Article
Cell Biology
Danai Georgiadou, Souad Boussata, Remco Keijser, Dianta A. M. Janssen, Gijs B. Afink, Marie van Dijk
Summary: Mutations in the LINC-HELLP non-coding RNA (HELLPAR) are associated with familial forms of the pregnancy-specific HELLP syndrome, impacting EVT differentiation and the binding of RNA splicing complex proteins PCBP1, PCBP2, and YBX1 to LINC-HELLP. Knockdown of PCBP2, and to a lesser extent YBX1 and PCBP1, leads to failure of EVTs to differentiate towards an invasive phenotype. PCBP2 silencing alters splicing for genes related to cellular assembly, organization, function, maintenance, growth, proliferation, and the cell cycle, indicating its crucial role in EVT differentiation mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Robert Morey, Omar Farah, Sampada Kallol, Daniela F. Requena, Morgan Meads, Matteo Moretto-Zita, Francesca Soncin, Louise C. Laurent, Mana M. Parast
Summary: During pregnancy, the EVT invades and remodels maternal blood vessels to ensure blood supply to the placenta, exhibiting polyploidy and senescence in early gestation. Comprehensive profiling of genomic organization and transcriptome shows that both first trimester and term EVT undergo senescence, are primarily tetraploid, and lack high rates of copy number variations. Genes and pathways related to senescence and polyploidy are important for normal EVT differentiation and maturation, with a key role identified for the unfolded protein response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea L. Miranda, Lucille T. Kourdova, Ana C. Racca, Mariano Cruz Del Puerto, Maria L. Rojas, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Yamila Gazzoni, Adriana Gruppi, Alexandre U. Borbely, Susana Genti-Raimondi, Graciela M. Panzetta-Dutari
Summary: KLF6 is essential for trophoblast cell differentiation and impaired expression or function of KLF6 promotes extravillous trophoblast cell migration and differentiation, potentially contributing to the physiopathology of abnormally invasive placenta.
Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Toxicology
Cassandra Meakin, Christine Kim, Thomas Lampert, Lauren M. Aleksunes
Summary: Migration and invasion of extravillous trophoblasts into the uterus are crucial for placenta formation, and disruption of these processes can lead to adverse pregnancy outcomes. A novel, high-throughput method for screening chemicals that can alter human trophoblast migration was developed. This method involves culturing trophoblast cells in migration plates and tracking their movement into a cell-free detection zone. The method was validated using known chemicals and tested on a panel of environmental chemicals. This real-time method has potential for screening placental toxicants.
TOXICOLOGY LETTERS
(2023)
Article
Endocrinology & Metabolism
Yanan Shan, Yan Chen, Jelena Brkic, Leslie Fournier, Haiying Ma, Chun Peng
Summary: miR-218-5p inhibits the TGF-β/SMAD2 pathway to induce IL1β expression and promote enEVT differentiation. IL1β, in turn, inhibits the expression of miR-218-5p, forming a negative feedback regulatory loop.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunali Ashar, Qiuxu Teng, John N. D. Wurpel, Zhe-Sheng Chen, Sandra E. Reznik
Summary: In this study, it was found that palmitic acid increases MRP1-mediated folate efflux in placental extravillous trophoblasts, thereby interfering with their role in early placental vascular remodeling.
Article
Multidisciplinary Sciences
Sandra Haider, Andreas Ian Lackner, Bianca Dietrich, Victoria Kunihs, Peter Haslinger, Gudrun Meinhardt, Theresa Maxian, Leila Saleh, Christian Fiala, Juergen Pollheimer, Paulina A. Latos, Martin Knoefler
Summary: Comparative gene expression analysis revealed the importance of transforming growth factor-beta (TGF-beta) signaling in the development of extravillous trophoblasts (EVTs), particularly in the differentiation of placental EVTs into decidual EVTs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Asli Ozmen, Ozlem Guzeloglu-Kayisli, Selcuk Tabak, Xiaofang Guo, Nihan Semerci, Chinedu Nwabuobi, Kellie Larsen, Ali Wells, Asli Uyar, Sefa Arlier, Ishani Wickramage, Hasan Alhasan, Hana Totary-Jain, Frederick Schatz, Anthony O. Odibo, Charles J. Lockwood, Umit A. Kayisli
Summary: In preeclampsia, the competition binding of IL-6 and IL-11 to gp130 impairs the function and morphology of extravillous trophoblast cells (EVT), and the reduced expression of ISG15 is associated with this effect.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Toxicology
Shoko Ogushi, Tsuyoshi Nakanishi, Tomoki Kimura
Summary: Cadmium inhibits trophoblast differentiation into extravillous cytotrophoblasts, leading to suppressed placental formation and a potential increase in the risks of gestational hypertension and early preterm birth.
TOXICOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Rachel D. Kelly, Kelly J. Baines, Adam Jaremek, Fei-Hung P. Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J. Renaud
Summary: GCM1 is a critical regulator of both EVT and ST development, affecting cell differentiation and invasive capacity, potentially leading to obstetrical complications such as preeclampsia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Reproductive Biology
Cassandra Meakin, Emily S. Barrett, Lauren M. Aleksunes
Summary: The migration and invasion of extravillous trophoblasts are crucial for proper placenta and fetus development during pregnancy. Environmental chemicals and pharmaceuticals can disrupt trophoblast migration and may lead to adverse pregnancy outcomes.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Rachel D. Kelly, Kelly J. Baines, Adam Jaremek, Fei-Hung P. Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J. Renaud
Summary: GCM1 is a critical regulator of human placenta development, playing a key role in the differentiation and function of EVT and ST. Knockdown of GCM1 hinders TS cell differentiation and impacts their functions in both ST and EVT pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Wei Zhou, Ellen Menkhorst, Evdokia Dimitriadis
Summary: This study identified the expression pattern of CLIC4 in the placenta and decidua, and revealed its association with trophoblast cell function and TGF beta signaling. Knockdown of CLIC4 led to increased cell adhesion, migration, and invasion, along with alterations in the expression of downstream targets of the TGF beta signaling pathway. These findings indicate an inhibitory role for CLIC4 in regulating trophoblast migration and invasion.
Article
Biochemistry & Molecular Biology
Heyam Hayder, Guodong Fu, Lubna Nadeem, Jacob A. O'Brien, Stephen J. Lye, Chun Peng
Summary: The overexpression of miR-210-3p reduces trophoblast migration and invasion, affects EVT outgrowth in early pregnancy explants, and decreases the ability of trophoblast to form endothelial-like networks. Furthermore, miR-210-3p downregulates the expression of certain cytokines, potentially influencing EVT invasion and immune cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Naoya Akiba, Takayuki Iriyama, Toshio Nakayama, Takahiro Seyama, Seisuke Sayama, Keiichi Kumasawa, Atsushi Komatsu, Shinichiro Yabe, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Summary: The study investigates the spontaneous outcomes of vascularized retained products of conception (RPOC) after second-trimester abortion and predictive factors for severe postpartum hemorrhage (SPPH). Patients with type 3 RPOC and a maximum vascularized mass diameter >= 30 mm are at a higher risk of developing SPPH. Ultrasonographic assessment focusing on the depth of vascularity in combination with the measurement of size is essential in identifying women with RPOC at high risk for SPPH.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Rheumatology
Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Masashi Deguchi, Yuki Sasagawa, Noriko Arase, Hisashi Arase, Hideto Yamada
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Obstetrics & Gynecology
Hiroaki Itoh, Keisuke Ishii, Naoya Shigeta, Atsuo Itakura, Hiromi Hamada, Takeshi Nagamatsu, Tomohiko Ishida, Yasuaki Bungyoku, Ali Falahati, Miori Tomisaka, Mikiya Kitamura
Summary: The study evaluated the efficacy and safety of dinoprostone vaginal insert (PROPESS) in pregnant post-term Japanese women requiring cervical ripening. Results showed that PROPESS administration for up to 12 hours significantly increased successful cervical ripening rate, shortened time to vaginal delivery, and reduced the need for uterotonic drugs such as oxytocin.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Tamae Nabeshima, Tatsuya Fujii, Takeshi Nagamatsu, Ayako Hashimoto, Takahiro Seyama, Kaori Kubota, Seisuke Sayama, Toshio Nakayama, Keiichi Kumasawa, Takayuki Iriyama, Yutaka Osuga, Tomoyuki Fujii
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Ryosuke Shindo, Shigeru Aoki, Toshihiro Misumi, Sayuri Nakanishi, Takeshi Umazume, Takeshi Nagamatsu, Hisashi Masuyama, Atsuo Itakura, Tomoaki Ikeda
Summary: In Japan, the criteria for the latent and active phases of the first stage of labor have not been determined. A study was conducted to construct a spontaneous labor curve, showing that labor progress is slow until 5 cm cervical dilation, accelerates between 5 and 6 cm, and steadily progresses after 6 cm dilation. The active phase of labor is proposed to start at 5 cm dilation of the cervix, divided into an acceleration phase (5-6 cm dilation) and a maximal phase (>6 cm dilation).
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Megumi Nakanishi, Takayuki Iriyama, Seisuke Sayama, Shouhei Hanaoka, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Yutaka Osuga
Summary: Uterine degeneration occurs during pregnancy in cases of adenomyosis, causing worsened symptoms, but this degeneration is transient and disappears completely after childbirth.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Eri N. Arai, Satoshi Yoneda, Noriko Yoneda, Mika Ito, Sayaka Tsuda, Arihiro Shiozaki, Tomoyoshi Nohira, Hironobu Hyodo, Kazumasa Kumazawa, Tomo Suzuki, Sumito Nagasaki, Shintaro Makino, Shigeru Saito
Summary: This study investigated the rate of recurrent spontaneous preterm delivery (sPTD) in pregnant women treated with probiotics.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Hematology
Hiroko Oda, Takeshi Nagamatsu, Yutaka Osuga
Summary: Thrombomodulin (TM) has multiple organ protective roles during pregnancy, aside from its anticoagulation function. Placental TM deficiency is associated with pregnancy complications such as miscarriage, fetal growth restriction, and preeclampsia. Recombinant TM shows promise as a therapeutic target for these conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Minori Kasuya, Naoya Akiba, Takayuki Iriyama, Seisuke Sayama, Kaori Kubota, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga
Summary: This study aimed to compare the impact of fetal growth restriction (FGR) and maternal organ dysfunction on the severity of maternal preeclamptic features. The results showed that PE cases preceded by FGR had earlier diagnosis and delivery, but there were no significant differences in maternal morbidities compared to cases without FGR. For early-onset PE, the results were comparable between two groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Mari Ichinose, Takayuki Iriyama, Seisuke Sayama, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Shouhei Hanaoka, Yutaka Osuga
Summary: This is the first report on the imaging findings of early postpartum degeneration of adenomyosis, based on a case of a patient who underwent pregnancy. The magnetic resonance imaging showed cyst-like degenerations with hemorrhagic changes.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Itakura Atsuo, Satoh Shoji, Aoki Shigeru, Fukushima Kotaro, Hasegawa Junichi, Hyodo Hironobu, Yoshimasa Kamei, Kondoh Eiji, Makino Shintaro, Matsuoka Ryu, Morikawa Mamoru, Nagamatsu Ttakeshi, Nakata Masahiko, Katsuhiko Naruse, Nishigori Hidekazu, Nishiguchi Tomizo, Obata-Yasuoka Mana, Ohno Yasumasa, Oura Kuniaki, Shimoya Koichiro, Shiozaki Arihiro, Suzuki Shunji, Tanaka Kanji, Yoshida Shiro, Kudo Yoshiki, Maeda Tsugio, Shozu Makio
Summary: The 2020 edition of the clinical guidelines for obstetrical practice in Japan provides standard obstetric diagnosis and management procedures that have reached consensus among Japanese obstetricians. It includes 113 clinical questions, answers, discussions, references, and tables and figures presenting common problems and questions in obstetrical practice.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Obstetrics & Gynecology
Kenji Horie, Kayo Takahashi, Makiko Mieno, Shiho Nagayama, Hiroaki Aoki, Takeshi Nagamatsu, Ayumi Kanatani, Hironobu Hyodo, Kayoko Terada, Masako Hayashi, Akihito Nakai, Noriko Yoneda, Shigeru Saito, Yoshio Matsuda, Shigeki Matsubara, Akihide Ohkuchi
Summary: This study compared the risk of spontaneous preterm birth (SPTB) before 35 weeks in symptomatic and asymptomatic women with cervical shortening at 16-34 weeks under mid-trimester universal screening of cervical length (CL). The results showed that the presence of uterine contractions at admission may not be an independent risk factor for the occurrence of SPTB before 35 weeks, while CL of 1-9 mm, CL of 10-14 mm, and vaginal bleeding at admission were identified as independent risk factors for SPTB before 35 weeks.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Risa Miyatake, Tatsuya Fujii, Keiichi Kumasawa, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Takeshi Nagamatsu, Yutaka Osuga
Summary: Hyperreactio luteinalis (HL) is a rare condition characterized by bilateral ovarian enlargement during pregnancy. It is usually caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. While the prognosis is generally good, obstetric complications such as preeclampsia (PE) and preterm births can occur. Monitoring the sFlt-1/PlGF ratio is found to be useful in managing HL cases associated with PE.
CASE REPORTS IN OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Yuko Takahashi, Takeshi Nagamatsu, Tatsuya Fujii, Ayako Hashimoto, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Keiichi Kumasawa, Yutaka Osuga, Tomoyuki Fujii
OXFORD MEDICAL CASE REPORTS
(2020)
Article
Medicine, General & Internal
Keiichi Kumasawa, Kaori Kubota, Yuko Takahashi, Toshio Nakayama, Takayuki Iriyama, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
CLINICAL CASE REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
