Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Ma, Fanghao Cai, Xiaohan Huang, Huijing Wang, Binfeng Yu, Junni Wang, Wanyun Nie, Kedan Cai, Yi Yang, Jianghua Chen, Liang Xiao, Fei Han
Summary: Increased serum mannose-binding lectin (MBL) level has been proven to correlate with the development of diabetic nephropathy (DN). This study found that MBL promotes the progression of DN by activating the nuclear factor-kappa B pathway in macrophages. This finding provides a new direction for the treatment of DN patients.
Article
Biochemistry & Molecular Biology
Na Yang, Minxiu Wang, Ke Lin, Mengyang Wang, Diyun Xu, Xue Han, Xia Zhao, Yi Wang, Gaojun Wu, Wu Luo, Guang Liang, Peiren Shan
Summary: The study demonstrates that Dectin-1 plays a critical role in the pathogenesis of diabetic cardiomyopathy by regulating inflammation. Dectin-1 deficient mice are protected against diabetes-induced cardiac dysfunction, cardiomyocyte hypertrophy, tissue fibrosis, and inflammation. Dectin-1 may be a potential target for the treatment of diabetic cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Chemistry, Medicinal
Xue Han, Jiajia Zhang, Li Zhou, Jiajia Wei, Yu Tu, Qiaojuan Shi, Yi Zhang, Juan Ren, Yi Wang, Huazhong Ying, Guang Liang
Summary: Sclareol may prevent and ameliorate diabetic nephropathy through its anti-inflammatory effects, which involve the regulation of the MAPK/NFKB signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin Kumar Singh, Niraj Kumar Jha, Piyush Kumar Gupta, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta
Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Abeer A. Al-Masri, Fuad Ameen
Summary: Banana is an important fruit crop worldwide. In this study, an anthocyanin-rich extract from banana bract (BBA) was prepared and characterized. BBA showed antioxidant and anti-inflammatory activity in LPS-stimulated macrophage-like cells. The presence of phenolic compounds, flavonoids, and anthocyanin in BBA was identified. BBA increased endogenous antioxidants and inhibited the nuclear translocation of NF-kappaB under LPS-stimulated conditions, indicating its potential as an anti-inflammatory agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, Research & Experimental
Zi-jun Sun, Dong-yuan Chang, Min Chen, Ming-hui Zhao
Summary: Accumulating evidence suggests the pathogenic role of immunity and metabolism in diabetic kidney disease (DKD). In this study, the researchers investigated the effect of complement factor B (CFB) on lipid metabolism in the development of DKD. They found that CFB deficiency inhibited activation of the complement alternative pathway and attenuated kidney damage in DKD, especially tubulointerstitial injury, by inhibiting the NF-KB signaling pathway, further blocking the transcription of ceramide synthases (CERS), which regulates the biosynthesis of ceramide. CFB may be a promising therapeutic target of DKD.
Article
Environmental Sciences
Dan Wang, Zhenzhen Tan, Jing Yang, Longfei Li, Haoran Li, Huaxing Zhang, Heqiong Liu, Yi Liu, Lei Wang, Qian Li, Huicai Guo
Summary: This study aimed to investigate the effects of PFOS exposure on atherosclerosis progression and the underlying mechanisms. The results showed that PFOS increased pulse wave velocity, intima-media thickness, aortic plaque burden, and levels of serum lipids and inflammatory cytokines. PFOS promoted M1 macrophage polarization and suppressed M2 macrophage polarization, leading to inflammation. NF-κB activation in macrophages was associated with this process. These findings highlight the role of PFOS in accelerating atherosclerosis progression through NF-κB-mediated inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kehinde S. Olaniyi, Stephanie E. Areloegbe
Summary: This study investigated the effects of acetate on cardiometabolic abnormalities associated with polycystic ovarian syndrome (PCOS) in a rat model. The results suggest that acetate protects against cardiac inflammation by suppressing PCSK9 and NF-kB-dependent mechanisms.
Article
Dentistry, Oral Surgery & Medicine
Shaohua Cong, Qian Peng, Liou Cao, Qingqing Yi, Yi Liu, Linhui Li, Qingchun Tong, Dongyu Liang
Summary: This study investigated the effects of diosgenin on periodontitis and found that it inhibited inflammatory responses and the activation of NF-kappa B pathway while promoting osteogenesis. Administering diosgenin to periodontitis rats also reduced the levels of inflammatory factors and NF-kappa B in gingival tissue, and promoted the expression of osteoblast-related genes. These findings suggest that diosgenin may be a potential therapeutic strategy for treating periodontitis in the future.
Article
Plant Sciences
Yating Wang, Xiurong Bao, Hao Xian, Fang Wei, Yining Song, Siyu Zhao, Yujie Zhang, Yumeng Wang, Ying Wang
Summary: This study investigates the role and potential mechanisms of ginsenoside metabolite compound K (CK) in the treatment of rheumatoid arthritis (RA). The results demonstrate that CK can reduce arthritis symptoms and inhibit inflammation-related genes and pathways. These findings contribute to the understanding of the molecular mechanism of CK in treating RA.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuoqiu Bai, Jingjing Zhou, Xiaolin Nong, Rongkang Shi, Zhong Yuan, Chubin Ma, Jiaquan Li
Summary: This study investigated the effects of diabetic periodontitis on liver function and found that artesunate can improve liver function. Artesunate protects diabetes-related liver function by inhibiting the expression of inflammatory factors, offering a new approach for diabetes treatment.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Review
Immunology
Yan Liu, Kai Xu, Yin Yao, Zheng Liu
Summary: This article reviews the role of A20 in allergic airway diseases, finding that A20 can regulate the inflammatory response in these diseases by inhibiting the NF-κB signaling pathway, thus exerting anti-inflammatory effects. The gene polymorphisms of A20 are also associated with allergic airway diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Jingyu Duan, Liangliang He, Wenhao Deng, Mengyuan Lu, Yutong Zhai, Feilong Pei, Shuang Liu, Chunping Zhang
Summary: Swietenine can alleviate inflammation and oxidative stress, and improve diabetic nephropathy by inhibiting the activation of NE-kappa B and NLRP3 through regulating the NF-kappa B/NLRP3/Caspase-1 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)