Article
Engineering, Biomedical
Long-Hai Wang, Braulio A. Marfil-Garza, Alexander U. Ernst, Rena L. Pawlick, Andrew R. Pepper, Kento Okada, Boris Epel, Navin Viswakarma, Mrignayani Kotecha, James Arthur Flanders, Ashim K. Datta, Hong-Jie Gao, Ye-Zi You, Minglin Ma, A. M. James Shapiro
Summary: A temporary controlled inflammation can induce neovascularization and create a subcutaneous cavity to support the transplantation and optimal function of encapsulated islet cells.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Ana Margarida Carvalho, Rute Nunes, Bruno Sarmento
Summary: Type 1 diabetes mellitus affects millions of people worldwide and is rapidly increasing. Current treatments rely on exogenous insulin administration, but the control of glycemia is not precise. Pluripotent stem cells offer a potential solution as they can be differentiated into insulin-producing cells and restore glycemic control. Overcoming the challenges of stem cell therapy would greatly improve the quality of life for individuals with type 1 diabetes mellitus.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and lower BV/TV. The new BMA parameter Ad.N/BS is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. A new BMA parameter, Ad.N/BS, is positively correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ziyuan Ma, Christiane Ruedl
Summary: The study reveals that pancreatic resident macrophages have different turnover kinetics and sources during aging and obesity, but obesity and type 2 diabetes do not affect the turnover kinetics of any macrophage subpopulation residing in the pancreas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Garima Singh, Shantibhusan Senapati, Sanghamitra Satpathi, Prativa Kumari Behera, Biswajit Das, Bismita Nayak
Summary: The study demonstrates the successful decellularization of caprine pancreas for pancreatic xenotransplantation, resulting in a decellularized pancreas tissue (DPT) with minimal immunogenicity and preserved key components like collagen and extracellular matrix. The recellularization of DPT with mouse islets showed no toxicity, retained biological and physical properties of the native ECM, making it a safer and better alternative for transplantable organs from xenogeneic sources.
Article
Multidisciplinary Sciences
Kai Dai, Qinghao Zhang, Shunshu Deng, Yuanman Yu, Fuwei Zhu, Shuang Zhang, YuanZhong Pan, Dandan Long, Jing Wang, Changsheng Liu
Summary: Constructing in vivo osteo-organoids by implanting bone morphogenetic protein-2-loaded scaffolds into the internal muscle pocket near the femur of mice supports the growth and subsequent harvest of therapeutically useful cells, and these cells demonstrate therapeutic potentials in cell therapies such as mitigating chronic liver fibrosis and reconstituting impaired immune organs.
Article
Endocrinology & Metabolism
Theodorus J. P. Jansen, Mijke Buitinga, Marti Boss, Michiel F. Nijhoff, Maarten Brom, Bastiaan E. de Galan, Marinette van der Graaf, Sebastiaan van Koeverden, Marie-Christine Vantyghem, Amandine Beron, Francois Pattou, Marten A. Engelse, Irina Velikyan, Olof Eriksson, Eelco J. P. de Koning, Martin Gotthardt
Summary: We demonstrated the feasibility of quantifying beta-cell mass in intrahepatic islet grafts using Ga-68-exendin PET/CT imaging. Compared with the control group, the ITx group showed significantly higher uptake of Ga-68-exendin. Our study provides the first clinical evidence for using radiolabeled exendin imaging to monitor viable transplanted islets after intraportal ITx.
Review
Endocrinology & Metabolism
Gregorio Correa Guimaraes, Joao Bosco Costa Coelho, Joao Gabriel Oliveira Silva, Ana Carolina Chalfun de Sant'Ana, Cassia Alves Carrilho de Sa, Julia Marques Moreno, Livia Marcal Reis, Camila Souza de Oliveira Guimaraes
Summary: There is a strong relationship between increased adiposity in bone marrow adipose tissue (BMAT) and the risk of bone fragility in the context of obesity and diabetes.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Hematology
Man K. S. Lee, Michael J. Kraakman, Dragana Dragoljevic, Nordin M. J. Hanssen, Michelle C. Flynn, Annas Al-Sharea, Gopalkrishna Sreejit, Camilla Bertuzzo-Veiga, Olivia D. Cooney, Fatima Baig, Elizabeth Morriss, Mark E. Cooper, Emma C. Josefsson, Benjamin T. Kile, Prabhakara R. Nagareddy, Andrew J. Murphy
Summary: Reducing platelet numbers through targeting the antiapoptotic protein Bcl-x(L) can effectively decrease atherosclerosis and reduce cardiovascular disease risk in diabetes, as demonstrated in genetic and pharmacological approaches in this study.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Marianna Santopaolo, Niall Sullivan, Anita Coral Thomas, Valeria Vincenza Alvino, Lindsay B. Nicholson, Yue Gu, Gaia Spinetti, Marinos Kallikourdis, Ashley Blom, Paolo Madeddu
Summary: Chronic low-grade inflammation and alterations in innate and adaptive immunity were found in Type 2 diabetes (T2D). Patients with T2D exhibited increased frequencies and activation markers on T cells in the bone marrow. Treatment with abatacept in mice reduced T cell activation and proinflammatory cytokine levels, improving cardiac function but not insulin sensitivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Erica L. Scheller, Meghan E. McGee-Lawrence, Beata Lecka-Czernik
Summary: The BMA2020 meeting aimed to facilitate communication and collaboration among scientists worldwide interested in bone marrow adiposity research, attracting experts from various fields including bone biology, endocrinology, and stem cell biology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Daniel Veloz Serrano, Samundeeswari Saseendar, Saseendar Shanmugasundaram, Rohan Bidwai, Diego Gomez, Riccardo D'Ambrosi
Summary: Osteonecrosis is a serious condition that can cause advanced arthritis in multiple joints, including the knee. Treatment options include joint replacement and joint preservation surgery, while non-operative treatments include observation, medication, and protective weight bearing.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Marta Klak, Michal Wszola, Andrzej Berman, Anna Filip, Anna Kosowska, Joanna Olkowska-Truchanowicz, Michal Rachalewski, Grzegorz Tymicki, Tomasz Bryniarski, Marta Kolodziejska, Tomasz Dobrzanski, Dominika Ujazdowska, Jaroslaw Wejman, Izabela Uhrynowska-Tyszkiewicz, Artur Kaminski
Summary: Recently, 3D bioprinting of the pancreas has gained clinical significance in tissue engineering and offers potential customized treatment for type 1 diabetes mellitus. This study evaluated the function of 3D-bioprinted pancreatic petals with islets in a murine model. The results showed that the bioprinted bionic petals significantly lowered plasma glucose concentration in the mice.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Editorial Material
Immunology
Erinke van Grinsven, Irina A. Udalova
Summary: This article proposes a mechanism for the impact of inflammatory insults on platelet production, suggesting that neutrophils pluck on megakaryocytes in the bone marrow to tune platelet release.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)