Article
Biochemistry & Molecular Biology
Natalia Kudryavtseva, Aleksey Ermolaev, Anton Pivovarov, Sergey Simanovsky, Sergey Odintsov, Ludmila Khrustaleva
Summary: Meiotic crossovers/chiasmata are not randomly distributed and are strictly controlled. The distribution of crossovers in Allium cepa and Allium fistulosum is determined by the parental locations. The localization of crossovers in F-1 hybrids is genetically controlled, and other factors also affect crossover distribution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Alexandra Pyatnitskaya, Jessica Andreani, Raphael Guerois, Arnaud De Muyt, Valerie Borde
Summary: This study uncovers the functional link between crossover formation and synaptonemal complex (SC) assembly during meiotic recombination and identifies the molecular mechanism involved.
GENES & DEVELOPMENT
(2022)
Editorial Material
Biochemistry & Molecular Biology
Meret Arter, Scott Keeney
Summary: A new study has discovered an elegant mechanism that tetraploid Arabidopsis arenosa plants evolved to accurately connect and separate pairs of homologous chromosomes.
Article
Multidisciplinary Sciences
Azahara C. Martin, Abdul Kader Alabdullah, Graham Moore
Summary: The study reveals the critical role of TaZIP4-B2 in wheat, as well as the potential value of the 'separation-of-function' mutant line zip4-ph1d in wheat breeding.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pavel Merkulov, Sofya Gvaramiya, Maxim Dudnikov, Roman Komakhin, Murad Omarov, Alina Kocheshkova, Zakhar Konstantinov, Alexander Soloviev, Gennady Karlov, Mikhail Divashuk, Ilya Kirov
Summary: Transposable element insertions (TEIs) are important for genomic innovation in plants, but identifying and tracking these insertions in complex genomes has been challenging. In this study, researchers combined Cas9-targeted Nanopore sequencing (CANS) with a novel pipeline called NanoCasTE to successfully trace both genetically inherited and somatic TEIs in plants. The study revealed the role of DNA methylation in shaping insertion preference and identified preferential targeting of genes downregulated during heat stress by the ONSEN transposon family. Hypomethylation of novel somatic insertions for two ONSENs was also detected. The study demonstrates the effectiveness of CANS and NanoCasTE in detecting TEIs and exploring mobilome organization in plants under stress and in different genetic backgrounds.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Chemistry, Physical
Rafal Bielas, Justyna Wrobel-Marek, Ewa U. Kurczynska, Dorota Neugebauer
Summary: A rhodamine B (RhB)-based initiator was synthesized and applied for preparation of PChMA, PHEMA, and PHEMATMS. The fluorescence of the polymers was confirmed by quantum yield determination, and it was found that the emission intensity depended on the polymer chain hydrophilicity and solvent type. The RhB-functionalized polymers were tested in plant materials and showed different cellular localizations.
Article
Biochemistry & Molecular Biology
Keyi Wang, Hui Tian, Lequn Wang, Lin Wang, Yacong Tan, Ziting Zhang, Kai Sun, Meng Yin, Qinggong Wei, Baohua Guo, Jinyu Han, Peiru Zhang, Han Li, Yulong Liu, Hongwei Zhao, Xiaoyong Sun
Summary: This study provides insights into the nature and origin of eccDNA in plants, showing that eccDNA is not only related to transposon activity, but also contains tRNA genes, suggesting a potential link to tRNA abundance and protein synthesis control under stress conditions.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Longfei Zhu, Nadia Fernandez-Jimenez, Maja Szymanska-Lejman, Alexandre Pele, Charles J. Underwood, Heidi Serra, Christophe Lambing, Julia Dluzewska, Tomasz Bieluszewski, Monica Pradillo, Ian R. Henderson, Piotr A. Ziolkowski
Summary: This study reveals the importance of the SMC5/6 complex in ensuring the proper progress of meiotic recombination in plants, showing the impact of SNI1 mutations and interactions with other genes on crossover distribution.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Dmitri Demidov, Inna Lermontova, Michael Moebes, Andriy Kochevenko, Joerg Fuchs, Oda Weiss, Twan Rutten, Eberhard Sorge, Erika Zuljan, Ricardo Fabiano Hettwer Giehl, Martin Mascher, Saravanakumar Somasundaram, Udo Conrad, Andreas Houben
Summary: Targeted degradation of CENH3 protein can be used to generate haploids in Arabidopsis thaliana. By using a recombinant anti-GFP nanobody fused to ligase proteins, EYFP-tagged CENH3 can be recognized and degraded through the ubiquitin-proteasome pathway. This strategy achieves a haploid frequency of up to 7.6%.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Marie Sarens, Gregory P. Copenhaver, Nico De Storme
Summary: A new method was introduced to quantitatively express chromatid interference (CI) and research showed random involvement of sister chromatids in double CO events across chromosomes in Arabidopsis and maize, indicating an absence of CI. However, on a genome-wide level, CI was found to vary with physical distance between COs, with differing effects in the two plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Xiang Li, Mingsen Yu, Pablo Bolanos-Villegas, Jun Zhang, Di'an Ni, Hong Ma, Yingxiang Wang
Summary: The study revealed the crucial role of FANCM in shaping the distribution of meiotic Class-I crossovers in plants, with evolutionary divergent roles observed between Arabidopsis and lettuce in meiotic bivalent formation.
Article
Biotechnology & Applied Microbiology
Qinghao Zhang, Bo Jiang, Luke Nelson, Steven Huhn, Zhimei Du, Lawrence A. Chasin
Summary: CHO8A, a multiauxotrophic mutant of CHO-K1 cells, was created by restoring the prototrophy of the cells through transfection of complementary DNA-based genes. This cell line allows for the selection of transfectant clones with multiple polypeptide genes, as well as the single-step selection of high producers of a specific protein.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Multidisciplinary Sciences
Qichao Lian, Victor Solier, Birgit Walkemeier, Stephanie Durand, Bruno Huettel, Korbinian Schneeberger, Raphael Mercier
Summary: This study reveals the recombination landscape in the genome of Arabidopsis and its relationship with polymorphisms. The results show that the recombination frequency varies along different chromosomal regions and is highly correlated with sequence divergence. However, polymorphisms are not the main determinant of the shape of the recombination landscape. Instead, it is predominantly influenced by chromatin accessibility and DNA methylation. In inbred lines with minimal polymorphisms, the megabase-scale recombination landscape is similar to that in hybrids, except for cases where heterozygous large rearrangements prevent recombination locally. These findings provide new insights into the relationship between recombination landscape and polymorphisms.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dong Liang, Pengju Zhao, Jingfang Si, Lingzhao Fang, Erola Pairo-Castineira, Xiaoxiang Hu, Qing Xu, Yali Hou, Yu Gong, Zhengwen Liang, Bing Tian, Huaming Mao, Marnoch Yindee, Md Omar Faruque, Siton Kongvongxay, Souksamlane Khamphoumee, George E. Liu, Dong-Dong Wu, James Stuart F. Barker, Jianlin Han, Yi Zhang
Summary: This study revealed that a 2,809-bp-long LINE-1 insertion in the ASIP gene is the causative mutation for the white coat phenotype in swamp buffalo. This LINE-1 insertion acts as a strong proximal promoter leading to increased transcription of ASIP, which prevents melanocyte maturation and results in absence of pigment in white buffalo skin and hairs. Phylogenetic analyses suggest the white buffalo-specific ASIP allele originated from a recent genetic transposition event. Furthermore, a similar LINE-1 insertion was identified in the cattle ASIP gene, indicating a convergent mechanism of coat color evolution in the Bovini tribe.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Computer Science, Information Systems
Rusan Kumar Barik, Slawomir Koziel, Eirikur Bernhardsson
Summary: This paper proposes an efficient and simple passive reconfiguration technique to adjust the operating frequency of a branch-line crossover (BLCO). The technique involves filling rectangular dielectric channels (RDCs) with air or materials of different relative permittivity to modify the operating frequency. The size and positions of the RDCs are optimized using electromagnetic simulations to achieve maximum tunability range and reasonable bandwidth. Two prototypes are realized to validate the computational models, with the first prototype exhibiting a frequency tuning range of 15.8% and the second prototype featuring a tuning range of 36.9%.
Article
Plant Sciences
Hanaki Maeda, Koharu Takahashi, Yoshifumi Ueno, Kei Sakata, Akari Yokoyama, Kozue Yarimizu, Fumiyoshi Myouga, Kazuo Shinozaki, Shin-Ichiro Ozawa, Yuichiro Takahashi, Ayumi Tanaka, Hisashi Ito, Seiji Akimoto, Atsushi Takabayashi, Ryouichi Tanaka
Summary: The assembly process of PSII in plants requires various auxiliary proteins to form intermediates, including OHP1, OHP2, and HCF244 proteins along with D1, D2 subunits. Analysis of the OHP1 complexes revealed their composition and ability to bind chlorophylls and carotenoids for quenching. These auxiliary proteins play a crucial role in acclimating plants to high-light conditions by maintaining the yields of PSII.
JOURNAL OF PLANT RESEARCH
(2022)
Article
Plant Sciences
Takashi Kuromori, Miki Fujita, Fuminori Takahashi, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki
Summary: Plants respond to drought stress through intracellular regulation of gene expression and signaling, as well as inter-tissue and inter-organ signaling, which helps enhance stress resistance. Abscisic acid is a key phytohormone involved in drought stress response, primarily synthesized in vascular tissues and guard cells of leaves, regulating stomatal closure and stress-related gene expression for drought stress resistance. Multiple sensors detect molecular patterns of abiotic stress signals, transmitting them through separate signaling networks to induce downstream responses such as stomatal closure and synthesis of stress-related proteins and metabolites.
Article
Biochemistry & Molecular Biology
Kaoru Urano, Kyonoshin Maruyama, Tomotsugu Koyama, Nathalie Gonzalez, Dirk Inze, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki
Summary: This study reveals that the dehydration-inducible Arabidopsis CIN-like TCP gene, TCP13, plays a crucial role in inducing morphological changes and regulating growth in leaves and roots, thus conferring dehydration stress tolerance in plants.
PLANT MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
June-Sik Kim, Yuki Sakamoto, Fuminori Takahashi, Michitaro Shibata, Kaoru Urano, Sachihiro Matsunaga, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki
Summary: In this study, NOBIRO6/TAF12b was identified as a transcription cofactor that interacts with bZIP60, contributing to the control of environment-responsive root growth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Physical
Akio Sayano, Kazuo Shinozaki, Hiroyuki Ohshima, Kouichi Yasuda, Takaaki Tsurumi
Summary: The Hamaker constant is theoretically constant, but experimental results show significant variability. This is due to changes in the composition and structure of the particle surface layer, which affect the Hamaker constant.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Correction
Biochemistry & Molecular Biology
Kaoru Urano, Kyonoshin Maruyama, Tomotsugu Koyama, Nathalie Gonzalez, Dirk Inze, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki
PLANT MOLECULAR BIOLOGY
(2022)
Article
Plant Sciences
Khurram Bashir, Daisuke Todaka, Sultana Rasheed, Akihiro Matsui, Zarnab Ahmad, Kaori Sako, Yoshinori Utsumi, Anh Thu Vu, Maho Tanaka, Satoshi Takahashi, Junko Ishida, Yuuri Tsuboi, Shunsuke Watanabe, Yuri Kanno, Eigo Ando, Kwang-Chul Shin, Makoto Seito, Hinata Motegi, Muneo Sato, Rui Li, Saya Kikuchi, Miki Fujita, Miyako Kusano, Makoto Kobayashi, Yoshiki Habu, Atsushi J. Nagano, Kanako Kawaura, Jun Kikuchi, Kazuki Saito, Masami Yokota Hirai, Mitsunori Seo, Kazuo Shinozaki, Toshinori Kinoshita, Motoaki Seki
Summary: This study demonstrates that exogenous application of ethanol can significantly enhance drought tolerance in Arabidopsis thaliana, rice, and wheat. Ethanol treatment leads to the upregulation of genes related to sugar and phenylpropanoid metabolism, as well as the accumulation of sugars and drought-tolerance-related amino acids. Ethanol treatment induces stomatal closure and decreases transpiration rate, resulting in enhanced drought tolerance. ABA signaling and acetic acid biosynthesis are involved in ethanol-mediated drought tolerance.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomoyuki Takeda, Kazumasa Shirai, You-wang Kim, Mieko Higuchi-Takeuchi, Minami Shimizu, Takayuki Kondo, Tomokazu Ushijima, Tomonao Matsushita, Kazuo Shinozaki, Kousuke Hanada
Summary: A large-scale intergenomic gene transfer event in Arabidopsis thaliana created a small coding gene that regulates floral timing. This de novo gene derived from the mitochondrial genome has an important regulatory effect on floral transition. Transcriptomic and phenotypic analyses support these findings.
PLANT MOLECULAR BIOLOGY
(2023)
Review
Multidisciplinary Sciences
Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki
Summary: This review article describes the 30-year experience of the authors in using functional genomics to understand the sophisticated molecular mechanisms of plant response and adaptation to environmental stress conditions. They focused on drought-inducible genes and their regulation, as well as the perception and cellular signal transduction of stress signals. Key genes and factors involved in complex responses and tolerance to dehydration and temperature stresses were identified.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2022)
Retraction
Biochemistry & Molecular Biology
Lianwei Peng, Yoichiro Fukao, Fumiyoshi Myouga, Reiko Motohashi, Kazuo Shinozaki, Toshiharu Shikanai
Review
Plant Sciences
June-Sik Kim, Keiichi Mochida, Kazuo Shinozaki
Summary: This review provides an overview of the current knowledge on ER stress sensing, activation, and downstream regulation of the unfolded protein response (UPR). Recent studies have shown that the UPR is also involved in plant growth and development, and it modulates both plant growth and stress tolerance by maintaining ER homeostasis.
Article
Multidisciplinary Sciences
Satoshi Kidokoro, Izumi Konoura, Fumiyuki Soma, Kazuo Shinozaki, Takamasa Suzuki, Masaru Tanokura, Takuya Miyakawa, Takato Imaizumi, Kazuko Yamaguchi-Shinozaki
Summary: Plants respond to severe temperature changes by inducing the expression of numerous genes whose products enhance stress tolerance and responses. DREB1 genes are rapidly and strongly induced by cold stress and their molecular mechanisms are vital for recognizing the initial responses to cold stress in plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Materials Science, Ceramics
Haruki Zayasu, Takahiko Kawaguchi, Hiroki Nakane, Nobuyoshi Koshida, Kazuo Shinozaki, Hisao Suzuki, Naonori Sakamoto, Naoki Wakiya
Summary: Epitaxial growth of yttria-stabilized zirconia (YSZ) thin film on through-hole-type porous silicon (tht-PSi(001)) was achieved, and the strain applied to the YSZ thin film was found to affect the ionic conduction.
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2022)
Article
Plant Sciences
Fabiane Kletke de Oliveira, Cristiane Jovelina Da-Silva, Natalia Garcia, Darwin Alexis Pomagualli Agualongo, Ana Claudia Barneche de Oliveira, Norihito Kanamori, Hironori Takasaki, Kaoru Urano, Kazuo Shinozaki, Kazuo Nakashima, Kazuko Yamaguchi-Shinozaki, Alexandre Lima Nepomuceno, Liliane Marcia Mertz Henning, Luciano do Amarante
Summary: Soil waterlogging has a major impact on plant growth and agricultural productivity. This study found that overexpression of the NCED gene increases the sensitivity of soybean plants to waterlogging and reoxygenation, leading to increased lipid peroxidation levels, decreased antioxidant activity and alcohol dehydrogenase activity, as well as reduced seed weight and grain yield.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
