Article
Cell Biology
Madeleine Eichler, Ute Distler, Usman Nasrullah, Aswini Krishnan, Manuel Kaulich, Koraljka Husnjak, Wolfgang Eberhardt, Krishnaraj Rajalingam, Stefan Tenzer, Josef Pfeilschifter, Gergely Imre
Summary: This study uncovers a previously unknown mechanism of caspase-2 tumor suppressor function in human tumor cells, in which selective cleavage of p54nrb disrupts its role in RNA editing, transport, and transcriptional regulation, leading to reduced tumorigenic potential.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Rashid Houshdarpour, Farangis Ataei, Saman Hosseinkhani
Summary: This study focused on identifying proteins that reduce the effectiveness of cancer treatment, with survivin showing promise in regulating cell death and survival. Overexpression of survivin in HEK cells led to increased resistance to apoptotic stimuli and decreased caspase activity. Furthermore, survivin decreased ROS levels, increased ATP content, and reduced apoptosis rates, suggesting its potential for cancer treatment applications.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhaoshi Bai, Yiran Zhou, Xinyue Ye, Yupeng Li, Yaling Peng, Qi Guan, Weige Zhang, Lingman Ma
Summary: Research has shown that BZML can induce p53-dependent senescence in MDR cells, demonstrating an anticancer effect. This senescence is a secondary effect of MC in overcoming MDR. During MC, BZML-induced disruption of the protein-degradation system leads to an increase in p53 protein and the accumulation of survivin in the nucleus of cells. The nuclear accumulation of survivin is a result, not an inducer of BZML-induced MC, promoting the survival of senescent cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Oncology
Christian Vay, Philipp M. Schlunder, Levent Dizdar, Irene Esposito, Markus P. H. Ghadimi, Wolfram T. Knoefel, Andreas Krieg
Summary: The study demonstrated abundant expression of survivin in LPS, particularly in less-differentiated tumor subtypes. In vitro experiments showed that YM155, a survivin inhibitor, significantly reduced cell viability and induced apoptosis in dedifferentiated LPS (DDLPS) and pleomorphic LPS (PLS) cells. Additionally, combined treatment with doxorubicin or etoposide and YM155 enhanced cytotoxic effects on DDLPS and PLS cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Veterinary Sciences
Ryo Miyamoto, Hiroyuki Tani, Tomoyo Ikeda, Hono Saima, Kyoichi Tamura, Makoto Bonkobara
Summary: The study found that the survivin inhibitor YM155 can inhibit the growth of canine squamous cell carcinoma cells by activating autophagy, leading to cell death.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Qing-Min Li, Gui-Shan Lin, Wen-Gui Duan, Yu-Cheng Cui, Fang-Yao Li, Fu-Hou Lei, Dian-Peng Li
Summary: Eighteen novel longifolene-derived tetralin pyrimidine compounds were designed and synthesized using survivin as the target. These compounds exhibited promising antiproliferative activities and low cytotoxicity towards normal liver cells. The study also established a 3D-QSAR model and conducted molecular docking to investigate the structure-activity relationship and interaction mode between compounds and survivin protein.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Pengxiang Lin, Liangliang Zhang, Dongxia Chen, Jiayao Xu, Yulong Bai, Shulin Zhao
Summary: A multifunctional biomass nanoprobe was developed for photodynamic therapy of tumors, cancer cell identification, and antitumor drug screening based on the ratiometric fluorescence imaging of intracellular survivin mRNA.
Article
Oncology
Yuki Yoshino, Hiroaki Goto, Mieko Ito, Yoshinori Tsurusaki, Junko Takita, Yasuhide Hayashi, Masakatsu Yanagimachi
Summary: In this study, effective therapeutic agents against SMARCB1/INI1-deficient tumors were explored using an in vitro drug screening system. It was found that YM155 and chrysin synergistically suppressed survivin expression and enhanced cytotoxicity.
Article
Biochemistry & Molecular Biology
Wen-Hsuan Chang, Yinzhe Liu, Emma A. Hammes, Kirsten L. Bryant, Richard A. Cerione, Marc A. Antonyak
Summary: In this study, it was discovered that the inhibitor of apoptosis protein Survivin mediates the cooperative actions of KRAS and MYC in pancreatic cancer. Survivin expression is regulated by KRAS through the extracellular signal-regulated kinase 1/2 pathway, which protects MYC from degradation and enhances its transcriptional activity. Targeting Survivin can effectively downregulate MYC expression and inhibit the growth of pancreatic cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Jing-Ting Chiou, Yuan-Chin Lee, Chia-Hui Huang, Liang-Jun Wang, Yi-Jun Shi, Long-Sen Chang
Summary: The study revealed that YM155 induces apoptosis in human AML cells through the p38 MAPK-modulated autophagy pathway, inhibiting Sp1-mediated survivin and MCL1 expression and leading to cell death. Additionally, SLC35F2 increases the sensitivity of U937 cells to YM155, while MPO enhances YM155 cytotoxicity in U937 and HL-60 cells.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Sen Hong, Shiquan Li, Miaomiao Bi, Haiyao Yu, Zhenkun Yan, Tao Liu, Helei Wang
Summary: In colorectal cancer, the lncRNA ILF3-AS1 and EZH2 levels are increased, while CDKN2A is reduced. The expression of ILF3-AS1 and EZH2 is associated with Dukes stage, distant metastasis, vascular invasion, and lymph node metastasis in CRC patients. Depletion of ILF3-AS1 or reduction of EZH2 inhibits proliferation, migration, colony formation, and invasion of CRC cells, promotes apoptosis, and attenuates tumor growth in CRC mice.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Peilong Li, Qi Mi, Suzhen Yan, Yan Xie, Zilian Cui, Shujun Zhang, Yifan Wang, Huiru Gao, Yunshan Wang, Juan Li, Lutao Du, Chuanxin Wang
Summary: The study reveals the regulatory role of circSLC38A1 in bladder cancer metastasis, demonstrating its interaction with ILF3 to stabilize ILF3 protein and activate the transcription of TGF-beta 2. This finding provides insights into the importance of circRNA-mediated transcriptional regulation in bladder cancer metastasis.
CELL DEATH & DISEASE
(2023)
Article
Hematology
Swati Naik, Spyridoula Vasileiou, Ifigeneia Tzannou, Manik Kuvalekar, Ayumi Watanabe, Catherine Robertson, Natalia Lapteva, Wang Tao, Mengfen Wu, Bambi Grilley, George Carrum, Rammurti T. Kamble, LaQuisa Hill, Robert A. Krance, Caridad Martinez, Priti Tewari, Bilal Omer, Stephen Gottschalk, Helen E. Heslop, Malcom K. Brenner, Cliona M. Rooney, Juan F. Vera, Ann M. Leen, Premal D. Lulla
Summary: Infusion of donor-derived multiple leukemia antigen-specific T cells may prevent disease relapse in patients with acute lymphoblastic leukemia (ALL) by targeting leukemia cells and minimizing the risk of graft-versus-host disease.
Article
Multidisciplinary Sciences
Xin Dong, Wenbin Liu, Xiaoying Li, Yu Gan, Li Zhou, Wei Li, Li Xie
Summary: Survivin is frequently overexpressed in human malignancies and is associated with poor prognosis. This study shows that survivin is highly expressed in nasopharyngeal carcinoma (NPC) tumor tissues. Depleting survivin with shRNA inhibits NPC cell viability, colony formation, and in vivo tumorigenesis. Butein, identified through natural product screening, reduces survivin protein level and promotes its ubiquitination-mediated degradation by enhancing the interaction between survivin and E3 ligase Fbxl7. Butein also suppresses Akt-Wee1-CDK1 signaling, decreases survivin Thr34 phosphorylation, and exhibits strong in vivo anti-tumor activity.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Linlong Xu, Wenpeng Yu, Han Xiao, Kang Lin
Summary: BIRC5 is an immune-related gene highly expressed in tumors, affecting patient prognosis by potentially regulating DNA methylation and immune cell infiltration in various tumor types. This study lays the groundwork for investigating how BIRC5 modulates tumor immune cells and could lead to more effective targeted tumor immunotherapies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)