Article
Ophthalmology
Deepika Parameshwarappa, Satabdi Nanda, N. Kavya, Roopashri Matada, Gowri Murthy, Praveen Murthy
Summary: This article describes a modified surgical technique for cataract surgery in eyes with varying degrees of corneal opacity using chandelier illumination through the pars plana.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Forestry
Gregoire Le Provost, Theo Gerardin, Christophe Plomion, Oliver Brendel
Summary: In this study, physiological and molecular research on WUE characteristics of sessile oaks was conducted. The study found subtle differences in drought response between different WUE genotypes, identified key genes regulating this trait, and revealed the molecular strategies employed by different genotypes to cope with drought, providing new insights into the within-species diversity in drought adaptation strategies.
Article
Behavioral Sciences
Benjamin W. Domingue, Klint Kanopka, Travis T. Mallard, Sam Trejo, Elliot M. Tucker-Drob
Summary: The study expands the traditional GxE model to directly model genetic and environmental moderation of the dispersion of the outcome, introducing a test statistic for inferring interactions. Results suggest that genotype-by-birth year interactions for BMI may represent a more general pattern of expanding BMI variation across generations, with certain individual variants influencing BMI sensitivity to unmeasured factors.
Review
Environmental Sciences
Dylan J. Wallis, Lisa Truong, Jane La Du, Robyn L. Tanguay, David M. Reif
Summary: Exposure to endocrine-disrupting chemicals (EDCs) can lead to a variety of disorders by disrupting the complex endocrine signaling pathways that regulate development, physiology, and behavior across the body. The mechanisms of endocrine disruption, such as gene regulation and DNA/protein binding, are linked to differences in individual susceptibility within diverse populations. Research is needed to further understand how gene-environment interactions across these pathways may contribute to differences in susceptibility to EDCs, with a focus on the intricate thyroid pathway.
Article
Ophthalmology
R. Sankarananthan, Senthil Prasad, Rishwa Hariyani, Balagiri Sundar, Madhu Shekhar
Summary: This retrospective study evaluated the outcomes of manual small incision cataract surgery (MSICS) in patients with corneal opacity. The results showed that MSICS can provide favorable visual outcomes in patients where corneal opacity makes it difficult to perform phacoemulsification surgery.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Peihong Wang, Peng Hao, Xi Chen, Linghan Li, Yongying Zhou, Xiaohan Zhang, Lin Zhu, Ming Ying, Ruifang Han, Liming Wang, Xuan Li
Summary: This study found that inhibiting HMGB1 expression with GLY can alleviate inflammation and neovascularization in corneal alkali burn. GLY reduced VEGF expression by inhibiting the HMGB1/NF-kappa B/HIF-1 alpha signaling pathway, resulting in a reduction in corneal neovascularization. In addition, GLY reduced infiltrating inflammatory cells and the expression of inflammatory cytokines. GLY also reduced corneal opacity by inhibiting the extracellular function of HMGB1.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Angeles C. Ochoa-Martinez, Yesenia Araiza-Gamboa, Jose A. Varela-Silva, Sandra T. Orta-Garcia, Leticia Carrizales-Yanez, Ivan N. Perez-Maldonado
Summary: This study evaluated the impact of gene-environment interaction on serum levels of cardiovascular disease biomarkers in Mexican women, finding significant associations between arsenic exposure, PON1 Q192R polymorphism, and CVDs biomarkers. Results showed higher concentrations of CVDs biomarkers in R allele carriers, highlighting the importance of gene-environment interactions in cardiovascular disease research.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Matthias Munz, Mohammad Khodaygani, Zouhair Aherrahrou, Hauke Busch, Inken Wohlers
Summary: Mice have been extensively used as animal models to study genotype to phenotype relationships, with inbred mice being particularly useful due to genetic homogeneity. A method for in silico fine-mapping using genotypic data of 37 inbred mouse strains and user-provided phenotypic data is presented in this study. This method efficiently queries public genome-wide genotype data to propose candidate variants and genes for the phenotype under study.
Article
Genetics & Heredity
Jingjia Li, Jason B. West, Alexander Hart, Jill L. Wegrzyn, Matthew A. Smith, Jean-Christophe Domec, Carol A. Loopstra, Claudio Casola
Summary: The response to water limitation in drought-tolerant and -sensitive loblolly pine genotypes differs significantly at the gene level, although involving similar genetic networks. Upregulated transcripts under drought conditions represent the most diverging component between genotypes, which might depend on the activation and repression of substantially different groups of transcription factors.
FRONTIERS IN GENETICS
(2021)
Article
Behavioral Sciences
Laurel R. Seemiller, Sheree F. Logue, Thomas J. Gould
Summary: Understanding the genetic basis of nicotine and alcohol use predisposition is crucial for public health efforts, as genetic contributions may vary with age. Animal models allow the study of genetic background and age effects on drug-related behaviors, controlling important variables like drug exposure. Inbred mouse lines have shown genetic contributions to nicotine and alcohol addiction-related behaviors. This review summarizes the differences in these behaviors across inbred mouse strains and discusses their changes from adolescence to adulthood.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Immunology
Susana Barbosa-Mendez, Maura Matus-Ortega, Ricardo Hernandez-Miramontes, Alberto Salazar-Juarez
Summary: This study evaluated the immune response and protective efficacy of the M6TT vaccine in three inbred mouse strains, demonstrating that the vaccine generated specific antibodies and reduced the antinociceptive and reinforcing effects of heroin.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiehan Li, Christopher Jin, Stefan Gustafsson, Abhiram Rao, Martin Wabitsch, Chong Y. Park, Thomas Quertermous, Joshua W. Knowles, Ewa Bielczyk-Maczynska
Summary: Adipogenesis is the process of fat-specific progenitor cells differentiating into adipocytes that perform key metabolic functions of adipose tissue. This study provides a single-cell RNA-Sequencing dataset of adipogenic differentiation in 3T3-L1 and SGBS cells, allowing for comparative analysis and understanding of cell-to-cell variability in these widely used in vitro models.
Article
Criminology & Penology
Hexuan Liu, Breanna Clark
Summary: This study investigates how paternal incarceration affects the genetic association with children's educational attainment. The findings suggest that experiencing paternal incarceration reduces the genetic potential for educational achievement.
JOURNAL OF DEVELOPMENTAL AND LIFE-COURSE CRIMINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yun Long, Qianqian Qin, Jiajun Zhang, Zhan Zhu, Yin Liu, Longjiang Gu, Haiyang Jiang, Weina Si
Summary: Heat stress leads to cellular homeostasis imbalance, growth impairment and yield loss in crop production. Transcriptome analysis of two maize inbreds revealed that CIMBL55 had higher thermotolerance and different metabolic pathways were altered in response to heat stress. Co-expression analysis identified hub genes related to heat stress response and recovery in CIMBL55, which are promising for breeding.
Article
Psychology, Developmental
Xiaoya Zhang, Jay Belsky
Summary: Gene x Environment interaction (GxE) research can be categorized into three phases: single candidate genes, composited (multiple) candidate genes, and GWAS-derived polygenic scores. The selection of genes and decisions made in these studies are influenced by implicit or explicit theoretical assumptions, which have not been clearly addressed or fully recognized.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Psychiatry
Chie Shimamoto-Mitsuyama, Tetsuo Ohnishi, Shabeesh Balan, Hisako Ohba, Akiko Watanabe, Motoko Maekawa, Yasuko Hisano, Yoshimi Iwayama, Yuji Owada, Takeo Yoshikawa
SCHIZOPHRENIA RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Takeo Yoshikawa, Tadaho Nakamura, Kazuhiko Yanai
Summary: Histamine serves various roles in brain function as a neurotransmitter, influencing wakefulness, appetite, and memory. Dysfunctions in histamine have been linked to neuropsychiatric disorders. Medications targeting the brain histamine system have been developed, including pitolisant for narcolepsy treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Yo Yamada, Takeo Yoshikawa, Fumito Naganuma, Takako Kikkawa, Noriko Osumi, Kazuhiko Yanai
Article
Medicine, General & Internal
Yuina Wada, Motoko Maekawa, Tetsuo Ohnishi, Shabeesh Balan, Shigeru Matsuoka, Kazuya Iwamoto, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Yasuko Hisano, Yayoi Nozaki, Tomoko Toyota, Tomomi Shimogori, Masanari Itokawa, Tetsuyuki Kobayashi, Takeo Yoshikawa
Article
Medicine, Research & Experimental
Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima-Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Summary: The study reveals the gene expression regulation mechanism related to mental disorders by conducting experiments on Ldb2 knockout mice, highlighting the association between Ldb2 and the EGR family genes, providing new insights into the pathogenesis of mental disorders.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takuro Matsuzawa, Masanobu Morita, Ai Shimane, Rina Otsuka, Yu Mei, Fumitoshi Irie, Yu Yamaguchi, Kazuhiko Yanai, Takeo Yoshikawa
Summary: Heparan sulfate plays a crucial role in the differentiation of white adipocytes through BMP4-FGF1 signaling pathways, contributing to insulin sensitivity and glucose homeostasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Fumito Naganuma, Tadaho Nakamura, Hiroshi Kuroyanagi, Masato Tanaka, Takeo Yoshikawa, Kazuhiko Yanai, Nobuyuki Okamura
Summary: Activation or inhibition of HA(TMN) neurons significantly affects locomotor activity, aggressive behaviors, and the sleep-wake cycle in mice. Chemoactivation of HA(TMN) increases wakefulness and aggression while decreasing NREM sleep, whereas chemoinhibition has the opposite effects. These findings suggest the important role of HA(TMN) neurons in regulating exploratory activity, territorial aggression, and vigilance.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Daisuke Watanabe, Shinsuke Nakagawa, Yoichi Morofuji, Andrea E. Toth, Monika Vastag, Jun Aruga, Masami Niwa, Maria A. Deli
Summary: Culture models of the blood-brain barrier (BBB) play an important role in drug development, with primate models showing predictive value for drug transport to the human brain. The non-human primate co-culture BBB model has been proven to enhance barrier properties and transport properties, making it a valuable tool for drug discovery.
Article
Biochemistry & Molecular Biology
Tadaho Nakamura, Fumito Naganuma, Uta Kudomi, Sueji Roh, Kazuhiko Yanai, Takeo Yoshikawa
Summary: This study demonstrates the importance of oral histidine supplementation in the histaminergic nervous system and its positive effects on impaired working memory induced by sleep deprivation. Histidine intake replenishes brain histamine and enhances neuronal activity, leading to the recovery of memory function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Rina Otsuka, Fumito Naganuma, Tadaho Nakamura, Hideki Miwa, Rumi Nakayama-Naono, Takuro Matsuzawa, Yurika Komatsu, Yuki Sato, Yuna Takahashi, Haruna Tatsuoka-Kitano, Kazuhiko Yanai, Takeo Yoshikawa
Summary: This study demonstrates that astrocytic HNMT contributes to histamine clearance after histamine release in the cortex, and plays a role in the regulation of motor coordination, locomotor activity, and vigilance state.
Article
Oncology
Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Masaki Saito, Takeo Yoshikawa, Takuya Mizuno, Manabu Kawada, Mika K. K. Kaneko, Yukinari Kato
Summary: The study demonstrates that the anti-HER2 monoclonal antibody H77Bf possesses high binding affinity and exerts antitumor activities against dHER2-positive canine cancers, suggesting it could be a valuable treatment regimen for canine cancers.
Article
Medicine, Research & Experimental
Guanjie Li, Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Miyuki Yanaka, Takuro Nakamura, Takeo Yoshikawa, Manabu Kawada, Mika K. K. Kaneko, Yukinari Kato
Summary: EpCAM is a type I transmembrane glycoprotein highly expressed on tumor cells, and it has been considered as a promising target for tumor diagnosis and therapy. In this study, a defucosylated version of an anti-EpCAM monoclonal antibody was generated and evaluated for its antitumor activity against EpCAM-positive cells. The results showed that the antibody exhibited potent cytotoxicity for EpCAM-overexpressing cells and suppressed tumor development in xenograft mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Nami Tateyama, Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Takuya Mizuno, Takeo Yoshikawa, Manabu Kawada, Mika K. Kaneko, Yukinari Kato
Summary: The bispecific antibody E134Bf-H77scFv exhibited antitumor activities against dEGFR/dHER2-positive canine tumors, suggesting its potential as a valuable treatment regimen.
Article
Immunology
Nami Tateyama, Teizo Asano, Hiroyuki Suzuki, Guanjie Li, Takeo Yoshikawa, Tomohiro Tanaka, Mika K. K. Kaneko, Yukinari Kato
Summary: CCR3 is a receptor for CC chemokines and is involved in various allergic diseases and cancers. In this study, the binding epitopes of specific monoclonal antibodies targeting CCR3 were investigated, revealing the N-terminal region of CCR3 as the key recognition site for these antibodies. This research provides a foundation for further drug development and studies of CCR3-related therapies.
Article
Immunology
Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Tomokazu Ohishi, Manabu Kawada, Takeo Yoshikawa, Mika K. K. Kaneko, Yukinari Kato
Summary: In this study, an anti-EpCAM monoclonal antibody called EpMab-37-mG(2a)-f was found to have antitumor activities against breast and pancreatic cancers by inducing antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. The administration of this antibody significantly suppressed the development of xenograft tumors.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)