conjugates of soy protein isolate (SPI) and citrus pectin (CP). The stability of the nanoemulsions was improved by both electrostatic complexation/covalent conjugation and ultrasound treatment. The complexes showed better controlled release of beta-carotene, while the conjugate-stabilized nanoemulsion had higher overall bioaccessibility. The ultrasound-prepared complexes/conjugates also exhibited the highest storage stability.
Article
Engineering, Biomedical
Hongwei Lu, Ji Xu, Jinfan Yang, Zhongling Wang, Peng Xu, Qian Hao, Wen Luo, Shuaijun Li, Zhengqing Li, Xiangdong Xue, Hongbo Zheng, Zhangjian Zhou, Hao Wu, Xiaobin Ma, Yuanpei Li
Summary: This study presents a smart on-demand targeting nanotheranostic system that improves drug delivery efficiency for ovarian cancer through stimuli-responsive releasing.
Article
Chemistry, Applied
Xiaobin Ma, Chengdeng Chi, Yunfeng Pu, Song Miao, Donghong Liu
Summary: There has been a recent interest in enhancing the emulsifying properties of soy protein isolate (SPI) through Maillard reaction. Pectin, as a commonly-used grafting polysaccharide, has shown usefulness in modifying proteins. The structural characteristics of pectin, such as molecular weight and degree of methoxylation and acetylation, significantly influence conjugation. Lower molecular weight and fewer main chains in pectin result in a higher conjugate yield when conjugated with SPI. The protein structure becomes more loosened after the Maillard reaction, as indicated by reduced fluorescence intensity and surface hydrophobicity. Enzymolysis pectin proves to be the optimal grafting polysaccharide, considering its simple preparation procedures and highest emulsifying properties of the resulting conjugates.
Article
Oncology
Luyao Dai, Hanxiao Cui, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Hao Wu, Huafeng Kang, Xiaobin Ma
Summary: Immediate postmastectomy reconstruction has a survival benefit for patients with TNBC, with implant reconstruction showing the most obvious advantage.
Article
Infectious Diseases
Peng Song, Huaichen Li, Tingting Liu, Yao Liu, Xiaobin Ma, Lili Su
Summary: This case study illustrates the importance of using metagenomic Next Generation Sequencing (mNGS) in combination with traditional testing for diagnosing challenging parasitic infections in immunocompromised patients. mNGS is a valuable adjunct method for rapid screening of potential parasitic causes.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Luyao Dai, Hanxiao Cui, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Shuai Lin, Xin Zhang, Hao Wu, Huafeng Kang, Xiaobin Ma
Summary: This study aims to evaluate the actual prognostic impact of radiotherapy on breast cancer patients undergoing immediate breast reconstruction and construct survival prediction models. The results showed that radiotherapy can improve overall survival and breast cancer-specific survival in certain stages of patients. The study provides useful prediction tools for personalized treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Rui-Na Zhou, Xiao-Bin Ma, Li Wang, Hua-Feng Kang
Summary: This article presents two rare cases of incidental discovery of PLSVC during PORT implantation via the internal jugular vein. PORT was successfully implanted under ultrasound guidance in two breast cancer patients undergoing chemotherapy. Postoperative chest X-ray examination confirmed the correct placement of the catheter. The ultrasound examination showed that the ratio of PORT outer diameter to PLSVC inner diameter was in line with the recommendations of relevant literature and operating guidelines.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Food Science & Technology
Xiaobin Ma, Donghong Liu, Furong Hou
Summary: Sono-activation of enzymes has attracted significant attention in food research over the past decade. This emerging application of ultrasound has shown promising potential in expanding the use of food enzymes, improving industrial operations and productivity, and increasing target product yields. This review provides an overview of ultrasound activation of food protease, carbohydrase, and lipase, as well as recent developments in mechanisms, influencing factors, modification effects, and applications in real food systems. The challenges and future prospects for the scalability of ultrasound in these areas are also discussed.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Chemistry, Multidisciplinary
Luyao Dai, Shuaijun Li, Qian Hao, Ruina Zhou, Hui Zhou, Wenxi Lei, Huafeng Kang, Hao Wu, Yuanpei Li, Xiaobin Ma
Summary: Low-density lipoprotein (LDL) is a crucial component in lipid metabolism control and has unique physicochemical properties that make it an ideal targeted delivery carrier. This review covers the structure, composition, advantages, defects, and reconstruction of LDL delivery systems. It also summarizes the research status and progress of LDL as a targeted diagnosis and therapy tool, as well as its potential clinical applications.
NANOSCALE ADVANCES
(2023)
Article
Cell Biology
Baofeng Wang, Xiaobin Ma, Wenjie Zhang, Liang Li, Ying Zan, Jianshui Zhan, Xufeng Guo, Ming Lei, Hongbing Ma
Summary: The up-expression of NOTCH1 gene is associated with advanced liver cancer and is linked to tumor size, stage, metastasis, and invasion. This study aimed to assess the relationship between NOTCH1 genetic variants and liver cancer risk. The findings suggest that rs10521-G, rs2229971-A, and rs4489420-A may serve as protective factors against liver cancer susceptibility in the Chinese Han population.
Article
Oncology
Ying Wu, Yujiao Deng, Zhijun Dai, Yubo Ma, Lijuan Lyu, Chen Lei, Yi Zheng, Yizhen Li, Ziming Wang, Jie Gao
Summary: Based on the Global Burden of Disease Study 2019, high fasting plasma glucose (FPG) has been identified as a risk factor for bladder cancer globally. The death and DALY rates of bladder cancer attributable to high FPG have significantly increased since 1990, particularly among older males.
Article
Immunology
Hanxiao Cui, Xueting Ren, Luyao Dai, Lidan Chang, Dandan Liu, Zhen Zhai, Huafeng Kang, Xiaobin Ma
Summary: The study developed a gene signature based on nicotinamide metabolism, which can predict the survival rate, tumor microenvironment, and treatment efficacy in breast cancer patients. The low-risk group showed better clinical outcomes and higher abundance of anti-tumor immunocyte infiltration. This novel gene signature is of great significance in evaluating the prognosis and treatment efficacy in breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Shiqin Peng, Meifei Zhu, Shanshan Li, Xiaobin Ma, Fuliang Hu
Summary: This study used a novel ultrasound-assisted approach to extract polyphenols from Chinese propolis in order to improve extraction yield and reveal the relevant mechanisms. The optimum ultrasound-assisted extraction conditions were determined and the results showed increased antioxidant activities and enhanced extraction of phenolic compounds compared to traditional maceration. The qualitative and quantitative analysis of polyphenol compositions showed that ultrasound did not change the polyphenol types in the extract but significantly improved the contents of various flavonoids and phenolic acids. The use of ultrasound also increased the contact areas between propolis and ethanol by breaking down the propolis particles and eroding the propolis surface.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
