Article
Environmental Sciences
Samira Barangi, Pardis Ghodsi, Adeleh Mehrabi, Soghra Mehri, A. Wallace Hayes, Gholamreza Karimi
Summary: The study found that melatonin has a protective effect against BaP-induced heart and lung injury through suppressing oxidative stress and apoptosis, and inducing the Sirt1/autophagy pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Samira Barangi, Pardis Ghodsi, Adeleh Mehrabi, Soghra Mehri, A. Wallace Hayes, Gholamreza Karimi
Summary: This study investigated the potential protective impact of melatonin on cardiopulmonary toxicity induced by Benzo(a)pyrene (BaP). The results showed that melatonin exhibited a protective effect against BaP-induced heart and lung injury through the suppression of oxidative stress and apoptosis and the induction of the Sirt1/autophagy pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nadia Papini, Roberta Todisco, Paola Giussani, Michele Dei Cas, Rita Paroni, Chiara Giallanza, Cristina Tringali
Summary: Autophagic impairment is observed in lysosomal storage diseases and adult neurodegenerative diseases, and it may contribute to worsen metabolite accumulation and lysosomal distress. In Krabbe disease, autophagy alterations were also identified. In this study, the inhibitory AKT-mediated phosphorylation of beclin-1 and the BCL2-beclin-1 complex were found to reduce autophagosomes formation in response to starvation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang
Summary: Tan IIA, an active ingredient of Salvia miltiorrhiza, inhibits lung cancer growth by inducing autophagic apoptosis.
Article
Biochemistry & Molecular Biology
Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
Summary: This study demonstrates that 3-OHB delays the progression of diabetic nephropathy (DN) by enhancing autophagy and inhibiting oxidative stress, as observed in both in vivo and in vitro models.
Article
Dermatology
Ghada M. El-Hanafy, Hanan R. Nada, Laila A. Rashed, Marwa F. Mousa, Maha F. Elmasry
Summary: This study found that vitiligo patients had lower levels of autophagy and higher levels of oxidative stress, which could play an important role in the pathogenesis of vitiligo.
JOURNAL OF EGYPTIAN WOMENS DERMATOLOGICAL SOCIETY
(2021)
Article
Medicine, Research & Experimental
Perrine Renard, Laure Caccavelli, Antoine Legendre, Caroline Tuchmann-Durand, David Balakirouchenane, Benoit Blanchet, Marjolene Straube, Celine Narjoz, Arnaud Hubas, Alexa Garros, Karine Mention, Nathalie Bednarek, Nicolas Goudin, Christine Broissand, Joel Schlatter, Salvatore Cisternino, Nicolas Cagnard, Peter van Endert, Julien Diana, Hortense de Calbiac, Pascale de Lonlay
Summary: This study tested the effect of hydroxychloroquine sulfate treatment in Lipin-1 deficient patients. It was found that the physical conditions of the patients improved, but there was a risk of rhabdomyolysis at high concentrations. The study also found that hydroxychloroquine sulfate can reduce oxidative stress at low concentrations.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Fisheries
Kishanthini Nadarajapillai, H. M. V. Udayantha, Sarithaa Sellaththurai, T. D. W. Kasthuriarachchi, Gaeun Kim, Jehee Lee
Summary: This study identified and cloned the beclin-1 cDNA in red-spotted grouper and investigated its role in viral infection and oxidative stress. The findings demonstrated that EaBECN-1 plays a protective role against viral pathogenesis and oxidative stress through autophagy.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Ying Shan, Chuanyan Yang, Xiaoxiao Guo, Jiejie Sun, Zhaoyu He, Dongli Jiang, Wenwen Yang, Lingling Wang, Linsheng Song
Summary: In this study, a Beclin 1 and a LC3 were identified from Yesso scallop, with significantly higher expression levels in gill and haemocytes. The mRNA transcripts of PyBeclin 1 and PyLC3 showed changes in response to acute high temperature stress, indicating their involvement in regulating autophagy activation in scallops.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leilei Zang, Yanmei Song, Yanhua Tian, Ning Hu
Summary: TAT-Beclin 1, as an autophagic promoter, can inhibit the tumorigenesis of DUSP4-positive PTC by regulating autophagy. The expression levels of autophagic proteins decreased with the increase of DUSP4 expression in PTC tissues. In PTC cells, the inhibitory effects of DUSP4 overexpression on autophagic activity and cell proliferation and migration were reversed by TAT-Beclin 1 administration. In vivo assays also showed that TAT-Beclin 1 could block the tumorigenic ability and restore autophagic activity in DUSP4-overexpressed PTC cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Reynold I. I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang
Summary: This study found that enhancing autophagy can reduce fibrosis caused by renal injury. By observing mice after kidney surgery, it was found that the use of active mutant Beclin-1 can inhibit the fibrosis process, alleviate inflammation and cellular stress response caused by kidney injury. These findings provide new methods for treating fibrosis after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Miriam Scicchitano, Cristina Carresi, Saverio Nucera, Stefano Ruga, Jessica Maiuolo, Roberta Macri, Federica Scarano, Francesca Bosco, Rocco Mollace, Antonio Cardamone, Anna Rita Coppoletta, Lorenza Guarnieri, Maria Caterina Zito, Irene Bava, Luca Cariati, Marta Greco, Daniela Patrizia Foti, Ernesto Palma, Micaela Gliozzi, Vincenzo Musolino, Vincenzo Mollace
Summary: Our study showed that Ica pretreatment of H9c2 cells before Doxo exposure improved cell viability, reduced ROS generation, prevented mitochondrial dysfunction and mPTP opening. Additionally, it was found that Ica inhibited Caveolin-1 expression levels and PDE5a activity, enhancing mitochondrial function and preventing apoptotic cell death while regulating autophagic processes.
Article
Cell Biology
Masataka Sano, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano
Summary: An increasing body of evidence suggests that neutrophil extracellular traps (NETs) play a critical role in the development of atherosclerosis. This study further reveals that NETs promote atherosclerosis by modulating the autophagy activity in macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Jian Zhang, Jiafu Guo, Nannan Yang, Yan Huang, Tingting Hu, Chaolong Rao
Summary: The endoplasmic reticulum (ER) plays a crucial role in maintaining cellular homeostasis, and ER stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse external stimuli. Different modes of cell death, including autophagy, apoptosis, ferroptosis, and pyroptosis, are induced by ERS through three major transmembrane receptors on the ER membrane. These modes of cell death are important in the occurrence and development of various diseases. The liver, as the largest metabolic organ, has a well-developed ER system in hepatocytes. ERS is closely related to liver injury and modulating ERS shows promise for treating liver injury.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Yuan Zhang, Wanpeng Yu, Wenguang Chang, Man Wang, Lei Zhang, Fei Yu
Summary: Cardiac amyloidosis is a disease where the heart is affected by the deposition of amyloid fibrillar material, and the most severe form is AL amyloidosis. The toxicity of AL is caused by lysosomal dysfunction, oxidative stress, and impaired autophagy, leading to cellular dysfunction and death. Multiple myeloma complicated with cardiac amyloidosis is speculated to be caused by the deposition of lambda LC fibrils in cardiomyocytes, resulting in dysregulated autophagy and cell death.
LABORATORY INVESTIGATION
(2023)
Review
Food Science & Technology
Jingjing Xu, Min Zhang, Yuchuan Wang, Bhesh Bhandari
Summary: Flavor is crucial for the acceptance of meat products, and conventional cooking methods often result in decreased quality and inadequate flavor release. To meet consumers' demands for good flavors and high quality, researchers are exploring emerging technologies for enhancing flavor formation and nutritional value during thermal or non-thermal processing of meat products.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Nadia Kashif, Boris Albijanic, Jing Jing Xu, Syahida Syahida, Teresa McGrath, Bogale Tadesse, Muhammad Kashif Nazir
Summary: The influence of bentonite on the grinding efficiencies of ores has been examined in this study. It was found that the presence of bentonite in the ore negatively affected the grinding performance of the ore, but this negative effect was mitigated by adding Ca2+ ions. The addition of Ca2+ ions reduced the repulsive forces between bentonite particles, leading to improved settling rates and grinding performance.
APPLIED CLAY SCIENCE
(2023)
Article
Cell Biology
Lin-Yan Huang, Ju-Yun Ma, Jin-Xiu Song, Jing-Jing Xu, Rui Hong, Hai-Di Fan, Heng Cai, Wan Wang, Yan-Ling Wang, Zhao-Li Hu, Jian-Gang Shen, Su-Hua Qi
Summary: This study found that succinate levels increased in serum and brain tissue after ischemia/reperfusion injury. Oxygen-glucose deprivation and reoxygenation stimulated neural stem cells to produce abundant succinate. Exogenous diethyl succinate inhibited neural stem cell proliferation and worsened cerebral ischemia/reperfusion injury. The study suggests that ischemic accumulation of succinate decreases Cdc42 GTPase activity by induction of Cdc42 succinylation, which inhibits neural stem cell proliferation and worsens cerebral ischemia/reperfusion injury.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Mechanical
Zechao Di, Shaohui Li, Dongsheng Huang, Xuetao Zhang, Yuan Li, Yu Jiang, Mengjia Zhang, Jingjing Xu, Zhiyu Zhao
Summary: The anti-shudder effects of glycerol monoisostearate friction modifier (FM) in automatic transmission fluid (ATF) were investigated using a disc-on-disc tribometer. The presence of FM greatly influenced the anti-shudder durability of ATF, despite FM itself having no inherent anti-shudder properties. Chemical characterization of the tribosurface revealed that the proper presence of FM improved the reaction probability of certain components in ATF, leading to the formation of a more effective calcium hydroxyphosphate type tribofilm, thereby enhancing the anti-shudder performance.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Toxicology
Chijing Zuo, Yan Liu, Jie Wang, Weidong Yu, Yujie Liu, Yanyan Zhang, Jingjing Xu, Daiyin Peng, Can Peng
Summary: Compound diclofenac sodium chlorphenamine maleate tablets (CDCT) commonly used in Asia for the cold can cause hematuria symptoms, but the underlying mechanism is unclear. This study investigated the CDCT-induced changes in kidney morphology and metabolites in order to explore the possible mechanisms of CDCT-induced nephrotoxicity. CDCT exposure in rats led to kidney injury and death, accompanied by pathological changes and disruptions in energy and glycerophospholipid metabolism pathways. Specific metabolites, such as succinate, leukotriene B-4 (LTB4), and cardiolipin (CL), were found to be significantly altered. Functionally, succinate accumulation caused mitochondrial damage, LTB4 activated NF-kappa B signaling, and reduced CL triggered apoptosis, inflammation, and mitochondrial reactive oxygen species (mito SOX). This study provides comprehensive information on the mechanism of CDCT-induced nephrotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Neurosciences
Jie Xu, Yan-Tian Lv, Xiao-Yun Zhao, Jing-Jing Wang, Zhong-Shan Shen, Jian Li, Fei-Fei Zhang, Jing Liu, Xiao-Hui Wang, Yun Xu, Qi Geng, Yi-Tong Ding, Jing-Jing Xu, Meng-Jiao Tan, Zhi-Xiao Li, Ran Wang, Jian Chen, Wen Sun, Meng Cui, Diomedes E. Logothetis, Jun-li Cao, Qiong-Yao Tang, Zhe Zhang
Summary: In this study, two potential sodium-sensitive sites were identified in the C-terminal domain of the rat Slack channel, and R379 was determined to be a chloride interaction site. These findings contribute to a better understanding of the sodium gating mechanism and the regulation of Slack channel function.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Dermatology
Hongyang Li, Jiayi Li, Jingjing Xu, Lingjun Li, Yurong Wang, Chunhui Liu, Jia Zhou
Summary: Compared with systemic administration methods like injection and oral administration, traditional transdermal drug delivery has the advantages of rapid onset of activity and low side effects. However, hydrophilic drugs and bioactive substances are often unsuitable for traditional transdermal drug delivery. The application of microneedles made from gelatin methylacryloyl (GelMA) has greatly expanded the possibilities for skin transdermal drug delivery. GelMA hydrogel microneedles exhibit huge potency in the diagnosis and treatment of skin diseases, and this technology also brings broad application prospects for subcutaneous micro-invasive transdermal targeted drug delivery, which mainly used in skin tissue fluid collection, local substance delivery and wound healing.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Acoustics
Na Guo, Shuang Ye, Ganghua Zhou, Yimeng Zhang, Fangyan Zhang, Jingjing Xu, Shenyu Pan, Guilan Zhu, Ziying Wang
Summary: Ultrasound treatment was found to enhance the binding degree between whey protein isolate and rutin, and improve the solubility and surface hydrophobicity of the WPI-rutin complex. The treated complex also developed a more ordered secondary structure with small and uniform pore sizes. This research provides a theoretical reference for studying protein-polyphenol interactions and their applications in food delivery systems.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Jingjing Xu, Zhengye Cao, Chunqin Miao, Minming Zhang, Xiaojun Xu
Summary: This study used machine learning algorithms based on computed tomography (CT) imaging to predict disease severity and outcome in Omicron pneumonia, and compared its performance with clinical and biological features. The results showed that CT and clinical assessment had similar accuracy in predicting severity and outcome of Omicron pneumonia. Oxygen saturation, IL-6, and chest CT infiltration were found to be important biomarkers.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jinhua Ren, QiaoXian Lin, Qi Chen, Jingjing Xu, Dabin Chen, Renli Chen, Kangni Lin, Haojie Zhu, Chenjing Ye, Xiaofeng Luo, Shaozhen Chen, Hui Kong, Qiong Lin, Nan Li, Xu Lin, Zhizhe Chen, Jianda Hu, Ting Yang
Summary: Adoptive transfer of HBV immunity was investigated in 112 patients without HBsAb at the time of their first allo-HSCT. After allo-HSCT, HBV-DNA and HBsAg cleared in HBsAg+ patients, while all HBsAg- patients acquired HBsAb immediately. However, HBsAb subsequently declined, with 58.2% of patients losing HBsAb during follow-up. Multivariate analysis suggested that lack of CMV clearance, aGVHD, and no HBsAb loss were independent risk factors for overall survival. Overall, adoptive immune transfer provides anti-HBV protection, and HBsAb loss after allo-HSCT predicts better survival.
Article
Cell Biology
Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao
Summary: The study reveals that JMJD1C is highly expressed in a PAH mouse model, and its inhibition can ameliorate pathological features of PAH. JMJD1C knockdown reduces PASMC proliferation and impairs their adaptation to hypoxia, while suppressing the STAT3 signaling pathway. The findings suggest that JMJD1C induces glycolytic processes and promotes PASMC proliferation and pulmonary vascular remodeling in PAH.
CELL DEATH DISCOVERY
(2023)
Article
Computer Science, Artificial Intelligence
Jingjing Xu
Summary: This article builds a sentiment analysis model based on natural language processing technology and proposes an improved TF-IDF algorithm. The emotional value of each emotional word is determined using a weighted average method. Inspirational words are used to obtain the emotional tendency and emotional value of the English corpus. The results show that the model has high classification accuracy and operation efficiency when selecting feature words. The improved TF-IDF algorithm significantly improves the efficiency of college English learning by adding necessary information weight processing and word density weight processing.
PEERJ COMPUTER SCIENCE
(2023)
Article
Chemistry, Physical
Maja Hanic, Lewis M. Antill, Angela S. Gehrckens, Jessica Schmidt, Katharina Gortemaker, Rabea Bartolke, Tarick J. El-Baba, Jingjing Xu, Karl-Wilhelm Koch, Henrik Mouritsen, Justin L. P. Benesch, P. J. Hore, Ilia A. Solov'yov
Summary: Experimental and computational investigations were conducted to explore the dimerization of robin Cry4a protein. It was found that disulfide-linked dimers are routinely formed, especially under blue light exposure. Computational modeling and molecular dynamics simulations were used to assess possible dimer structures. The relevance of these findings to avian magnetoreception was discussed.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Food Science & Technology
Jingjing Xu, Ruyue Wang, Weibao Liu, Zhongwei Yin, Jianrong Wu, Xun Yu, Wen Wang, Hongtao Zhang, Zhitao Li, Minjie Gao, Li Zhu, Xiaobei Zhan
Summary: This study found that ten non-digestible carbohydrates have different effects on gut microbial metabolism, and xanthan gum oligosaccharides and gellan gum oligosaccharides have significant impact on butyrate-producing bacteria and butyrate production.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biology
Joe Wynn, Bo Leberecht, Miriam Liedvogel, Lars Burnus, Raisa Chetverikova, Sara Doege, Thiemo Karwinkel, Dmitry Kobylkov, Jingjing Xu, Henrik Mouritsen
Summary: The role of inherited orientation programmes in determining migratory routes of birds is well understood, but not much is known about the influence of inherited information on return migration. This study shows that juvenile Eurasian blackcaps, which have never left northwest Europe, exhibit significant spring orientation in a direction similar to that expected based on ringing recoveries. It suggests that birds may inherit an orientation programme for both spring and autumn migration, and that inherited spring migratory trajectories could be accurate enough for targeting breeding sites.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
