Article
Immunology
Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Christina T. Fulton, Adam M. Goldsmith, Antonia P. Popova
Summary: Premature infants with bronchopulmonary dysplasia (BPD) develop chronic respiratory symptoms after viral infections. Hyperoxia exposure increases activated lung dendritic cells (DCs) and proinflammatory responses in neonatal mice. This study found that early-life hyperoxia stimulates Flt3L expression, leading to expansion and activation of lung CD103+ DCs, thus mediating inflammation. In preterm infants, FLT3L levels positively correlated with proinflammatory cytokines levels and may contribute to the development of BPD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Baihe Li, Xu Chen, Weihui Ma, Ning Li, Qin Chen, Jinfeng Liao, Sanfeng Luo, Xiaomei Lu, Yaozhong Zhang, Siping Li, Xingyun Wang, Fengdan Xu
Summary: This study aims to reveal the relationship between amniotic fluid (AF) peptides and lung development by analyzing the differences in their composition at different gestational periods. It provides new prospects for the prevention and treatment of bronchopulmonary dysplasia (BPD) in preterm infants.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Maria Hurskainen, Ivana Mizikova, David P. Cook, Noora Andersson, Chanele Cyr-Depauw, Flore Lesage, Emmi Helle, Laurent Renesme, Robert P. Jankov, Markku Heikinheimo, Barbara C. Vanderhyden, Bernard Thebaud
Summary: This study utilizes single-cell RNA sequencing to investigate cellular dynamics during normal or impaired lung development in mice, finding that exposure to hyperoxia alters cell composition, with inflammatory signaling identified as a key driver of changes induced by hyperoxia.
NATURE COMMUNICATIONS
(2021)
Article
Respiratory System
Jason L. Chang, Jiannan Gong, Salu Rizal, Abigail L. Peterson, Julia Chang, Chenrui Yao, Phyllis A. Dennery, Hongwei Yao
Summary: This study found that upregulating Cpt1a by baicalin or l-carnitine can improve hyperoxia-induced lung endothelial cell dysfunction and persistent lung injury. These findings provide potential therapeutic avenues for using l-carnitine and baicalin as Cpt1a upregulators to prevent persistent lung injury in premature infants with BPD.
RESPIRATORY RESEARCH
(2022)
Article
Pediatrics
Alona Bin-Nun, Irina Shchors, Rawan Abu-Omar, Yair Kasirer, Francis Mimouni, Cathy Hammerman
Summary: The SFR ratio reflects pulmonary function in preterm neonates, with early decreases in SFR possibly predicting subsequent chronic lung disease related to patent ductus arteriosus (PDA) shunting.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yanrong Long, Hongbin Chen, Junchao Deng, Junjie Ning, Pengbo Yang, Lina Qiao, Zhongwei Cao
Summary: Hyperoxia-induced lung injury is associated with the development of BPD. This study found that the expression of FGFR1 is upregulated in lung endothelial cells and deficiency of endothelial Fgfr1 can improve hyperoxia-induced BPD. Targeting FGFR1 may provide a new therapeutic strategy for the prevention and treatment of BPD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Kacie Dillon, Vineet Lamba, Ranjit R. Philip, Mark F. Weems, Ajay J. Talati
Summary: This study aimed to assess the efficacy of sildenafil in infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH). The study found that sildenafil treatment led to improvement in PH as evaluated by transthoracic echocardiography (TTE), and infants showed improvement in their respiratory severity score (RSS) and FiO2 after prolonged therapy. However, TTE improvements did not correlate with clinical improvements.
Review
Medicine, General & Internal
Emily Y. Y. Zhang, Colleen M. Bartman, Y. S. Prakash, Christina M. Pabelick, Elizabeth R. Vogel
Summary: Chronic airway diseases, such as wheezing and asthma, are significant sources of morbidity and mortality in children, particularly in preterm infants. Perinatal risk factors, such as respiratory support and mechanical ventilation, may contribute to the development of chronic airway disease. Lower levels of oxygen and stretch exposure due to mechanical ventilation or CPAP may also play a role in this development. This review summarizes the current knowledge on the impact of perinatal oxygen and mechanical respiratory support on the development of chronic pediatric lung disease, with a focus on pediatric airway disease, and explores potential mechanisms for novel therapies.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Xin Wen, Hui Zhang, Bo Xiang, Weiyu Zhang, Fang Gong, Shiling Li, Hongyan Chen, Xuan Luo, Juan Deng, Yaoyao You, Zhangxue Hu, Changke Jiang
Summary: The study suggests that miR-342-5p mimic therapy may hold promise in the treatment or prevention of BPD by improving lung pathology and survival rates, and its regulation of Spred3 is implicated in the process.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Sara Taghizadeh, Cho-Ming Chao, Stefan Guenther, Lea Glaser, Luisa Gersmann, Gabriela Michel, Simone Kraut, Kerstin Goth, Janine Koepke, Monika Heiner, Ana Ivonne Vazquez-Armendariz, Susanne Herold, Christos Samakovlis, Norbert Weissmann, Francesca Ricci, Giorgio Aquila, Laurent Boyer, Harald Ehrhardt, Parviz Minoo, Saverio Bellusci, Stefano Rivetti
Summary: The study found that the development of bronchopulmonary dysplasia in premature babies is associated with decreased expression of Fibroblast growth factor 10 (FGF10). Administration of Fgf10 and rFGF10 to transgenic mice improved the defects in alveologenesis caused by hyperoxia. Alveolosphere assays and single-cell RNA sequencing identified subpopulations of mesenchymal cells that may serve as cellular targets for alveologenesis.
Letter
Pediatrics
Chiharu Ota, Ryoko Saito, Junya Tominaga, Shinya Iwasawa, Takashi Hirama, Yasushi Matsuda, Katsunori Ono, Takehiko Onoki, Masato Kimura, Yoshinori Kawabata, Yoshinori Okada
Summary: This case report describes a 9-year-old girl with BPD-induced PH who underwent BLTx, with stable condition and no signs of PH after 6 months post-surgery.
PEDIATRIC PULMONOLOGY
(2021)
Article
Immunology
Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Chase Anderson, Antonia P. Popova
Summary: Activated IL-17a+ γδ T cells and NKG2D signaling play a central role in neonatal LPS-induced lung injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pragnya Das, Suchismita Acharya, Varsha M. Prahaladan, Ogan K. Kumova, Shadi Malaeb, Sumita Behera, Beamon Agarwal, Dale J. Christensen, Alison J. Carey, Vineet Bhandari
Summary: Bronchopulmonary dysplasia is a common complication of prematurity, associated with high healthcare burden and longer hospital stays. It may lead to pulmonary hypertension and increased neonatal mortality. A study found that a small molecule derivative can improve experimental BPD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Karen Van Mechelen, Elke van Westering-Kroon, Matthias Hutten, Ludo Mahieu, Eduardo Villamor
Summary: Different pathophysiological pathways may lead to distinct clinical phenotypes of bronchopulmonary dysplasia (BPD), with Ureaplasma playing a unique role in its pathogenesis. The interaction between Ureaplasma and host factors may contribute variably to the development of BPD. Ureaplasma infection mainly affects the parenchyma, interstitium, and small airways, while its role in the vascular phenotype of BPD is limited.
Article
Critical Care Medicine
Alia Dani, Don Hayes, Amalia Guzman-Gomez, Md Monir Hossain, Jason C. Woods, David L. S. Morales, Russel Hirsch, Farhan Zafar, Erik B. Hysinger
Summary: Patients with bronchopulmonary dysplasia (BPD) may benefit from lung transplant (LTx) as their post-LTx outcomes are similar to those with other diagnoses.
Article
Gastroenterology & Hepatology
Kohei Shigeta, Meenal Datta, Tai Hato, Shuji Kitahara, Ivy X. Chen, Aya Matsui, Hiroto Kikuchi, Emilie Mamessier, Shuichi Aoki, Rakesh R. Ramjiawan, Hiroki Ochiai, Nabeel Bardeesy, Peigen Huang, Mark Cobbold, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda
Article
Multidisciplinary Sciences
Kentaro Oniki, Taisei Kawakami, Azusa Nakashima, Keishi Miyata, Takehisa Watanabe, Haruka Fujikawa, Ryunosuke Nakashima, Aoi Nasu, Yuka Eto, Noriki Takahashi, Hirofumi Nohara, Mary Ann Suico, Shunsuke Kotani, Yui Obata, Yuki Sakamoto, Yuri Seguchi, Junji Saruwatari, Tadashi Imafuku, Hiroshi Watanabe, Toru Maruyama, Hirofumi Kai, Tsuyoshi Shuto
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kazutoyo Terada, Michio Sato, Daisuke Torigoe, Jun Morinaga, Toshiro Moroishi, Yuichi Oike
Summary: Previous studies have shown that ANGPTL2 functions as a promoter in certain cancer contexts, but recent research indicates that it can also have a tumor suppressive role by enhancing immune responses. However, the mechanisms underlying ANGPTL2-mediated tumor suppression are complex and not well understood.
Article
Cardiac & Cardiovascular Systems
Hirotaka Fukami, Jun Morinaga, Yusuke Okadome, Yoshihiko Nishiguchi, Yasunobu Iwata, Tomoko Kanki, Terumasa Nakagawa, Yuichiro Izumi, Yutaka Kakizoe, Takashige Kuwabara, Haruki Horiguchi, Michio Sato, Tsuyoshi Kadomatsu, Keishi Miyata, Tetsuya Tajiri, Yuichi Oike, Masashi Mukoyama
Article
Gastroenterology & Hepatology
Shuichi Aoki, Koetsu Inoue, Sebastian Klein, Stefan Halvorsen, Jiang Chen, Aya Matsui, Mohammad R. Nikmaneshi, Shuji Kitahara, Tai Hato, Xianfeng Chen, Kazumichi Kawakubo, Hadi T. Nia, Ivy Chen, Daniel H. Schanne, Emilie Mamessier, Kohei Shigeta, Hiroto Kikuchi, Rakesh R. Ramjiawan, Tyge C. E. Schmidt, Masaaki Iwasaki, Thomas Yau, Theodore S. Hong, Alexander Quaas, Patrick S. Plum, Simona Dima, Irinel Popescu, Nabeel Bardeesy, Lance L. Munn, Mitesh J. Borad, Slim Sassi, Rakesh K. Jain, Andrew X. Zhu, Dan G. Duda
Summary: Elevated levels of placental growth factor (PIGF) in human ICC stromal cells and circulating blood plasma were associated with disease progression. Inhibition of PIGF led to reduction in intratumorous hypoxia and metastatic dissemination, enhanced chemotherapy sensitivity, and increased survival in mice-bearing aggressive ICC.
Article
Multidisciplinary Sciences
Michio Sato, Tsuyoshi Kadomatsu, Keishi Miyata, Junco S. Warren, Zhe Tian, Shunshun Zhu, Haruki Horiguchi, Aman Makaju, Anna Bakhtina, Jun Morinaga, Taichi Sugizaki, Kaname Hirashima, Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, Yoshihiro Komohara, Tomohiko Wakayama, Shinichi Nakagawa, Sarah Franklin, Koichi Node, Kimi Araki, Yuichi Oike
Summary: The cytoplasmic lncRNA Caren decreases translation of a distant gene encoding Hint1, maintaining cardiomyocyte function and protecting cardiac function under pathological stress by inactivating the DNA damage response and activating mitochondrial bioenergetics.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Tai Hato, Hiroaki Kashimada, Masatoshi Yamaguchi, Ato Sugiyama, Yoshiaki Inoue, Kohei Aoki, Hiroki Fukuda, Masatoshi Gika, Jun Kikuchi, Takashi Fujino, Takehiko Yamaguchi, Jun-Ichi Tamaru, Mitsutomo Kohno, Mitsuo Nakayama
Summary: Desmoplastic fibroblastoma, a benign tumor, is rare in the mediastinum with most cases found in the limbs, neck, or trunk. Early surgical resection is suitable for diagnosis and treatment planning in this extremely rare disease.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike
Summary: Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis by upregulating OB-cadherin expression and blocking destruction complex-independent proteasomal degradation of beta-catenin proteins. It also leads to decreased cell surface integrin alpha 5 beta 1 expression.
Article
Surgery
Tai Hato, Masatoshi Yamaguchi, Ato Sugiyama, Kohei Aoki, Hiroki Fukuda, Mitsutomo Kohno, Mitsuo Nakayama
Summary: We report a rare case of postoperative cerebral infarction caused by aplastic/twig-like middle cerebral artery. The patient experienced extensive bleeding during surgery and developed pneumonia postoperatively. He exhibited writing difficulties and was found to have cerebral infiltration in the left middle cerebral artery region. Magnetic resonance angiography revealed an aplastic/twig-like middle cerebral artery.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Biology
Yoshitaka Murakami, Fan-Yan Wei, Yoshimi Kawamura, Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kyoko Miura, Yuichi Oike, Yukio Ando, Mitsuharu Ueda, Kazuhito Tomizawa, Takeshi Chujo
Summary: A study found that a mitochondrial tRNA modification enzyme, NSUN3, is crucial for embryonic development in mice. Whole-body knockout leads to embryonic death, while heart-specific knockout causes heart aberration in older mice. The research highlights the importance of mitochondrial tRNA anticodon modification for mammalian embryonic development and demonstrates that the loss of a single mitochondrial tRNA modification can induce tissue aberration that worsens with age.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Kazutoyo Terada, Michio Sato, Jun Morinaga, Keishi Miyata, Yuichi Oike
Summary: This study investigates the role of Angiopoietin-like protein 2 (ANGPTL2) in ICI-related autoimmune myocarditis and demonstrates its immunostimulatory function in promoting T cell recruitment. These findings provide insight into the mechanisms regulating irAEs and highlight the importance of cardiac myofibroblast/immune cell crosstalk in enhancing autoimmune responses.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Michio Sato, Keishi Miyata, Tsuyoshi Kadomatsu, Koichi Node, Yuichi Oike
Article
Cell Biology
Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Takashige Kuwabara, Keishi Miyata, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike
Summary: This study developed a peptide vaccine targeting ANGPTL3, with the E3 peptide significantly reducing dyslipidemia in obese mice and attenuating atherosclerosis in a severe familial hypercholesterolemia model mice. Vaccination with ANGPTL3 could be an effective therapeutic strategy against dyslipidemia and associated diseases.
CELL REPORTS MEDICINE
(2021)
Meeting Abstract
Oncology
Meenal Datta, Kohei Shigeta, Tai Hato, Shuji Kitihara, Ivy X. Chen, Aya Matsui, Hiroto Kikuchi Emilie Mamessier, Shuichi Aoki, Rakesh R. Ramjiawan, Hiroki Ochiai, Nabeel Bardeesy, Peigen Huang, Rakesh K. Jain, Mark Cobbold, Andrew X. Zhu, Dan G. Duda
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Oncology
Kohei Shigeta, Aya Matsui, Hiroto Kikuchi, Sebastian Klein, Emilie Mamessier, Ivy X. Chen, Shuichi Aoki, Shuji Kitahara, Koetsu Inoue, Ayako Shigeta, Tai Hato, Rakesh R. Ramjiawan, Daniel Staiculescu, Dieter Zopf, Lukas Fiebig, Gabriela S. Hobbs, Alexander Quaas, Simona Dima, Irinel Popescu, Peigen Huang, Lance L. Munn, Mark Cobbold, Lipika Goyal, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)