Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling

The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding

(2015) Thorsten Maretzky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation

(2014) Eun-Jung Lee et al.   JOURNAL OF IMMUNOLOGY

Thrombospondin-1 Activation of Signal-Regulatory Protein-  Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury

(2014) M. Yao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The γ-secretase complex: from structure to function

(2014) Xian Zhang et al.   Frontiers in Cellular Neuroscience

Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

(2014) Derong Ding et al.   MedChemComm

The IκB kinase complex in NF-κB regulation and beyond

(2013) Michael Hinz et al.   EMBO REPORTS

Signal Regulatory Protein-α Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling

(2013) Ding-Sheng Jiang et al.   HYPERTENSION

SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells

(2013) Eun-Ju Kim et al.   INFLAMMATION RESEARCH

CD47 fusion protein targets CD172a+cells in Crohn’s disease and dampens the production of IL-1β and TNF

(2013) Nobuyasu Baba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synapse maturation by activity-dependent ectodomain shedding of SIRPα

(2013) Anna B Toth et al.   NATURE NEUROSCIENCE

Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state

(2013) Ke Zen et al.   Nature Communications

Surfactant Protein D (Sp-D) Binds to Membrane-proximal Domain (D3) of Signal Regulatory Protein α (SIRPα), a Site Distant from Binding Domain of CD47, while Also Binding to Analogous Region on Signal Regulatory Protein β (SIRPβ)

(2012) Bénédicte Fournier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRP ) from the cell surface

(2012) A. Stenberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1

(2012) Yuan Pan et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress

(2012) Lang Wang et al.   JOURNAL OF NEUROCHEMISTRY

Soluble extracellular domains of human SIRPα and CD47 expressed in Escherichia coli enhances the phagocytosis of leukemia cells by macrophages in vitro

(2012) Yan Lin et al.   PROTEIN EXPRESSION AND PURIFICATION

Immune inhibitory receptors: Essential regulators of phagocyte function

(2011) Tessa A. M. Steevels et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

(2011) B. B. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Self inhibition of phagocytosis: The affinity of ‘marker of self’ CD47 for SIRPα dictates potency of inhibition but only at low expression levels

(2010) Richard K. Tsai et al.   BLOOD CELLS MOLECULES AND DISEASES

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Targeting SIRP-α protects from type 2-driven allergic airway inflammation

(2010) Marianne Raymond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Identification of Novel SHPS-1-associated Proteins and Their Roles in Regulation of Insulin-like Growth Factor-dependent Responses in Vascular Smooth Muscle Cells

(2009) Xinchun Shen et al.   MOLECULAR & CELLULAR PROTEOMICS

Masking of a Nuclear Signal Motif by Monoubiquitination Leads to Mislocalization and Degradation of the Regulatory Enzyme Cytidylyltransferase

(2009) B. B. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

(2008) William J. Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Signal regulatory protein α negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction

(2008) Li-Wei Dong et al.   MOLECULAR IMMUNOLOGY