Article
Biochemistry & Molecular Biology
Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu
Summary: The development of nonalcoholic fatty liver disease (NAFLD) is associated with the regulation of NRF2 by GCN2, which can attenuate hepatic steatosis and oxidative stress.
Article
Chemistry, Multidisciplinary
Tarfa Albrahim, Asirvatham Alwin Robert
Summary: The frequency of overweight and obesity is increasing globally, and these disorders are closely related to various health issues. This study found that lycopene has positive therapeutic effects on metabolic syndrome and kidney damage, helping to prevent fat and renal damage.
Article
Environmental Sciences
Isaac A. Adedara, Oluwatoyin O. Abioye, Gbemisola T. Oyedele, Cynthia N. Ikeji, Blessing A. Afolabi, Joao B. T. Rocha, Ebenezer O. Farombi
Summary: This study evaluated the toxicological impact of PFOA on Nauphoeta cinerea insects. The results showed that PFOA exposure led to reduced locomotory abilities and increased freezing time in the insects, along with changes in several biochemical markers. This indicates that PFOA poses an ecological risk to Nauphoeta cinerea.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Guangrong Xie, Qipeng Zhang, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, Xuemei Jiang, Jian Li, Mengmeng Sun, Yuanfeng Zou, Chao Huang, Lixia Li, De Wu, Bin Feng
Summary: This study found that excessive intake of oxidized fat during pregnancy and lactation can harm both the mother's body and the health of their offspring. However, supplementation of vitamin D and inulin during pregnancy and lactation can mitigate these damages.
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, Research & Experimental
Camilla dos Santos Tiburcio-Machado, Pauline Mastella Lang, Maria Martha Campos, Carlos Frederico Brilhante Wolle, Raquel Cristine Silva Barcelos, Natalia Brezolin Zago, Carlos Eduardo Leite, Adriana Etges, Carlos Alexandre Souza Bier
Summary: The study revealed that a high-fat diet led to weight loss, increased blood glucose levels, and exacerbated apical periodontitis in rats.
Review
Biochemistry & Molecular Biology
Jose Martinez-Orgado, Maria Martinez-Vega, Laura Silva, Angela Romero, Maria de Hoz-Rivera, Maria Villa, Aaron del Pozo
Summary: Oxidative stress is a critical factor in brain damage, especially in the immature brain. Protein carbonylation, a harmful consequence of oxidative stress, has significant implications for neonatal brain injury. The administration of potent antioxidants, like cannabidiol, can reduce cerebral damage and protect neuronal cells.
Review
Biochemistry & Molecular Biology
Chenxu Zhao, Han Guo, Yangxiao Hou, Tong Lei, Dong Wei, Yong Zhao
Summary: The serine/threonine-protein kinase GCN2 is a stress sensor that responds to amino acid starvation and other stresses, playing a critical role in maintaining cellular and organismal homeostasis. Research spanning over 20 years has revealed the structure, inducers, signaling pathways, and functions of GCN2 in various processes and diseases. GCN2 is closely involved in the immune system, regulating macrophage polarization and CD4(+) T cell differentiation. Understanding GCN2's functions in the immune system will aid in developing therapies for immune-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mariana Silva Thomaz, Marcela Nascimento Sertorio, Marcos Leoni Gazarini, Daniel Araki Ribeiro, Luciana Pellegrini Pisani, Marcia Regina Nagaoka
Summary: Non-alcoholic fatty liver is the leading cause of liver disease worldwide. This study investigated the role of kinins in experimental non-alcoholic steatohepatitis (NASH) and found that kinins affect the antioxidant system and reduce superoxide dismutase activity in NASH.
Review
Oncology
Yangjing Zhao, Hui Wang, Jingdong Zhou, Qixiang Shao
Summary: This review summarizes and discusses the relationship between GPX1 genetic polymorphisms and cancer susceptibility, as well as the dichotomous roles of GPX1 aberrant expressions in tumorigenesis. It highlights the importance of GPX1 as a potential prognostic biomarker and novel therapeutic target in various malignancies.
Article
Biochemistry & Molecular Biology
Sarah L. Weber, Karin Hustedt, Nadine Schnepel, Christian Visscher, Alexandra S. Muscher-Banse
Summary: This study investigated the effects of protein and/or phosphorus restriction on the GCN2/eIF2 alpha/ATF4 pathway and the induction of FGF21 in the liver of goats. The results demonstrated that dietary N restriction increased the expression of FGF21, while P restriction prevented the initiation of the AAR pathway and the increase in FGF21 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Francisco Moreno, Lucia Mendez, Ana Raner, Bernat Miralles-Perez, Marta Romeu, Sara Ramos-Romero, Josep Lluis Torres, Isabel Medina
Summary: A high intake of saturated fats and refined carbohydrates is associated with cognitive impairment and the aggravation of neurodegenerative diseases. This study found that this diet can lead to oxidative damage to brain proteins, but fish oil supplementation can counteract this damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Rong Xu, Tong Wang, Fei-Fei Ding, Nan-Nan Zhou, Fang Qiao, Li-Qiao Chen, Zhen-Yu Du, Mei-Ling Zhang
Summary: In this study, it was found that Lactobacillus plantarum MR1, a probiotic strain, can modulate gut microbiota, increase intestinal acetate content, and subsequently increase circulating uridine levels, thereby ameliorating high-carbohydrate diet-induced hepatic lipid accumulation and oxidative stress. This suggests that gut microbiota can regulate nucleotide metabolism to maintain host physiological homeostasis.
Article
Plant Sciences
Xiaona Cui, Kaili Gao, Linjuan Wang, Mengyang Lv, Ziwen Li, Donghua Zheng, Wenwu Wu, Wen Yao, Liying Ding, Xiao Li, Jian-Kang Zhu, Hairong Zhang
Summary: AtGCN1 plays a crucial role in gene expression and translation in Arabidopsis, affecting flower development, seed growth, and various physiological processes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biology
W. Wesley Dowd, George N. Somero
Summary: The physiological mechanisms that limit thermal tolerance are important in comparative biology and global change. This study compared three congeners of mussels and found that oxidative stress is not a major mediator of their thermal sensitivity. The more heat-tolerant species suffered comparable or even elevated levels of oxidative damage.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biochemical Research Methods
Yuki Muranishi, Laurent Parry, Julien Averous, Anne Terrisse, Anne-Catherine Maurin, Cedric Chaveroux, Florent Mesclon, Valerie Carraro, Alain Bruhat, Pierre Fafournoux, Celine Jousse
Article
Cell Biology
Rafik Boudra, Rosyne Lagrafeuille, Corinne Lours-Calet, Cyrille de Joussineau, Gaelle Loubeau-Legros, Cedric Chaveroux, Jean-Paul Saru, Silvere Baron, Laurent Morel, Claude Beaudoin
Article
Ophthalmology
Cecile Prat, Corinne Belville, Aurelie Comptour, Geoffroy Marceau, Gael Clairefond, Frederic Chiambaretta, Vincent Sapin, Loic Blanchon
EXPERIMENTAL EYE RESEARCH
(2017)
Editorial Material
Medicine, Research & Experimental
Alain Bruhat, Cedric Chaveroux, Valerie Carraro, Celine Jousse, Julien Averous, Anne-Catherine Maurin, Laurent Parry, Florent Mesclon, Yuki Muranishi, Patrick Baril, Anh Do Thi, Philippe Ravassard, Jacques Mallet, Pierre Fafournoux
M S-MEDECINE SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
M. Batisse-Lignier, I. Sahut-Barnola, F. Tissier, T. Dumontet, M. Mathieu, C. Drelon, J-C Pointud, C. Damon-Soubeyrand, G. Marceau, J-L Kemeny, J. Bertherat, I. Tauveron, P. Val, A. Martinez, A-M Lefrancois-Martinez
Article
Genetics & Heredity
Amelie Delabaere, Geoffroy Marceau, Karen Coste, Loic Blanchon, Pierre-Jean Dechelotte, Pierre Blanc, Vincent Sapin, Denis Gallot
PRENATAL DIAGNOSIS
(2017)
Article
Genetics & Heredity
Amelie Delabaere, Loic Blanchon, Karen Coste, Gael Clairefond, Corinne Belville, Pierre Blanc, Geoffroy Marceau, Vincent Sapin, Denis Gallot
PRENATAL DIAGNOSIS
(2018)
Article
Biochemistry & Molecular Biology
Nada Zabaiou, Allan Fouache, Amalia Trousson, Julio Bunay-Noboa, Geoffroy Marceau, Vincent Sapin, Amar Zellagui, Silvere Baron, Mesbah Lahouel, Jean-Marc A. Lobaccaro
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Article
Anesthesiology
Alexandrine Corriger, Martine Duclos, Jean-Benoit Corcuff, Celine Lambert, Geoffroy Marceau, Vincent Sapin, Nicolas Macian, Delphine Roux, Bruno Pereira, Gisele Pickering
Article
Oncology
Carmen Sarcinelli, Helena Dragic, Marie Piecyk, Virginie Barbet, Cedric Duret, Audrey Barthelaix, Carole Ferraro-Peyret, Joelle Fauvre, Toufic Renno, Cedric Chaveroux, Serge N. Manie
Article
Biochemistry & Molecular Biology
Marie Piecyk, Mouna Triki, Pierre-Alexandre Laval, Helena Dragic, Laura Cussonneau, Joelle Fauvre, Cedric Duret, Nicolas Aznar, Toufic Renno, Serge N. Manie, Cedric Chaveroux, Carole Ferraro-Peyret
Summary: The study found that in non-small cell lung cancer, the impact of pemetrexed (PEM) treatment on protein synthesis is regulated by glucose availability, with PEM inhibiting cell mass and translation when glucose is abundant, but its inhibitory effect is weakened at low glucose levels.
Article
Biology
Helena Dragic, Audrey Barthelaix, Cedric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugiere, Yohann Coute, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Serge N. Manie
Summary: The glucose-requiring hexosamine biosynthetic pathway (HBP) and the coat complex II (COPII) play a crucial role in the survival of lung adenocarcinoma (LUAD) cells in low glucose conditions. Up-regulation of HBP resists the production of abnormal proteins induced by low glucose, while up-regulation of COPII restores the cell surface expression of certain glycoproteins.
LIFE SCIENCE ALLIANCE
(2022)
Review
Oncology
Roumaissa Gouasmi, Carole Ferraro-Peyret, Stephane Nancey, Isabelle Coste, Toufic Renno, Cedric Chaveroux, Nicolas Aznar, Stephane Ansieau
Summary: The kynurenine pathway plays important roles in tumor development by protecting organs from immune reactions and providing essential metabolites to cells. Abnormal activation of this pathway promotes tumor growth, metastasis, and chemoresistance. The complex regulation of this pathway poses challenges for clinical interventions.
Review
Biochemistry & Molecular Biology
Helena Dragic, Cedric Chaveroux, Erika Cosset, Serge N. N. Manie
Summary: Advances in cancer biology have revealed that there are differences in cancer cell metabolism between in vitro and in vivo conditions. Current methodologies and tools can bridge this gap and generate new opportunities for effective therapies.
Article
Immunology
Nicolas Goncalves-Mendes, Jeremie Talvas, Christian Duale, Aline Guttmann, Violaine Corbin, Geoffroy Marceau, Vincent Sapin, Patrick Brachet, Bertrand Evrard, Henri Laurichesse, Marie-Paule Vasson
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)