Article
Virology
Marcia Bellon, Christophe Nicot
Summary: The Pim family of serine/threonine kinases play a role in promoting tumorigenesis and inhibiting apoptosis. The HTLV-1 oncogene Tax increases the expression of Pim-1 and Pim-3, while decreasing Pim-2 expression. The Pim kinases bind to Tax protein and reduce its expression, creating a feedback regulatory loop between these two oncogenes. This study suggests that Pim kinases may play an important role in immune escape of HTLV-1-infected cells.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Stefanie Heym, Caroline F. Mohr, Hanna C. Engelbrecht, Bernhard Fleckenstein, Andrea K. Thoma-Kress
Summary: Actin-bundling protein Fascin is upregulated in many types of cancers, including adult T-cell leukemia/lymphoma induced by HTLV-1. Transcriptional induction of Fascin by viral oncoproteins depends on activity of both classical and alternative NF-kappa B signaling. Non-oncogenic Tax-2 can induce Fascin expression to a lesser extent compared to Tax-1, and both Tax-1 and Tax-2 can activate key fragments in the Fascin promoter. Additionally, the activity of alternative NF-kappa B pathway is linked to Fascin induction.
Review
Oncology
Nicolas Ducasa, Daniel Grasso, Paula Benencio, Daniela L. Papademetrio, Mirna Biglione, Fatah Kashanchi, Carolina Berini, Maria Noe Garcia
Summary: HTLV-1, as the etiological agent of ATLL, interacts with host cells through its viral proteins to promote viral replication and T cell transformation by engaging NF-kappa B and autophagy pathways. Additionally, HTLV-1 utilizes the autophagy pathway to achieve its infective goals.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tatsuro Jo, Kazuhiro Noguchi, Takahiro Sakai, Ritsuko Kubota-Koketsu, Sadaharu Irie, Masatoshi Matsuo, Jun Taguchi, Kuniko Abe, Kazuto Shigematsu
Summary: This study investigated the characteristics of long-term survivors with Adult T-cell leukemia/lymphoma (ATLL) and found that Tax-specific memory CTLs may eradicate ATLL cells and prevent ATLL relapse in the long term, possibly in conjunction with anticancer agents. Strong activation of cellular immunity, such as infection with herpes virus, appears to be necessary to induce a large number of Tax-specific CTLs.
Article
Medicine, General & Internal
Anna Gutowska, Katherine McKinnon, Sarkis Sarkis, Melvin N. Doster, Massimiliano Bissa, Ramona Moles, James D. Stamos, Mohammad Arif Rahman, Robyn Washington-Parks, David Davis, Robert Yarchoan, Genoveffa Franchini, Cynthia A. Pise-Masison
Summary: This study suggests that treatment with the drug pomalidomide (Pom) increases the susceptibility of HTLV-1-infected cells to NK and CTL killing by increasing the surface expression levels of MHC-I, ICAM-1, and B7-2. Using the rhesus macaque model, it was found that Pom treatment activates the host immune system and allows recognition and clearance of HTLV-1-infected cells, although it may not be effective as a single-agent therapeutic.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Stephan Kohrt, Sarah Strobel, Melanie C. Mann, Heinrich Sticht, Bernhard Fleckenstein, Andrea K. Thoma-Kress
Summary: The study reveals that the interaction between Tax-1 and ELL2 enhances the transcription activation of HTLV-1 promotor, independent of Tax-1 point mutations but dependent on specific domains of both proteins. Tax-1:ELL2 complex formation is crucial for viral transactivation, while non-oncogenic Tax-2B does not interact with ELL2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Chie Ishikawa, Naoki Mori
Summary: The study showed that pimozide has anti-ATL effects by inhibiting cell growth, inducing apoptosis, increasing ROS production, and suppressing several signaling pathways activities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Virology
Huandi Liu, Jiaxiang Sun, Xuhong Cheng, Liangwei Duan, Shuaifeng Guo, Zhongxin Zhang, Jia Wan, Chunduo Wang, Xiaoying Zhi, Linghui Yuan, Hui Wang
Summary: The study discovered that hydrogen sulfide (H2S) can play an antiviral role by regulating autophagy, leading to decreased expression of human T-cell leukemia virus type-1 (HTLV-1) protein. This finding provides a new mechanism for defending against virus infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya, Shinsuke Nakajima, Masahito Tokunaga, Kisato Nosaka, Hiroyuki Hata, Atae Utsunomiya, Jun-ichi Fujisawa, Yorifumi Satou
Summary: In this study, researchers identified a previously unknown viral enhancer in the middle of the HTLV-1 provirus using proviral DNA-capture sequencing. The transcription factors SRF and ELK-1 were found to play a crucial role in the activity of this enhancer. The discovery of this enhancer resolves certain long-standing questions about HTLV-1 persistence and pathogenesis. Furthermore, the DNA-capture-seq approach used in this study can potentially be applied to analyze the regulatory mechanisms of other oncogenic viruses integrated into the host cellular genome.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yifei Liao, Blanca Lupiani, Yoshihiro Izumiya, Sanjay M. Reddy
Summary: The study revealed that the Marek's disease virus protein Meq interacts with chicken HDAC1 and HDAC2, leading to their proteasome-dependent degradation.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Muhammad Hamza Tariq, Rashid Bhatti, Nida Fatima Ali, Usman Ali Ashfaq, Farah Shahid, Ahmad Almatroudi, Mohsin Khurshid
Summary: The study describes the design and development process of a potential multi-epitope vaccine against HTLV-1 using the reverse vaccinology approach. Highly antigenic proteins were selected, and B- and T-cell epitopes were predicted. The vaccine was optimized through protein engineering, and its strong association with the human pathogenic immune receptor was confirmed through molecular docking and dynamics simulations.
Editorial Material
Hematology
Edward L. Murphy
Summary: In this study, the authors discuss the testing methods used by blood banks for HTLV-1 and the role of this testing in public health surveillance. They provide commentary on the current screening practices and offer recommendations for improvement.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Virology
Hadi Atabati, Seyed-Alireza Esmaeili, Abolghasem Allahyari, Abbas Shirdel, Hossein Rahimi, Seyed Abdolrahim Rezaee, Amir A. Momtazi-Borojeni, Houshang Rafatpanah
Summary: The proviral load of HTLV-I in ATL patients was significantly higher compared to healthy carriers, and correlated significantly with PBMC count. Additionally, the mRNA expression of PDGF β chain and PDGF-β receptors was higher in healthy carriers than in ATL patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Kunihiko Umekita, Yuki Hashikura, Akira Takaki, Masatoshi Kimura, Katsumi Kawano, Chihiro Iwao, Shunichi Miyauchi, Takeshi Kawaguchi, Motohiro Matsuda, Yayoi Hashiba, Toshihiko Hidaka
Summary: The study evaluated the utility of HTLV-1-infected cell analysis using flow cytometry (HAS-Flow) as a monitoring method for ATL development in HTLV-1-positive RA patients. CADM1 expression on CD4+ cells was used to identify HTLV-1-infected cells, and it was found that the population of CADM1+ CD4+ cells was significantly higher in HTLV-1-positive RA patients. The correlation between CADM1+ CD4+ cell population and HTLV-1 PVL suggests that HAS-Flow can be used to monitor high-risk HTLV-1-positive RA patients for ATL progression during antirheumatic therapies.
Article
Cell Biology
Hui Li, Bingxin Guan, Sen Liu, Haiting Liu, Lin Song, Guohao Zhang, Ruinan Zhao, Chengjun Zhou, Peng Gao
Summary: Gastric cancer is a highly heterogeneous disease with poor prognosis. Protein tyrosine phosphatases, specifically PTPN14, play a vital role in gastric cancer by promoting cell proliferation, migration, and invasion.
CELL DEATH & DISEASE
(2023)
Letter
Dermatology
Morgan Amigo, Kalyn Hoffman, Catherine Chung, Maryam Lustberg, Robert Wesolowski, Jeffrey VanDeusen, Daniel Stover, Gabriel Tinoco Suarez, Mathew Cherian, Benjamin Kaffenberger, Brittany Dulmage
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Oncology
Jasmine S. Sukumar, Dionisia Quiroga, Mahmoud Kassem, Michael Grimm, Namrata Vilas Shinde, Leslie Appiah, Marilly Palettas, Julie Stephens, Margaret E. Gatti-Mays, Ashley Pariser, Mathew Cherian, Daniel G. Stover, Nicole Williams, Jeffrey Van Deusen, Robert Wesolowski, Maryam Lustberg, Bhuvaneswari Ramaswamy, Sagar Sardesai
Summary: Non-adherence to adjuvant GnRHa treatment occurred in over a third of patients, with almost half opting for surgical ablation after initiating GnRHa. Treatment toxicities may impact personal preferences for OFS modality, highlighting the importance of personalized practices to target predictors of adjuvant GnRHa non-adherence.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Microbiology
Xiaogang Cheng, Ancy Joseph, Victor Castro, Alice Chen-Liaw, Zachary Skidmore, Jacqueline E. Payton, Lee Ratner, John R. Edwards, Takaharu Ueno, Jun-ichi Fujisawa, Daniel A. Rauch, Grant A. Challen, Michael P. Martinez, Patrick Green, Malachi Griffith
Summary: HTLV-1 is a retrovirus that causes leukemia, lymphoma, and inflammatory disorders. CTCF binding to the virus plays a pivotal role in regulating gene expression, DNA, and histone modifications, affecting virus replication in infected cells.
Article
Oncology
Otto Metzger-Filho, Katharine Collier, Sarah Asad, Peter J. Ansell, Mark Watson, Junu Bae, Mathew Cherian, Joyce O'Shaughnessy, Michael Untch, Hope S. Rugo, Jens B. Huober, Mehra Golshan, William M. Sikov, Gunter von Minckwitz, Priya Rastogi, Lang Li, Lijun Cheng, David Maag, Norman Wolmark, Carsten Denkert, W. Fraser Symmans, Charles E. Geyer, Sibylle Loibl, Daniel G. Stover
Summary: In the study, adding carboplatin +/- veliparib to neoadjuvant chemotherapy did not increase the odds of pathologic complete response in BRCA1/2 mutation carriers compared to non-carriers. Additionally, molecular, immune, chromosomal instability, and proliferation gene expression metrics did not show significant differences between the two groups.
Article
Biology
Chang Gong, Ziliang Cheng, Yaping Yang, Jun Shen, Yingying Zhu, Li Ling, Wanyi Lin, Zhigang Yu, Zhihua Li, Weige Tan, Chushan Zheng, Wenbo Zheng, Jiajie Zhong, Xiang Zhang, Yunjie Zeng, Qiang Liu, R. Stephanie Huang, Andrzej L. Komorowski, Eddy S. Yang, Francois Bertucci, Francesco Ricci, Armando Orlandi, Gianluca Franceschini, Kazuaki Takabe, Suzanne Klimberg, Naohiro Ishii, Angela Toss, Mona P. Tan, Mathew A. Cherian, Erwei Song
Summary: This study developed a model based on a 10-microRNA risk score that accurately predicts the pathological complete response to neoadjuvant chemotherapy in patients with hormone receptor-positive breast cancer. The model was also validated to be associated with disease-free survival.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Daniel G. Stover, Mathew A. Cherian
Summary: Highly selective ER beta agonists have been shown to effectively inhibit the viability of ER alpha+ breast cancer cell lines in vitro, suggesting a potential therapeutic strategy for ER alpha+ breast cancer. The combination of ER beta agonists with ER alpha antagonists shows strong synergy, maximizing the efficacy of ER beta agonists in blocking cell proliferation, migration, and inducing apoptosis. Negative correlation between ESR2 (ER beta gene) expression and ESR1 (ER alpha gene) and CCND1 RNA expression was observed in human metastatic ER alpha+/HER2- breast cancer samples.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jasmine M. Manouchehri, Jharna Datta, Natalie Willingham, Robert Wesolowski, Daniel Stover, Ramesh K. Ganju, William E. Carson, Bhuvaneswari Ramaswamy, Mathew A. Cherian
Summary: This study reveals that eATP modulates the chemotherapeutic response in TNBC cell lines, which could be exploited to enhance the efficacy of chemotherapy regimens for TNBC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jairam Krishnamurthy, Jingqin Luo, Rama Suresh, Foluso Ademuyiwa, Caron Rigden, Timothy Rearden, Katherine Clifton, Katherine Weilbaecher, Ashley Frith, Anna Roshal, Pavan K. Tandra, Mathew Cherian, Tracy Summa, Brittney Haas, Shana Thomas, Leonel Hernandez-Aya, Mattias Bergqvist, Lindsey Peterson, Cynthia X. Ma
Summary: In this single-arm phase II trial, the alternative 5-days-on/2-days-off weekly schedule of Palbociclib demonstrated reduced incidence of severe neutropenia without compromising efficacy in patients with hormone receptor positive, HER2-negative advanced/metastatic breast cancer. The activity of serum thymidine kinase 1 (sTK1) showed promise in monitoring the response to Palbociclib.
Article
Immunology
Janice K. Kiecolt-Glaser, Megan Renna, Juan Peng, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Rebecca Andridge
Summary: This study investigated the inflammatory responses of breast cancer survivors to a typhoid vaccine as an indicator of their innate immune response to new pathogens. The results showed that chemotherapy and central obesity were associated with smaller vaccine responses. Women with lower fitness levels also had reduced vaccine responses.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Medicine, General & Internal
Michael Grimm, Lindsey Radcliff, Mariann Giles, Ryan Nash, Erin Holley, Shannon Panda, Lynne Brophy, Nicole Williams, Mathew Cherian, Daniel Stover, Margaret E. Gatti-Mays, Robert Wesolowski, Sagar Sardesai, Preeti Sudheendra, Raquel Reinbolt, Bhuvaneswari Ramaswamy, Ashley Pariser
Summary: Survivors of advanced breast cancer often have limited treatment options and unique psychosocial and physical needs. This analysis examines the common side effects experienced by these patients, as well as their impact on caregiver support, financial burden, emotional strain, and spiritual and emotional distress. It also discusses strategies for mitigation, including nutrition, exercise, and participation in clinical research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C. Martin, Bruce A. Rosa, Makedonka Mitreva, Lee Ratner
Summary: This study provides a deeper understanding of the viral genetic determinants of coreceptor shift by combining single-genome sequence analysis and next-generation sequencing. It highlights the importance of low-frequency mutants in the development of drug resistance and the role of specific amino acid substitutions outside the V3 region. Additionally, it emphasizes the significance of residues in the V1/V2, V4, C3, and C4 domains in coreceptor shift.
MICROBIOLOGY SPECTRUM
(2022)
Article
Psychology, Clinical
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Maryam Lustberg, Stephen P. Povoski, Doreen M. Agnese, Raquel E. Reinbolt, Robert Wesolowski, Nicole O. Williams, Bhuvaneswari Ramaswamy, Sagar D. Sardesai, Anne M. Noonan, Jeffrey B. VanDeusen, Daniel G. Stover, Mathew Cherian, William B. Malarkey, Michael Di Gregorio, Janice K. Kiecolt-Glaser
Summary: Psychological disorders can worsen physical symptoms associated with breast cancer diagnosis and treatment, and a distress disorder history may increase the risk of pain, fatigue, sleep difficulties, and lower self-rated health in breast cancer survivors both before and after adjuvant treatment.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Immunology
Annelise A. Madison, Baldwin Way, Kyle G. Ratner, Megan Renna, Rebecca Andridge, Juan Peng, M. Rosie Shrout, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study examined whether a typhoid vaccine would increase social disconnection and avoidance behavior, and found that mild inflammatory stimuli did not affect social processes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Oncology
Annelise A. Madison, Rebecca Andridge, Anthony H. Kantaras, Megan E. Renna, Jeanette M. Bennett, Catherine M. Alfano, Stephen P. Povoski, Doreen M. Agnese, Maryam Lustberg, Robert Wesolowski, William E. Carson III, Nicole O. Williams, Raquel E. Reinbolt, Sagar D. Sardesai, Anne M. Noonan, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: Depression combined with inflammation or intestinal permeability may contribute to poorer subjective and objective cognitive function in breast cancer survivors. These findings suggest that survivors with depression accompanied by immune dysregulation may be more aware of depression-related cognitive deficits compared to other depressed survivors.
Article
Oncology
Dan Goldstein, Steven Ing, Jason Jimenez Ocasio, Mathew A. Cherian
Summary: Metastatic bone disease mimickers can lead to unnecessary biopsies, improper or delayed therapy, and patient anxiety. Considering a patient's past medical history and prior imaging findings when interpreting new imaging studies can help reduce unnecessary confusion. Patients with sclerosing bone disease should inform ordering and interpreting physicians about potential misinterpretation.
CURRENT PROBLEMS IN CANCER: CASE REPORTS
(2021)