Article
Biochemistry & Molecular Biology
Qingqing Wang, Zhigao Dong, Junnan Su, Jinmei Huang, Pingping Xiao, Lihong Tian, Yongquan Chen, Lili Ma, Xuyan Chen
Summary: Ixazomib inhibits the proliferation of myeloma cells by targeting UBE2K, leading to decreased cell survival and increased apoptosis in a dose-dependent manner. It also affects cell cycle, induces apoptosis, and increases the production of reactive oxygen species.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Xin Li, Mengping Chen, Yike Wan, Lu Zhong, Xiaofeng Han, Xiaotong Chen, Fei Xiao, Jia Liu, Yiwei Zhang, Di Zhu, Jing Xiang, Junling Liu, Honghui Huang, Jian Hou
Summary: Our study reveals that NK cell exhaustion in MM is associated with distinct transcriptomic features, including downregulation of activating receptors and cytolytic molecules and upregulation of inhibitory receptors. We identify ZNF683 as a transcriptional suppressor that directly binds to the promoter of SH2D1B, leading to downregulation of this gene and impaired NK cell cytotoxic activity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Elham Roshandel, Haniyeh Ghaffari-Nazari, Mozhdeh Mohammadian, Maryam Salimi, Saeid Abroun, Reza Mirfakhraie, Abbas Hajifathali
Summary: Recent advances in adoptive cell therapy have transformed cancer immunotherapy, with a focus on treating relapsed/refractory multiple myeloma (RR/MM) using natural killer (NK) cells. NK cells exhibit effective cytotoxic activity against myeloma cells and can be derived from the patient or allogenic donors for therapy. Novel cell-based products, such as NK cell lines and CAR-NK cells, offer promising options for off-the-shelf NK cell therapy in MM.
CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jaydeep K. Srimani, Paul M. Diderichsen, Michael J. Hanley, Richard Labotka, Neeraj Gupta
Summary: Ixazomib has been approved for maintenance therapy in multiple myeloma patients, with similar progression-free survival benefits seen across different exposure levels. Higher exposures were associated with increased probabilities of maintaining complete response and experiencing certain adverse events, while exposure did not predict hematological adverse events and peripheral neuropathy. Lower apparent clearance values were correlated with a reduced likelihood of escalating the dose to 4 mg. The dose titration approach balanced patient benefit and risk, maximizing the fraction of patients who benefited from the higher dose.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Oncology
Melody Caillot, Hassan Dakik, Frederic Mazurier, Brigitte Sola
Summary: Multiple myeloma (MM) is a neoplastic disease of plasma cells that is still fatal despite advancements in care, requiring new therapeutic approaches. The accumulation of malignant plasma cells in the bone marrow characterizes MM, and while treatment outcomes have improved, there is a need for new therapies to combat relapse. Plasma cells in MM produce high levels of immunoglobulins leading to intracellular ROS production, and inducing MM cell death through ROS-generating drugs shows promise in overcoming drug resistance.
Article
Biochemistry & Molecular Biology
Elisabetta Vulpis, Luisa Loconte, Chiara Cassone, Fabrizio Antonangeli, Giulio Caracciolo, Laura Masuelli, Francesca Fazio, Maria Teresa Petrucci, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Angela Santoni, Alessandra Zingoni
Summary: Natural Killer (NK) cells are innate cytotoxic lymphoid cells that play a crucial role in cancer immunosurveillance. The secretion of NKG2D ligands (NKG2DLs) through extracellular vesicles (EVs) is a mechanism used by cancer cells to evade NKG2D-mediated immunosurveillance. This study investigates the spreading of NKG2DLs through EV-mediated cross-dressing on multiple myeloma (MM) cells and the potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Seiichi Okabe, Yuko Tanaka, Akihiko Gotoh
Summary: The treatment of multiple myeloma has been improved with the introduction of new drugs, but relapse is still common. Hypoxia plays a crucial role in the bone marrow microenvironment. Inhibitors of PFKFB3 and PFKFB4 show potential in inhibiting myeloma cell growth and enhancing cytotoxicity. Combination treatment with proteasome inhibitors and PFKFB inhibitors has shown enhanced cytotoxic effects.
BIOMARKER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Francesca Alessandra Ambrosio, Giosue Costa, Maria Eugenia Gallo Cantafio, Roberta Torcasio, Francesco Trapasso, Stefano Alcaro, Giuseppe Viglietto, Nicola Amodio
Summary: Multiple myeloma (MM) is an aggressive and incurable disease, characterized by cycles of treatment, remission, and relapse. Proteasome inhibitors (PIs), such as Bortezomib, carfilzomib, and ixazomib, have become the gold standard for MM treatment, improving survival outcomes. Recent research has focused on natural compounds that can inhibit the proteasome, potentially leading to new anti-MM drugs.
Article
Immunology
Emily C. Matchett, Jacki Kornbluth
Summary: In recent years, there have been advancements in the therapeutic treatment of multiple myeloma (MM) using natural killer (NK) cells. However, there are concerns regarding their use, such as growth arrest, content variability, and potential risks for patients. Researchers are now exploring the use of extracellular vesicles (EVs) from NK cells as a new therapeutic tool.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen Zhang, Xueyuan Wang, Haoyang Zhang, Tiantian Wen, Lin Yang, Hang Miao, Jia Wang, Hailong Liu, Xu Yang, Meng Lei, Yongqiang Zhu
Summary: Novel tripeptide propylene oxide compounds were designed, synthesized and investigated as proteasome inhibitors, showing potential antitumor activities against multiple myeloma cancer cell lines. The compounds demonstrated stability and acceptable biological parameters in in vivo studies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Guangtao Gao, Yong Xu, Jingjing Gan, Xinya Cao, Xiaoqing Dong, Mengkun Fang, Ying Du, Peipei Xu, Junyi Che, Bing Chen
Summary: This study reports a targeting strategy for multiple myeloma using platelet membrane-coated nanoparticles encapsulating BTZ. Compared to non-targeted BTZ, the nanoparticle system shows significant improvements in selectivity, cellular uptake, and anticancer effects, demonstrating a high potential for multiple myeloma patients.
Article
Multidisciplinary Sciences
Toru Masuda, Shojiro Haji, Yasuhiro Nakashima, Mariko Tsuda, Daisaku Kimura, Akiko Takamatsu, Norifusa Iwahashi, Hironobu Umakoshi, Motoaki Shiratsuchi, Chie Kikutake, Mikita Suyama, Yasuyuki Ohkawa, Yoshihiro Ogawa
Summary: In this study, longitudinal single-cell transcriptome sequencing was performed on multiple myeloma (MM) cells from a patient with relapsed MM. The researchers observed dynamic changes in MM cells in response to anti-myeloma drugs and identified a drug-response gene, PELI2. Their integrated strategy provided new insights into the clonal dynamics of MM and identification of drug-response genes.
Article
Immunology
Minna Sivonen, Katja A. Sirvio, Sara Wojciechowski, Anssi Kailaanmaki, Satu Kaipainen, Aubrey Bailey, Martin Villalba, Tuija Kekarainen
Summary: In this study, we aimed to identify the optimal activation and expansion protocol for cytotoxic NK cells against glioblastoma in vitro. The results showed that the ex vivo proliferation capacity and functionality of NK cells were affected by multiple factors, including the donor, composition of starting material, cytokine combination, and the activation protocol. These findings could be utilized for upscaling clinical NK cell manufacturing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Priyanka Rawat, Asmita Das
Summary: NK cells play important immune functions in autoimmune diseases and successful pregnancies, providing immunity against viral infections and tumors. They are distributed in various organs and exhibit functional differences due to the regulation of transcription factors.
Article
Medicine, General & Internal
Jiazhuo Wu, Cunzhen Shi, Hongwen Li, Wenting Song, Shuo Huang, Jianxiang Zhang, Wencai Li, Zhaoming Li, Mingzhi Zhang
Summary: PARP inhibitors have been shown to effectively treat natural killer/T cell lymphoma (NKTCL) by inhibiting cell proliferation, promoting apoptosis, and inducing cell cycle arrest. The combination of PARP inhibitors and cisplatin demonstrated synergistic effects both in vitro and in vivo. LMO2 deficiency reduced the sensitivity of NKTCL cells to PARP inhibitors.
Letter
Oncology
M. Hao, R. Franqui-Machin, H. Xu, J. Shaughnessy, B. Barlogie, D. Roodman, D. E. Quelle, S. Janz, M. H. Tomasson, R. D. Sanderson, L. Qiu, I. Frech, G. Tricot, F. Zhan
Article
Oncology
Gege Chen, Zhijian Xu, Gaomei Chang, Jun Hou, Liangning Hu, Yiwen Zhang, Dandan Yu, Bo Li, Shuaikang Chang, Yongsheng Xie, Yong Zhang, Rong Wei, Huiqun Wu, Wenqin Xiao, Xi Sun, Yi Tao, Lu Gao, Bojie Dai, Jumei Shi, Weiliang Zhu
Article
Biotechnology & Applied Microbiology
Kalyan Nadiminti, Kamal Kant Singh Abbi, Sarah L. Mott, Lindsay Dozeman, Annick Tricot, Allyson Schultz, Sonya Behrends, Fenghuang Zhan, Guido Tricot
ONCOTARGETS AND THERAPY
(2017)
Article
Cell Biology
Xi Sun, Bo Li, Bingqian Xie, Zhijian Xu, Gaomei Chang, Yi Tao, Yong Zhang, Shuaikang Chang, Yingcong Wang, Dandan Yu, Yongsheng Xie, Tingye Li, Houcai Wang, Gege Chen, Liangning Hu, Jun Hou, Yiwen Zhang, Wenqin Xiao, Lu Gao, Jumei Shi, Weiliang Zhu
CELL DEATH & DISEASE
(2017)
Article
Oncology
Yi Tao, Guang Yang, Hongxing Yang, Dongliang Song, Liangning Hu, Bingqian Xie, Houcai Wang, Lu Gao, Minjie Gao, Hongwei Xu, Zhijian Xu, Xiaosong Wu, Yiwen Zhang, Weiliang Zhu, Fenghuang Zhan, Jumei Shi
Article
Medicine, General & Internal
Jiliang Xia, Hongwei Xu, Xiaoyan Zhang, Chantal Allamargot, Kristen L. Coleman, Randy Nessler, Ivana Frech, Guido Tricot, Fenghuang Zhan
Article
Oncology
Lu Gao, Bo Li, Guang Yang, Peng Liu, Xiucai Lan, Shuaikang Chang, Yi Tao, Zhijian Xu, Bingqian Xie, Xi Sun, Yingcong Wang, Liangning Hu, Dandan Yu, Yongsheng Xie, Wenxuan Bu, Xiaosong Wu, Weiliang Zhu, Jumei Shi
Article
Medicine, Research & Experimental
Reinaldo Franqui-Machin, Mu Hao, Hua Bai, Zhimin Gu, Xin Zhan, Hasem Habelhah, Yogesh Jethava, Lugui Qiu, Ivana Frech, Guido Tricot, Fenghuang Zhan
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Letter
Oncology
Chunyan Gu, Carol Holman, Ramakrishna Sompallae, Xuefang Jing, Michael Tomasson, Dirk Hose, Anja Seckinger, Fenghuang Zhan, Guido Tricot, Hartmut Goldschmidt, Ye Yang, Siegfried Janz
BLOOD CANCER JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Kristin E. Brandt, Kelly C. Falls, Joshua D. Schoenfeld, Samuel N. Rodman, Zhimin Gu, Fenghuang Zhan, Joseph J. Cullen, Brett A. Wagner, Garry R. Buettner, Bryan G. Allen, Daniel J. Berg, Douglas R. Spitz, Melissa A. Fath
Article
Oncology
Yingcong Wang, Jing Huang, Bo Li, Han Xue, Guido Tricot, Liangning Hu, Zhijian Xu, Xiaoxiang Sun, Shuaikang Chang, Lu Gao, Yi Tao, Hongwei Xu, Yongsheng Xie, Wenqin Xiao, Dandan Yu, Yuanyuan Kong, Gege Chen, Xi Sun, Fulin Lian, Naixia Zhang, Xiaosong Wu, Zhiyong Mao, Fenghuang Khan, Weiliang Zhu, Jumei Shi
Article
Medicine, Research & Experimental
Wan He, Zhijian Xu, Dongliang Song, Hui Zhang, Bo Li, Lu Gao, Yong Zhang, Qilin Feng, Dandan Yu, Liangning Hu, Gege Chen, Yi Tao, Xiaosong Wu, Jumei Shi, Weiliang Zhu
Article
Oncology
Yi Xie, Mengyu Jia, Jumei Shi, Yi Tao
Article
Oncology
S. K. Chang, J. Hou, G. G. Chen, D. D. Yu, H. Q. Wu, Y. S. Xie, L. N. Hu, L. Gao, W. Q. Xiao, Y. Y. Kong, Y. Tao, J. M. Shi
Article
Biochemistry & Molecular Biology
Liangning Hu, Huiqun Wu, Bo Li, Dongliang Song, Guang Yang, Gege Chen, Bingqian Xie, Zhijian Xu, Yong Zhang, Dandan Yu, Jun Hou, Wenqin Xiao, Xi Sun, Gaomei Chang, Yiwen Zhang, Lu Gao, Bojie Dai, Yi Tao, Jumei Shi, Weiliang Zhu
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)