Review
Oncology
Hyun Jung Kim, Jung Won Park, Jeong Ho Lee
Summary: This study explores the pathogenesis and cell-of-origin of glioblastoma (GBM). It is suggested that GBM may originate from somatic mutations in neural stem cells and glial precursor cells. Further research will aid in understanding the evolution of GBMs and developing effective targets for treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yuli Hu, Yang V. Li
Summary: Environmental changes can induce stress-induced cellular reprogramming, as evidenced by the expression of pluripotent stem cell markers following brief strong acid treatment. This phenomenon resulted in faster cell growth and shorter doubling time, along with sensitivity to metal ion chelation. The findings suggest that somatic cells have the potential to express pluripotent markers under stressful conditions, providing new insights into cellular survival mechanisms.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Ayyoob Khosravi, Seyyed Mehdi Jafari, Jahanbakhsh Asadi
Summary: The study revealed that TAZ plays a significant role in esophageal cancer stem cells, with its knockdown leading to decreased stemness properties as well as reduced migration and colony formation abilities in esophageal CSCs.
Article
Biochemistry & Molecular Biology
Yandong Zhang, Zheping Cai, Guanglei Hu, Songhui Hu, Yafei Wang, Na Li, Saiyong Chen, Qiong Liu, Lanhui Zeng, Tianxiang Tang, Yilan Zhang, Lei Xiao, Yu Gu, Yunli Xie
Summary: Tcf4 regulates neuronal positioning, with its deficiency leading to clustering of neurons. By controlling the expression of cell adhesion molecules, Tcf4 plays a role in neuronal positioning. Mutations in TCF4 result in disrupted neuronal functions, and are associated with schizophrenia and Pitt-Hopkins syndrome.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Flavia R. Oliveira, Maira Casalechi, Marcia M. Carneiro, Ivete de Avila, Cynthia Dela Cruz, Helen L. Del Puerto, Aroldo F. Camargos, Mauricio S. Abrao, Fernando M. Reis
Summary: The study found that Oct-4, C-kit and Musashi-1 are widely expressed in normal and endometriosis patients' endometrium, as well as in endometriotic lesions. However, these markers are not suitable for the characterization of endometrial SPCs.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Kee-Pyo Kim, Dong Wook Han, Johnny Kim, Hans R. Schoeler
Summary: The ectopic expression of Oct4, Sox2, Klf4 and c-Myc can reprogram somatic cells into induced pluripotent stem cells (iPSCs), with Oct4 not always being necessary for reprogramming. Different Oct family members and species display varying reprogramming capacities, indicating a complex mechanism for reprogramming. Epigenomes of donor cells can affect the reprogramming competence of Oct proteins.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biology
Alexander J. Tarashansky, Jacob M. Musser, Margarita Khariton, Pengyang Li, Detlev Arendt, Stephen R. Quake, Bo Wang
Summary: SAMap is a new method that can map cell atlas manifolds across species within phyla, identifying homologous cell types with shared expression programs, even in complex examples where homologous tissues emerge from distinct germ layers.
Article
Toxicology
Yahang Lin, Min He, Xiaoyun Zeng, Xia Sheng, Siyi Wang, Fengzhen Cui
Summary: This study investigated the effects of a benzophenone metabolite, 4-hydroxybenzophenone (4HBP), on hippocampal neural stem cells (NSCs), and found that treatment with 4HBP inhibited the growth and viability of NSCs. The study also identified the chemokine Cxcl1 as playing a crucial role in mediating these effects.
TOXICOLOGY IN VITRO
(2022)
Review
Biochemistry & Molecular Biology
Hyun Kyu Kim, Tae Won Ha, Man Ryul Lee
Summary: Cells are the basic units of organisms, with over 30 trillion cells generated from a single-cell fertilized egg through division and differentiation. Establishing the Human Cell Atlas aims to understand the mechanisms underlying diseases and cellular activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Divyambika Catakapatri Venugopal, Cynthia Leslie Caleb, Nandhini Priyadarshini Kirupakaran, Vidyarani Shyamsundar, Soundharya Ravindran, Madhavan Yasasve, Arvind Krishnamurthy, Thamizhchelvan Harikrishnan, Sathasivasubramanian Sankarapandian, Vijayalakshmi Ramshankar
Summary: Oral submucous fibrosis (OSMF) is a highly prevalent disease in South East Asia, particularly in the Indian subcontinent, with a higher risk of malignant transformation. This study investigated the expression of OCT 3/4 and SOX 2, two cancer stem cell markers, in OSMF and oral squamous cell carcinoma (OSCC) patients. The results showed a significant correlation between the expression of OCT 3/4 and SOX 2 and the presence of OSCC and OSMF, suggesting their potential as biomarkers for disease prognosis in OSMF.
Article
Genetics & Heredity
Ali Maisam Afzali, Lasse Stueve, Monika Pfaller, Lilian Aly, Katja Steiger, Benjamin Knier, Thomas Korn
Summary: AQP4 plays a critical role in neuroinflammation, and lack of AQP4 in the retina leads to sustained retinal thickening, hyperperfusion, albumin extravasation, and upregulation of GFAP. Furthermore, retinal ganglion cell loss is more severe in the absence of AQP4.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Oncology
Esha Madan, Antonio M. Palma, Vignesh Vudatha, Jose G. Trevino, Kedar Nath Natarajan, Robert A. Winn, Kyoung Jae Won, Trevor A. Graham, Ronny Drapkin, Stuart A. C. McDonald, Paul B. Fisher, Rajan Gogna
Summary: The majority of human cancers evolve through the accumulation of somatic mutations and clonal selection. The mechanisms governing clonal dynamics and selection during the early stages of tissue transformation are still unclear. Cell competition, known as "survival of the fittest" at the cellular level, can eliminate less fit cells or lead to the uncontrolled expansion of super-fit cancer cells. Recent research has highlighted the role of interclonal competition and cancer microenvironment competition in tumor progression.
Editorial Material
Cell Biology
Sebastian Memczak, Juan Carlos Izpisua Belmonte
Summary: A rapid chemical protocol for cellular reprogramming uncovers a state similar to diapause, retrovirus activation, and obstacles in cell fate transitions towards pluripotency. The system provides valuable insights into manipulating cellular regeneration and rejuvenation, showing promising therapeutic potential.
NATURE CELL BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Ta-Chin Lin, Kai-Hung Wang, Kuo-Hsiang Chuang, An-Pei Kao, Tsung-Cheng Kuo
Summary: Research has shown that tumor-initiating tumor stem cells are derived from normal stem cells through de-differentiation. These tumor cells possess high proliferation ability, plasticity, expression of multi-drug resistance proteins, and the ability to seed new tumors. This study aimed to investigate the characteristics of a stably transfected cell line, RL95-2/Oct-4, with Oct-4 gene.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2023)
Article
Plant Sciences
Yeo Jin Lee, Jae Kwang Kim, Seung-A Baek, Ji-Su Yu, Min Kyoung You, Sun-Hwa Ha
Summary: The OsIspH1 gene plays a crucial role in plastid terpenoid biosynthesis in rice plants, controlling the synthesis of chlorophylls and carotenoids. OsIspH1 is highly expressed in all tissues at different developmental stages, while another gene, OsIspH2, is barely expressed. The complementary relations of two residues are important for enzyme activity.
FRONTIERS IN PLANT SCIENCE
(2022)
Letter
Psychiatry
Hiroki Shiwaku, Hidekazu Masaki, Daisuke Yasugi, Kenji Narushima
AMERICAN JOURNAL OF PSYCHIATRY
(2015)
Article
Medicine, Research & Experimental
H. Shiwaku, H. Okazawa
CURRENT MOLECULAR MEDICINE
(2015)
Article
Multidisciplinary Sciences
Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa, Marius Sudol, Hitoshi Okazawa
NATURE COMMUNICATIONS
(2017)
Letter
Neurosciences
Hiroki Shiwaku, Yukio Kimura, Kenji Narushima, Hiroshi Matsuda, Toru Nishikawa
BIOLOGICAL PSYCHIATRY
(2018)
Letter
Pharmacology & Pharmacy
Hiroki Shiwaku, Toru Nishikawa
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
H. Ito, H. Shiwaku, C. Yoshida, H. Homma, H. Luo, X. Chen, K. Fujita, L. Musante, U. Fischer, S. G. M. Frints, C. Romano, Y. Ikeuchi, T. Shimamura, S. Imoto, S. Miyano, S-i Muramatsu, T. Kawauchi, M. Hoshino, M. Sudol, A. Arumughan, E. E. Wanker, T. Rich, C. Schwartz, F. Matsuzaki, A. Bonni, V. M. Kalscheuer, H. Okazawa
MOLECULAR PSYCHIATRY
(2015)
Letter
Psychiatry
Hiroki Shiwaku, Yuri Nakano, Maiko Kato, Hidehiko Takahashi
SCHIZOPHRENIA RESEARCH
(2020)
Article
Medicine, General & Internal
Hiroki Shiwaku, Masako Fujita, Hidehiko Takahashi
JOURNAL OF CLINICAL MEDICINE
(2020)
Letter
Clinical Neurology
Hiroki Shiwaku, Satomi Doi, Miho Miyajima, Yukiko Matsumoto, Junya Fujino, Nobuhide Hirai, Daisuke Jitoku, Shunsuke Takagi, Takehiro Tamura, Takashi Maruo, Yuki Shidei, Nanase Kobayashi, Masanori Ichihashi, Shiori Noguchi, Kanako Oohashi, Takashi Takeuchi, Genichi Sugihara, Takayuki Okada, Takeo Fujiwara, Hidehiko Takahashi
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Psychiatry
Yukiko Matsumoto, Junya Fujino, Hiroki Shiwaku, Miho Miyajima, Satomi Doi, Nobuhide Hirai, Daisuke Jitoku, Shunsuke Takagi, Takehiro Tamura, Takashi Maruo, Yuki Shidei, Nanase Kobayashi, Masanori Ichihashi, Shiori Noguchi, Kanako Oohashi, Takashi Takeuchi, Genichi Sugihara, Takayuki Okada, Takeo Fujiwara, Hidehiko Takahashi
Summary: Older age and female sex were common risk factors for anxiety, depression, and social stress among hospital workers. Occupational exposure to COVID-19 and being hospital staff other than doctors/fewer non-work days were risk factors for increased anxiety and depression, respectively. Living with families/others was a risk factor for increased social stress during this pandemic.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Letter
Immunology
Shingo Katayama, Tetsuo Kubota, Hidehiko Takahashi, Hiroki Shiwaku
AUTOIMMUNITY REVIEWS
(2022)
Article
Biology
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian J. F. Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akalsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Summary: The early-stage mechanisms of neuronal necrosis in VCPT262A-KI mice with FTLD have been discovered, and potential rescue through in utero gene therapy has been suggested. YAP-dependent necrosis was also found in neurons of FTLD patients, with pSer46-MARCKS as a specific marker for this process.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazawa
Summary: This study reveals that microglial PQBP1 plays a crucial role in sensing extrinsic Tau proteins and triggering an innate immune response through the cGAS-STING pathway, leading to cognitive impairment.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Hiroki Shiwaku, Shingo Katayama, Kanoh Kondo, Yuri Nakano, Hikari Tanaka, Yuki Yoshioka, Kyota Fujita, Haruna Tamaki, Hironao Takebayashi, Omi Terasaki, Yukihiro Nagase, Teruyoshi Nagase, Tetsuo Kubota, Kinya Ishikawa, Hitoshi Okazawa, Hidehiko Takahashi
Summary: This study found that autoantibodies against neural cell adhesion molecule (NCAM1) may be a potential mechanism underlying schizophrenia and could serve as a therapeutic target and biomarker.
CELL REPORTS MEDICINE
(2022)
Article
Neurosciences
Hiroki Shiwaku, Asami Umino, Masakazu Umino, Toru Nishikawa
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)