Article
Biochemistry & Molecular Biology
Der-Yuan Chen, Chih-Chen Tzang, Chuan-Ming Liu, Tsu-Man Chiu, Jhen-Wei Lin, Pei-Hua Chuang, Chia-Wei Kuo, Bor-Show Tzang, Tsai-Ching Hsu
Summary: This study investigates the impacts of B19V-VP1u in macrophages and BLE-induced SSc mice. The results show that B19V-VP1u treatment decreases viability and migration of macrophages, while celastrol exerts an inhibitory effect. Additionally, B19V-VP1u exacerbates skin fibrosis in SSc mice, leading to increased expressions of inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Kuo-Chuan Hung, Zi-Yun Huang, Jia Le Yow, Tsai-Ching Hsu, Bor-Show Tzang
Summary: The study demonstrated that the N-terminal region (residues 1-129) of B19V-VP1u induces an increase in cardiac injury markers, providing insights into the potential functional regions within B19V-VP1u.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Zhaoxi Liu, Kun Li, Xiaoyu Liu, Jiayu Zhao, Yue Yu, Lushan Wang, Yun Kong, Min Chen
Summary: N-glycosylation is an important post-translational modification of proteins. A cytoplasmic soluble N-glycosyltransferase (NGT) in bacteria can transfer different sugars to proteins, leading to heterogeneity and complexity of glycopeptides. A mutant ApNGT-P1 with increased substrate specificity was obtained, which can be used for efficient production of glycosylated peptides or proteins with uniform glucose at glycosylation sites. This study also provides a feasible pathway for further research on improving donor substrate selectivity of NGTs.
ENZYME AND MICROBIAL TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Kattareeya Kumthip, Pattara Khamrin, Hiroshi Ushijima, Niwat Maneekarn
Summary: Human bocavirus is recognized as an important pathogen causing respiratory infection and acute gastroenteritis in young children worldwide and has been detected in various environmental samples. This study found evidence of HBoV in oysters in Thailand, emphasizing the need for further monitoring of the potential food- and waterborne transmission of this virus.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Sumanta Saha, Nicolette Fozzard, Stephen B. Lambert, Robert S. Ware, Keith Grimwood
Summary: This study investigated the characteristics of human bocavirus-1 (HBoV1) infection in young Australian children. The incidence of HBoV1 infections increased with age, during winter, and with childcare attendance in infants younger than 2 years old. Symptoms were usually mild and associated with higher viral loads.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Virology
Fang-Fei You, Min-Yi Zhang, Fei Wu, Qiu-Shuang Li, Qing Chen
Summary: The study found human bocavirus (HBoV) in Rattus norvegicus captured in China, indicating that R. norvegicus may be a carrier of HBoV. Phylogenetic analysis revealed that the virus is closely related to HBoV-2, which is of significant importance for public health.
ARCHIVES OF VIROLOGY
(2022)
Article
Endocrinology & Metabolism
Bhavani S. Sahu, Maria Razzoli, Seth McGonigle, Jean Pierre Pallais, Megin E. Nguyen, Masato Sadahiro, Cheng Jiang, Wei-Jye Lin, Kevin A. Kelley, Pedro Rodriguez, Rachel Mansk, Cheryl Cero, Giada Caviola, Paola Palanza, Loredana Rao, Megan Beetch, Emilyn Alejandro, Yuk Y. Sham, Andrea Frontini, Stephen R. Salton, Alessandro Bartolomucci
Summary: This study developed a mouse model with selective knockout of TLQP-21 neuropeptide and provided multiple independent validations. The DTLQP-21 mice showed no gross behavioral and metabolic abnormalities but exhibited a unique metabolic phenotype characterized by temperature-dependent resistance to diet-induced obesity and activation of brown adipose tissue. This research is important for understanding the necessary role of TLQP-21 in physiology and disease, as well as testing novel antibodies or immunoassays targeting TLQP-21.
MOLECULAR METABOLISM
(2023)
Article
Microbiology
Kattareeya Kumthip, Pattara Khamrin, Arpaporn Yodmeeklin, Hiroshi Ushijima, Niwat Maneekarn
Summary: This study reported the detection of multiple HBoV genotypes in environmental waters in Thailand, with all four genotypes closely related to those detected in patients with acute gastroenteritis in the same geographical area. These findings demonstrate a considerable contamination of HBoV in environmental waters, indicating the potential risk of waterborne transmission.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Carlos A. H. Fernandes, Dania Zuniga, Charline Fagnen, Valerie Kugler, Rosa Scala, Gerard Pehau-Arnaudet, Renaud Wagner, David Perahia, Said Bendahhou, Catherine Venien-Bryan
Summary: This study revealed the unique structural features of human Kir2.1 channels, as well as the connection between the G-loop and gating, shedding light on the pathological mechanisms associated with this channel.
Article
Multidisciplinary Sciences
Renhong Yan, Pingping Cao, Wenqi Song, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan
Summary: The sterol regulatory element-binding protein (SREBP) pathway is controlled by membrane-embedded sterol sensors Scap, Insig-1 and Insig-2, with 25-hydroxycholesterol (25HC) serving as a master switch. Cryo-electron microscopy analysis revealed the structure of the human Scap and Insig-2 complex in the presence of 25HC, showing the critical role of 25HC binding and Insig association in regulating the pathway.
Article
Biochemistry & Molecular Biology
Han Li, Jiachen Zang, Xiaoyu Xia, Zhenyu Wang, Li-Shu Wang, Hesham R. EI-Seedi, Xianbing Xu, Guanghua Zhao, Ming Du
Summary: In this study, it is found that oyster ferritin (GF1) with its high catalytic activity and high binding ability of Fe2+ can effectively convert toxic Fe2+ into non-toxic Fe3+, reducing the occurrence of Fenton reaction and inhibiting the formation of harmful reactive oxygen species (ROS). This advantage is attributed to the presence of Asp at the 120th position in GF1, which increases the negatively charged area of the channels and enhances its oxidation rate and ability.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Infectious Diseases
David Polo, Alberto Lema, Enia Gandara, Jesus L. Romalde
Summary: Through a systematic review and meta-analysis of 35 studies in Europe, it was found that HBoV has a moderate prevalence among European countries, with no significant differences in prevalence by country. The study also analyzed the prevalence of HBoV as a single infection or co-infection with other viruses.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Multidisciplinary Sciences
Agata M. Rudolf, Qi Wu, Li Li, Jun Wang, Yi Huang, Jacques Togo, Christopher Liechti, Min Li, Chaoqun Niu, Yonggang Nie, Fuwen Wei, John R. Speakman
Summary: This study demonstrates the profound effects of a single-nucleotide mutation in a key endocrine-related gene on the metabolic phenotype, including changes in body size, energy expenditure, organ sizes, and gut microbiota, in both giant pandas and mice. The findings have significant implications for ecology and evolution.
NATIONAL SCIENCE REVIEW
(2022)
Article
Dermatology
Janan Mohamad, Ofer Sarig, Paula Beattie, Kiril Malovitski, Sari Assaf, Edel O'Toole, Janice Schwartz, Holly Evans, Liat Samuelov, Eli Sprecher
Summary: This study reports on a novel clinical phenotype resulting from germline mosaicism for a large genomic deletion spanning six keratin genes. The genomic variant leads to a truncated form of keratin 17, which disrupts keratinocyte cell cytoskeleton formation in vitro.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Sang-Ho Choi, Jin Won Huh, Sang-Bum Hong, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Heungsup Sung, Eun Jin Chae, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Yang Soo Kim, Jun Hee Woo, Younsuck Koh
Summary: In Seoul, South Korea, severe human bocavirus-associated pneumonia cases were reported in adults, with a mortality rate of 54.5%. Higher death rates were observed in cases of co-infection (83.3%) and immunocompromise (80.0%).
EMERGING INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Jingwei Shui, Wenpei Liu, Yuanhao Liang, Jian Zhang, Zhengwei Wan, Haiying Wang, Xiaowang Qu, Shixing Tang
JOURNAL OF GENERAL VIROLOGY
(2019)
Article
Gastroenterology & Hepatology
Bo Wen, Jian Zhang, Wenpei Liu, Ping Tang, Ting Xie, Liyan Huang, Yabin Hu, Kun Jin, Ping Zhang, Ziyan Liu, Ling Niu, Xiaowang Qu
JOURNAL OF VIRAL HEPATITIS
(2019)
Article
Multidisciplinary Sciences
Jian Zhang, Wenpei Liu, Bo Wen, Ting Xie, Ping Tang, Yabin Hu, Liyan Huang, Kun Jin, Ping Zhang, Ziyan Liu, Ling Niu, Xiaowang Qu
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Jian Zhang, Wenpei Liu, Ting Xie, Liyan Huang, Yabin Hu, Bo Wen, Ping Tang, Fengfan Guo, Kun Jin, Ping Zhang, Ling Niu, Ziyan Liu, Xiaowang Qu
IMMUNOLOGY LETTERS
(2019)
Article
Gastroenterology & Hepatology
Xiao-Ben Pan, Jian Yu, Hong-Juan Li, Nan Wu, Guo-Wei Zhang, Tian Wu, Jun-Yi Liao, Wen-Pei Liu, Xiao-Wang Qu, Ping Si, Wen-Yuan Shi, Sheng-Tao Li, Xin Lv, Ping Liu, Rui Zhao, Yu-Jing Song, Zheng Yang, Wu-Ning Mo, Hong-Zhi Wang, Yun-Feng Liu, Zhen-Wen Zhou, Li-Yan Ge, Hong Zhu, Yu-Qiang Zheng, Wen-Li Zhang, Zhi-Li Yang, Xiao-Qun Zheng
JOURNAL OF VIRAL HEPATITIS
(2020)
Article
Microbiology
Jian Zhang, Qian Wu, Ziyan Liu, Qijie Wang, Jiajing Wu, Yabin Hu, Tingting Bai, Ting Xie, Mincheng Huang, Tiantian Wu, Danhong Peng, Weijin Huang, Kun Jin, Ling Niu, Wangyuan Guo, Dixian Luo, Dongzhu Lei, Zhijian Wu, Guicheng Li, Renbin Huang, Yingbiao Lin, Xiangping Xie, Shuangyan He, Yunfan Deng, Jianghua Liu, Weilang Li, Zhongyi Lu, Haifu Chen, Ting Zeng, Qingting Luo, Yi-Ping Li, Youchun Wang, Wenpei Liu, Xiaowang Qu
Summary: COVID-19 is caused by SARS-CoV-2, and the majority of convalescent individuals maintain neutralizing antibodies against SARS-CoV-2. Those who experienced severe COVID-19 had higher levels of neutralizing antibodies, a faster increase in lymphocyte counts, and a higher frequency of CXCR3(+) T-follicular help cells.
NATURE MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qianqian Li, Jianhui Nie, Jiajing Wu, Li Zhang, Ruxia Ding, Haixin Wang, Yue Zhang, Tao Li, Shuo Liu, Mengyi Zhang, Chenyan Zhao, Huan Liu, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Junkai Liu, Haoyu Liang, Yi Shi, Yuelei Shen, Liangzhi Xie, Linqi Zhang, Xiaowang Qu, Wenbo Xu, Weijin Huang, Youchun Wang
Summary: The 501Y.V2 variants of SARS-CoV-2 with multiple mutations are rapidly spreading from South Africa to other countries, showing reduced susceptibility to neutralizing antibodies and potential compromise of monoclonal antibodies and vaccines. Enhanced infectivity in murine ACE2-overexpressing cells suggests the possibility of transmission to mice.
Article
Immunology
Jiajing Wu, Li Zhang, Yue Zhang, Haixin Wang, Ruxia Ding, Jianhui Nie, Qianqian Li, Shuo Liu, Yongxin Yu, Xiaoming Yang, Kai Duan, Xiaowang Qu, Youchun Wang, Weijin Huang
Summary: In this study, convalescent sera, inactivated virus vaccine-elicited sera, mRNA vaccine-elicited sera were found to still possess neutralizing capability against the top five epidemic SARS-CoV-2 variants in the UK, while different types of vaccines showed varying responses in neutralizing antibody levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Tao Li, Zhimin Cui, Yunfei Jia, Ziteng Liang, Jianhui Nie, Li Zhang, Meng Wang, Qianqian Li, Jiajing Wu, Nan Xu, Shuo Liu, Xueli Li, Yimeng An, Pu Han, Mengyi Zhang, Yuhua Li, Xiaowang Qu, Qihui Wang, Weijin Huang, Youchun Wang
Summary: This study investigates the impact of high-frequency amino acid changes in SARS-CoV-2 variants on infectivity and antigenicity. The aggregation of multiple receptor-binding domain (RBD) mutations reduces infectivity, while there is no significant antigenic drift. These findings are important for vaccine development strategies.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Meiyu Wang, Li Zhang, Qianqian Li, Bo Wang, Ziteng Liang, Yeqing Sun, Jianhui Nie, Jiajing Wu, Xiaodong Su, Xiaowang Qu, Yuhua Li, Youchun Wang, Weijin Huang
Summary: The Lambda variant of SARS-CoV-2, mainly found in South America, contains mutations that affect its infectivity and antigenicity. This study shows that the Lambda variant has enhanced infectivity in certain cell lines and reduced sensitivity to neutralizing monoclonal antibodies and sera from convalescent or vaccinated individuals.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Youchun Wang, Li Zhang, Qianqian Li, Ziteng Liang, Tao Li, Shuo Liu, Qianqian Cui, Jianhui Nie, Qian Wu, Xiaowang Qu, Weijin Huang
Summary: The Omicron variant shows greater potential for immune escape compared to other variants, suggesting a significant impact on immunity from previous infections and vaccines.
EMERGING MICROBES & INFECTIONS
(2022)
Letter
Virology
Jun Chen, Jing Yang, Fangfang Chang, Yabin Hu, Qian Wu, Shishan Teng, Yongchen Liu, Jian Zhang, Rongzhang He, Bo Liu, Xingyu Zheng, Ze Liu, Yanxi Peng, Zhenhua Xie, Yuanfang Zhang, Rui Lu, Dong Pan, You Wang, Liting Peng, Wenpei Liu, Yi-Ping Li, Xiaowang Qu
Article
Biochemistry & Molecular Biology
Jiajing Wu, Jianhui Nie, Li Zhang, Hao Song, Yimeng An, Ziteng Liang, Jing Yang, Ruxia Ding, Shuo Liu, Qianqian Li, Tao Li, Zhimin Cui, Mengyi Zhang, Peng He, Youchun Wang, Xiaowang Qu, Zhongyu Hu, Qihui Wang, Weijin Huang
Summary: The study found that the antigenicity changes of the current SARS-CoV-2 variants were mostly within four folds, while the antigenicity changes among different H3N2 flu vaccine strains were approximately 10-100-fold.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
