Article
Endocrinology & Metabolism
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
Summary: Bone regeneration is a complex process involving the coordination of osteogenesis and osteoclastogenesis, with the balance between osteogenesis and adipogenesis of BMSCs playing a critical role. Recent studies have shown that exosomes from M2 macrophages facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis, potentially serving as a therapeutic tool for bone loss diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu, Jingjun Zhao
Summary: BMSC-derived EVs, carrying miRNAs, have shown similar efficacy to BMSCs in treating skin dysfunction in SSc, by regulating the WNT and TGF beta signaling pathways.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hyun-Ji Park, Jessica R. Hoffman, Milton E. Brown, Sruti Bheri, Olga Brazhkina, Young Hoon Son, Michael E. Davis
Summary: Small extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering molecular cargo and mediating cellular signaling. Knocking down miR-192-5p and miR-432-5p in cardiac c-kit+ cell-derived sEVs enhances their therapeutic capabilities and improves cardiac function, reducing fibrosis and necrotic inflammatory responses. This study suggests that targeting deleterious miRNAs in sEVs could be a promising therapeutic strategy for chronic myocardial infarction.
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Biochemistry & Molecular Biology
Enrico C. Torre, Mesude Bicer, Graeme S. Cottrell, Darius Widera, Francesco Tamagnini
Summary: Adipose-derived mesenchymal stromal cells (ASCs) have the potential to differentiate into various cell types and exhibit spontaneous Ca2+ oscillations. The effects of differentiation treatments on ASCs' Ca2+ dynamics, in terms of oscillation fraction and frequency, were examined in this study. Both adipogenic and osteogenic differentiation resulted in reduced Ca2+ dynamics, with adipogenic differentiation showing a more pronounced effect. Changes in Ca2+ oscillations were observed as early as 7 days in vitro (DIV). Further research is needed to understand the molecular and mechanistic correlates of these changes for the development of interventions in regenerative medicine.
Article
Chemistry, Multidisciplinary
Tiemei Li, Xiaotao Su, Pinglan Lu, Xinmei Kang, Mengyan Hu, Chunyi Li, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Yuxin Liu, Xiaohui Deng, Wei Cai, Lei Wei, Zhengqi Lu
Summary: Pneumonia is a common cause of death in patients with acute ischemic stroke (AIS), and antibiotics are not effective in improving the prognosis due to the negative impact on the immune system. However, a recent study found that bone marrow mesenchymal stem cells (BM-MSC) can reduce bacterial load in the lungs of stroke mice, and this is achieved by modulating the activities of pulmonary macrophages. The study also identified that BM-MSC releases migrasomes, which contain the antibacterial peptide dermcidin (DCD) and enhance the phagocytosis of macrophages.
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Polymer Science
Liang Chen, Guoping Cheng, Shu Meng, Yi Ding
Summary: Fish scale collagen membrane, prepared with a high denaturation temperature and composed of a natural collagen composite, demonstrated good thermal stability, cytocompatibility, and osteogenic activity.
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Yan Huang, Chengtie Wu, Xiaoling Zhang, Jiang Chang, Kerong Dai
ACTA BIOMATERIALIA
(2018)
Article
Biochemistry & Molecular Biology
De Li, Hui Wang, Zhuokai Li, Chenglong Wang, Fei Xiao, Yuan Gao, Xiang Zhang, Peng Wang, Jianping Peng, Guiquan Cai, Bin Zuo, Yun Shen, Jin Qi, Niandong Qian, Lianfu Deng, Weidong Song, Xiaoling Zhang, Lei Shen, Xiaodong Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Cell Biology
Chuandong Wang, Fei Xiao, Yaokai Gan, Weien Yuan, Zhanjing Zhai, Tuo Jin, Xiaodong Chen, Xiaoling Zhang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Rheumatology
Wenxue Tong, Yelin Zeng, Dick Ho Kiu Chow, Wai Yeung, Jiankun Xu, Yujie Deng, Shihui Chen, Hui Zhao, Xiaoling Zhang, Kevin Kiwai Ho, Ling Qin, Kingston King-Lun Mak
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Article
Pharmacology & Pharmacy
Jin Long Liu, Jing Li, Jia Jia Xu, Fei Xiao, Peng Lei Cui, Zhi Guang Qiao, Xiao Dong Chen, Wei Dong Tao, Xiao Ling Zhang
MOLECULAR PHARMACOLOGY
(2019)
Article
Cell Biology
Penglei Cui, Xiaoying Zhao, Jinlong Liu, Xiaodong Chen, Yuan Gao, Kun Tao, Chuandong Wang, Xiaoling Zhang
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Danyang Zhao, Wenbo Jiang, Yu Wang, Chuandong Wang, Xiaoling Zhang, Qingfeng Li, Dong Han
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Engineering, Biomedical
Wei Zhang, Zhiguo Yuan, Xiangchao Meng, Jue Zhang, Teng Long, Zhao Yaochao, Chunxi Yang, Ruixin Lin, Bing Yue, Quanyi Guo, You Wang
BIOMEDICAL MATERIALS
(2020)
Article
Health Care Sciences & Services
Xibai Li, Yan Sun, Juyang Jiao, Haoyu Wu, Chunxi Yang, Xubo Yang
Summary: The aim of this study was to develop software to diagnose discoid lateral menisci on knee joint radiograph images, achieving a high success rate in segmenting and measuring parameters of the images. The software showed promising results in accurately identifying key features, demonstrating potential for future joint database establishment and knee joint disease diagnosis.
JOURNAL OF HEALTHCARE ENGINEERING
(2021)
Article
Orthopedics
Jiajie Yang, Yaqiang Li, Xiaojian Shi, Meihua Shen, Kaibing Shi, Lingjie Shen, Chunxi Yang
Summary: Mechanical strength, pore morphology and size are crucial factors for 3D printed porous titanium scaffolds, with regular hexahedron, regular tetrahedron, and imitation diamond-120 degrees structures showing promising results for large pore sizes and high compressive strength.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Chemistry, Applied
Yaqiang Li, Xiaowei Xun, Yong Xu, Anqi Zhan, Erji Gao, Fan Yu, You Wang, Honglin Luo, Chunxi Yang
Summary: The study successfully developed 3D hierarchical porous BC/DCECM scaffolds with biomimetic cartilage regeneration microenvironment, which showed enhanced cell adhesion and proliferation. The scaffolds achieved satisfactory neocartilage tissue regeneration in both in vitro and in vivo experiments, demonstrating their potential for further application in cartilage tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Integrative & Complementary Medicine
Zhiwei Fu, Changming Xu, You Wang, Xinhua Qu, Chunxi Yang
Summary: The objective of this study was to investigate the effect of quadriceps acupoint massage on reducing pain and increasing range of motion in patients after total knee arthroplasty. The results showed that in the early postoperative period, the acupoint massage group had better pain scores, flexion range, and tenderness threshold compared to the control group, but there was no significant difference at 12 weeks postoperatively.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Materials Science, Multidisciplinary
Zhiwei Fu, Chunxi Yang
Summary: The tendon-bone junction (TBJ) is a complex structure consisting of tendons, fibrocartilage, and bone, and its healing process presents challenges. Injuries such as ACL tears and rotator cuff injuries are common and serious sports injuries, often leading to re-tear after surgery. Recent studies have focused on promoting tendon-bone integration by using biomaterial coatings that facilitate bone growth and ligament attachment. This study aims to highlight the application of biomaterial coatings in promoting tendon-bone healing and provide a comprehensive review of approaches to enhancing TBJ healing.
Article
Cell Biology
Yuhang Liu, Xudong Zhang, Xiaodong Chen, Bingjun Zhang, Liming Dai, Chenglong Wang, Yang Li, Xiaoling Zhang
Summary: MicroRNAs are crucial in the chondrogenesis of bone marrow mesenchymal stem cells (MSCs) and regulate joint regeneration in osteoarthritis. This study aimed to determine the role of miR146a in the chondrogenic differentiation of MSCs and its underlying mechanisms. The results showed that miR146a inhibits chondrogenesis in MSCs by directly targeting Lsm11.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Yaqiang Li, Jing Wang, Jiaji Yue, Yu Wang, Chunxi Yang, Quanjun Cui
CELL BIOLOGY INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)