Article
Plant Sciences
Daniela M. L. de Andrade, Mikaelle C. Correia, Matheus G. de Oliveira, Eder S. A. Santos, Bruno J. Neves, Jose R. de Paula, Matheus L. Rocha
Summary: Hydroalcoholic extract of Hydrocotyle umbellata L. induces relaxation of arterial vessels, possibly by blocking calcium influx.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesco Nappi, Antonio Fiore, Joyce Masiglat, Teresa Cavuoti, Michela Romandini, Pierluigi Nappi, Sanjeet Singh Avtaar Singh, Jean-Paul Couetil
Summary: The endothelium plays a crucial role in regulating vascular tone by releasing vasodilatory mediators. Reactive oxygen species have deleterious effects on the endothelium, especially in obese and elderly individuals. Shear stress-induced endothelial nitric oxide may delay the development of atherosclerosis. Perivascular adipose tissue contributes to reparative measures against atherosclerosis, but can become pathological in obese subjects. These factors may serve as potential targets for future pharmaceutical agents.
Review
Biochemistry & Molecular Biology
Oguzhan Yildiz, Kemal Gokhan Ulusoy
Summary: This review summarizes the role of taurine in vascular tone and blood pressure modulation. Taurine supplementation prevents hypertension and reduces blood pressure in hypertensive patients. The mechanisms underlying taurine's vascular effects are still largely unknown.
Article
Endocrinology & Metabolism
Farnaz Shamsi, Mary Piper, Li-Lun Ho, Tian Lian Huang, Anushka Gupta, Aaron Streets, Matthew D. Lynes, Yu-Hua Tseng
Summary: Vascular smooth muscle cells expressing Trpv1 are identified as previously unrecognized thermogenic adipocyte progenitors, playing a role in the expansion and differentiation of highly thermogenic adipocytes in response to cold stimuli.
Article
Biochemistry & Molecular Biology
Chihiro Sakai, Mei Mikawa, Takeshi Yamamoto, Tomoyuki Uchida, Yoshihide Nakamura, Hideaki Akase, Takeshi Suetomi, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Takayuki Okamura, Shigeki Kobayashi, Masafumi Yano
Summary: This study investigated the inhibitory effect of Dantrolene on smooth muscle cell proliferation and migration, and found that Dantrolene effectively suppressed vascular smooth muscle cell proliferation, migration, and neointimal formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ge Liu, Mizuki Kaneko, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Summary: In this study, the effects of platelet-activating factor (PAF) on the contractile activities of guinea pig and mouse urinary bladder smooth muscle tissues were investigated. The results showed that PAF can enhance the basal tone and spontaneous contractile activities of the smooth muscle tissues through its receptor. The mRNA expression of PAF-synthesizing and -degrading enzymes was also detected in the urinary bladder tissues. These findings suggest that PAF plays a role in regulating the contractility of the urinary bladder smooth muscle and may contribute to detrusor overactivity.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Shohei Koyama, Atsushi Yamashita, Yunosuke Matsuura, Yusuke Saito, Kazunari Maekawa, Toshihiro Gi, Kazuo Kitamura, Yujiro Asada
Summary: This study showed that EES implantation can reduce neointima formation, SMC infiltration, and TF expression. Moreover, everolimus can increase intracellular levels of amino acid metabolites and reduce procoagulant activity. The findings suggest that intracellular glutamine levels may play a crucial role in determining vascular SMC-related thrombogenicity.
Article
Cell Biology
Zhenzhen Chen, Chenxi Ouyang, Haizeng Zhang, Yuanrui Gu, Yue Deng, Congkuo Du, Changting Cui, Shuangyue Li, Wenjie Wang, Wei Kong, Jingzhou Chen, Jun Cai, Bin Geng
Summary: Vascular smooth muscle cells (VSMCs) contribute to plaque stability, and their endogenous CTH-H2S is involved in the pathogenesis of plaque stability through activation of TFEB, increasing autophagy, promoting collagen secretion, and inhibiting apoptosis.
Article
Endocrinology & Metabolism
Yefei Pang, Peter Thomas
Summary: The rapid effects of progesterone on cytosolic Ca2+ levels and relaxation of VSMCs through mPRα involve regulation of the functions of SERCA2 and PLB through Gi, MAP kinase, and Akt signaling pathways and downregulation of RhoA activity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Michael G. Stencel, Mark VerMeer, Jennifer Giles, Quang-Kim Tran
Summary: Calmodulin (CaM) is a crucial protein for multiple functions of vascular smooth muscle cells (VSMCs) and its expression and interactions with target proteins in VSMCs can be regulated by endothelial cells (ECs). In this study, it was discovered that proliferating ECs can upregulate total CaM expression and enhance Ca2+-bound CaM levels in VSMCs co-cultured with ECs. This endothelium-dependent upregulation of CaM in VSMCs is mediated by vascular endothelial growth factor receptors. These findings reveal a new role of ECs in regulating vascular functions through upregulating CaM and its interactions in VSMCs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Claudia Rodriguez, Mercedes Munoz, Cristina Contreras, Dolores Prieto
Summary: AMPK serves as a crucial cellular energy sensor activated during energy stress, playing a key role in maintaining energy homeostasis. It is involved in various functions such as mitochondrial biogenesis, redox regulation, cell growth, autophagy, and inflammation. Recent studies have highlighted the protective role of AMPK in cardiovascular function and its association with cardiovascular disease pathogenesis.
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Adrian Sowka, Pawel Dobrzyn
Summary: Adipose tissue serves as both an energy-storing tissue and an endocrine organ due to its secretion of adipose-specific factors called adipokines. Among these, adiponectin is a well-known adipokine with metabolic, anti-inflammatory, and antidiabetic properties. Perivascular adipose tissue (PVAT) acts on the vascular wall through adipokine secretion and adiponectin can affect the vascular wall through endothelial cells and vascular smooth muscle cells. Studies have suggested that adiponectin and its receptors may be potential therapeutic targets.
Review
Neurosciences
Osama F. Harraz, Lars Jorn Jensen
Summary: Changes in cellular Ca2+ levels due to vascular ageing can significantly impact vascular function, blood pressure regulation and cardiovascular diseases. Ageing may cause abnormal Ca2+ signalling in SMCs and ECs, leading to dysregulation of vascular tone and blood flow distribution, thereby increasing the risk of cardiovascular diseases. Research on specific ageing-related Ca2+ signalling deficits is crucial to combat accelerated vascular ageing and its associated health risks in an ageing population.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cell Biology
Jan Klimas, Michael Olvedy, Katarina Ochodnicka-Mackovicova, Peter Kruzliak, Sona Cacanyiova, Frantisek Kristek, Peter Krenek, Peter Ochodnicky
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2015)
Meeting Abstract
Peripheral Vascular Disease
A. Berenyiova, M. Drobna, F. Kristek, I. Dovinova, M. Kvandova, S. Cacanyiova
JOURNAL OF HYPERTENSION
(2016)
Meeting Abstract
Peripheral Vascular Disease
S. Cacanyiova, A. Berenyiova, F. Kristek, M. Drobna
JOURNAL OF HYPERTENSION
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
I. Dovinova, E. Hrabarova, E. Jansen, M. Majzunova, M. Kvandova, S. Cacanyiova
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Cell Biology
Andrea Berenyiova, Ima Dovinova, Miroslava Kvandova, Frantisek Kristek, Eugene Jansen, Miroslava Majzunova, Sona Cacanyiova
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Biochemistry & Molecular Biology
Peter Balis, Andrea Berenyiova, Anton Misak, Marian Grman, Zuzana Rostakova, Iveta Waczulikova, Sona Cacanyiova, Enrique Dominguez-Alvarez, Karol Ondrias
Summary: Phthalic selenoanhydride, when dissolved in physiological buffer, releases various reactive selenium species including H2Se. It is a potential compound for selenium supplementation and exerts various biological effects, although its effect on the cardiovascular system is still unknown. This study aimed to investigate the effects of R-Se on rat hemodynamic parameters and vasoactive properties in isolated arteries, and the results suggest that R-Se acts on vascular smooth muscle cells, which may explain its effects on rat hemodynamic parameters.
Article
Physiology
A. Berenyiova, M. Drobna, M. Cebova, F. Kristek, S. Cacanyiova
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2018)
Article
Physiology
S. Cacanyiova, A. Berenyiova, P. Balis, F. Kristek, M. Grman, K. Ondrias, J. Breza, J. Breza
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2017)
Article
Physiology
F. Kristek, M. Drobna, S. Cacanyiova
PHYSIOLOGICAL RESEARCH
(2017)
Article
Cell Biology
Miroslava Majzunova, Zuzana Pakanova, Peter Kvasnicka, Peter Balis, Sona Cacanyiova, Ima Dovinova
JOURNAL OF BIOMEDICAL SCIENCE
(2017)
Meeting Abstract
Physiology
A. Berenyioya, A. Puzserova, M. Grman, F. Kristek, S. Cacanyiova
Meeting Abstract
Physiology
F. Kristek, M. Drobna, S. Cacanyiova
Article
Physiology
S. Cacanyiova, A. Berenyiova, F. Kristek, M. Drobna, K. Ondrias, M. Grman
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2016)
Review
Physiology
S. Cacanyiova, A. Berenyiova, F. Kristek
PHYSIOLOGICAL RESEARCH
(2016)
Article
Physiology
M. Drobna, A. Misak, T. Holland, F. Kristek, M. Grman, L. Tomasova, A. Berenyiova, S. Cacanyiova, K. Ondrias
PHYSIOLOGICAL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)