Article
Biology
Rungroch Sungthong, Hnin Ei Ei Khine, Somruethai Sumkhemthong, Pithi Chanvorachote, Rossarin Tansawat, Chatchai Chaotham
Summary: This study found that prolonging the anchorage-free lifetime of non-small-cell lung cancer cells enhances their resistance to anoikis, promotes cell migration, and triggers metabolic reprogramming. Metabolomics analysis revealed significant changes in the levels of several metabolites associated with anoikis resistance. These findings provide insights into the mechanisms of anoikis resistance in lung cancer cells and offer potential biomarkers for early diagnosis.
BIOLOGICAL RESEARCH
(2023)
Article
Biology
Kelvin W. Pond, Julia M. Morris, Olga Alkhimenok, Reeba P. Varghese, Carly R. Cabel, Nathan A. Ellis, Jayati Chakrabarti, Yana Zavros, Juanita L. Merchant, Curtis A. Thorne, Andrew L. Paek
Summary: The establishment and maintenance of different cellular compartments in tissues is crucial for all metazoans, especially in the human colon. This study reveals the critical role of wave-like ERK signaling induced by apoptotic cells in maintaining tissue patterning and homeostasis.
Article
Multidisciplinary Sciences
Johanna Wagner, Markus Masek, Andrea Jacobs, Charlotte Soneson, Sujana Sivapatham, Nicolas Damond, Natalie de Souza, Mark D. Robinson, Bernd Bodenmiller
Summary: In this study, the EMT transition phenotypes in four non-cancerous human mammary epithelial cell lines were comprehensively profiled and compared to breast cancer cell lines. The results revealed a spectrum of EMT transition phenotypes in each cell line. These findings contribute to a better understanding of the complexity of EMT and provide valuable insights for the design of EMT time course experiments.
Review
Biochemistry & Molecular Biology
Han Yeoung Lee, Seung Wan Son, Sokviseth Moeng, Soo Young Choi, Jong Kook Park
Summary: Cancer metastasis is a complex process involving cancer cells acquiring the abilities of anoikis resistance and anchorage-independent cell growth. Noncoding RNAs play a crucial role in regulating cellular events and pathways, contributing to cancer aggressiveness. Researchers are exploring the potential of ncRNA-based therapy for more effective strategies against cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lingyan Chen, Dejian Chen, Jiwei Li, Lipeng He, Ting Chen, Dandan Song, Shuang Shan, Jiaxin Wang, Xiaoang Lu, Bin Lu
Summary: Ciclopirox (CPX), an antifungal drug, has shown promising potential as a treatment for gastric cancer (GC). It inhibits GC growth through suppressing proliferation and stimulating autophagic cell death. Mechanistically, CPX regulates the phosphorylation of STAT3 at Tyr705 and Ser727 residues to regulate cell growth and autophagic cell death.
CELL DEATH & DISEASE
(2022)
Article
Microbiology
Ying Xie, Andrea Chupina Estrada, Becca Nelson, Hanping Feng, Charalabos Pothoulakis, Laurent Chesnel, Hon Wai Koon
Summary: ADS024, a Bacillus velezensis strain, can prevent intestinal injury and toxin-induced apoptosis. The sterile filtrate and ethyl acetate extract of ADS024 can protect against toxin-mediated mucosal epithelial injury and apoptosis by inhibiting caspase 3 cleavage.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaoyang Liu, Sandhya Chipurupalli, Peijia Jiang, Mahtab Tavasoli, Byong Hoon Yoo, Michael McPhee, Sina Mazinani, Giulio Francia, Robert S. Kerbel, Kirill Rosen
Summary: We discovered a novel mechanism of ErbB2-driven 3D breast tumor growth mediated by ErbB2-dependent BLNK downregulation. In addition, we found that upregulating BLNK can inhibit tumor growth, and increased mRNA levels of BLNK are associated with increased relapse-free survival.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Xiangyu Wang, Xuejun Ge, Wang Liao, Yong Cao, Ran Li, Fang Zhang, Bin Zhao, Jie Du
Summary: The study reveals that under inflammatory conditions, the interaction between ZFP36 and VDR mRNA AU elements leads to mRNA degradation, while the binding of VDR with YBX-1 can prevent YBX-1 nuclear translocation and promote cell survival.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Fan Zhang, Qianqian Li, Yaqin Zhang, Na Li, Mengjiao Rao, Shi Li, Zhiying Ai, Siyuan Yan, Zhichao Tian
Summary: COPS3 is a key component of the COP9 signalosome complex and is closely related to multiple cancers. It promotes cell proliferation, progression, and metastasis in various cancer cells. This study found that COPS3 is highly expressed in osteosarcoma and its overexpression enhances cell proliferation, viability, migration, and invasion. Knockdown of COPS3 further enhances the cytotoxicity of oxaliplatin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Ling-Yen Chiu, I-Lun Hsin, Jen-Ning Tsai, Chih-Jung Chen, Chu-Chyn Ou, Wen-Jun Wu, Gwo-Tarng Sheu, Jiunn-Liang Ko
Summary: The combination treatment of Saracatinib and GMI showed synergistic and additive cytotoxic effects on A549 and A400 cells, inducing caspase-7 activation in A549 cells. The study suggests a novel strategy for treating lung cancer, with or without drug resistance, using a combination of GMI and Saracatinib.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Dandan Wang, Letian Zhang, Ajin Hu, Yuxiang Wang, Yan Liu, Jing Yang, Ningning Du, Xiuli An, Congying Wu, Congrong Liu
Summary: The loss of 4.1N is associated with progression and poor survival in EOC patients, inducing EMT, anoikis resistance, and entosis-induced cell death resistance. Therapeutic approaches targeting 4.1N, 14-3-3 antagonists, and entosis inhibitors show promise in inhibiting tumor spread in EOC.
Article
Biochemistry & Molecular Biology
Ying Zhou, Rishun Fu, Mei Yang, Weihuang Liu, Zan Tong
Summary: Lycopene, a natural carotenoid, inhibits the growth and induces apoptosis in gastric cancer cells. It decreases CCNE1 expression and increases the levels of TP53, making it a potential target therapy reagent for gastric cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Cell Biology
Yalan Dai, Xinyi Zhang, Yingjun Ou, Linglin Zou, Duoli Zhang, Qingfan Yang, Yi Qin, Xiuju Du, Wei Li, Zhanpeng Yuan, Zhangang Xiao, Qinglian Wen
Summary: Breast cancer has the highest global incidence among all tumor types and metastasis is a critical cause of poor prognosis. Anoikis, a form of apoptosis induced by cell detachment from the native environment, is a crucial process in tumor metastasis. Understanding the mechanisms of anoikis resistance can inform strategies for preventing and regressing metastatic breast cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Medicine, General & Internal
Chao Li, Wei Wang, Shuai-shuai Xie, Wen-xian Ma, Qian-wen Fan, Ying Chen, Yuan He, Jia-nan Wang, Qin Yang, Hai-di Li, Juan Jin, Ming-ming Liu, Xiao-ming Meng, Jia-gen Wen
Summary: Sepsis-induced acute kidney injury (AKI) is a severe complication that involves multiple types of cells such as macrophages, ECs, and TECs, with programmed cell death playing a significant role. Mitochondrial dysfunction and oxidative stress are traditionally considered as the main triggers, while recent research highlights the involvement of autophagy, mitochondria quality control, and epigenetic modification in the process of programmed cell death.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Rene Roth, Ekaterina Safroneeva, Catherine Saner Zilian, Philipp Schreiner, Jean-Benoit Rossel, Matthias Bopp, Thomas Greuter, Michael Scharl, Valerie Pittet, Gerhard Rogler, Alain Schoepfer, Alex Straumann, Luc Biedermann
Summary: The study found that a significantly higher proportion of eosinophilic esophagitis patients had a high level of education compared to patients with inflammatory bowel disease and the Swiss general population.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Medicine, General & Internal
Brian G. Feagan, Silvio Danese, Edward V. Loftus, Severine Vermeire, Stefan Schreiber, Timothy Ritter, Ronald Fogel, Rajiv Mehta, Sandeep Nijhawan, Radoslaw Kempinski, Rafal Filip, Ihor Hospodarskyy, Ursula Seidler, Frank Seibold, Ian L. P. Beales, Hyo Jong Kim, John McNally, Chohee Yun, Sally Zhao, Xiaopeng Liu, Chia-Hsiang Hsueh, Chantal Tasset, Robin Besuyen, Mamoru Watanabe, William J. Sandborn, Gerhard Rogler, Toshifumi Hibi, Laurent Peyrin-Biroulet
Summary: The study assessed the efficacy and safety of filgotinib in treating ulcerative colitis, with the results showing that 200 mg of filgotinib was more effective than placebo in inducing and maintaining clinical remission.
Article
Biochemistry & Molecular Biology
Cheryl de Valliere, Jesus Cosin-Roger, Katharina Baebler, Anja Schoepflin, Celine Mamie, Michelle Mollet, Cordelia Schuler, Susan Bengs, Silvia Lang, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Martin Hausmann, Gerhard Rogler
Summary: This study investigated the expression and signaling of OGR1 in patients with inflammatory bowel disease (IBD), and found its association with the pathogenesis of IBD. The results showed increased OGR1 expression in IBD patients compared to non-IBD patients, and increased OGR1-dependent signaling in IBD patients. This suggests an active role of OGR1 in IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
S. F. Schoch, J. L. Castro-Mejia, L. Krych, B. Leng, W. Kot, M. Kohler, R. Huber, G. Rogler, L. Biedermann, J. C. Walser, D. S. Nielsen, S. Kurth
Summary: This study reveals the interrelationship between sleep habits, gut microbiota, and the maturation of brain and behavior during infancy. The findings suggest that adequate sleep and age-appropriate gut microbiota in infancy may promote health across the lifespan.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marlene Schwarzfischer, Gerhard Rogler
Summary: Nano- and microparticles are present in human diet, but their impact on human health is not fully understood. This review focuses on the effects of titanium dioxide (TiO2) and plastic particles ingested through food on epithelial integrity, gut homeostasis, and intestinal inflammation, which are currently hot topics of research attracting public attention.
Article
Cell Biology
Emilie Gueguen, Yasser Morsy, Michael Scharl, Stefanie D. Kraemer, Michael Zaugg, Martin Hersberger, Gerhard Rogler, Marcin Wawrzyniak
Summary: Lipid emulsions are crucial for total parenteral nutrition. However, high concentrations of certain lipid emulsions can impair the barrier function of endothelial cells, leading to side effects.
Article
Gastroenterology & Hepatology
Silvio Danese, Marc Ferrante, Brian G. Feagan, Laurent Peyrin-Biroulet, Toshifumi Hibi, William J. Sandborn, Stefan Schreiber, Timothy Ritter, Edward V. Loftus, Gerhard Rogler, Alessandra Oortwijn, Chohee Yun, Franck-Olivier Le Brun, Jason Dinoso, Jeremy Hsieh, Severine Vermeire
Summary: This study evaluated the efficacy and sustainability of filgotinib in treating moderately to severely active ulcerative colitis (UC) patients using the Mayo Clinic Score (pMCS) and patient-reported subscores. The results showed that treatment with filgotinib improved UC symptoms within 7 days and a higher proportion of patients achieved clinical remission at weeks 10 and 58.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leonie Perren, Moana Busch, Cordelia Schuler, Pedro A. Ruiz, Federica Foti, Nathalie Weibel, Cheryl de Valliere, Yasser Morsy, Klaus Seuwen, Martin Hausmann, Gerhard Rogler
Summary: G-protein-coupled receptors OGR1 and TDAG8 play opposite roles in inflammatory bowel disease, with OGR1 deficiency reducing inflammation severity and TDAG8 deficiency increasing inflammation. These findings suggest the potential importance of OGR1 and TDAG8 as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
S. Kurth, S. Schoch, J. Castro-Mejia, L. Krych, B. Leng, W. Kot, M. Kohler, R. Huber, G. Rogler, L. Biedermann, J-C Walser, D. Nielsen
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
S. Schoch, J. L. Castro-Meija, L. Krych, W. Kot, B. Leng, M. Kohler, R. Huber, G. Rogler, L. Biedermann, J. -C. Walser, D. Nielsen, S. Kurth
Meeting Abstract
Gastroenterology & Hepatology
M. Martinho-Grueber, I. Kapoglou, F. Bravo, R. Sarraj, E. Benz, S. Restellini, L. Biedermann, G. Rogler, S. R. Vavricka, A. Schoepfer, M. Maillard, P. Michetti, F. Brunner, C. Clair, M. P. Barry, R. Von Kaenel, P. Juillerat
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
S. Vavricka, J. Zeitz, M. Madanchi, L. Biedermann, Y. Morsy, M. Scharl, M. Gassmann, T. Lutz, A. Kunz, D. Bron, G. Rogler, T. Greuter
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Alexander R. Siebenhuner, Jean-Benoit Rossel, Philipp Schreiner, Matthias Butter, Thomas Greuter, Niklas Krupka, Sebastian B. U. Jordi, Luc Biedermann, Gerhard Rogler, Benjamin Misselwitz, Roland von Kanel
Summary: The study found that anti-tumor necrosis factor and immunomodulator therapies can significantly improve anxiety and depressive symptoms in patients with inflammatory bowel diseases, with benefits for disease activity as well.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl, Isabelle Frey-Wagner
Summary: The study found that in Crohn's disease patients, carrying the major alleles of NLRP3 polymorphisms was associated with a less severe disease course, while in ulcerative colitis patients, homozygous genotype for the major alleles of these polymorphisms may indicate a more severe disease activity.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Sebastian Bruno Ulrich Jordi, Federica Botte, Brian Matthew Lang, Thomas Greuter, Niklas Krupka, Bianca Auschra, Philipp Schreiner, Michael Christian Sulz, Luc Biedermann, Roland von Kaenel, Gerhard Rogler, Stefan Begre, Benjamin Misselwitz
Summary: Among Swiss IBD cohort patients, 29.5% had Type D personality, which was comparable to its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)