Editorial Material
Endocrinology & Metabolism
Ke Zhu, Jochen Reiser
Summary: Diabetic kidney disease is affected by both genetic and environmental factors. A recent study has identified risk variants in the XOR promoter that increase its own activity in response to high blood sugar levels, which play a causative role in the development and progression of diabetic kidney disease.
Article
Food Science & Technology
Xiaohong Lin, Weiye Xu, Liu Liu, Shiyi Ou, Xichun Peng
Summary: The metabolites of flaxseed polysaccharide fermented by fecal bacteria were found to inhibit glucose intake and lipid accumulation, which might be a weight-loss mechanism of flaxseed polysaccharide through regulating intestinal microbiota.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Masayuki Yamamoto, Yasuna Nagasawa, Ko Fujimori
Summary: Glycyrrhizic acid (GA) inhibits adipogenesis in mouse 3T3-L1 cells by modulating the glycerite pathway and suppressing the expression of adipogenic and lipogenic genes, thus showing potential as an agent for treating obesity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Susu Guo, Yuxin Chen, Yueyue Yang, Xiao Zhang, Lifang Ma, Xiangfei Xue, Yongxia Qiao, Jiayi Wang
Summary: This study demonstrates that TRIB2 reduces Ub levels by stimulating proteasome degradation and interacts with PCBP2 to modulate PSMB5 activity, which is crucial for liver cancer cell viability and tumor growth. The interaction between TRIB2 and PCBP2 also protects liver cancer cells from oxidative damage through the function of glutathione peroxidase 4. Targeting TRIB2 may enhance the effectiveness of therapeutic agents for liver cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Agriculture, Multidisciplinary
Tongyao Du, Chao Ma, Zixu Wang, Yuejing Hao, Wangang Zhang
Summary: This study investigated the distribution and degradation pattern of FLNC in pork during postmortem aging. The results showed that FLNC had a highly overlapped spatial colocalization with actin and integrin. FLNC was mainly localized in subsarcolemmal areas and surrounding the myofibrils at the level of the Z-discs in muscle cells. Furthermore, the study found that mu-calpain and caspase-3 were involved in the degradation of FLNC.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Yongcheng Zhu, Yunyao Liu, Yuxiang Ma, Cheng Tan, Yuan He, Lei Qiang, Liu Chen, He Huang, Siting Huang, Huiling Zhang, Yuying He
Summary: Macroautophagy has a significant role in the development of atopic dermatitis (AD), regulating inflammation and macrophage phenotype transition.
Article
Cell Biology
Han Yan, Qi Li, Mengying Li, Xiuqun Zou, Ningning Bai, Zichao Yu, Jie Zhang, Dan Zhang, Qun Zhang, Jiamin Wang, Hao Jia, Yingjie Wu, Zhaoyuan Hou
Summary: The study shows that depletion of Ajuba in 3T3-L1 cells reduces the expression of PPARγ and C/EBPα, impairing adipocyte differentiation, while overexpression increases their expression and promotes differentiation. Restoring C/EBPα or PPARγ expression in Ajuba-deficient cells improves impaired lipid accumulation. Ajuba interacts with C/EBPβ and recruits CBP to enhance binding to the promoter regions of PPARγ and C/EBPα, leading to increased gene expression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Oncology
Mei Qin, Fei Han, Jian Wu, Feng-Xia Gao, Yuan Li, De-Xin Yan, Xue-Mei He, Yang Long, Xiao-Ping Tang, De-Lian Ren, Yan Gao, Tian-Yang Dai
Summary: This study reveals that KDM6B promotes ESCC progression by enhancing C/EBP beta transcription through its H3K27 demethylase activity. Additionally, the chemical inhibitor GSK-J4 can effectively inhibit ESCC cell proliferation and metastasis.
Article
Biochemistry & Molecular Biology
Ana Sierra-Magro, Fernando Bartolome, David Lozano-Munoz, Jesus Alarcon-Gil, Elena Gine, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Marta Cortes-Canteli, Eva Carro, Ana Perez-Castillo, Jose A. Morales-Garcia
Summary: Parkinson's disease (PD) is a neurodegenerative disorder caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The transcription factor CCAAT/Enhancer Binding Protein beta (C/EBP beta) may be a good therapeutic target for PD treatment due to its altered levels in neurodegenerative diseases. A list of PD-related genes regulated by C/EBP beta was generated, including mitochondrial transcription factor A (TFAM). The absence of C/EBP beta may lead to the accumulation of non-functional mitochondria due to impaired autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yihua Bei, Yujiao Zhu, Meng Wei, Mingming Yin, Lin Li, Chen Chen, Zhenzhen Huang, Xuchun Liang, Juan Gao, Jianhua Yao, Petra H. van der Kraak, Aryan Vink, Zhiyong Lei, Yuxiang Dai, Huihua Chen, Yueyang Liang, Joost P. G. Sluijter, Junjie Xiao
Summary: It is observed that HIPK1 is increased during pathological cardiac hypertrophy. Both genetic ablation and gene therapy targeting HIPK1 are protective against pathological hypertrophy and heart failure in vivo. HIPK1 inhibition prevents cardiomyocyte hypertrophy and transcription of pathological response genes.
Article
Multidisciplinary Sciences
Yuta Takanezawa, Shogo Tanabe, Daiki Kato, Rie Ozeki, Masayo Komoda, Tatsunori Suzuki, Hiroko Baba, Rieko Muramatsu
Summary: Deficiency of Chd8 or Tsc2 in microglia leads to reduced expression of insulin-like growth factor-1 (Igf1) and inhibited phagocytosis activity. Tsc2 deficiency also inhibits microglia-mediated oligodendrocyte development, while Chd8 or Tsc2 deficiency prevents the differentiation of oligodendrocyte precursor cells to oligodendrocytes. This suggests that ASD-related gene expression in microglia plays a role in oligodendrocyte differentiation, potentially contributing to white matter pathology in ASD.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yanjun Chen, Wenying Yan, Yuqi Chen, Jinghan Zhu, Jiayu Wang, Haiyan Jin, Hongya Wu, Guangbo Zhang, Shenghua Zhan, Qinhua Xi, Tongguo Shi, Weichang Chen
Summary: The study reveals that SLC6A14 is involved in regulating ferroptosis in ulcerative colitis by inhibiting PAK6 expression, suggesting it as a potential therapeutic target for UC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hui Ding, Jinjun Chen, Jingping Qin, Ruhua Chen, Zili Yi
Summary: The study confirmed that deacetylation of C/EBP beta in A549 cells successfully ameliorated TGF-beta 1-induced EMT, as shown by reduction in alpha-SMA expression and excessive collagen-I accumulation. This indicates that the EMT and fibrotic effect of TGF-beta 1 depend on acetylated C/EBP beta-mediated regulation of alpha-SMA gene activity.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Qing Yuan, Bo Zhao, Yu-hua Cao, Jia-cheng Yan, Li-jun Sun, Xia Liu, Yang Xu, Xiao-yu Wang, Bing Wang
Summary: This study reveals a novel mechanism of BAP31 in regulating macrophages and provides potential solutions for the prevention and treatment of chronic wounds.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sebastien Soubeyrand, Paulina Lau, Ruth McPherson
Summary: Tribbles related homolog 1 (TRIB1) is involved in the regulation of lipid and glucose metabolism by promoting the degradation of target cargos through the proteasome. In this study, it was found that proteasome inhibitors significantly increased the levels of TRIB1 mRNA and protein in transformed hepatocyte cell lines HuH-7 and HepG2. Further experiments showed that suppressing proteasome function via PSMB3 silencing upregulated TRIB1 mRNA expression. Although proteasome inhibition delayed TRIB1 degradation, it did not completely prevent it, suggesting the presence of an inhibitor resistant proteasome activity responsible for TRIB1 degradation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)