Article
Biochemistry & Molecular Biology
Andrew J. Nickerson, Vazhaikkurichi M. Rajendran
Summary: The corticosteroid hormone aldosterone enhances K+ secretion in the colon and plays a critical role in maintaining K+ balance. Previous studies showed that aldosterone up-regulates basolateral NKCC1 specifically in the distal colon to support K+ secretion, but its effects on the proximal colon are unclear. Understanding these region-specific effects is important for managing gastrointestinal pathologies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
David Manneck, Gisela Manz, Hannah-Sophie Braun, Julia Rosendahl, Friederike Stumpff
Summary: Research indicates the therapeutic potential of cinnamaldehyde in inflammatory bowel disease through activation of the TRPA1 channel and modulation of ion transport in the colon. Cinnamaldehyde may also influence cellular environments through different signaling pathways to prevent damage to colonic epithelium and microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Ng'Andwe Kalungwana, Lisa Marshall, Alan Mackie, Christine Boesch
Summary: To accurately assess the absorption of nutrients in food, it is important to simulate human digestion using model settings. This study compared the uptake and transportation of dietary carotenoids using two different models. The results showed that the mouse intestinal tissue had a higher uptake and absorption efficiency than the Caco-2 cells. These findings demonstrate the usefulness of physiologically relevant models for studying human intestinal absorption.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Fiona McCartney, Diego R. Perinelli, Mattia Tiboni, Robert Cavanagh, Simone Lucarini, Giovanni Filippo Palmieri, Luca Casettari, David J. Brayden
Summary: The study compared the performance of three monoesters with varying sugar moieties as intestinal permeation enhancers. Results showed that all three esters enhanced permeability in rat intestinal tissue likely via tight junction modulation, while C12-trehalose was slightly less efficacious but also less damaging to the tissue. All three esters have potential for oral formulations as permeation enhancers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Kazuya Maeda
Summary: The prediction of intestinal absorption of drugs is crucial in the development of oral drugs, but is challenging due to various factors influencing drug absorption and the differences between animal and human bioavailability. Traditionally, Caco-2 cell transcellular transport assay has been used for screening drug absorption properties, but its predictability is limited. Recently, novel in vitro experimental systems, such as human-derived intestinal samples and differentiated epithelial cells from intestinal stem cells, have been proposed. Crypt-derived differentiated epithelial cells show advantages in characterizing species and regional differences in drug absorption.
DRUG METABOLISM AND DISPOSITION
(2023)
Review
Cell Biology
Krittikan Chanpaisaeng, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Narattaphol Charoenphandhu
Summary: For decades, the ability of intestinal mucosal cells to sense calcium levels has been a mystery. Recent studies have shown that enterocytes can use CaSR to monitor and regulate extracellular calcium levels, thereby limiting calcium absorption through a negative feedback loop.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Wacharaporn Tiyasatkulkovit, Sirion Aksornthong, Punyanuch Adulyaritthikul, Pornpailin Upanan, Kannikar Wongdee, Ratchaneevan Aeimlapa, Jarinthorn Teerapornpuntakit, Catleya Rojviriya, Nattapon Panupinthu, Narattaphol Charoenphandhu
Summary: The study found that long-term excessive salt consumption can lead to impaired skeletal mass and integrity, possibly through negative calcium balance, affecting bone structure.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Satit Thiengwittayaporn, Pichayut Wattanapreechanon, Phraew Sakon, Apatha Peethong, Nantaporn Ratisoontorn, Narattaphol Charoenphandhu, Supiya Charoensiriwath
Summary: Knee osteoarthritis is a degenerative joint disease that requires long-term maintenance. To address the issue of limited healthcare resources, we developed a mobile application that provides disease background and exercise plans.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Medicine, Research & Experimental
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Busarin Arunsak, Wichwara Nawara, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on metabolic disturbance, aging, and bone remodeling in D-galactose-induced aging rats with and without obesity. The results showed that a high-fat diet exacerbated bone dysregulation in D-galactose-treated rats. However, HBOT restored bone remodeling and structure/strength, and ameliorated bone dysregulation in the obesity group. These findings suggest that HBOT has the potential to decrease the risk of osteoporosis and bone fractures in aging individuals with or without obesity.
Article
Multidisciplinary Sciences
Tueanjai Khunluck, Kornkamon Lertsuwan, Chartinun Chutoe, Supagarn Sooksawanwit, Ingon Inson, Jarinthorn Teerapornpuntakit, Rutaiwan Tohtong, Narattaphol Charoenphandhu
Summary: The endocannabinoid system provides protective effects during breast cancer bone metastasis by interfering cancer and bone cell interaction and directly suppressing cancer cell growth and migration.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Narattaphol Charoenphandhu, Supagarn Sooksawanwit, Ratchaneevan Aeimlapa, Natchayaporn Thonapan, Pornpailin Upanan, Punyanuch Adulyaritthikul, Saowalak Krungchanuchat, Nattapon Panupinthu, Jarinthorn Teerapornpuntakit, Catleya Rojviriya, Kornkamon Lertsuwan, Saovaros Svasti, Kannikar Wongdee
Summary: A study found that mild-intensity physical activity can reduce iron accumulation in the heart and bones of patients with thalassemia, which is beneficial for those with limited physical fitness or deteriorated cardiac performance. However, mild-intensity physical activity does not improve bone mechanical properties or reduce bone porosity.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Busarin Arunsak, Wichwara Nawara, Benjamin Ongnok, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study aimed to compare the time-course effect of D-galactose-induced aging, obesity, and their combined effects on bone homeostasis. The results showed that aging aggravated bone dyshomeostasis in the obese condition in a time-dependent manner.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Sukpapohn Phummisutthigoon, Kornkamon Lertsuwan, Nattapon Panupinthu, Ratchaneevan Aeimlapa, Jarinthorn Teerapornpuntakit, Wasutorn Chankamngoen, Jirawan Thongbunchoo, Narattaphol Charoenphandhu, Kannikar Wongdee
Summary: The study found that ferric ions have an inhibitory effect on 1,25-dihydroxyvitamin D3-induced calcium transport in the intestine, rapidly reducing transepithelial resistance and increasing calcium flux.
Article
Multidisciplinary Sciences
Mayuree Rodrat, Kannikar Wongdee, Jarinthorn Teerapornpuntakit, Jirawan Thongbunchoo, Duangrudee Tanramluk, Ratchaneevan Aeimlapa, Nithipak Thammayon, Natchayaporn Thonapan, Pathnaree Wattano, Narattaphol Charoenphandhu
Summary: VIP and CFTR are involved in intestinal calcium transport. These findings support the existence of neurocrine control of intestinal calcium absorption.
Article
Chemistry, Multidisciplinary
Tanatsaparn Tithito, Siwapech Sillapaprayoon, Wittaya Pimtong, Jirawan Thongbunchoo, Narattaphol Charoenphandhu, Nateetip Krishnamra, Aurachat Lert-itthiporn, Weerakanya Maneeprakorn, Weeraphat Pon-On
Summary: This study synthesized inhomogeneous hydroxyapatite based on biomimetic trace elements co-doped into HA, and evaluated its physical properties, bioactivities with osteoblast cells, and in vivo cytotoxicity using zebrafish. The synthesized THA samples showed nanorod structures, positive surface charge, and paramagnetic behavior. THA substrate induced apatite particles to cover its surface and be in contact with simulated body fluid. In vitro assays demonstrated good cell attachment, growth, and enhanced ALP activity on THA compared to control substrates. In vivo studies showed the THA particles were non-toxic. Controlled release of ions was achieved successfully. These preliminary results indicate that THA could be a promising material for bone tissue engineering applications.
Article
Biochemistry & Molecular Biology
Mayuree Rodrat, Kannikar Wongdee, Wasutorn Chankamngoen, Jarinthorn Teerapornpuntakit, Jirawan Thongbunchoo, Duangrudee Tanramluk, Narattaphol Charoenphandhu
Summary: The study found that an excessive influx of calcium ions induced a calcium hyperabsorptive state (CHS) and regulated it through the calcium-sensing receptor (CaSR) and fibroblast growth factor (FGF)-23 to prevent excessive calcium uptake and its toxicity. Calcineurin may mediate CaSR's regulatory effect on FGF-23, inhibiting calcium transport by enhancing FGF-23 production.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Panan Suntornsaratoon, Thachakorn Thongklam, Thaweechai Saetae, Buapuengporn Kodmit, Sarawut Lapmanee, Suchinda Malaivijitnond, Narattaphol Charoenphandhu, Nateetip Krishnamra
Summary: Inadequate calcium intake during childhood and adolescence can negatively affect bone development. This study suggests that calcium supplementation prepared from tuna bone with tuna head oil may be more beneficial for skeletal development than CaCO3. Low calcium diet for 2 weeks led to low bone mineral density and impaired bone mechanical properties in young rats, but supplementation with calcium from tuna bone successfully restored bone health.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Physiology
Narattaphol Charoenphandhu, Krittikan Chanpaisaeng, Jarinthorn Teerapornpuntakit, Kannikar Wongdee
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sarawut Lapmanee, Sakkarin Bhubhanil, Siriwan Sriwong, Chaowalit Yuajit, Prapimpun Wongchitrat, Jarinthorn Teerapornpuntakit, Panan Suntornsaratoon, Jantarima Charoenphandhu, Narattaphol Charoenphandhu
Summary: Oral calcium and vitamin D supplements have positive effects on exploratory behavior, anxiety-like behaviors, and memory in male rats. They also upregulate the expression of DCX protein in the hippocampus, indicating their potential benefits on neurogenesis.
Meeting Abstract
Endocrinology & Metabolism
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Busarin Arunsak, Wichwara Nawara, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)