Article
Agriculture, Dairy & Animal Science
Sae-Young Won, Yong-Chan Kim, Kyoungtag Do, Byung-Hoon Jeong
Summary: Prion disease is a fatal infectious disease caused by the accumulation of PrPSc in several mammals, but has not been reported in horses. This study investigated the genetic characteristics of the equine SPRN gene and found four SNPs with different distributions among three horse breeds. Notably, there were no non-synonymous SNPs in the equine SPRN gene, which are commonly found in prion disease-susceptible animals.
Article
Microbiology
Juan Carlos Espinosa, Olivier Andreoletti, Alba Marin-Moreno, Severine Lugan, Patricia Aguilar-Calvo, Herve Cassard, Patricia Lorenzo, Jean-Yves Douet, Ana Villa-Diaz, Naima Aron, Irene Prieto, Alvina Huor, Juan Maria Torres
Summary: This study shows that interference with prion propagation in a host expressing two different prion protein genes is related to the transmissibility of the prion in the host expressing only the interfering prion protein. The interference detected occurs in a prion strain-dependent manner and favors the propagation of the murine PrP allele. These findings suggest that host-specific factors may play a role in interfering with prion propagation in addition to the PrP amino acid sequence.
Review
Clinical Neurology
Gavin Langlands, Jan Mackenzie, Cat Graham, Neil Watson, Anna Molesworth, David Summers, Alison Green, Colin Smith, Suvankar Pal
Summary: Approximately 3% of sCJD cases in the UK are non-White, despite non-Whites representing approximately 10% of the UK population. Non-White cases tend to be younger and have a lower likelihood of undergoing autopsy. The reasons for these differences in non-White populations are unclear and warrant further evaluation.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Neil Watson, Jack Kirby, Hatice Kurudzhu, Margaret Leitch, Janet MacKenzie, Blaire Smith-Bathgate, Colin Smith, David Summers, Alison J. E. Green, Suvankar Pal
Summary: The COVID-19 pandemic has had some impact on UK CJD surveillance, but it has not affected case ascertainment or survival. However, there have been disruptions in diagnostic evaluation and clinical care.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Aaron Jesuthasan, Danielle Sequeira, Harpreet Hyare, Hans Odd, Peter Rudge, Tze How Mok, Akin Nihat, John Collinge, Simon Mead
Summary: This study reviewed the reporting sensitivity of MRI scans for sporadic Creutzfeldt-Jakob disease (sCJD) cases a decade later. While there has been improvement in local MRI reporting, characteristic abnormalities are still significantly under-detected on initial scans. Sensitivity is higher when the cerebral cortex and multiple regions are involved.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Sigrid Klotz, Theresa Konig, Marcus Erdler, Andreas Ulram, Anita Nguyen, Thomas Strobel, Alexander Zimprich, Elisabeth Stogmann, Gunther Regelsberger, Romana Hoftberger, Herbert Budka, Gabor G. Kovacs, Ellen Gelpi
Summary: This study presents a rare case of a patient with both C9orf72 expansion mutation-related frontotemporal lobe degeneration and sporadic Creutzfeldt-Jakob disease. The neuropathology exhibited multiple protein aggregates along with a high degree of Alzheimer-related pathology. Further studies are needed to investigate a potential link between these two neurodegenerative pathologies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Microbiology
Alicia Otero, Tomas Barrio, Hasier Erana, Jorge M. Charco, Marina Betancor, Carlos M. Diaz-Dominguez, Belen Marin, Olivier Andreoletti, Juan M. Torres, Qingzhong Kong, Juan J. Badiola, Rosa Bolea, Joaquin Castilla
Summary: In this study, the effect of glycosylation on the characteristics of BSE isolates was assessed using a non-glycosylated human PrPC-expressing mouse model. The findings showed that BSE prions could be propagated in a non-glycosylated human PrPC environment without losing their strain properties. BSE prions transmitted to the transgenic mouse model exhibited neuropathological and biochemical signs compatible with BSE, confirming that the glycosylation of human PrPC is not essential for the propagation of this particular prion strain.
Article
Neurosciences
Jean-Yves Douet, Alvina Huor, Herve Cassard, Severine Lugan, Naima Aron, Chloe Mesic, Didier Vilette, Tomas Barrio, Nathalie Streichenberger, Armand Perret-Liaudet, Marie-Bernadette Delisle, Patrice Peran, Jean-Philippe Deslys, Emmanuel Comoy, Jean-Luc Vilotte, Katayoun Goudarzi, Vincent Beringue, Marcelo A. Barria, Diane L. Ritchie, James W. Ironside, Olivier Andreoletti
Summary: The treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt-Jakob disease (iCJD) cases, with France and the UK experiencing the largest numbers. Differences in PRNP codon 129 polymorphisms and estimated incubation periods did not lead to significant differences in the prion strains identified in hGH-iCJD cases from the two countries.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Simone Baiardi, Marcello Rossi, Angela Mammana, Brian S. Appleby, Marcelo A. Barria, Ignazio Cali, Pierluigi Gambetti, Ellen Gelpi, Armin Giese, Bernardino Ghetti, Jochen Herms, Anna Ladogana, Jacqueline Mikol, Suvankar Pal, Diane L. Ritchie, Viktoria Ruf, Otto Windl, Sabina Capellari, Piero Parchi
Summary: The current classification of sporadic Creutzfeldt-Jakob disease (sCJD) includes six major clinicopathological subtypes based on the physicochemical properties of the protease-resistant core of the pathologic prion protein (PrPSc), defining two major PrPSc types (1 and 2), and the codon 129 genotype on the prion protein gene (PRNP). The research analyzed 208 individuals affected by genetic CJD (gCJD), identifying six major groups based on the combination of PrPSc type and codon 129 genotype on PRNP mutated allele. The phenotypic variability of gCJD is mostly consistent with that previously found in sCJD.
ACTA NEUROPATHOLOGICA
(2021)
Article
Veterinary Sciences
Eric D. Cassmann, Alexis J. Frese, Kelsey A. Becker, Justin J. Greenlee
Summary: The study found that the E211K genotype of H-BSE in cattle has a shorter incubation period in both homozygous and heterozygous forms, and the type of inoculum does not significantly affect the incubation period.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Microbiology
Christine Fast, Catherine Graham, Martin Kaatz, Kristina Santiago-Mateo, Tammy Kaatz, Kendra MacPherson, Anne Balkema-Buschmann, Ute Ziegler, Martin H. Groschup, Stefanie Czub
Summary: The study aimed to identify type-specific PrPSc profiles in different forms of BSE using Immunohistochemistry. Brain samples from 21 cattle infected with C-, H-, and L-type BSE were analyzed, along with samples from orally C-type BSE infected animals. The immunohistochemical analysis revealed distinct PrPSc profiles for different BSE types, providing new insights into the pathogenesis of BSE.
Review
Biochemistry & Molecular Biology
Monika Olech
Summary: Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease caused by abnormally folded prion protein (PrPSc). It primarily affects cattle, but can also infect sheep and goats. Discriminatory testing is required to differentiate BSE from scrapie, as well as differentiate classical BSE from atypical strains. Various methods have been developed for BSE detection, including identification of characteristic lesions and detection of PrPSc in the brain. This paper aims to summarize these methods, evaluate their diagnostic performance, and highlight their advantages and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ahamad Hassan, Tracy Campbell, Lee Darwent, Hans Odd, Alison Green, John Collinge, Simon Mead
Summary: Inherited prion diseases are rare autosomal dominant disorders caused by mutations in the PRNP gene. A Chinese patient with a rapidly progressive cognitive and motor disorder was found to carry a homozygous PRNP E200D mutation, suggesting a likely causal role in the development of CJD. This case is compatible with recessively inherited prion disease.
Article
Biochemistry & Molecular Biology
Sae-Young Won, Yong-Chan Kim, Byung-Hoon Jeong
Summary: The occurrence of PRNP K200 somatic mutation in the frontal cortex and hippocampus was significantly increased in sporadic CJD patients, and this mutation resulted in a change in the electrostatic potential of human PrP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Yong-Chan Kim, Sae-Young Won, Min-Ju Jeong, Byung-Hoon Jeong
Summary: This study conducted enhanced surveillance of prion disease-related factors in Korean cattle, did not find the E211K mutation in the PRNP gene, and found significantly different genotype, allele, and haplotype distributions among different cattle breeds. The enhanced surveillance system of BSE was carried out for the first time in Korean cattle.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Viviana Teresa Orlandi, Eleonora Martegani, Cristina Giaroni, Andreina Baj, Fabrizio Bolognese
Summary: Synthetic derivatives are widely used in various fields, but their chemical approach has drawbacks, making microorganisms and their pigments a promising alternative with huge potential for exploration and application.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
A. M. Poma, D. Bonuccelli, R. Giannini, E. Macerola, P. Vignali, C. Ugolini, L. Torregrossa, A. Proietti, M. Pistello, A. Basolo, F. Santini, A. Toniolo, F. Basolo
Summary: The study found that the SARS-CoV-2 virus can spread to endocrine organs in severe cases of COVID-19, with evidence of virus presence in abdominal subcutaneous adipose tissue, testes, and thyroid samples; Further research is needed to assess the occurrence rate of this phenomenon in clinically mild cases; Potential long-term effects of COVID-19 on endocrine functions should be taken into consideration.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Letter
Biophysics
Marco Salvini, Fabrizio Maggi, Camilla Damonte, Lorenzo Mortara, Antonino Bruno, Barbara Mora, Marco Brociner, Roberta Mattarucchi, Alessia Ingrassia, Davide Sirocchi, Benedetta Bianchi, Stefania Agnoli, Matteo Gallazzi, Michele Merli, Andrea Ferrario, Raffaella Bombelli, Daniela Barraco, Andreina Baj, Lorenza Bertu, Paolo A. Grossi, Francesco Passamonti
BONE MARROW TRANSPLANTATION
(2022)
Article
Biotechnology & Applied Microbiology
Md. Abdus Sobur, Md. Saiful Islam, Zobayda Farzana Haque, Ebiowei Samuel F. Orubu, Antonio Toniolo, Md. Abu Choudhury, Md. Tanvir Rahman
Summary: The study revealed the presence of Staphylococcus aureus and MRSA in house flies in hospital environments, with high levels of resistance and an increased occurrence with higher temperatures. Higher temperatures around hospitals significantly increased the occurrence of MRSA in house flies, posing potential risks to human and animal health.
FOLIA MICROBIOLOGICA
(2022)
Article
Multidisciplinary Sciences
F. Gianfagna, G. Veronesi, A. Baj, D. Dalla Gasperina, S. Siclari, F. Drago Ferrante, F. Maggi, L. Iacoviello, M. M. Ferrario
Summary: The immune response to the SARS-CoV-2 vaccine shows significant variation between individuals, even in those who have previously been infected with SARS-CoV-2. Individuals with prior infection have higher BMI and CRP levels, as well as lower neutrophil count compared to those without prior infection. Baseline levels of IgG are associated with CRP, independent of BMI and inflammatory diseases. Among vaccinated individuals, three patterns of antibody kinetics were observed, with the rapid growth pattern associated with higher baseline IgG levels, as well as higher CRP and MCHC levels. Those previously exposed to SARS-CoV-2 showed higher CRP levels, suggesting persistent unresolved inflammation. These CRP levels are the primary determinant of baseline IgG levels and characterize individuals with the most favorable post-vaccine antibody kinetics.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Federica Novazzi, Emanuela Giombini, Martina Rueca, Andreina Baj, Lavinia Fabeni, Angelo Genoni, Francesca Drago Ferrante, Giulia Gramigna, Cesare Ernesto Maria Gruber, Sara Boutahar, Claudia Minosse, Ornella Butera, Renee Pasciuta, Daniele Focosi, Alberto Colombo, Andrea Antinori, Enrico Girardi, Francesco Vaia, Fabrizio Maggi
Summary: With an increase in COVID-19 cases at the end of 2022 in China, some countries have started or expanded testing and genomic surveillance of travelers. Screening results in Italy in late December 2022 showed that 22.7% of flight passengers from two Chinese provinces tested positive for SARS-CoV-2. Whole genome sequencing revealed Omicron variants among the positive samples, consistent with data from China.
Article
Virology
Pietro Giorgio Spezia, Andreina Baj, Francesca Drago Ferrante, Sara Boutahar, Lorenzo Azzi, Angelo Genoni, Daniela Dalla Gasperina, Federica Novazzi, Francesco Dentali, Daniele Focosi, Fabrizio Maggi
Summary: The study found that TTV and ReDoV are commonly present in saliva samples, with similar average viral loads. Individuals infected with only one virus had lower viral loads compared to dually infected samples.
Article
Medicine, General & Internal
Lorenzo Azzi, Daniela Dalla Gasperina, Giovanni Veronesi, Mariam Shallak, Vittorio Maurino, Andreina Baj, Francesco Gianfagna, Pierpaolo Cavallo, Francesco Dentali, Lucia Tettamanti, Fabrizio Maggi, Lorenzo Stefano Maffioli, Angelo Tagliabue, Roberto Sergio Accolla, Greta Forlani
Summary: Limited studies have been conducted on the development of mucosal immune response after BNT162b2-booster vaccination. Serum and saliva samples were collected from 50 healthcare workers before and after the booster dose. The results showed that the booster dose elicited a stronger systemic immune response but failed to activate effective mucosal immunity against the Omicron BA.1 variant.
Review
Infectious Diseases
Chiara Morreale, Cristina Giaroni, Andreina Baj, Laura Folgori, Lucia Barcellini, Amraj Dhami, Massimo Agosti, Ilia Bresesti
Summary: Antibiotic therapy is crucial for treating bacterial infections, but its excessive use, especially during the perinatal period, can have long-lasting negative effects on human health. This includes the spread of antibiotic resistance and disruptions to the gut microbiota, which are detrimental to the health of infants. This review summarizes recent evidence on how antibiotic treatment influences the neonatal gut microbiota and discusses potential microbiome-based approaches for restoring a healthy microbiota in newborns.
Article
Genetics & Heredity
Anello Marcello Poma, Diana Bonuccelli, Elisabetta Macerola, Sara Niballi, Alessio Basolo, Ferruccio Santini, Fulvio Basolo, Antonio Toniolo
Summary: Altered gene expression in endocrine organs is observed in COVID-19, with enhanced interferon response and specific changes in endocrine-specific genes. Adipose tissue shows independent enhanced interferon response regardless of virus presence. Important genes such as insulin, thyroid-stimulating hormone receptor, and leptin are affected in COVID-19.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Infectious Diseases
Juan Ambrosioni, Marta Hernandez-Meneses, Emanuele Durante-Mangoni, Pierre Tattevin, Lars Olaison, Tomas Freiberger, John Hurley, Margaret M. Hannan, Vivian Chu, Bruno Hoen, Asuncion Moreno, Guillermo Cuervo, Jaume Llopis, Jose M. Miro
Summary: This study compared the epidemiological features and outcomes of infective endocarditis (IE) in different European regions and time periods in the 21st century. The results showed that despite an increase in the complexity of IE cases, prognosis has improved in recent years with a significant decrease in 6-month mortality. The source of infection differed between regions, but the outcomes were not different.
INFECTIOUS DISEASES AND THERAPY
(2023)
Editorial Material
Endocrinology & Metabolism
Antonio Toniolo
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Therese Weider, Angelo Genoni, Francesco Broccolo, Trond H. Paulsen, Knut Dahl-Jorgensen, Antonio Toniolo, Sara Salehi Hammerstad
Summary: This study found a high prevalence of common viruses in thyroid tissue, with enteroviruses, human herpesvirus 6, and parvovirus B19 being the most common. The significance of these detected viruses as causal agents, possible cofactors, or bystanders remains to be determined.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Letter
Infectious Diseases
Federica Novazzi, Daniele Focosi, Andreina Baj, Andrea Ambrosini, Sara Bouthar, Fabrizio Maggi
JOURNAL OF CLINICAL VIROLOGY PLUS
(2022)
Article
Infectious Diseases
Andreina Baj, Daniela Dalla Gasperina, Daniele Focosi, Greta Forlani, Francesca Drago Ferrante, Federica Novazzi, Lorenzo Azzi, Fabrizio Maggi
Summary: Given the ongoing COVID19 pandemic and the upcoming flu season, COVID19 vaccines are being administered together with vaccines against seasonal pathogens. This study confirms that concurrent vaccination against influenza has no negative impact on the serological response to COVID19 vaccines.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
