Article
Engineering, Biomedical
Wenjing Liu, Haiyun Luo, Qinwei Wei, Jia Liu, Junrong Wu, Yanli Zhang, Lili Chen, Wencai Ren, Longquan Shao
Summary: This study found that nanographene oxide (NGO) synthesized by one-step water electrolytic oxidation has smaller particle size and better biocompatibility, which can promote angiogenesis in vivo and provide a good microenvironment for bone regeneration. The study also discovered that NGO activates endothelial tip cell differentiation by coupling with lysophosphatidic acid (LPA), and promotes the formation of migratory tip cells through the Hippo/YAP pathway.
BIOACTIVE MATERIALS
(2022)
Article
Plant Sciences
Valerie Wattelet-Boyer, Marina Le Guedard, Franziska Dittrich-Domergue, Lilly Maneta-Peyret, Verena Kriechbaumer, Yohann Boutte, Jean-Jacques Bessoule, Patrick Moreau
Summary: Phosphatidic acid and lysophosphatidic acid acyltransferases play a critical role in the efficiency of intracellular protein trafficking in Arabidopsis thaliana root cells.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Pathology
Kanako Minami, Nanami Ueda, Kaichi Ishimoto, Rio Kurisu, Miyu Takamoto, Hiroko Ikeda, Toshifumi Tsujiuchi
Summary: Activation of LPA signaling via LPA(2) and LPA(3) by endothelial cells modulates the cell motile activity of MG-63 cells, enhancing their migratory potential.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Hematology
Anna M. Randi, Daisy Jones, Claire Peghaire, Deepa J. Arachchillage
Summary: This review discusses the organotypic differences in the hemostatic profile of endothelial cells, focusing on two major endothelial regulators, von Willebrand factor and thrombomodulin, as examples of transcriptional mechanisms that control heterogeneity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Multidisciplinary Sciences
Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Huebner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn Y. Ho
Summary: This study found that lysophosphatidic acid receptor 1 (LPAR1) plays a crucial role in the development of hypertrophy and fibrosis in a mouse model of hypertrophic cardiomyopathy (HCM). LPAR1 is primarily expressed by lymphatic endothelial cells (LECs) and cardiac fibroblasts in the heart. In addition, LPAR1 ablation affects the population and distribution of LECs and fibroblasts.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Ana Gomez-Larrauri, Patricia Gangoiti, Natalia Presa, Asier Dominguez-Herrera, Chiara Donati, Paola Bruni, Miguel Trueba, Antonio Gomez-Munoz, Alberto Ouro
Summary: Phosphatidic acid stimulates myoblast proliferation through interaction with LPA1 and LPA2 receptors, activating the PI3K/Akt and MEK/ERK1-2 pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Chi Zhang, Weiyun Li, Xiaobo Lei, Zhenfei Xie, Linlin Qi, Hui Wang, Xia Xiao, Jun Xiao, Yuxiao Zheng, Chen Dong, Xin Zheng, Shiyang Chen, Jianfeng Chen, Bing Sun, Jun Qin, Qiwei Zhai, Jinsong Li, Bin Wei, Jianwei Wang, Hongyan Wang
Summary: The study reveals that in viral infection, LPA suppresses interferon production through the LPA1 receptor, affecting immune responses. Additionally, LPA1 and ROCK1/2 may impact viral infections by promoting vascular leaking or lung fibrosis. Therefore, targeting the LPA1-ROCK module could be beneficial for treating SARS-CoV-2 or other virus infections.
Article
Medicine, Research & Experimental
Kaire Ojasalu, Sonja Lieber, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Imke Bullwinkel, Florian Finkernagel, Silke Reinartz, Sabine Mueller-Bruesselbach, Robert Grosse, Johannes Graumann, Rolf Mueller
Summary: Lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high-grade serous cancer (HGSC) and are associated with short relapse-free survival. LPA supports metastatic spread of cancer cells by activating multiple signaling pathways. However, a systematic analysis of the LPA-regulated signal transduction network in ovarian cancer cells has not been reported.
Article
Biochemistry & Molecular Biology
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G. Alexopoulos, Christoph Ullmer, Vassilis Aidinis
Summary: This study investigated the response of human proximal tubular epithelial cells to LPA and other pathological stimuli, identifying signaling pathways and inflammatory factors that may play a role in the pathogenesis of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shufan Jiang, Huili Yang, Mingqing Li
Summary: Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates various cell biological functions. Macrophages, present in most human tissues, play important roles in both physiology and pathology. The review highlights the significant role of LPA signaling in macrophages and its involvement in diseases such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. The therapeutic strategies targeting LPA are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Anna Janovicz, Aliz Majer, Monika Kosztelnik, Miklos Geiszt, Jerold Chun, Satoshi Ishii, Gabor Jozsef Tigyi, Zoltan Benyo, Eva Ruisanchez
Summary: This study investigates the molecular mechanisms underlying LPC-induced impairment of endothelium-dependent vasorelaxation and identifies the involvement of the ATX-LPA-LPA5 receptor axis in this process.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Review
Cell Biology
Pravita Balijepalli, Ciera C. Sitton, Kathryn E. Meier
Summary: Lysophosphatidic acid (LPA) is a family of phospholipids that act as ligands for G protein-coupled receptors, playing a significant role in cancer by stimulating cell proliferation and migration through multiple LPARs. Understanding the mechanisms underlying LPA signaling and its interactions with other receptors is crucial for drug discovery targeting GPCRs in cancer therapy.
Article
Biochemistry & Molecular Biology
Narengerile Li, Xiyuan Xu, Zhimin Qi, Chanchan Gao, Pengfei Zhao, Jingping Yang, Alatangaole Damirin
Summary: Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a condition characterized by acute respiratory failure and injury to the vascular endothelium and lung alveolar epithelium. This study investigated the effects of lysophosphatidic acid (LPA) on the survival and functional properties of endothelial progenitor cells (EPCs). The results demonstrated that LPA promoted EPC proliferation, migration, and upregulated the expression of vascular endothelial growth factor (VEGF), suggesting its potential therapeutic efficacy in ARDS.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Oncology
Mahdi Rafiyan, Mohammad Hassan Jafari Najaf Abadi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Mahboubeh Mousavi, Hamed Mirzaei
Summary: MiRNAs play critical roles in regulating gene expression in both normal and cancer cells. Lysophosphatidic acid (LPA) signaling can induce overexpression of miRNAs, whose functional roles remain to be fully clarified. RNA-based treatments hold great promise in personalized medicine.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lan-Yun Chang, Chao-Han Lai, Cheng-Hsiang Kuo, Bi-Ing Chang, Hua-Lin Wu, Tsung-Lin Cheng
Summary: Our study found that rTMD1 attenuates Pg-LPS-enhanced M1 macrophage polarization, osteoclastogenesis and periodontal bone resorption, showing therapeutic promise for periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Hematology
Cheng-Hsiang Kuo, Yi-Hsun Huang, Po-Ku Chen, Gang-Hui Lee, Ming-Jer Tang, Edward M. Conway, Guey-Yueh Shi, Hua-Lin Wu
Summary: The study reveals that the VEGF-ROCK2-ezrin-TM-F-actin axis plays a critical role in promoting the formation of 3DPs in endothelial cells during sprouting angiogenesis. TM expression enhances angiogenic activity in endothelial cells by interacting with ezrin and maintaining the integrity of its lectin-like domain. Mice lacking the lectin-like domain of TM show reduced neovascularization in wound healing and retinal neovascularization, indicating the importance of TM in angiogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Hsun Huang, Cheng-Hsiang Kuo, I-Chen Peng, Yi-Sheng Chang, Sung-Huei Tseng, Edward M. Conway, Hua-Lin Wu
Summary: The study reveals that rTMD1 not only inhibits VEGF-induced angiogenesis in vitro, but also significantly reduces retinal neovascularization in an OIR animal model while sparing normal physiological vessel growth. Furthermore, loss of TMD1 promotes PA in OIR.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jui-Chung Chiang, Wei-Min Chen, Ciara Newman, Benjamin P. C. Chen, Hsinyu Lee
Summary: The study reveals the crucial role of LPA(3) in regulating mitochondrial homeostasis, suppressing mitochondrial stress, and improving mitochondrial function. LPA(3) is found to be a promising therapeutic target for maintaining cellular youth and preventing mitochondrial oxidative stress.
Article
Biology
Ching-Te Kuo, Yu-Sheng Lai, Siang-Rong Lu, Hsinyu Lee, Hsiu-Hao Chang
Summary: Personalized drug cocktails have become popular in cancer treatment due to their use of drug combinations for better efficacy. In this study, a microcrater-arrayed (mu CA) chip was developed using laser direct writing to optimize cell amount and reagent usage. The results showed that the mu CA chip had better drug prediction accuracy compared to the conventional assay. This research has important implications for high-throughput drug screening and personalized medicine.
Article
Pharmacology & Pharmacy
Cheng-Hsiang Kuo, Ban-Hua Zhang, Shang-En Huang, Jong-Hau Hsu, Yan-Hsiung Wang, Thi Tuyet Ngan Nguyen, Chao-Han Lai, Jwu-Lai Yeh
Summary: This study demonstrates the therapeutic potential of KMUP-1 in the treatment of periodontitis. KMUP-1 attenuates inflammation and osteoclast differentiation, thus reducing the symptoms of periodontitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yueh-Chien Lin, Yuan-Li Huang, Ming-Hua Wang, Chih-Yu Chen, Wei-Min Chen, Yi-Cheng Weng, Pei-Yi Wu
Summary: Prostate cancer is a common and deadly cancer in aging men worldwide, and recent research suggests that calreticulin (CRT) plays an important role in its regulation. In this study, we investigated the effects of CRT on the expression of beta 1-integrin in prostate cancer cells and found that it affects beta 1-integrin expression through distinct regulatory mechanisms.
Article
Cell Biology
Yu-Chia Hsu, Hao-Chun Chuang, Kun-Ling Tsai, Ting-Yuan Tu, Yan-Jye Shyong, Cheng-Hsiang Kuo, Yuan-Fu Liu, Shu-Shien Shih, Cheng-Li Lin
Summary: The study found that under oxidative stress, levels of p-p38 significantly increased in both hypertrophic and healthy LF cells, while iNOS was elevated only in hypertrophic LF cells. This suggests that oxidative stress negatively impacts both hypertrophic and healthy LF cells, with hypertrophic LF cells showing more active inflammation. After H2O2 treatment, levels of p-p38, p-p65, iNOS, TGF-beta, vimentin, and collagen I all increased significantly, and NAC treatment reversed the effects of oxidative stress.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Integrative & Complementary Medicine
Pei-Tzu Yen, Shang-En Huang, Jong-Hau Hsu, Cheng-Hsiang Kuo, Yu-Ying Chao, Lung-Shuo Wang, Jwu-Lai Yeh
Summary: The study found that puerarin, derived from the root of Pueraria lobate, has cardioprotective effects and can reduce the risk of cardiovascular disease in postmenopausal women. Puerarin alleviates cytotoxicity and oxidative stress, restores normal gene expression, and protects the heart from damage.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Biochemical Research Methods
Thi Kim Ngan Ngo, Cheng-Hsiang Kuo, Ting-Yuan Tu
Summary: Despite improvements in cancer immunotherapy, more study is needed. Microfluidic-based cancer immunotherapy-on-a-chip systems help researchers replicate the tumor microenvironment and immune system. This review summarizes recent advancements in microfluidic devices for cancer treatment and presents future perspectives on immunotherapy research.
Article
Plant Sciences
Yi-Ju Chen, Boon Huat Cheah, Chih-Yu Lin, Yu-Ting Ku, Cheng-Hsiang Kuo, Yuan-Yun Zhang, Bing-Rong Chen, Olga Nean, Cheng-Han Hsieh, Pei-Min Yeh, Freddy Kuok San Yeo, Ya-Ping Lin, Wen-Po Chuang, Cheng-Ruei Lee, Hieng-Ming Ting
Summary: We identified Mungbean genotypes resistant (R1) and susceptible (S1) to the common cutworm through screening. RNA-Seq data suggested the involvement of CaMK, MAPK and JA signaling in the defense response of R1 plants. R1 plants exhibited higher expression levels of defense-related genes and accumulated higher amounts of JA, tryptophan, and tyrosine, leading to the production of glucosylated kaempferols and emission of (E)-beta-ocimene. However, R1 plants showed lower drought tolerance and endogenous proline levels.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Nguyen Thi Nha Trang, Chao -Yang Lai, Hsiao-Chi Tsai, Yuan-Li Huang, Shan -Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Huey -En Tzeng, Chih-Hsin Tang
Summary: In this study, higher levels of APLN expression were found in osteosarcoma tissue compared to normal tissue, along with upregulation of PLOD2 mRNA synthesis. APLN increased PLOD2 expression and cell migration in osteosarcoma cell lines through MST1, MOB1, and YAP cascades, as well as through hsa_circ_0000004 acting as a sponge for miR-1303. Knockdown of APLN antagonized lung metastasis in mice with osteosarcoma. These findings suggest that APLN may be a potential therapeutic target for osteosarcoma metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jwu-Lai Yeh, Cheng-Hsiang Kuo, Po-Wen Shih, Jong-Hau Hsu, Peng I-Chen, Yi-Hsun Huang
Summary: This study investigated the effects of KMUP-1, a xanthine-based derivative, on retinopathy in vitro and in vivo. KMUP-1 showed anti-angiogenic, anti-inflammatory, and anti-apoptotic effects on hypoxic endothelium, reducing vascular endothelial growth factor (VEGF) expression and inhibiting endothelial migration and tube formation. KMUP-1 also increased the BCL-2/BAX ratio and decreased the expression of pro-inflammatory cytokines in the oxygen-induced retinopathy mouse retina samples.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Chian-Wei Chen, Chun-Ping Chang, Yi-Shuan Wen, Cheng-Hsiang Kuo, Shang-Wen Lin, Jui-Chen Tsai, Yan-Jye Shyong
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu
Summary: CD248 expression in melanoma cells promotes malignant transformation by increasing the activity of cell adhesion, migration, and vascular mimicry, whereas rCD248 protein functions as a molecular decoy interfering with tumor-promoting effects of CD248 in melanoma cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)