Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 431, Issue 4, Pages 680-685Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.01.060
Keywords
Liposomes; Flavonoids; Quercetin; Taxifolin; Lipid phase transitions; Iron chelators
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Funding
- Ministry of Education and Science of the Russian Federation [14.B37.21.1515]
- ONEXIM group
- Skolkovo Foundation
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We studied complex formation of flavonoids quercetin and taxifolin with iron(II) and the complex influence on phase transitions of phospholipid bilayer. UV-Vis spectroscopy revealed that the stoichiometry of flavonoid/iron complexes was equal to 3:2 and 2:1. Molecular modeling and experimental measurements demonstrated the increase of flavonoids lipophilicity after the complex formation. A considerable influence of quercetin-iron complex on Palmitoyl-Oleoyl-Phosphatidylethanolamine transitions from bilayer to hexagonal H-II phase was detected by differential scanning calorimetry. The obtained data are related to flavonoid/iron complexes bioavailability, their influence on cell membrane functioning, and should be considered in designing liposomal vehicles for drug and gene delivery. (C) 2013 Elsevier Inc. All rights reserved.
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