Article
Biochemistry & Molecular Biology
Kojiro Matsushita, Chiharu Nakahara, Shun Kimura, Naoya Sakamoto, Satoshi Ii, Hiromi Miyoshi
Summary: Cell nuclei exhibit viscoelastic properties, with the mesoscale viscoelasticity within the nuclei of stem cells changing during differentiation. This change in viscoelasticity affects force transmission efficiency, gene expression pattern, and mechanosensitivity in the nucleus, with chromatin condensation playing a critical role in modulating these properties during stem cell differentiation.
Article
Multidisciplinary Sciences
Sajjad Shirazi, Chun-Chieh Huang, Miya Kang, Yu Lu, Sriram Ravindran, Lyndon F. Cooper
Summary: The study found that modulation of miRNA biosynthesis and regulation can influence osteoblastic differentiation of human mesenchymal stem cells (hMSCs).
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jayavardini Vasanthan, Narasimman Gurusamy, Sheeja Rajasingh, Vinoth Sigamani, Shivaani Kirankumar, Edwin L. Thomas, Johnson Rajasingh
Summary: Mesenchymal stem cells (MSCs) are multipotent cells with the potential for tissue regeneration, can be easily isolated and cultured in vitro, and have been proven to be valuable for therapy. Quality control parameters, mechanisms of action, and applications in regenerative medicine and tissue engineering are important aspects to consider when utilizing MSCs.
Article
Biochemistry & Molecular Biology
Marta Cadenas-Martin, Francisco Arnalich-Montiel, Maria P. De Miguel
Summary: This study developed a protocol for deriving human limbal stem cells (LSCs) from adipose-derived mesenchymal stem cells (ADSCs) that is compatible with the standard carrier human amniotic membrane. The best protocol achieved optimal differentiation efficiency and will benefit patients with LSC deficiency, aiding in the restoration of vision.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Stefanska, Lucie Nemcova, Malgorzata Blatkiewicz, Wojciech Pienkowski, Marcin Rucinski, Maciej Zabel, Paul Mozdziak, Marzenna Podhorska-Okolow, Piotr Dziegiel, Bartosz Kempisty
Summary: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) possess multilineage differentiation potential and specific surface markers. In this study, RNA sequencing analysis revealed differentially expressed genes associated with apoptosis and identified upregulation of ZBTB16 and FOXO1, as well as downregulation of TGFA, in all differentiated groups. Additionally, several novel marker genes related to WJ-MSCs differentiation were identified. This study sheds light on the molecular mechanisms involved in long-term culture and differentiation of WJ-MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jeniffer Farias Dos Santos, Bruna Leticia Freitas-Marchi, Gustavo Roncoli Reigado, Silvia Romano de Assis, Silvya Stuchi Maria Engler, Felipe Santiago Chambergo Alcalde, Viviane Abreu Nunes
Summary: In skin traumas, tissue engineering using mesenchymal stem cells (MSC) from the umbilical cord shows promise for skin regeneration. MSCs can differentiate into keratinocytes and express important epidermal markers, indicating their potential use in producing skin substitutes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Environmental Sciences
Shuo Yang, Biao Zhu, Xiao Yu Tian, Han Ying Yu, Bo Qiao, Li Sheng Zhao, Bin Zhang
Summary: This study found that hUCMSC-exo could significantly promote cell proliferation and osteogenic differentiation in hPDLSCs under HG conditions, in a dose-dependent manner. Further experiments revealed that hUCMSC-exo increased the levels of p-PI3K and p-AKT through the PI3K/AKT signaling pathway, and this effect was inhibited by LY294002 (PI3K inhibitor) or MK2206 (AKT inhibitor). Moreover, LY294002 and MK2206 significantly suppressed the increase in osteogenic indicators induced by hUCMSC-exo.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Physiology
Yubo Liu, Xiao Yu, Anquan Huang, Xiangxin Zhang, Yijun Wang, Wei Geng, Renjie Xu, Suoyuan Li, Hui He, Bo Zheng, Guangxiang Chen, Yaozeng Xu
Summary: The interaction between INTS7 and ABCD3/HDLBP plays a crucial role in the proliferation and differentiation of BM-MSCs, with inhibition of this interaction impairing cell proliferation and inducing apoptosis. Additionally, inhibition of INTS7 and ABCD3 can lead to decreased osteoblastic differentiation and accelerated adipogenic differentiation of BM-MSCs, potentially through suppression of oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nidaa A. Ababneh, Ban Al-Kurdi, Fatima Jamali, Abdalla Awidi
Summary: This study compared the differentiation abilities of MSCs isolated from different human tissue sources, and found that WJ-MSCs had a higher potential to differentiate into NSC and dopaminergic-like cells. This could provide an additional or alternative source of cells for neurological cell-based therapies.
Article
Cell Biology
Giedre Valiuliene, Aiste Zentelyte, Elizabet Berzanskyte, Ruta Navakauskiene
Summary: hAFSCs derived from pathological gestations with polyhydramnios exhibit differences in metabolic and inflammatory status compared to hAFSCs from normal gestations, as well as possessing lower neurogenic potential. Further studies are necessary to explore the potential of hAFSCs from polyhydramnios in stem cell-based therapies and strategies to enhance their characteristics for regenerative medicine purposes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pathology
Jun Zhang, Tao Zhang, Bensen Tang, Jing Li, Zhengang Zha
Summary: miR-187 may have a significant therapeutic effect in osteoporotic fractures by promoting bone healing and reconstruction through regulating BARX2.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Stefanska, Lucie Nemcova, Malgorzata Blatkiewicz, Agnieszka Zok, Mariusz Kaczmarek, Wojciech Pienkowski, Paul Mozdziak, Hanna Piotrowska-Kempisty, Bartosz Kempisty
Summary: Wharton's jelly (WJ) from umbilical cords contains mesenchymal stem cells (MSCs) with immunomodulatory properties and differentiation capacity, which makes them a promising tool for cellular therapies. In this study, WJ-MSCs were cultured for differentiation into osteogenic, chondrogenic, adipogenic, and neurogenic lineages, and differentially expressed genes were identified using RNA analysis. The study provides insights into the transcriptomic changes and identification of novel markers in the differentiation process of WJ-MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Review
Biochemistry & Molecular Biology
Ana G. Rodriguez-Hernandez, Rafael Vazquez-Duhalt, Alejandro Huerta-Saquero
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Nutrition & Dietetics
Ana Laura de la Garza, Miguel A. Garza-Cuellar, Ivan A. Silva-Hernandez, Robbi E. Cardenas-Perez, Luis A. Reyes-Castro, Elena Zambrano, Brenda Gonzalez-Hernandez, Lourdes Garza-Ocanas, Lizeth Fuentes-Mera, Alberto Camacho
Article
Nanoscience & Nanotechnology
Alfredo Nunez-Rivera, Pierrick G. J. Fournier, Danna L. Arellano, Ana G. Rodriguez-Hernandez, Rafael Vazquez-Duhalti, Ruben D. Cadena-Nava
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2020)
Article
Environmental Sciences
A. G. Rodriguez-Hernandez, Angelica Chiodoni, Sergio Bocchini, Rafael Vazquez-Duhalt
ENVIRONMENTAL POLLUTION
(2020)
Article
Biochemistry & Molecular Biology
Ibna Suli Trejo Rodriguez, Luz Eugenia Alcantara Quintana, Paola Algara Suarez, Miguel Angel Ruiz Cabrera, Alicia Grajales Lagunes
Summary: The study evaluated physicochemical properties, prebiotic activity, and anticancer potential of jackfruit seed flour, finding that drying at 60 degrees Celsius is optimal for obtaining good flour. The flour showed good nutritional value, antioxidant activity, prebiotic potential, and functional properties.
Article
Parasitology
Diana G. Rios-Valencia, Yazmin Mompala-Garcia, Adrian Marquez-Navarro, Rocio Tirado-Mendoza, Javier Ambrosio
Summary: This study investigates the localization and expression of annexin in cysticerci of Taenia crassiceps. The results show that annexin is mainly localized in the tegument and the protonephridia ducts. This research is significant for the development of new compounds against this protein.
ACTA PARASITOLOGICA
(2022)
Article
Materials Science, Multidisciplinary
S. Lopez Ortiz, V Rodriguez Lugo, D. Salado-Leza, M. Reyes-Valderrama, L. E. Alcantara-Quintana, P. Gonzalez-Martinez, D. Mendoza Anaya
Summary: Nanostructured hydroxyapatite (nano-Hap) was synthesized via a hydrothermal process with different amounts of dysprosium oxide (Dy2O3). The study found that nano-Hap with 2.0 wt% Dy2O3 exhibited the highest thermoluminescence response, and assessed its toxicity on human prostatic epithelial cells. The results suggest nano-Hap as a promising candidate for ionizing radiation sensing and potential development of a drug-free nanotherapeutic platform.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Microscopy
Alejandra Loyola-Leyva, Luz E. Alcantara-Quintana, Yolanda Teran-Figueroa, Francisco Javier Gonzaleza
Summary: This study evaluated the effect of different glucose concentrations and time series on erythrocyte cell viability and morphology parameters. The results showed that higher glucose concentrations led to decreased cell viability and increased cell diameter and height. Continuous exposure to high glucose concentrations resulted in changes in erythrocyte morphology.
Article
Engineering, Chemical
Cynthia Guerrero-Bermea, Nayeli Rodriguez Fuentes, Jose Manuel Cervantes-Uc, Luz Eugenia Alcantara Quintana, Fernando Diaz-Barriga, Francisco Perez-Vazquez, Karen Gonzalez-Palomo, Jorge Alonso Uribe-Calderon
Summary: In this study, an antiviral material was developed by preparing polypropylene/(1-Hexadecyl) trimethyl-ammonium bromide composites. It was found that increasing the CTAB content in the polymer matrix can reduce the virus retention on the surface.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Toxicology
Maritza Roxana Garcia Garcia, Noelia Casares, Luz Andrea Martinez Perez, Efren Juarez Curiel, Andres Alberto de Jesus Hernandez, Nina Bogdanchikova, Diana Garibo, Ana G. Rodriguez-Hernandez, Alexey Pestryakov, Sandra Castro Gamboa, Luis Felipe Arias Ruiz, Olivia Torres Bugarin, Pedro Berraondo
Summary: This study evaluated the ability of silver nanoparticles (AgNP) to induce immunogenic cell death (ICD) and their anti-cancer effects in vitro and in vivo. The results showed that AgNP had anti-proliferative effects on CT26 and MCA205 cell lines and could release calreticulin. However, immunization with AgNP-treated tumor cell debris failed to induce a protective immune response in vivo. Further research is needed to explore the combination of AgNP with other ICD inducers to enhance their anti-tumor effect in vivo.
JOURNAL OF IMMUNOTOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Evgenii V. Plotnikov, Maria S. Tretayakova, Diana Garibo-Ruiz, Ana G. Rodriguez-Hernandez, Alexey N. Pestryakov, Yanis Toledano-Magana, Nina Bogdanchikova
Summary: This study synthesized silver nanoparticles by irradiation treatment of silver nitrate solution with various stabilizers in a liquid medium and investigated their cytotoxic properties against cancer cells. The results showed that the silver nanoparticles had a dose-dependent cytotoxic effect on tumor cells, and the particles obtained with the combination of polyvinylpyrrolidone and collagen hydrolysate exhibited stronger cytotoxicity compared to samples stabilized with only collagen or only polyvinylpyrrolidone. The AgNPs formulation prepared with a mixture of PVP and PH showed significantly higher activity than other reported formulations.
Article
Agriculture, Multidisciplinary
Paola Alvarez Garcia, Luz Eugenia Alcantara Quintana, Miguel Angel Ruiz Cabrera, Fidel Martinez Gutierrez, Raul Gonzalez Garcia, Alicia Grajales Lagunes
Summary: The anticancer potential and prebiotic effect of fructan mixtures from Agave salmiana and chicory inulin were evaluated in different ratios and concentrations. The mixtures showed a synergic effect on healthy colon cells and induced apoptosis in cancerous cells without toxic effects on healthy cells. The growth of Lactobacillus acidophilus and Bifidobacterium longum subsp. infantis was better when the fructans from Agave salmiana were in a higher proportion than chicory inulin. Fructan mixtures also increased the production of lactic acid and short-chain fatty acids by the bacteria.
COGENT FOOD & AGRICULTURE
(2023)
Review
Nanoscience & Nanotechnology
Mariana Sarai Silva-Lopez, Luz E. Alcantara-Quintana
Summary: Conditions, accidents, and aging processes have resulted in the need for advanced implants that can not only replace missing tissue but also regenerate and restore its function. The development of implants has been made possible by advancements in molecular-biochemistry, materials engineering, and tissue regeneration.
ACS APPLIED BIO MATERIALS
(2023)
Article
Horticulture
Cristian Perez-Caselles, Nuria Alburquerque, Lydia Faize, Nina Bogdanchikova, Juan Carlos Garcia-Ramos, Ana G. Rodriguez-Hernandez, Alexey Pestryakov, Lorenzo Burgos
Summary: This study aimed to develop an effective protocol for apricot micropropagation and investigate the conditions for introducing silver nanoparticles (AgNPs) into apricot plants, as well as their effects on proliferation-related parameters. The results showed that the best micropropagation rate was achieved under specific culture conditions (40 initial shoots, 2 minutes of immersion every 6 hours, and 3 minutes of aeration every 3 hours). Furthermore, it was found that AgNPs can only be introduced into apricot plants when cultured in liquid media without chloride ions.
Review
Oncology
Ma de Lourdes Zuniga Martinez, Carlos Miguel Lopez Mendoza, Jared Tenorio Salazar, Alejandro Manuel Garcia Carranca, Marco Antonio Cerbon Cervantes, Luz Eugenia Alcantara-Quintana
Summary: Cell lines play a significant role in cancer research, and this review paper focuses on the establishment, authenticity, and characterization of cervical cancer cell lines. However, there are diverse criteria for their characterization.
MOLECULAR & CELLULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
