Dynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

Two Pathways Mediate Interdomain Allosteric Regulation in Pin1

(2015) Jingjing Guo et al.   STRUCTURE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites

(2014) Guido Scarabelli et al.   BIOPHYSICAL JOURNAL

Integrating protein structural dynamics and evolutionary analysis with Bio3D

(2014) Lars Skjærven et al.   BMC BIOINFORMATICS

A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in Gαi1

(2014) Tarjani M. Thaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric GiProtein α Subunit

(2014) Ali I. Kaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis on long-range residue-residue communication using molecular dynamics

(2014) Sangwook Wu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Domain-Opening and Dynamic Coupling in the α-Subunit of Heterotrimeric G Proteins

(2013) Xin-Qiu Yao et al.   BIOPHYSICAL JOURNAL

Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells

(2013) Rabia U. Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energetic analysis of the rhodopsin–G-protein complex links the α5 helix to GDP release

(2013) Nathan S Alexander et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia

(2013) M. Andrew Nesbit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mapping the Structural and Dynamical Features of Kinesin Motor Domains

(2013) Guido Scarabelli et al.   PLoS Computational Biology

Exploring Residue Component Contributions to Dynamical Network Models of Allostery

(2012) Adam T. VanWart et al.   Journal of Chemical Theory and Computation

Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar G  proteins

(2012) J. C. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities

(2012) P. M. Gasper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ins and outs of pertussis toxin

(2011) Camille Locht et al.   FEBS Journal

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

(2011) N. Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural flexibility of the G s  -helical domain in the  2-adrenoceptor Gs complex

(2011) G. H. Westfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of a Self-Activating G Protein   Subunit Reveals Its Distinct Mechanism of Signal Initiation

(2011) J. C. Jones et al.   Science Signaling

Long-Range Intra-Protein Communication Can Be Transmitted by Correlated Side-Chain Fluctuations Alone

(2011) Kateri H. DuBay et al.   PLoS Computational Biology

Helix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in GαiSubunits†,‡

(2009) Anita M. Preininger et al.   BIOCHEMISTRY

Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins

(2009) Neeraj Kapoor et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamical networks in tRNA:protein complexes

(2009) A. Sethi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the Nucleotide and Isoform-Dependent Structural and Dynamical Features of Ras Proteins

(2008) Alemayehu A. Gorfe et al.   STRUCTURE

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY