Article
Robotics
Filip Bjelonic, Arne Sachtler, Alin Albu-Schaffer, Cosimo Della Santina
Summary: This paper introduces the addition of elastic elements to mechanical structures to enable robots to perform oscillatory tasks and discusses the characterization of natural oscillations in nonlinear systems using nonlinear modal theory. The paper proposes control strategies to excite and sustain oscillations in complex systems and applies them to the KUKA iiwa robot with simulated parallel springs.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Tyler R. Naibert, Hryhoriy Polshyn, Rita Garrido-Menacho, Malcolm Durkin, Brian Wolin, Victor Chua, Ian Mondragon-Shem, Taylor Hughes, Nadya Mason, Raffi Budakian
Summary: This study utilizes scanning probe techniques to investigate the dynamics of vortices in superconducting systems, successfully imaging and controlling vortices while extracting key energy scales of vortex interactions in the system. The experimental results reveal the energy landscape of vortices in the system, interpret and extract the relative strengths of vortex dynamics and energy scales, and demonstrate the tunability of interactions and their variation with applied bias.
Article
Computer Science, Interdisciplinary Applications
Marco Zurru
Summary: This study presents a model for the non-linear dynamic behavior of pre-stressed cable trusses, which can provide a simplified description of the in-plane non-linear behavior of cable structures. The model identifies non-linear normal modes through harmonic balance and time-integration analysis, showing consistent results when compared to simulations on a finite element truss model with satisfactory results.
COMPUTERS & STRUCTURES
(2021)
Article
Multidisciplinary Sciences
Mariana P. Proenca, Javier Rial, Joao P. Araujo, Celia T. Sousa
Summary: The diameter and length of cylindrical magnetic nanowires play a crucial role in determining the magnetization reversal modes and the type of domain walls formed, with critical thresholds around 30 nm and 100 nm respectively. Different diameters and aspect ratios of nanowires result in various reversal modes, providing important implications for the configuration of storage devices.
SCIENTIFIC REPORTS
(2021)
Article
Astronomy & Astrophysics
Walberto Guzman-Ramirez, Ricardo Becerril, Susana Valdez-Alvarado, Alexei A. Deriglazov
Summary: In this study, we investigate the motion of a spinning particle with gravimagnetic moment in Schwarzschild-like spacetimes. By introducing the Hamiltonian system of equations and utilizing the symmetries of the spacetimes and spin supplementary conditions, we transform the problem of solving differential equations into solving algebraic equations, obtaining solutions for the momenta. The conditions for the existence of solutions in the gravimagnetic particle and MPTD system are analyzed, and a numerical algorithm is provided to generate solutions.
Article
Nanoscience & Nanotechnology
S. Perna, F. Bruckner, C. Serpico, D. Suess, M. D'Aquino
Summary: The spatially-inhomogeneous magnetization dynamics in a cylindrical magnetic nanodot driven by ac spin-torque is analyzed. The Landau-Lifshitz-Gilbert-Slonczewski equation is reformulated as a system of coupled nonlinear ordinary differential equations describing the time-evolution of normal modes amplitudes. This approach provides a class of models with reduced degrees of freedom and incremental accuracy between macrospin and full micromagnetics.
Article
Mechanics
Alexandra Sabrio, Mojdeh Rasoulzadeh
Summary: The motion and deformation of microfilaments in complex structured porous systems are influenced by the geometry and roughness of the pore space. Local fluid flow features and changing shear stresses result in deformation and reverse flow of the filaments. Higher Reynolds numbers and rougher wall geometries lead to more irregular filament shapes. Intermediate roughness and Reynolds numbers can result in a hairpin-like filament shape.
Article
Cell Biology
Ted Moldenhawer, Eduardo Moreno, Daniel Schindler, Sven Flemming, Matthias Holschneider, Wilhelm Huisinga, Sergio Alonso, Carsten Beta
Summary: The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton. Different cell types often show diverse modes of locomotion. Recent experiments have shown that different motility modes can be induced in mutated D. discoideum cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biophysics
Yves Dehouck, Ugo Bastolla
Summary: This study investigates the correlation between low-frequency normal modes in elastic network models and large conformational changes in proteins, finding that mode anharmonicity is more strongly related to collectivity than amplitude. Strategies such as reducing degrees of freedom or regularization by torsional harmonic potentials significantly improve the collectivity and harmonicity of normal modes.
BIOPHYSICAL JOURNAL
(2021)
Article
Mechanics
Andrea Baldassarri
Summary: The ABBM model, introduced in the context of hysteresis physics in magnetic materials, has been applied to describe crackling noise phenomena. Through exact calculations of avalanche shapes and comparisons with multi-avalanche shapes, it was found that their normalized shapes are exactly the same. This finding applies to various stochastic processes, demonstrating a correspondence between the excursion and bridge shape distributions.
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2021)
Article
Physics, Condensed Matter
Yuwen Fang, Yuhui Luo, Tao Huang, Chunhua Zeng
Summary: This study investigates the ratchet effect of active particles in biased velocity potential in the presence of cross-correlated noises through theoretical analysis and numerical simulation. It is found that cross-correlated noises can lead to the ratchet effect, influencing the mean velocity, mobility, and diffusion of active particles. Weak interaction between particles enhances the ratchet effect, while strong interaction weakens or eliminates it.
EUROPEAN PHYSICAL JOURNAL B
(2022)
Article
Chemistry, Physical
Wenjun Zheng
Summary: In order to computationally identify hidden binding sites for allosteric modulators, a fast and simple conformational sampling scheme guided by coarse-grained normal modes solved from the elastic network models followed by atomistic backbone and sidechain reconstruction has been developed. This method can adequately restructure cryptic sites so they are detectable by pocket finding programs like Concavity, making it suitable for high-throughput screening of protein structures at the genome scale. Our method has been used to locate known allosteric sites and predict new promising allosteric sites, and it is both faster and more flexible compared to other sampling methods.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Robotics
Alin Albu-Schaeffer, Dominic Lakatos, Stefano Stramigioli
Summary: This paper discusses different generalizations of linear oscillation modes to nonlinear systems and proposes necessary and sufficient conditions for the existence of strict oscillation modes on systems with a Riemannian metric and a potential field. Additionally, a constructive example in the case of an elastic double pendulum demonstrates the method of designing such modes.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Physics, Multidisciplinary
Jorgen S. Frederiksen
Summary: This study analyses dynamical vectors that characterize instability and can be applied as ensemble perturbations for prediction with geophysical fluid dynamical models. The relationships between various types of Lyapunov vectors, singular vectors, Floquet vectors and finite-time normal modes are examined in both periodic and aperiodic systems. The findings provide insights into the convergence and asymptotic behavior of these vectors, and propose efficient numerical methods for their calculation.
Article
Mathematics, Applied
Ivan Bizyaev, Sergey Bolotin, Ivan Mamaev
Summary: This paper investigates nonholonomic systems with periodically varying mass distribution and analyzes the potential existence of indefinite acceleration in the system. Depending on coefficient choices, the system velocities may have different asymptotic speeds, and it is possible to determine regions in phase space where trajectories will accelerate.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)