Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Food Science & Technology
Min Gun Kim, Sojin Kim, Kyung-Hwan Boo, Jae-Hoon Kim, Chang Sook Kim
Summary: This study investigated the anti-inflammatory effects of immature Citrus unshiu fruit extract, finding that the ethyl acetate fraction showed the highest inhibition of NO production and pro-inflammatory cytokine production. Additionally, it inhibited the expression of inflammation-related proteins and the activity of NF-kappa B and MAPK signaling pathways. Furthermore, three major anti-inflammatory components, beta-sitosterol, campesterol, and isoferulic acid, were identified in the ethyl acetate fraction.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Seoyun Yum, Minghao Li, Yan Fang, Zhijian J. Chen
Summary: This study shows that STING can function independently of type I interferons and autophagy, and that TBK1 recruitment to STING is essential for antiviral and antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Vinicius Wanatable Nakao, Caio Henrique Yokowama Mazucanti, Larissa de Sa Lima, Paloma Segura de Mello, Natacha Medeiros de Souza Port's, Paula Fernanda Kinoshita, Jacqueline Alves Leite, Elisa Mitiko Kawamoto, Cristoforo Scavone
Summary: Alpha-Klotho is an anti-aging protein that has anti-inflammatory and protective effects on renal cells and in the central nervous system. It shows potential in inhibiting neuroinflammation and improving neuronal health.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Julia Busch, Rita Moreno, Laureano de la Vega, Vera Vivian Saul, Susanne Bacher, Felix von Zweydorf, Marius Ueffing, Axel Weber, Christian Johannes Gloeckner, Uwe Linne, Michael Kracht, Michael Lienhard Schmitz
Summary: Phosphorylation of TRAF6 by IKKε plays a crucial role in regulating its degradation, signaling networks and linking metabolic and inflammatory processes, which has implications for cancer research.
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Immunology
Kaihe Xiang, Peng Shen, Ziyang Gao, Zhuoyu Liu, Xiaoyu Hu, Bin Liu, Yunhe Fu
Summary: Formononetin (FOR), a natural flavonoid, has been shown to have anti-inflammatory and anti-oxidative effects. This study investigated the protective mechanism of FOR against LPS-induced mastitis and found that it inhibits inflammation and enhances blood-milk barrier integrity through the AhR-induced Src inactivation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Lisa-Marie Wackernagel, Mohsen Abdi Sarabi, Sonke Weinert, Werner Zuschratter, Karin Richter, Klaus Dieter Fischer, Ruediger C. Braun-Dullaeus, Senad Medunjanin
Summary: The NF-κB pathway plays a central role in inflammatory and immune responses, and the activation of NF-κB is dependent on IKK gamma/NEMO. This study reveals that GSK-3 beta phosphorylates NEMO, leading to its localization into multivesicular bodies (MVBs) and endosomes. The AAA-ATPase Vps4A is identified as a key player in NEMO stability and NF-κB activation, interacting directly with phosphorylated NEMO. Manipulation of Vps4A expression results in changes in NEMO expression and NF-κB activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Weiwei Zhu, Wu Luo, Jibo Han, Qiuyan Zhang, Lijun Ji, Aleksandr V. Samorodov, Valentin N. Pavlov, Zaishou Zhuang, Daona Yang, Lina Yin, Lijiang Huang, Guang Liang, Joo Young Huh, Yi Wang
Summary: This study investigated the anti-inflammatory mechanism of Schisandrin B (Sch B) in macrophages and an animal model of acute lung injury (ALI) and found that Sch B directly binds to MyD88 to regulate inflammatory responses and inhibit the expression of inflammatory factors. The study suggests that Sch B has therapeutic potential for ALI and other MyD88-dependent inflammatory diseases.
Article
Biochemistry & Molecular Biology
Shu Yang, Jianhong Wang, Duozi Wang, Lei Guo, Dalin Yu
Summary: Ramelteon ameliorates LPS-induced inflammatory responses in astrocytes by reducing expressions of inflammatory cytokines and inhibiting the TLR4/I kappa B alpha/NF-kappa B p65 axis, suggesting its potential as a protective agent against LPS-induced damage in astrocytes.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, Chao-Hsiung Lin
Summary: Galgravin has anti-inflammatory effects, it can suppress NF-kappa B activation and reduce the expression of proinflammatory molecules, suggesting its potential application in inflammation diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Robert Naclerio, Ignacio J. Ansotegui, Jean Bousquet, G. Walter Canonica, Gennaro D'Amato, Nelson Rosario, Ruby Pawankar, David Peden, Karl-Christian Bergmann, Leonard Bielory, Luis Caraballo, Lorenzo Cecchi, S. Alfonso M. Cepeda, Herberto Jose Chong Neto, Carmen Galan, Sandra N. Gonzalez Diaz, Samar Idriss, Todor Popov, German D. Ramon, Erminia Ridolo, Menachem Rottem, Wisuwat Songnuan, Philip Rouadi
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Review
Allergy
Michael Levin, Ignacio J. Ansotegui, Jonathan Bernstein, Yoon-Seok Chang, Manana Chikhladze, Motohiro Ebisawa, Alessandro Fiocchi, Enrico Heffler, Bryan Martin, Mario Morais-Almeida, Nikolaos G. Papadopoulos, David Peden, Gary W. K. Wong
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Review
Allergy
Mario Morais-Almeida, Rita Aguiar, Bryan Martin, Ignacio J. Ansotegui, Motohiro Ebisawa, L. Karla Arruda, Marco Caminati, Giorgio Walter Canonica, Tara Carr, Geoffrey Chupp, Jonathan Corren, Ignacio Davila, Hae-Sim Park, Nicola A. Hanania, Lanny Rosenwasser, Mario Sanchez-Borges, J. Christian Virchow, Anahi Yanez, Jonathan A. Bernstein, Luis Caraballo, Yoon-Seok Chang, Manana Chikhladze, Alessandro Fiocchi, Sandra N. Gonzalez-Diaz, Luciana Kase Tanno, Michael Levin, Jose Antonio Ortega-Martell, Giovanni Passalacqua, David B. Peden, Philip W. Rouadi, James L. Sublett, Gary W. K. Wong, Eugene R. Bleecker
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Letter
Toxicology
Allison J. Burbank, Michelle L. Hernandez, Carole Robinette, Ting Wang, Haibo Zhou, Neil Alexis, William D. Bennett, David B. Peden
INHALATION TOXICOLOGY
(2020)
Article
Microbiology
Amir Barzin, John L. Schmitz, Samuel Rosin, Rameet Sirpal, Martha Almond, Carole Robinette, Samantha Wells, Michael Hudgens, Andrew Olshan, Stephanie Deen, Patrick Krejci, Eugenia Quackenbush, Kevin Chronowski, Caleb Cornaby, Janette Goins, Linda Butler, Julia Aucoin, Kim Boyer, Janet Faulk, Devena Alston-Johnson, Cristen Page, Yijun Zhou, Lynne Fiscus, Blossom Damania, Dirk P. Dittmer, David B. Peden
Review
Allergy
Philip W. Rouadi, Samar A. Idriss, Robert M. Naclerio, David B. Peden, Ignacio J. Ansotegui, Giorgio Walter Canonica, Sandra Nora Gonzalez-Diaz, Nelson A. Rosario Filho, Juan Carlos Ivancevich, Peter W. Hellings, Margarita Murrieta-Aguttes, Fares H. Zaitoun, Carla Irani, Marilyn R. Karam, Jean Bousquet
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Letter
Critical Care Medicine
Michelle L. Hernandez, Sally Ivins, Kelly Chason, Allison J. Burbank, Meghan E. Rebuli, Aaron Kobernick, Stephen A. Schworer, Haibo Zhou, Neil E. Alexis, David B. Peden
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Allergy
Nelson Augusto Rosario Filho, Marilyn Urrutia-Pereira, Gennaro D'Amato, Lorenzo Cecchi, Ignacio J. Ansotegui, Carmen Galan, Anna Pomes, Margarita Murrieta-Aguttes, Luis Caraballo, Philip Rouadi, Isabella Annesi-Maesano, Ruby Pawankar, Herberto J. Chong-Neto, David B. Peden
Summary: Indoor environments significantly contribute to human exposure to air pollutants, especially affecting the health of children and adults. Education, community, and health professional involvement can help reduce household pollutants and promote health.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Luciana Kase Tanno, Pascal Demoly, Bryan Martin, Jonathan Berstein, Mario Morais-Almeida, Michael Levin, Alessandro Fiocchi, Mario Sanchez-Borges, Luis R. Caraballo, Gary Wong, Jose Antonio Ortega-Martell, Philip Rouadi, Anahi Yanez, Liang Lu Wang, David B. Peden, Manana Chikhladze, Sandra N. Gonzalez-Diaz, Jean-Francois Fontainet, James Sublett, Yoon-Seok Chang, Giovanni Passalacqua, Ignacio J. Ansotegui, Motohiro Ebisawa, Gianenrico Senna, Marco Caminati
Summary: The COVID-19 outbreak posed unprecedented challenges to the world, prompting the allergy societies to produce guidance documents. An international survey revealed that managing allergic patients during the pandemic does not increase the risk of contracting COVID-19. This data can serve as a starting point for feedback on recommendations and new strategies for healthcare professionals.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Editorial Material
Respiratory System
Isabella Annesi-Maesano, Francesco Forastiere, John Balmes, Erika Garcia, Jack Harkema, Stephen Holgate, Frank Kelly, Haneen Khreis, Barbara Hoffmann, Cara Nichole Maesano, Rob McConnell, David Peden, Kent Pinkerton, Tamara Schikowski, George Thurston, Laura S. Van Winkle, Christopher Carlsten
EUROPEAN RESPIRATORY JOURNAL
(2021)
Editorial Material
Allergy
David B. Peden
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Computer Science, Information Systems
Ridwan Alam, David B. Peden, John C. Lach
Summary: This study explores inferring respiratory parameters from wearable ECG and wrist motion signals and proposes a modular and generalizable classification-regression pipeline to learn context-conditioned inference models, including physical activity. Evaluations on data from 15 subjects highlight the potential of wearable sensors not only in continuous monitoring, but also in designing biomarker-driven preventive measures.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Qing Jiang, Suji Im, James G. Wagner, Michelle L. Hernandez, David B. Peden
Summary: Studies have shown that gamma T has unique antioxidant and anti-inflammatory activities compared to alpha T, providing superior protection for mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Health Care Sciences & Services
Karamarie Fecho, Stanley C. Ahalt, Stephen Appold, Saravanan Arunachalam, Emily Pfaff, Lisa Stillwell, Alejandro Valencia, Hao Xu, David B. Peden
Summary: This study demonstrates the use of the open-source ICEES as a tool for exposing and exploring integrated clinical and environmental data. The results show significant associations between factors such as proximity to major roadways or highways, exposure to high levels of particulate matter or ozone, female sex, Caucasian race, low residential density, lack of health insurance, low household income, and asthma exacerbations.
JMIR FORMATIVE RESEARCH
(2022)
Article
Respiratory System
William D. Bennett, Allison Burbank, Martha Almond, Jihong Wu, Agathe Ceppe, Michelle Hernandez, Richard C. Boucher, David B. Peden
Summary: The study showed that inhaling 7% hypertonic saline can acutely enhance mucociliary clearance in asthmatic patients, but this effect is not sustained 4 hours post-treatment. While not supporting maintenance therapy, these findings suggest a benefit for treating acute exacerbations in patients with moderate-severe asthma.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)