Article
Oncology
I. M. Modlin, M. Kidd, M. Falconi, P. L. Filosso, A. Frilling, A. Malczewska, C. Toumpanakis, G. Valk, K. Pacak, L. Bodei, K. E. Oberg
Summary: In this study, the clinical efficacy of the multigenomic blood biomarker NETest was compared to CgA in neuroendocrine tumors (NETs). The results showed that NETest outperformed CgA in terms of diagnostic accuracy, grading identification, metastatic identification, and disease status assessment.
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Shunxing Teh, Fam Xeng Inn, Iqbal Hussain Rizuana, Wan Muhaizan Wm
Summary: This article presents a case of rare and highly aggressive small cell prostate neuroendocrine carcinoma. The case describes the patient's clinical presentation, imaging findings, and treatment plan. Consensus on the management of this disease is still lacking.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Matteo Scopel, Eugenio De Carlo, Francesca Bergamo, Sabina Murgioni, Riccardo Carandina, Anna Rita Cervino, Marta Burei, Federica Vianello, Vittorina Zagonel, Matteo Fassan, Roberto Vettor
Summary: The study found that patients with synchronous bone metastases tend to have primary tumors with a higher degree of malignancy compared to patients with metachronous bone metastases. Additionally, GEP-NETs patients in the synchronous group had significantly higher Ki-67 levels at the diagnosis of bone metastases.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Matteo Scopel, Eugenio De Carlo, Francesca Bergamo, Sabina Murgioni, Riccardo Carandina, Anna Rita Cervino, Marta Burei, Federica Vianello, Vittorina Zagonel, Matteo Fassan, Roberto Vettor
Summary: This study analyzed the occurrence and factors influencing bone metastases in patients with neuroendocrine tumors. The findings suggest that synchronous metastases are associated with more malignant primary tumors and a higher disease burden in low-grade NETs. Parameters of phospho-calcium metabolism were within the normal range and bone complications were not correlated with the site of origin of the primary tumor. Survival analysis showed a cumulative survival rate of 33% at 10 years, with an average survival of 80 months and a 58% survival rate for synchronous patients, indicating a worse prognosis.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Dalvinder Mandair, Mohid S. Khan, Andre Lopes, Luke Furtado O'Mahony, Leah Ensell, Helen Lowe, John A. Hartley, Christos Toumpanakis, Martyn Caplin, Tim Meyer
Summary: The study identified the optimal CTC thresholds of 1 and 2 for predicting survival and progression-free survival in metastatic PanNET and midgut NETs, respectively. These thresholds can assist in patient stratification and clinical trial design.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Marta Opalinska, Anna Sowa-Staszczak, Helena Olearska, Magdalena Ulatowska-Bialas, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk
Summary: Ovarian neuroendocrine tumors are rare neoplasms that most commonly occur within mature cystic teratomas, with a minority presenting as monodermal teratomas (strumal carcinoid). The prognosis for patients with ovarian neuroendocrine tumors is good, with surgical intervention proving to be an effective treatment method.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Abbas Eshraghi, Mohammad Mehdi Riyahi, Afshin Ghaderi, Maedeh Alsadat Fatemi, Azhar Eshraghi, Danial Fazilat-Panah
Summary: This is a case report of small cell carcinoma of the bladder with extensive lymph node metastases, who underwent radical cystoprostatectomy followed by adjuvant systemic chemotherapy and chemoradiotherapy.
CLINICAL CASE REPORTS
(2022)
Review
Oncology
Manuel Weber, Tugce Telli, David Kersting, Robert Seifert
Summary: The monitoring of neuroendocrine tumors in patients is challenging and specialized imaging techniques are required. Somatostatin receptor-targeting molecular imaging methods have been proposed to accurately visualize the disease manifestations. However, the prognostic value of total tumor volume, expression level, and related metrics is not yet fully understood.
Article
Endocrinology & Metabolism
Sami Matrood, Leonidas Apostolidis, Joerg Schrader, Sebastian Krug, Harald Lahner, Annette Ramaswamy, Damiano Librizzi, Zoltan Kender, Anke Kroecher, Simon Kreutzfeldt, Thomas Matthias Gress, Anja Rinke
Summary: The study found that presacral NENs are histopathologically similar to rectal NENs. The majority of tumors are non-functioning, and PRRT shows promising activity in treatment. Further investigation and molecular characterization are needed to understand this rare tumor entity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Evelyn Kidess, Yvonne Giesecke, Ines Eichhorn, Raphael Mohr, Henning Jann, Christian Fischer, Bertram Wiedenmann, Christoph Roderburg, Frank Tacke, Michael Sigal
Summary: The study aimed to analyze plasma concentrations of OPN in patients with NEN and explore its diagnostic and prognostic value. The results showed that OPN levels were significantly higher in NEN patients compared to healthy controls, with the highest levels in high-grade tumors (grade 3). In addition, patients with initial OPN levels above 200 ng/ml had a poor prognosis in terms of shorter progression-free survival, both in the overall NEN patient group and within the subgroup of well-differentiated G1/G2 tumors. Therefore, OPN can serve as a surrogate prognostic biomarker in NEN patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Stefan Keckes, Julius Palaj, Iveta Waczulikova, Daniel Dyttert, Emilia Mojtova, Gustav Kovac, Stefan Durdik
Summary: This study investigated the predictive values of CgA and NSE in long-term survival of patients with neuroendocrine neoplasms (NENs). Elevated NSE levels before histology were significantly associated with worse survival outcomes. Therefore, NSE can serve as a valuable additional predictor for long-term survival in patients with NEN.
Article
Medicine, Research & Experimental
Elena Stingu, Jerome-Maurice Dobrowolski, Paula Bombach, Dominik Nann, Stephan Singer, Marius Horger, Ulrich M. Lauer, Lars Zender, Clemens Hinterleitner, Martina Hinterleitner
Summary: This study reports a rare case of myasthenia gravis (MG) that initially presented as a pancreatic neuroendocrine neoplasm, with improved symptoms after surgical resection. Although MG is commonly associated with thymic neoplasms, the possibility of other solid tumors should also be considered.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Endocrinology & Metabolism
Giuseppe Pelosi, Fabrizio Bianchi, Elisa Dama, Jasna Metovic, Marco Barella, Angelica Sonzogni, Adriana Albini, Mauro Papotti, Yulan Gong, Namrata Vijayvergia
Summary: High-grade neuroendocrine carcinomas in the gastroenteropancreatic tract may evolve from pre-existing well-differentiated neuroendocrine tumors, potentially linked to transitions in specific genetic mutation clusters, with different clinical manifestations and prognoses.
ENDOCRINE PATHOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Riccardo Pirisino, Luca Filippi, Antonio D'Agostini, Oreste Bagni
Summary: This article reports a case of a 76-year-old woman with pancreatic neuroendocrine tumor and meningioma. After receiving peptide receptor radionuclide therapy, the patient showed partial response in the liver and stability of the brain mass. No neurological complications occurred during treatment and follow-up.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Yi-Wei Li, Yi-Ping He, Fang-Qi Liu, Jun-Jie Peng, San-Jun Cai, Ye Xu, Ming-He Wang
Summary: This study compared the clinicopathologic features of rectal neuroendocrine tumors (NETs) with G1 and G2 grades. The results showed that G2 tumors were larger and more invasive than G1 tumors, with a significantly higher incidence of lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)