Article
Fisheries
Marta Maruszewska-Cheruiyot, Katarzyna Donskow-Lysoniewska, Katarzyna Krawczak, Maja Machcinska, Maria Doligalska
Summary: In an inflammatory environment, the mouse intestinal parasite adaptively affects dendritic cell function, exacerbating inflammatory colitis symptoms.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hae-Bin Park, So-Jung Kim, Dhananjay Yadav, Eun-Koung An, Wei Zhang, Hee-Yun Eom, Minseok Kwak, Tatsuya Oda, Peter Chang-Whan Lee, Jun-O Jin
Summary: This study found that porphyran derived from Pyropia yezoensis has an inhibitory effect on dextran sodium sulfate (DSS)-induced colitis in mice. Oral or intraperitoneal administration of porphyran can inhibit the progression of colitis and prevent immune cell infiltration in the colon. Porphyran inhibits T cell activation by suppressing dendritic cells and macrophages and attenuates chronic colitis caused by long-term DSS administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Ranit Kedmi, Tariq A. Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, Caleb A. Lareau, Ansuman T. Satpathy, Mark S. Anderson, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Helena Paidassi, James M. Gardner, Marlon Stoeckius, Dan R. Littman
Summary: The mutualistic relationship between gut-resident microbiota and the host immune system is crucial for maintaining homeostasis. Helicobacter species and other gut bacteria direct T cell differentiation through targeting specific antigen-presenting cells.
Article
Immunology
Mario Kuttke, Dominika Hromadova, Ceren Yildirim, Julia S. Brunner, Andrea Vogel, Hannah Paar, Sophie Peters, Maria Weber, Melanie Hofmann, Martina Kerndl, Markus Kieler, Hannes Datler, Laszlo Musiejovsky, Manuel Salzmann, Michaela Lang, Klara Soukup, Angela Halfmann, Omar Sharif, Gernot Schabbauer
Summary: This study found that the PI3K/PTEN signaling pathway in dendritic cells enhances IL-6 production, leading to exacerbated Th1 cell responses and increased mortality in inflammatory bowel diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B. Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Summary: Deletion of PTPN2 in DCs led to increased infiltration of various immune cells into the lamina propria in unchallenged mice, with elevated Th1 abundance during acute DSS colitis. However, this did not result in increased colitis susceptibility, likely due to compensatory effects of increased macrophage infiltration in the intestine upon loss of PTPN2 in DCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Wei Wei, Sucheng Mu, Yi Han, Yao Chen, Zhongshu Kuang, Xingyue Wu, Yue Luo, Chaoyang Tong, Yiqun Zhang, Yilin Yang, Zhenju Song
Summary: This study found that GPR174 is involved in the pathogenesis of IBD by regulating the maturation of dendritic cells to maintain immune homeostasis. The TNF-alpha (NF-kappa B) signaling pathway, leukocyte transendothelial migration, and Th1/Th2 cell differentiation pathways may be the target pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
Summary: Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide. Probiotic bacteria may impact immunomodulation by regulating dendritic cells to produce tolerogenic DCs, which could play a role in the treatment of IBD and associated conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qingqing Xu, Zhaoyang Liu, Zhiqiang Cao, Yongjian Shi, Ning Yang, Guangshang Cao, Chunmin Zhang, Rong Sun, Chunhong Zhang
Summary: The study demonstrates the therapeutic effects of astilbin in an IMQ-induced psoriasis-like murine model. It alleviates skin lesions by promoting epidermal keratinocyte differentiation and reducing inflammatory cytokine expression. These findings support the potential clinical application of astilbin for psoriasis treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Wei Zhang, Eun-Koung An, So-Jung Kim, Hae-Bin Park, Peter C. W. Lee, Jun-O Jin
Summary: This study demonstrated the side effects of FimH and indicated that the use of FimH can aggravate the disease in patients with colitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Aleksandra Kaluzna, Pawel Olczyk, Katarzyna Komosinska-Vassev
Summary: This review paper summarizes the current understanding of the involvement of the innate and adaptive immune systems in the pathogenesis of ulcerative colitis (UC). It discusses the role of various immune cells, such as neutrophils, dendritic cells, macrophages, innate lymphoid cells, cytotoxic lymphocytes, regulatory T cells, and helper T cells in the development of UC. The review also highlights the influence of B lymphocytes and cytokines on the disease. The paper concludes by mentioning the advancement in immune-targeted treatments for UC, known as biologic agents.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Article
Biochemical Research Methods
Yurui Shi, Jing Xie, Rongda Chen, Guiming Liu, Yanzhou Tao, Yangyang Fan, Xiaolin Wang, Li Li, Jiaming Xu
Summary: The study suggests that the three flavonoid isomers may increase the risk of food/drug-drug interactions by affecting the activities of CYP3A4 and 2D6.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyu Han, Jing Sun, Tianmei Niu, Beibei Mao, Shijie Gao, Pan Zhao, Linlin Sun
Summary: This study investigated the interaction between astilbin and human serum albumin (HSA) and their effects on the antioxidant activity of astilbin. The results showed that astilbin quenches the fluorescence emission of HSA through a static quenching mechanism and preferentially binds at the Site I position. The presence of HSA also reduced the antioxidant capacity of astilbin, indicating potential effects on its clinical use.
Article
Immunology
Valentina Ugalde, Francisco Contreras, Carolina Prado, Ornella Chovar, Alexandra Espinoza, Rodrigo Pacheco
Summary: This passage highlights the role of the high-affinity dopamine receptor D3 (DRD3) in regulating immunosuppressive potency of Treg in inflammatory bowel diseases, showing that Drd3 deficiency enhances Treg's immunosuppressive ability and mitigates colitis manifestation. DRD3-signalling attenuates IL-10 production and limits the acquisition of gut-tropism, making it a major regulator of Treg in gut inflammation.
MUCOSAL IMMUNOLOGY
(2021)
Article
Cell Biology
Nupur Aggarwal, M. Elizabeth Deerhake, Devon DiPalma, Shailesh K. Shahi, Margaret R. Gaggioli, Ashutosh K. Mangalam, Mari L. Shinohara
Summary: This study demonstrates that OPN generated by CD4(+) T cells helps control aGVHD by limiting gastrointestinal pathology and modulating gut microbiota. Secreted OPN (sOPN) is solely responsible for the protective role of OPN.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)