Article
Physiology
Mahmoud M. A. Abulmeaty, Dara Aldisi, Ghadeer S. Aljuraiban, Ali Almajwal, Eman El Shorbagy, Yara Almuhtadi, Batool Albaran, Zaid Aldossari, Thamer Alsager, Suhail Razak, Mohammed Berika, Mohamed Al Zaben
Summary: The study found that gastric myoelectrical activity may be associated with gastric hormone levels in different obesity phenotypes, particularly in metabolically healthy obese and metabolically unhealthy obese individuals.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
P. Trevisi, D. Luise, F. Correa, S. Messori, M. Mazzoni, J. P. Lalles, P. Bosi
Summary: The study revealed that the maternal environment can impact the sensing for umami taste and ghrelin regulation in pig offspring, while the development of acid secretion, orexigenic signaling, and taste perception in the stomach are mainly developmentally controlled.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Helge Waldum, Reidar Fossmark
Summary: Despite a decrease in prevalence over the past few decades, gastric cancer remains a significant global cause of death, with Helicobacter pylori infection reduction being a key factor. The carcinogenic effects of H. pylori are likely due to hypergastrinemia and autoimmune gastritis, while long-term use of proton pump inhibitors may also predispose individuals to ECL cell neoplasia. Additionally, gastric polyps, although generally low in malignant potential, can still pose a cancer risk and share some common risk factors and mechanisms with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Valli De Re, Stefano Realdon, Roberto Vettori, Alice Zaramella, Stefania Maiero, Ombretta Repetto, Vincenzo Canzonieri, Agostino Steffan, Renato Cannizzaro
Summary: In this study, the researchers assessed the accuracy of a novel noninvasive serum DSC test in predicting gastric cancer risk. Two groups of individuals from Italy were enrolled for the study, and the DSC test combined variables such as age, sex, pepsinogen levels, gastrin 17, and anti-Helicobacter pylori IgG concentrations to predict the risk. The test was found to be 74.657% accurate in predicting neoplastic gastric lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Jimil Shah, Nikhil Bush, T. Mahesh, C. K. Nain, Rakesh Kochhar
Summary: The study revealed that patients with caustic-induced esophageal stricture have significantly lower gastric acid secretion compared to healthy controls, with those with lower esophageal involvement showing the most severe impairment.
Article
Surgery
Ponnie Robertlee Dolo, Libin Yao, Yong Shao, Jason Widjaja, Chao Li, Xiaocheng Zhu
Summary: The study assessed the effects of ablating the gastric mucosa on obesity and diabetes, showing that gastric mucosa ablation and sleeve gastrectomy significantly decreased fasting ghrelin concentration, increased GLP-1 AUC postoperatively, contributing to weight loss and glycemic control.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Oncology
Eivind Ness-Jensen, Erling Audun Bringeland, Fredrik Mattsson, Patricia Mjones, Jesper Lagergren, Jon Erik Gronbech, Helge Lyder Waldum, Reidar Fossmark
Summary: The study conducted in Norway revealed that hypergastrinemia is associated with an increased risk of developing gastric adenocarcinoma, especially in the proximal stomach and intestinal histological type. However, there was no significant association found for gastric adenocarcinoma with distal location and diffuse histological type.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Physiology
Maria Nunez-Salces, Hui Li, Christine Feinle-Bisset, Richard L. Young, Amanda J. Page
Summary: This review discusses the physiological functions of ghrelin, its regulation in feeding behavior, and its therapeutic potential in metabolic disorders. It also explores the impact of ghrelin in eating disorders such as anorexia nervosa and Prader-Willi syndrome.
Article
Nutrition & Dietetics
Mette Glavind Bulow Pedersen, Esben Sondergaard, Camilla Bak Nielsen, Mogens Johannsen, Lars Christian Gormsen, Niels Moller, Niels Jessen, Nikolaj Rittig
Summary: Oral lactate administration can directly affect the upper gastrointestinal tract, altering gut hormone secretion, motility, and appetite sensations, which cannot be solely mediated by lactate in the systemic circulation. This may have implications for the treatment of metabolic diseases.
CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Xiaopei Guo, Marco W. J. Schreurs, Fleur E. Marijnissen, Michiel C. Mommersteeg, Stella A. V. Nieuwenburg, Michail Doukas, Nicole S. Erler, Lisette G. Capelle, Marco J. Bruno, Maikel P. Peppelenbosch, Manon C. W. Spaander, Gwenny M. Fuhler
Summary: This study investigated the prevalence and characteristics of autoimmune gastritis (AIG) in gastric precancerous lesion (GPL) patients. The results showed that the prevalence of AIG is higher in GPL patients but often goes undiagnosed. Using G17 and PG I/II as diagnostic markers can help identify patients with AIG and improve surveillance programs for GPL patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Michael Camilleri, Jessica Atieh
Summary: Prokinetic agents enhance gastrointestinal muscular contractions to improve transit of intra-luminal content. Metoclopramide is the only FDA-approved medication for gastroparesis in the United States, while domperidone can be prescribed through a special program. Newer agents are being developed targeting different gastric motor functions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Duan Chen, Susan J. Hagen, Malcolm Boyce, Chun-Mei Zhao
Summary: The physiology of gastric acid secretion has been studied since 1833 and has led to the development of therapeutic strategies for acid-related diseases. Understanding the physiology of parietal cells has resulted in the development of various drugs such as histamine 2 receptor blockers, proton pump inhibitors, and potassium-competitive acid blockers. Further research on the mechanism of acid secretion and the physiological significance of gastric acidity in gut microbiome is needed in the future.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Oncology
Helge Waldum, Patricia Mjones
Summary: The prevalence of gastric cancer has declined, but it is still a serious disease due to high mortality rates. Gastric cancer can be classified into intestinal type and diffuse type, both of which are adenocarcinomas. Helicobacter pylori is believed to be the main cause of gastric cancer, and its infection leads to gastric hypochlorhydria and hypergastrinemia. Hypergastrinemia induces abnormal cell proliferation, resulting in the development of neuroendocrine tumors and carcinomas.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Takahiro Suzuki, Tomohiro Higuchi, Takuma Kagami, Takahiro Uotani, Mihoko Yamade, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Takahisa Furuta
Summary: Pirenzepine can improve hypergastrinemia induced by vonoprazan without enhancing acid inhibition.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Reuben Veysey-Smith, Andrew R. Moore, Senthil Murugesan, Laszlo Tiszlavicz, Graham J. Dockray, Andrea Varro, D. Mark Pritchard
Summary: This study demonstrated that PPI use, Helicobacter pylori infection, and atrophic gastritis significantly increased fasting serum gastrin concentrations. However, some patients with potential risk factors for hypergastrinaemia still showed normal fasting serum gastrin concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)