Article
Biochemistry & Molecular Biology
Luis G. Guijarro, David Cano-Martinez, M. Val Toledo-Lobo, Lidia Ruiz-Llorente, Maria Chaparro, Ivan Guerra, Marisa Iborra, Jose Luis Cabriada, Luis Bujanda, Carlos Taxonera, Valle Garcia-Sanchez, Ignacio Marin-Jimenez, Manuel Barreiro-de Acosta, Isabel Vera, Maria Dolores Martin-Arranz, Francisco Mesonero, Laura Sempere, Fernando Gomollon, Joaquin Hinojosa, Sofia Zoullas, Jorge Monserrat, Cesar Menor-Salvan, Melchor Alvarez-Mon, Javier P. Gisbert, Miguel A. Ortega, Borja Hernandez-Breijo
Summary: This study found that levels of serum AIF-1 decrease in Crohn's disease (CD) patients after treatment with anti-TNFs. The study also revealed that active CD patients have higher levels of serum AIF-1 compared to inactive CD patients. The combination of serum AIF-1 and CRP levels improves the predictive ability for classifying CD patients by their severity.
Article
Health Care Sciences & Services
Lara Sanchez-Trujillo, Oscar Fraile-Martinez, Cielo Garcia-Montero, Luis M. Garcia-Puente, Luis G. Guijarro, Diego De Leon-Oliva, Diego Liviu Boaru, David Gardon-Alburquerque, Maria del Val Toledo Lobo, Mar Royuela, Ignacio Garcia-Tunon, Antonio Rios-Parra, Juan A. De Leon-Luis, Coral Bravo, Melchor Alvarez-Mon, Julia Bujan, Miguel A. Saez, Natalio Garcia-Honduvilla, Miguel A. Ortega
Summary: Chronic venous disease (CVD) is a common condition that affects the veins in the lower limbs, leading to symptoms such as swelling, pain, and varicose veins. Pregnancy increases the vulnerability to CVD due to hormonal, hemodynamic, and mechanical changes. This study examined the inflammatory status of the umbilical cord in women with CVD during pregnancy through the expression of inflammatory markers. The results showed increased expression of AIF-1, IL-12A, and IL-18, along with decreased IL-10, suggesting an inflammatory state related to CVD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Xin Liu, Dandan Zhang, Jianping Hu, Sikai Xu, Chengyun Xu, Yang Shen
Summary: This study finds that AIF-1 is upregulated in most cancers and has predictive value. AIF-1 expression is positively correlated with immune cell infiltration and immune checkpoint-related genes. Additionally, AIF-1 promoter methylation levels vary in different tumors, and high methylation levels are associated with poor prognosis in some cancers but better prognosis in others. Functionally, silencing AIF-1 reduces the proliferation, migration, and invasion abilities of kidney cancer cells.
Article
Fisheries
Yaling Lai, Yilin Wang, Xianyang Fan, Yanying Zhao
Summary: AIF-1 is a calcium-binding protein associated with inflammatory diseases, which promotes cell proliferation, inhibits cell apoptosis, improves mitochondrial function, and regulates immune response by influencing cytokine production and cell migration.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ricardo Louzada da Silva, Diana M. Elizondo, Nailah Z. D. Brandy, Naomi L. Haddock, Thomas A. Boddie, Lais Lima de Oliveira, Amelia Ribeiro de Jesus, Roque Pacheco de Almeida, Tatiana Rodrigues de Moura, Michael W. Lipscomb
Summary: The study revealed that Leishmania donovani inhibits AIF1 expression in macrophages to block pro-inflammatory responses during infection, leading to increased parasite load. Ectopic overexpression of AIF1 in macrophages provided protection from infection, while inhibiting AIF1 expression in bone marrow cells or monocytes impaired differentiation into functional macrophages. This highlights AIF1 as a critical regulatory component in governing monocyte and macrophage immune functions during parasitic infections and demonstrates how the parasite can suppress this gene as an immune evasion tactic.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Mario Altamura, Giovanna D'Andrea, Eleonora Angelini, Fabio M. P. Tortorelli, Angela Balzotti, Piero Porcelli, Maurizio Margaglione, Natale D. Brunetti, Tommaso Cassano, Antonello Bellomo
Summary: Psychosomatic syndromes have been found to be an important source of comorbidity in cardiac patients and are associated with increased risk for adverse outcomes in patients with heart failure (HF). This study examined the connection between immune activity and psychosomatic psychopathology in HF patients and found a significant positive correlation between IL-6 levels and psychosomatic psychopathology, while the association with TNF-alpha levels was not significant.
Article
Neurosciences
Asmahan Elgellaie, Susan J. J. Thomas, Jacqueline Kaelle, Jessica Bartschi, Theresa Larkin
Summary: This study found that pro-inflammatory cytokines IL-1 alpha, IL-6, and TNF-alpha are associated with major depressive disorder, psychological distress, cardiovascular health, and obesity. However, there is limited research on the multiple associations between these variables, especially among untreated individuals with major depressive disorder, compared to a control group, and including sex differences. The study analyzed data from 60 individuals with major depressive disorder and 60 controls, measuring various factors such as plasma levels of cytokines, adiposity measures, cardiovascular health indices, and psychological symptoms. The results showed that plasma IL-1 alpha and IL-6 were higher in the major depressive disorder group compared to the control group, with a sex interaction observed for IL-6. TNF-alpha did not differ between the groups. Moreover, IL-1 alpha and IL-6 were correlated with depressive severity, anxiety, hostility, and stress, while TNF-alpha only correlated with anxiety and hostility. The association between psychopathology and pro-inflammatory cytokines varied by sex. None of the cytokines were correlated with measures of adiposity, cardiovascular health indices, or psychological health. The findings suggest that the group by sex interaction for IL-6 and the sex-specific associations between pro-inflammatory cytokines and psychometrics could have important implications for depression interventions and treatments, particularly for females. Further research is warranted.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Education, Scientific Disciplines
Takashi Ishijima, Kazuyuki Nakajima
Summary: Through utilizing an animal model with LPS-induced rat brain, the study revealed that microglia induce different inflammatory cytokines through specific combinations of MAPKs and by the presence or absence of nitric oxide.
Article
Biochemistry & Molecular Biology
Suzhao Li, Liqiong Jiang, Karsten Beckmann, Jesper Falkesgaard Hojen, Ulrich Pessara, Nicholas E. Powers, Dennis M. de Graaf, Tania Azam, Jared Lindenberger, Elan Z. Eisenmesser, Stephan Fischer, Charles A. Dinarello
Summary: Unchecked inflammation can lead to severe diseases with high mortality, such as macrophage activation syndrome (MAS). Interleukin-18 (IL-18) is elevated in MAS and COVID-19 patients, correlating with the severity of COVID-19 symptoms, and initiates inflammatory signaling through the IL-1R5 and IL-1R7 receptor complex. A novel anti-IL-1R7 antibody has been developed to specifically block IL-18-mediated inflammation, showing promising results in human cell lines and blood samples.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Surgery
Cynthia L. L. Miller, Joren C. C. Madsen
Summary: Outcomes of heart transplantation remain suboptimal due to acute and chronic rejection. IL-6, a pro-inflammatory cytokine, plays a critical role in allograft injury and immune response after heart transplantation. Inhibiting IL-6 signaling has emerged as a promising strategy to prevent rejection and improve outcomes in heart transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Madelene Lindkvist, Mulugeta M. Zegeye, Magnus Grenegard, Liza U. Ljungberg
Summary: IL-6 family cytokines induce specific and overlapping molecular responses in endothelial cells through the gp130 signaling receptor, regulating the expression of genes and proteins involved in angiogenesis and immune cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Linda L. Tran, Truong Dang, Rintu Thomas, David R. Rowley
Summary: Stromal cells in the tumor microenvironment, specifically carcinoma-associated fibroblasts exhibiting an inflammatory phenotype (iCAFs), play a crucial role in regulating tumor progression. This study identified the ELF3 transcription factor as a key mediator in the differentiation of prostate mesenchymal stem cells into iCAFs in response to IL-1 alpha. Additionally, IL-1 alpha-induced iCAFs showed resistance to trans-differentiation into myCAFs, a subtype of carcinoma-associated fibroblasts, due to YAP protein phosphorylation. The results highlight the coordinated role of the IL-1 alpha/ELF3/YAP pathways in regulating inflammatory carcinoma-associated fibroblast differentiation.
Review
Endocrinology & Metabolism
Samuel T. Orange, Jack Leslie, Mark Ross, Derek A. Mann, Henning Wackerhage
Summary: IL-6 has both anticancer and procancer effects depending on the context, known as the 'exercise IL-6 enigma'. Exercise-induced IL-6 can protect against cancer by improving insulin sensitivity, stimulating the production of anti-inflammatory cytokines, mobilizing immune cells, and reducing DNA damage. However, IL-6 continuously produced in inflammatory sites drives tumorigenesis by promoting chronic inflammation. This review explores the roles of IL-6 in chronic inflammation, tumorigenesis, and exercise-associated cancer prevention and identifies the factors underlying the exercise IL-6 enigma.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Angela Oranger, Roberta Zerlotin, Cinzia Buccoliero, Lorenzo Sanesi, Giuseppina Storlino, Ernestina Schipani, Kenneth Michael Kozloff, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano
Summary: Bone fractures are a common clinical event caused by falls, trauma, diseases, and aging. Recent research has found a link between irisin and bone fractures. In an experiment on mice with tibial fractures, treatment with r-Irisin reduced inflammation and promoted angiogenesis, cartilage matrix degradation, and bone formation, suggesting it as a potential molecule for fracture treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Takuya Sugahara, Yukiko Tanaka, Masahide Hamaguchi, Maya Fujii, Koki Shimura, Kanae Ogawa, Taisuke Mori, Izumi Kusuki, Michiaki Fukui, Jo Kitawaki
Summary: The study found that the proportion of ILC2 and 3 was reduced in the endometrium of patients with endometriosis, while ILCs were increased in ovarian endometrioma. This may indicate a new immunological approach to understand the pathophysiology of endometriosis.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yoshitaka Hashimoto, Masahide Hamaguchi, Takuro Okamura, Naoko Nakanishi, Akihiro Obora, Takao Kojima, Michiaki Fukui
Summary: The study found an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD), while fatty liver disease (FLD) without metabolic dysfunction was not associated with CKD.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Chihiro Munekawa, Hiroshi Okada, Masahide Hamaguchi, Momoko Habu, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study found that the risk of developing type 2 diabetes among individuals with a fasting plasma glucose concentration of 90-99 mg/dL increased progressively with higher levels of fasting plasma glucose concentration in the Japanese population.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Rheumatology
Yutaka Kawahito, Akio Morinobu, Yuko Kaneko, Masataka Kohno, Shintaro Hirata, Mitsumasa Kishimoto, Yohei Seto, Takahiko Sugihara, Eiichi Tanaka, Hiromu Ito, Toshihisa Kojima, Isao Matsushita, Keiichiro Nishida, Masaaki Mori, Atsuko Murashima, Hisashi Yamanaka, Takeo Nakayama, Masayo Kojima, Masayoshi Harigai
Summary: The Japan College of Rheumatology has updated the clinical practice guidelines for rheumatoid arthritis, providing a useful tool for rheumatologists, healthcare professionals, and patients to make shared decisions in various clinical situations.
MODERN RHEUMATOLOGY
(2023)
Article
Environmental Sciences
Takuro Okamura, Masahide Hamaguchi, Yuka Hasegawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Ryoichi Sasano, Yuki Nakanishi, Hiroshi Seno, Hirohisa Takano, Michiaki Fukui
Summary: The study found that microplastics can cause metabolic disturbances, such as diabetes and nonalcoholic fatty liver disease, in mice on a high-fat diet. The results highlight the importance of reducing oral exposure to microplastics through environmental measures to improve metabolic disturbance under high-fat diet conditions.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Nutrition & Dietetics
Hanako Nakajima, Hiroshi Okada, Ayaka Kobayashi, Fuyuko Takahashi, Takuro Okamura, Yoshitaka Hashimoto, Naoko Nakanishi, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes. The relationship between dietary protein intake and the metabolites concerning sarcopenia was analyzed, and the factors affecting sarcopenic risk were clarified. Leucine and glutamic acid were found to be useful biomarkers for sarcopenia.
Article
Geriatrics & Gerontology
Takuro Okamura, Masahide Hamaguchi, Hanako Nakajima, Nobuko Kitagawa, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Ryoichi Sasano, Michiaki Fukui
Summary: This study aimed to clarify the effect of milk on the prevention of sarcopenic obesity in db/db mice. The results showed that milk administration increased muscle mass and strength, and decreased visceral fat mass in the mice. Fecal microbiota transplantation from mice fed milk improved sarcopenic obesity and glucose intolerance. The findings suggest that milk consumption not only increases nutrient intake but also alters the intestinal environment, contributing to the improvement of sarcopenic obesity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Endocrinology & Metabolism
Yoshitaka Hashimoto, Masahide Hamaguchi, Michiaki Fukui
Summary: The number of patients with type 2 diabetes mellitus is increasing, and prevention and management are important. Fermented soybean food modifies gut microbiota-related metabolites by altering dysbiosis. Fermented soybean foods also have antioxidant, anti-inflammatory, and anti-diabetic effects.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Dan Imai, Emi Ushigome, Masahide Hamaguchi, Satoru Hashimoto, Michiaki Fukui
Summary: This study aimed to investigate the rates of different diabetes status in severe COVID-19 patients and the factors associated with bleeding complications. The results showed that glycated hemoglobin level and renal failure were significantly correlated with bleeding complications. Additional attention to the course of COVID-19 is recommended for patients with diabetes, especially those with COVID-19-related diabetes, to reduce the risk of bleeding complications.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Yuta Yoshimura, Yoshitaka Hashimoto, Hiroshi Okada, Maya Takegami, Hanako Nakajima, Tomoki Miyoshi, Takashi Yoshimura, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to investigate the effects of dapagliflozin on skeletal muscle mass in individuals with type 1 diabetes, as well as the impact of good glycemic control on skeletal muscle mass. The findings suggest that dapagliflozin treatment may lead to loss of skeletal muscle mass in non-obese individuals and older men. However, good glycemic control during treatment may prevent the onset and progression of sarcopenia.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Shintaro Kajiyama, Naoko Nakanishi, Shinta Yamamoto, Takahiro Ichikawa, Takuro Okamura, Yoshitaka Hashimoto, Noriyuki Kitagawa, Masahide Hamaguchi
Summary: This study investigated the relationship between nutritional status and low phase angle (PhA). It was found that dietary habits and serum nutritional markers were related to PhA. Low PhA values were associated with poor exercise habits and lower body mass index in males. Total energy intake was significantly correlated with PhA in males, with the low-PhA group having lower total energy and carbohydrate intake.
Article
Infectious Diseases
Wataru Fujii, Liu Chang, Taka-aki Inui, Shigeyasu Ishizaka, Yutaka Kawahito
Summary: A female patient with rheumatoid arthritis treated with JAK inhibitors developed gradually enlarging bilateral submandibular lymph nodes swelling. Lymph node biopsy revealed granulomatous lymphadenitis with caseous necrosis, and Mycobacterium avium was identified. A CT scan showed no evidence of mass or infection elsewhere, and the mass was excised without antimicrobial treatment. No recurrence was observed 9 months after excision. Physicians should be aware of rare complications such as cervical lymphadenitis caused by nontuberculous mycobacteria when using JAK inhibitors.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Respiratory System
Masataka Kuwana, Masashi Bando, Yutaka Kawahito, Shinji Sato, Takafumi Suda, Yasuhiro Kondoh, CTD-ILD Delphi Collaborators
Summary: The study aimed to develop expert consensus statements and an algorithm for managing connective tissue disease-associated interstitial lung disease (CTD-ILD). Consensus was reached on important statements regarding screening, diagnosis and severity assessment, follow-up, and multidisciplinary management of CTD-ILD. An algorithm was developed based on these consensus statements.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Shinnosuke Hata, Mai Asano, Hiroyuki Tominaga, Masahide Hamaguchi, Fumiya Hongo, Takeshi Usui, Eiichi Konishi, Michiaki Fukui
Summary: Recently, there has been rapid progress in uncovering the genetic background of pheochromocytomas/paragangliomas (PPGLs). These tumors, previously known as the ten percent tumor, are now found to have a higher frequency of genetic variants than expected. This report presents a case of bilateral pheochromocytoma with a variant in the MYC-associated factor X (MAX) gene.
CLINICS AND PRACTICE
(2022)
Article
Medicine, General & Internal
Chihiro Munekawa, Yoshitaka Hashimoto, Noriyuki Kitagawa, Takafumi Osaka, Masahide Hamaguchi, Michiaki Fukui
Summary: Teriparatide was shown to have a positive effect on bone mineral density and trabecular bone score in osteoporosis patients with type 2 diabetes mellitus, compared to bisphosphonates and no medication.
MEDICINA-LITHUANIA
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
