Article
Chemistry, Inorganic & Nuclear
Isabelle Gerz, Sergio Augusto Venturinelli Jannuzzi, Knut T. Hylland, Chiara Negri, David S. Wragg, Sigurd Oien-Odegaard, Mats Tilset, Unni Olsbye, Serena DeBeer, Mohamed Amedjkouh
Summary: A series of Cu(I) complexes with bidentate or tetradentate Schiff base ligands containing 1-H-imidazole or pyridine moieties were synthesized and studied using NMR and X-ray spectroscopic techniques. The nature of the heterocycle in the ligands strongly affected the coordination shifts of N-15(imine) in the complexes, which correlated well with the Cu-N-imine bond lengths from single-crystal X-ray diffraction measurements. Variable-temperature NMR experiments revealed a temperature-dependent interconversion in one complex, while Cu K-edge XAS and VtC XES studies suggested the formation of polynuclear oligomers in solid state for complexes with tetradentate imidazole ligands. Incorporation of a Cu(II) analogue into a MOF resulted in discrete, mononuclear complexes in the solid state.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Justus S. Diercks, Juan Herranz, Maximilian Georgi, Natasa Diklic, Piyush Chauhan, Kathrin Ebner, Adam H. Clark, Maarten Nachtegaal, Alexander Eychmuller, Thomas J. Schmidt
Summary: Palladium is an electrocatalyst that can selectively generate carbon monoxide or formate at high and low overpotentials, respectively. Previous studies have been inconclusive about palladium's ability to form a hydride phase and its effect on CO2 reduction reaction (CO2RR) selectivity. This study used electrochemical measurements and in situ X-ray absorption spectroscopy to reveal the strong influence of adsorbed CO on the formation rate of Pd-hydride, and confirmed the complete formation of beta-phase PdHx at all applied potentials under CO2RR conditions.
Article
Biochemistry & Molecular Biology
Darshan Jayasinghe Karunarathne, Alireza Aminifazl, Tori E. Abel, Karen L. Quepons, Teresa D. Golden
Summary: In this study, the inhibitive performance of pyridine-2-thiol in a corrosive solution for brass was investigated. The results showed that the addition of pyridine-2-thiol significantly reduced the corrosion rate of the brass, and resulted in fewer surface defects.
Article
Electrochemistry
Daseul Han, Sooyeon Hwang, Seong-Min Bak, Kyung-Wan Nam
Summary: Molybdenum oxides (MoO2 and MoO3) are attractive anode materials for Li- and Na- ion batteries, and a facile synthesis method has been demonstrated to control the phase and oxidation state in the MoOx/CNTs nanocomposites. By comparing the structure and electrochemical properties of MoO2/CNTs and MoO3/CNTs, it was found that MoO2&3/CNTs electrodes show much-improved cycling stability and rate performance in lithium-ion batteries. Additionally, MoOx/CNTs electrodes demonstrate impressive energy and power densities and excellent cycling stability when employed in a high-power lithium-ion capacitor.
ELECTROCHIMICA ACTA
(2021)
Review
Chemistry, Physical
George E. Cutsail, Serena DeBeer
Summary: X-ray spectroscopy plays a significant role in catalysis research by providing essential electronic and geometric structural information. The development of dedicated synchrotron-based X-ray emission spectrometers has expanded experimental capabilities, offering more detailed data. There is a continuous demand for conventional XAS applications and the integration with more advanced techniques.
Article
Chemistry, Physical
Mauricio Lopez Luna, Janis Timoshenko, David Kordus, Clara Rettenmaier, See Wee Chee, Adam S. Hoffman, Simon R. Bare, Shamil Shaikhutdinov, Beatriz Roldan Cuenya
Summary: The study investigates the structural and chemical evolution of oxide-supported iron nanoparticles during the activation stages and the CO2 hydrogenation reaction, revealing the preferential formation of iron surface oxides under reaction conditions. The results highlight the important role played by the oxide support in the final structure and composition of nanosized catalysts.
Review
Biochemistry & Molecular Biology
Valentina Bonanni, Alessandra Gianoncelli
Summary: Scanning transmission X-ray microscopy (STXM) allows imaging of biological specimens and collection of localized spectroscopic information through X-ray fluorescence (XRF) and/or X-ray Absorption Near Edge Spectroscopy (XANES). Recent publications in synchrotrons have utilized soft X-ray spectro-microscopy in life science and environmental research to explore complex metabolic mechanisms by tracing chemical elements involved in metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Ceramics
Mingyue Yuan, Jordi Bonet, Marine Cotte, Nadine Schibille, Bernard Gratuze, Trinitat Pradell
Summary: Little is known about the production of ruby red copper stained glasses from the Medieval and Renaissance periods, and the key ingredient in the process might be sulphur. This study analyzed historical red glasses using various microanalytical techniques and found that the oxidation of S2- into S6+ in the glass is responsible for the precipitation of copper nanoparticles. The presence of a sulphide-silicate partition and Fe3+ in the melt also contribute to the formation of the high-pressure tetragonal polymorph of chalcocite (Cu2S).
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Kefu Zhu, Shiqiang Wei, Quan Zhou, Shuangming Chen, Yunxiang Lin, Pengjun Zhang, Yuyang Cao, Changda Wang, Yixiu Wang, Yujian Xia, Dengfeng Cao, Zeinab Mohamed, Xin Guo, Xiya Yang, Xiaojun Wu, Li Song
Summary: A novel Cu2Se@C material has been designed to improve the performance of selenide electrodes, providing a new approach for the development of lithium batteries.
Article
Biochemistry & Molecular Biology
Umesh I. Kaluarachchige I. Don, Ahmad S. Almaat, Cassandra L. Ward, Stanislav Groysman
Summary: In this study, Cu(I) complexes were synthesized, characterized, and their reactions were investigated. New complexes [Cu(PMe3)(LigH(2))] and [CuCN(2,6-Me2C6H3)(LigH(2))] were synthesized and characterized. Furthermore, the first structurally characterized multinuclear complex combining both Mo(VI) and Cu(I) metal ions within the same system was obtained and characterized.
Article
Environmental Sciences
Gonzalo Bia, M. Gabriela Garcia, Nicolas J. Cosentino, Laura Borgnino
Summary: This study investigates the abundance, speciation, and dispersion of arsenic (As) in fresh volcanic ash from explosive Patagonian eruptions. Results show that the concentration, speciation, and mobility of As depend on the silica content of source magmas. Arsenic mainly accumulates on the surface of Al-silicate glass in volcanic ash. Atmospheric dispersion simulations reveal the impact of As-bearing ash on groundwater in Patagonia and surrounding areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Materials Science, Multidisciplinary
Yann Morizet, Valentin Jolivet, Nicolas Trcera, Tomo Suzuki-Muresan, Jonathan Hamon
Summary: The study investigated the possibility of dissolving iodine in borosilicate glasses using high-pressure synthesis, finding that I predominantly dissolves as iodide and using XPS and XAS methods to determine the speciation and surroundings of I. The results suggest that the borosilicate network is affected by the dissolution of I.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Chemistry, Physical
Khagesh Kumar, Sasawat Jamnuch, Leily Majidi, Saurabh Misal, Alireza Ahmadiparidari, Michael A. Dato, George E. Sterbinsky, Tianpin Wu, Amin Salehi-Khojin, Tod A. Pascal, Jordi Cabana
Summary: In this study, researchers investigated the electronic structure changes of MoS2 nanosheets during the carbon dioxide reduction reaction (CO2RR) through experimental and computational methods. They discovered the existence of Mo-CO2 binding in the active state, which perturbs the hybridized Mo 4d-S 3p states and is influenced by electrochemically induced sulfur vacancies. These findings provide insights into the excellent performance of MoS2 in CO2RR and could be used as a screening criterion for improving the activity and selectivity of transition-metal dichalcogenides (TMDCs) in general.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Emily Seelen, Van Liem-Nguyen, Urban Wunsch, Zofia Baumann, Robert Mason, Ulf Skyllberg, Erik Bjorn
Summary: This study demonstrates that the concentration of thiol compounds associated with dissolved organic matter controls the bioavailability of methylmercury in aquatic systems.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
S. M. Kumawat, G. D. Dwivedi, Y. H. Chien, P. F. Su, Z. H. Huang, H. Chou
Summary: We report an increase in magnetic ordering temperature and a structural phase transition in the (Mn1-xFex)(3)O-4 (x = 0.00-0.40) system. The lattice constants gradually converge with Fe-substitution and the room temperature magnetic moments increase. Fe3+ cations preferentially occupy octahedral sites and their presence is confirmed by X-ray absorption spectra.
MATERIALS RESEARCH BULLETIN
(2022)
Article
Acoustics
Holger M. Strunk, Caroline Luetzow, Jana Henseler, Martin Muecke, Maximilian Rauch, Christian Marx, Hans H. Schild, Milka Marinova
ULTRASCHALL IN DER MEDIZIN
(2018)
Article
Immunology
Julia Leonhardt, Silke Grosse, Christian Marx, Fatina Siwczak, Sven Stengel, Tony Bruns, Reinhard Bauer, Michael Kiehntopf, David L. Williams, Zhao-Qi Wang, Alexander S. Mosig, Sebastian Weis, Michael Bauer, Regine Heller
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Genetics & Heredity
Ralf A. Husain, Mona Grimmel, Matias Wagner, J. Christopher Hennings, Christian Marx, Rene G. Feichtinger, Abdelkrim Saadi, Kevin Rostasy, Florentine Radelfahr, Andrea Bevot, Marion Doebler-Neumann, Hans Hartmann, Laurence Colleaux, Isabell Cordts, Xenia Kobeleva, Hossein Darvish, Somayeh Bakhtiari, Michael C. Kruer, Arnaud Besse, Andy Cheuk-Him Ng, Diana Chiang, Francois Bolduc, Abbas Tafakhori, Shrikant Mane, Saghar Ghasemi Firouzabadi, Antje K. Huebner, Rebecca Buchert, Stefanie Beck-Woedl, Amelie J. Mueller, Lucia Laugwitz, Thomas Naegele, Zhao-Qi Wang, Tim M. Strom, Marc Sturm, Thomas Meitinger, Thomas Klockgether, Olaf Riess, Thomas Klopstock, Ulrich Brandl, Christian A. Huebner, Marcus Deschauer, Johannes A. Mayr, Penelope E. Bonnen, Ingeborg Kraegeloh-Mann, Saskia B. Wortmann, Tobias B. Haack
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Multidisciplinary Sciences
L. Marx-Bluemel, C. Marx, F. Weise, J. Frey, B. Perner, G. Schlingloff, N. Lindig, J. Hampl, J. Sonnemann, D. Brauer, A. Voigt, S. Singh, B. Beck, Ute-Maria Jaeger, Z. Q. Wang, J. F. Beck, A. Schober
Article
Biochemistry & Molecular Biology
Trim Lajqi, Christian Marx, Hannes Hudalla, Fabienne Haas, Silke Grosse, Zhao-Qi Wang, Regine Heller, Michael Bauer, Reinhard Wetzker, Reinhard Bauer
Summary: Microglia exhibit long-term response changes indicative of innate immune memory, with patterns of trained immunity and immune tolerance after low and high dose challenges with pathogen-associated molecular patterns, respectively. Immunometabolic reprogramming is involved in IIM in a dose-dependent manner via the glycolytic pathway, oxygen consumption and ATP production: ULP increases it, while HP reduces it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Christian Marx, Marc U. Schaarschmidt, Joanna Kirkpatrick, Lisa Marx-Bluemel, Melisa Halilovic, Martin Westermann, Doerte Hoelzer, Felix B. Meyer, Yibo Geng, Katrin Buder, Hauke M. Schadwinkel, Kanstantsin Siniuk, Sabine Becker, Rene Thierbach, James F. Beck, Juergen Sonnemann, Zhao-Qi Wang
Summary: The study suggests that combination treatment with HSP90 inhibitor and ATR inhibitor may be an effective therapeutic approach for Ewing's sarcoma, regardless of the p53 status.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Christian Marx, Juergen Sonnemann, Mandy Beyer, Oliver D. K. Maddocks, Sergio Lilla, Irene Hauzenberger, Andrea Piee-Staffa, Kanstantsin Siniuk, Suneetha Nunna, Lisa Marx-Bluemel, Martin Westermann, Tobias Wagner, Felix B. Meyer, Rene Thierbach, Christina S. Mullins, Said Kdimati, Michael Linnebacher, Francesco Neri, Thorsten Heinzel, Zhao-Qi Wang, Oliver H. Kraemer
Summary: Acetylation of p53, specifically at the C-terminal, controlled by HDACs, plays a crucial role in determining cellular stress responses and apoptosis in p53-positive CRC cells. The combination of irinotecan and entinostat represents clinically tractable agents for the therapy of p53-proficient CRC due to this mechanism.
MOLECULAR ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Murat Kirtay, Josefine Sell, Christian Marx, Holger Haselmann, Mihai Ceanga, Zhong-Wei Zhou, Vahid Rahmati, Joanna Kirkpatrick, Katrin Buder, Paulius Grigaravicius, Alessandro Ori, Christian Geis, Zhao-Qi Wang
Summary: ATR, a key regulator of DNA damage response and replication stress, also plays a role in regulating neuronal activity beyond its known functions. Deletion of ATR in neurons leads to increased intrinsic activity, aberrant firing, and heightened epileptiform activity, potentially increasing susceptibility to ataxia and epilepsy.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Raendler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Summary: Posttranslational mechanisms, specifically modification by advanced glycation end products such as carboxymethyllysine, play a key role in cellular protein abundance and function. The authors identified over 1000 sites of protein carboxymethylation and demonstrated that this modification affects protein homeostasis and cell proliferation, providing insights into the molecular roles of advanced glycation end products during aging.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Lisa Marx-Bluemel, Christian Marx, Jurgen Sonnemann, Frank Weise, Jorg Hampl, Jessica Frey, Linda Rothenburger, Emilio Cirri, Norman Rahnis, Philipp Koch, Marco Groth, Andreas Schober, Zhao-Qi Wang, James F. Beck
Summary: By combining artificial 3D PDMS scaffolds with optimized HSC culture medium, high numbers of undifferentiated HSCs can be amplified in vitro, activating key molecular signaling pathways that promote HSC expansion and maintenance of pluripotency.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Felix B. Meyer, Christian Marx, Sonja B. Spangel, Rene Thierbach
Summary: The BALB/c cell transformation assay (BALB-CTA) allows for a direct comparison between untransformed and malignant cells, taking into account tumor heterogeneities. Monoclonal cell lines derived from BALB-CTA were used to study the effects of metformin and butyrate on phenotypes, revealing anti-carcinogenic effects and reduced glucose uptake in the BALB-TTM. Metabolic characterization of the cell clones showed three distinct phenotypes, with surprising opposite metabolic shifts induced by metformin or butyrate treatment across all clones.
Article
Biochemistry & Molecular Biology
Alena Gschwind, Christian Marx, Marie D. Just, Paula Severin, Hannah Behring, Lisa Marx-Blumel, Sabine Becker, Linda Rothenburger, Martin Foester, James F. Beck, Juergen Sonnemann
Summary: This study identified the relationship between autophagy and the cell cycle, and provided clear evidence of high autophagy in G2/M-phase cells using the Cyto-ID technique.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Leonie K. Stabenow, Darya Zibrova, Claudia Ender, Dario L. Helbing, Katrin Spengler, Christian Marx, Zhao-Qi Wang, Regine Heller
Summary: Vascular aging is associated with endothelial dysfunction, which is influenced by the accumulation of senescent cells in aged tissues and their environment. Senescence is closely linked to changes in cell metabolism, with senescent cells showing enhanced glycolytic and oxidative glucose metabolism.
Article
Oncology
Christian Marx, Juergen Sonnemann, Oliver D. K. Maddocks, Lisa Marx-Bluemel, Mandy Beyer, Doerte Hoelzer, Rene Thierbach, Claudia Maletzki, Michael Linnebacher, Thorsten Heinzel, Oliver H. Kraemer
Summary: Chemotherapeutics that cause DNA replication stress increase the metabolism of colorectal cancer (CRC) cells, and glucose restriction might improve the effectiveness of classical chemotherapy against p53-positive cells.
CANCER & METABOLISM
(2022)
Letter
Hematology
Juergen Sonnemann, Miriam Zimmermann, Christian Marx, Franziska Ebert, Sabine Becker, Marie-Luise Lauterjung, James F. Beck
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)