Review
Virology
Yafei Qu, Weili Wang, Maggie Z. X. Xiao, Yuejuan Zheng, Qiming Liang
Summary: As intracellular parasites, viruses exploit cellular machinery and manipulate cellular metabolism pathways to replicate themselves. They also exploit cellular lipid metabolism by targeting the biogenesis, hydrolysis, and lipophagy of lipid droplets (LDs) during viral infection. This review summarizes the current understanding of how different viruses modulate cellular LDs, with a focus on Hepatitis C virus, Dengue virus, and SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yannick Treguier, Anne Bull-Maurer, Philippe Roingeard
Summary: Apolipoprotein E (ApoE) plays a crucial role in the lifecycles of hepatitis B virus (HBV) and hepatitis C virus (HCV), particularly in the morphogenesis and entry processes of infectious particles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Neerajana Datta, Shrabastee Chakraborty, Malini Basu, Mrinal K. Ghosh
Summary: Cancer progression involves multiple genetic and epigenetic events, where some tumor suppressor genes may act as double agents promoting tumor development. This review discusses how four important tumor suppressors-pRb, PTEN, FOXO, and PML-display their oncogenic potentials and pro-survival traits in cancer.
Article
Biochemistry & Molecular Biology
Ebony A. Monson, Donna R. Whelan, Karla J. Helbig
Summary: Lipid droplets are now recognized as critical organelles that play dynamic roles in cellular responses to stress and infections, with their movement influencing the outcome of viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Hafiza Rida Farooq Chudhary, Amjad Ali, Sadia Bibi, Muhammad Waqas, Shazia Rafique, Muhammad Idrees, Sobia Ahsan Halim, Magda H. Abdellattif, Ajmal Khan, Ahmed Al-Harrasi
Summary: HCV is a global public health problem with a high number of infections worldwide. It is a leading cause of liver cancer due to the frequent occurrence of HCV infection, especially in those with HCV cirrhosis. This study analyzed the transcriptional analysis of the TP53 gene in HCV-infected patients treated with different antiviral therapies. The results showed that TP53 expression was significantly upregulated in patients with virological responses and HCC, and sofosbuvir + daclatasvir treatment had a significant impact on TP53 expression.
Article
Biochemistry & Molecular Biology
Mosleh Abomughaid, Enoch S. E. Tay, Russell Pickford, Chandra Malladi, Scott A. Read, Jens R. Coorssen, Brian S. Gloss, Jacob George, Mark W. Douglas
Summary: HCV infection increases neutral lipid and phospholipids in cells and induces the expression of PEMT, a key enzyme promoting lipid accumulation and virus replication. The induction of PEMT may explain the genotype-specific differences in hepatic steatosis caused by the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Hussein A. AbdEl-maksoud, Mohamed G. Elharrif, Omnia Abd El-hamid, Saad M. Alsaab, Eman M. El-sorady
Summary: The study monitored iron, lipid, and liver profiles in hepatitis C patients before and during treatment with sofosbuvir antiviral drug. Results showed significant improvement in serum iron, cholesterol, and other parameters, while serum ferritin, transferrin, and other indicators increased significantly after treatment with sofosbuvir, indicating amelioration of disruption caused by hepatitis C virus infection.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Gastroenterology & Hepatology
Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla
Summary: The World Health Organization's goal of eliminating Hepatitis C virus (HCV) by 2030 using direct-acting antiviral treatments has become less attainable post the 2020 pandemic of coronavirus disease 2019. Therefore, a more realistic approach of micro-elimination in population segments where targeted strategies of prevention and treatment are easily attained has been promoted in Europe. Active involvement of stakeholders and community participation are essential components for the success of a micro-elimination project tailored at the geographical level according to HCV epidemiology and individual country's income.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biology
Michela Sgarzi, Martina Mazzeschi, Spartaco Santi, Elisa Montacci, Tito Panciera, Enea Ferlizza, Cinzia Girone, Alessandra Morselli, Valerio Gelfo, Rikke Sofie Kuhre, Carola Cavallo, Sabrina Valente, Gianandrea Pasquinelli, Balazs Gyorffy, Gabriele D'Uva, Donatella Romaniello, Mattia Lauriola
Summary: This study reveals that overactivation of MET disrupts the perinuclear actin cap by inhibiting YAP1, leading to changes in nuclear shape and cell motility.
COMMUNICATIONS BIOLOGY
(2023)
Review
Oncology
Sophiya Siddiqui, Rainer Glauben
Summary: This review article discusses the influence of metabolic changes in the tumor microenvironment on immune cells, with a focus on the role of fatty acids stored in lipid droplets. Understanding the importance of lipid droplets in modulating immune cell function and phenotype is crucial for identifying new therapeutic targets and addressing immunosuppression in cancer.
Article
Microbiology
Laura Riva, Corentin Spriet, Nicolas Barois, Costin-Ioan Popescu, Jean Dubuisson, Yves Rouille
Summary: This study investigates the dynamics and intracellular localization of the NS5A protein of hepatitis C virus, shedding light on its role in viral assembly rather than RNA replication. The findings contribute to a better understanding of the interplay between HCV proteins during the viral life cycle.
Article
Microbiology
Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian-Wei Wang
Summary: White spot syndrome virus (WSSV) utilizes host autophagy and lipid metabolism for reproduction, causing a serious impact on global shrimp farming. This study reveals the mechanism by which WSSV exploits host machinery for infection and provides targets for WSSV prevention and control.
Article
Microbiology
Christelle Granier, Johan Toesca, Chloe Mialon, Maureen Ritter, Natalia Freitas, Bertrand Boson, Eve-Isabelle Pecheur, Francois-Loic Cosset, Solene Denolly
Summary: Hepatitis C virus (HCV) particles are stable when secreted from cells, but become highly unstable after freeze-thawing of producer cells. Cell-secreted proteins can protect HCV particles from degradation, specifically those that are lipidated and low-density. HCV particles are sensitive to oxidation, but can be protected from lipid oxidation by secreted factors.
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Koudai Kawano, Aurelien J. Doucet, Mikinori Ueno, Ryusho Kariya, Wenfeng An, Flavia Marzetta, Misao Kuroki, Priscilla Turelli, Sayaka Sukegawa, Seiji Okada, Klaus Strebel, Didier Trono, Yasuo Ariumi
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Shinya Satoh, Daichi Onomura, Youki Ueda, Hiromichi Dansako, Masao Honda, Shuichi Kaneko, Nobuyuki Kato
BIOCHEMICAL JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Mikinori Ueno, Masato Nogawa, Rokeya Siddiqui, Koichi Watashi, Takaji Wakita, Nobuyuki Kato, Masanori Ikeda, Takasi Okimura, Shogo Isaka, Tatsuya Oda, Yasuo Ariumi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Youki Ueda, Weilin Gu, Hiromichi Dansako, Hironori Nishitsuji, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Virology
Nobuyuki Kato, Youki Ueda, Hiroe Sejima, Weilin Gu, Shinya Satoh, Hiromichi Dansako, Masanori Ikeda, Kunitada Shimotohno
ARCHIVES OF VIROLOGY
(2020)
Article
Genetics & Heredity
Naoki Yamamoto, Yasuo Ariumi, Nao Nishida, Rain Yamamoto, Georg Bauer, Takashi Gojobori, Kunitada Shimotohno, Masashi Mizokami
Review
Biochemistry & Molecular Biology
Naoki Yamamoto, Rain Yamamoto, Yasuo Ariumi, Masashi Mizokami, Kunitada Shimotohno, Hiroshi Yoshikura
Summary: Individuals with comorbidities are more susceptible to severe cases of COVID-19 after infection with SARS-CoV-2, possibly due to genetic polymorphisms such as those of the angiotensin-converting enzyme 1 (ACE1) gene, which may increase their risk. However, there is still debate surrounding the association between ACE1 D/I polymorphism and comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hiromichi Dansako, Youki Ueda, Shinya Satoh, Nobuyuki Kato
Summary: This study showed that HBV infection activated the ATM-Chk2 signaling pathway in certain human hepatocyte cells, and proposed a novel model that EVs mediate this activation by transferring mtDNA intercellularly.
Article
Virology
Yasuo Ariumi
Summary: SARS-CoV-2 infection is regulated by host cellular RNA helicases, with DDX21 and MOV10 limiting viral infection and replication, and DDX1, DDX5, and DDX6 being required for SARS-CoV-2 infection. The virus disrupts P-body formation and attenuates or suppresses stress granule formation. SARS-CoV-2 hijacks host cellular RNA helicases to facilitate viral infection and replication while suppressing the host innate immune system.
JOURNAL OF VIROLOGY
(2022)
Review
Genetics & Heredity
Naoki Yamamoto, Nao Nishida, Rain Yamamoto, Takashi Gojobori, Kunitada Shimotohno, Masashi Mizokami, Yasuo Ariumi
Summary: The renin-angiotensin-aldosterone system plays a significant role in SARS-CoV-2 infection, with ACE1 gene polymorphisms potentially linked to the severity of COVID-19 symptoms. Variations in ACE1 insertion/deletion polymorphism may explain mortality differences between regions, while research on the ACE1 genotype could offer new insights into the pathogenesis, treatment, and diagnosis of SARS-CoV-2 infections.
Article
Genetics & Heredity
Yasuo Ariumi
Summary: Hepatitis B virus (HBV) restricts the retrotransposition of long interspersed element-1 (LINE-1, L1) in a reverse transcriptase (RT)-independent manner, with HBV polymerase (Pol) playing a key role in inhibiting L1 retrotransposition.
Article
Biochemistry & Molecular Biology
Weilin Gu, Youki Ueda, Hiromichi Dansako, Shinya Satoh, Nobuyuki Kato
Summary: This study focused on the anti-HCV activity of N-89 (N-251) and found that the acquisition of N-89 (N-251) resistance in HCV-RNA replication involved both host factors (RAC2 and CKMT1B genes) and viral factors (M414I mutation in HCV NS5B), which acted additively to increase resistance.
Article
Biochemistry & Molecular Biology
Daichi Onomura, Shinya Satoh, Youki Ueda, Hiromichi Dansako, Nobuyuki Kato
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Hiromichi Dansako, Hirotaka Imai, Youki Ueda, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
Article
Biochemistry & Molecular Biology
Youki Ueda, Weilin Gu, Hiromichi Dansako, Hye-Sook Kim, Sayaka Yoshizaki, Nobuaki Okumura, Tomohiro Ishikawa, Hironori Nishitsuji, Fumihiro Kato, Takayuki Hishiki, Shinya Satoh, Koji Ishii, Michiaki Masuda, Kunitada Shimotohno, Masanori Ikeda, Nobuyuki Kato
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)